{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P23443","secondaryAccessions":["B2R779","B4DLT4","B4DTG1","E7ESB8","F6UYM1","Q7Z721"],"uniProtkbId":"KS6B1_HUMAN","entryAudit":{"firstPublicDate":"1991-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-10-11","entryVersion":239,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ribosomal protein S6 kinase beta-1"},"shortNames":[{"value":"S6K-beta-1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22017876"}],"value":"S6K1"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15899889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18952604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28178239"}],"value":"2.7.11.1"}]},"alternativeNames":[{"fullName":{"value":"70 kDa ribosomal protein S6 kinase 1"},"shortNames":[{"value":"P70S6K1"},{"value":"p70-S6K 1"}]},{"fullName":{"value":"Ribosomal protein S6 kinase I"}},{"fullName":{"value":"Serine/threonine-protein kinase 14A"}},{"fullName":{"value":"p70 ribosomal S6 kinase alpha"},"shortNames":[{"value":"p70 S6 kinase alpha"},{"value":"p70 S6K-alpha"},{"value":"p70 S6KA"}]}]},"genes":[{"geneName":{"value":"RPS6KB1"},"synonyms":[{"value":"STK14A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P67999"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BSK8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11500364"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12801526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14673156"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15071500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15341740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15899889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16286006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17052453"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17053147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18952604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19720745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19935711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19995915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22017876"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23429703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28178239"}],"value":"Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:22017876, PubMed:23429703, PubMed:28178239). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (PubMed:16286006). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (PubMed:16286006). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (PubMed:16286006). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (PubMed:17053147). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (PubMed:15341740). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (PubMed:11500364). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (PubMed:15899889, PubMed:19720745, PubMed:19935711, PubMed:19995915). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (PubMed:17936702). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (PubMed:17936702). Mediates TNF-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (PubMed:17052453). May be involved in cytoskeletal rearrangement through binding to neurabin (By similarity). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15899889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18952604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28178239"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18952604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28178239"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17446865"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19570988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28178239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9445476"}],"value":"Activation requires multiple phosphorylation events on serine/threonine residues. Activation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits activating phosphorylation at Thr-412. Activated by PDPK1"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P67999"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12150926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12801526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15341740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16286006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18952604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26496226"}],"value":"Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR (PubMed:12150926). Interacts with IRS1 (PubMed:18952604). Interacts with EIF3B and EIF3C (PubMed:16286006). Interacts with TRAF4 (PubMed:12801526). Interacts with POLDIP3 (PubMed:15341740). Interacts (via N-terminus) with IER5 (PubMed:26496226)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32295907"}],"value":"(Microbial infection) Interacts with Mumps virus phosphoprotein; this interaction may play a role in the viral replication and transcription"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"Q06481-5","geneName":"APLP2","intActId":"EBI-25646567"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"P55884","geneName":"EIF3B","intActId":"EBI-366696"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"P08151","geneName":"GLI1","intActId":"EBI-308084"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"Q5VY09","geneName":"IER5","intActId":"EBI-1774000"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"P42345","geneName":"MTOR","intActId":"EBI-359260"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"Q00005","geneName":"PPP2R2B","intActId":"EBI-1052159"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"Q8N122","geneName":"RPTOR","intActId":"EBI-1567928"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443","intActId":"EBI-1775921"},"interactantTwo":{"uniProtKBAccession":"P13051-2","geneName":"UNG","intActId":"EBI-25834258"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443-2","intActId":"EBI-6093204"},"interactantTwo":{"uniProtKBAccession":"P08151","geneName":"GLI1","intActId":"EBI-308084"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443-4","intActId":"EBI-25882353"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P23443-4","intActId":"EBI-25882353"},"interactantTwo":{"uniProtKBAccession":"P27986-2","geneName":"PIK3R1","intActId":"EBI-9090282"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Colocalizes with URI1 at mitochondrion"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Synapse, synaptosome","id":"SL-0261"}},{"location":{"value":"Mitochondrion outer membrane","id":"SL-0172"}},{"location":{"value":"Mitochondrion","id":"SL-0173"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Alpha I","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform Alpha II","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"Alpha I"},"synonyms":[{"value":"p80-S6K 1"}],"isoformIds":["P23443-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"Alpha II"},"isoformIds":["P23443-2"],"sequenceIds":["VSP_018839"],"isoformSequenceStatus":"Described"},{"name":{"value":"2"},"isoformIds":["P23443-3"],"sequenceIds":["VSP_054613"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P23443-5"],"sequenceIds":["VSP_055026"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P23443-4"],"sequenceIds":["VSP_054614"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804755"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The TOS (TOR signaling) motif is essential for activation by mTORC1"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17936702"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18925875"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19864428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22017876"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23429703"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29236692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9445476"}],"value":"Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism (PubMed:18925875, PubMed:19085255, PubMed:22017876, PubMed:23429703, PubMed:29236692). Activated by phosphorylation at Thr-252 by PDPK1 (PubMed:19864428, PubMed:9445476). Dephosphorylation by PPP1CC at Thr-412 in mitochondrion (PubMed:17936702)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Ribosomal protein S6 kinase beta-1","featureId":"PRO_0000024342"},{"type":"Domain","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Domain","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"AGC-kinase C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"Autoinhibitory domain"},{"type":"Motif","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"TOS motif"},{"type":"Compositional bias","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Phosphothreonine; by PDPK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19864428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9445476"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"}]},{"type":"Modified residue","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Phosphothreonine; by MTOR, NEK6 and NEK7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29236692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29750193"}]},{"type":"Modified residue","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P67999"}]},{"type":"Modified residue","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19085255"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":516,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P67999"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054613","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in isoform Alpha II","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1922062"}],"featureId":"VSP_018839","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_055026","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_054614","alternativeSequence":{"originalSequence":"PVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL","alternativeSequences":["TAMC"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040639","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in dbSNP:rs766645749","featureCrossReferences":[{"database":"dbSNP","id":"rs766645749"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040640","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_040641","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in a colorectal cancer sample; 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