{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UBF6","secondaryAccessions":["A8K1H9","A8MTB5","C9JYL3","D3DNF7","D3DNF8","Q9BXN8","Q9Y5M7"],"uniProtkbId":"RBX2_HUMAN","entryAudit":{"firstPublicDate":"2003-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-01","entryVersion":199,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11506706"}],"value":"RING-box protein 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11506706"}],"value":"Rbx2"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16874460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33268465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34518685"}],"value":"2.3.2.27"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19250909"}],"value":"2.3.2.32"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12748192"}],"value":"CKII beta-binding protein 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12748192"}],"value":"CKBBP1"}]},{"fullName":{"value":"RING finger protein 7"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10230407"}],"value":"Regulator of cullins 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10512750"}],"value":"Sensitive to apoptosis gene protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10070"}],"value":"RNF7"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11506706"}],"value":"RBX2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10230407"}],"value":"ROC2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10512750"}],"value":"SAG"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WTZ1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10082581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19250909"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21980433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25505247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27910872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33268465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34518685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35512830"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38418882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38574733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40440427"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40963025"}],"value":"Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830, PubMed:40440427, PubMed:40963025). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:21980433, PubMed:33268465, PubMed:38418882, PubMed:38574733). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:21980433, PubMed:33268465). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (PubMed:34518685). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (PubMed:21980433, PubMed:25505247). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (By similarity). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (PubMed:33268465). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (PubMed:38418882). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (PubMed:40440427). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (PubMed:27910872). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (PubMed:34518685, PubMed:38418882). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (PubMed:40963025). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (PubMed:19250909). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (PubMed:19250909). May play a role in protecting cells from apoptosis induced by redox agents (PubMed:10082581)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11506706"}],"value":"Inactive"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22190037"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23300442"}],"value":"(Microbial infection) Following infection by HIV-1 virus, catalytic component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, which catalyzes ubiquitination and degradation of APOBEC3F and APOBEC3G"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16874460"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33268465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34518685"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.","ecNumber":"2.3.2.32","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19250909"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23300442"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21980433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25505247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27910872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33268465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38418882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38574733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40440427"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19250909"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23300442"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40963025"}],"value":"Protein modification; protein neddylation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10230407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10512750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10851089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19250909"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21980433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24337577"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25505247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27910872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31387940"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33268465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35512830"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38418882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38574733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40440427"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40963025"}],"value":"Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes) composed of CUL5, Elongin BC (ELOB and ELOC), RNF7/RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component (PubMed:10230407, PubMed:21980433, PubMed:24337577, PubMed:25505247, PubMed:27910872, PubMed:31387940, PubMed:33268465, PubMed:38418882, PubMed:38574733, PubMed:35512830, PubMed:40440427, PubMed:40963025). Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B; additional evidence is however required to confirm this result in vivo (PubMed:10230407, PubMed:10851089). Interacts with UBE2F (PubMed:19250909). Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2 (PubMed:10512750). May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5 (PubMed:26906416)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22190037"}],"value":"(Microbial infection) Following infection by HIV-1 virus, component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"Q9Y576","geneName":"ASB1","intActId":"EBI-2323092"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"Q9NWX5","geneName":"ASB6","intActId":"EBI-6425205"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"Q9H672","geneName":"ASB7","intActId":"EBI-3916346"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"Q93034","geneName":"CUL5","intActId":"EBI-1057139"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"Q9Y6K9","geneName":"IKBKG","intActId":"EBI-81279"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"P12004","geneName":"PCNA","intActId":"EBI-358311"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UBF6","intActId":"EBI-398632"},"interactantTwo":{"uniProtKBAccession":"P12504","geneName":"vif","intActId":"EBI-779991"},"numberOfExperiments":4,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10082581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16874460"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10082581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16874460"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9UBF6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11506706"}],"value":"SAG-v"}],"isoformIds":["Q9UBF6-2"],"sequenceIds":["VSP_008449"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9UBF6-3"],"sequenceIds":["VSP_041444"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q9UBF6-4"],"sequenceIds":["VSP_044525"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10512750"}],"value":"Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10082581"}],"value":"By 1,10-phenanthroline"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34518685"}],"value":"The RING-type zinc finger domain is essential for ubiquitin ligase activity (PubMed:34518685). It coordinates an additional third zinc ion (PubMed:34518685)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10512750"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12748192"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16874460"}],"value":"Phosphorylation at Thr-10 by CK2 promotes its degradation by the proteasome"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the RING-box family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44108/RNF7","ftp":false}],"features":[{"type":"Initiator 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