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CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16652147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17377532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20100835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9751710"}],"value":"Heterodimer with CBFB. RUNX3 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization (By similarity). Interacts with TLE1 and SUV39H1 (PubMed:16652147, PubMed:9751710). The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain) (PubMed:20100835). Interacts with FYN and LCK (PubMed:20100835). Interacts with FOXP3 (PubMed:17377532). Interacts with ZFHX3 (PubMed:20599712). 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