{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P41220","secondaryAccessions":["Q6I9U5"],"uniProtkbId":"RGS2_HUMAN","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":218,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Regulator of G protein signaling 2"},"shortNames":[{"value":"RGS2"}]},"alternativeNames":[{"fullName":{"value":"Cell growth-inhibiting gene 31 protein"}},{"fullName":{"value":"G0/G1 switch regulatory protein 8"}}]},"genes":[{"geneName":{"value":"RGS2"},"synonyms":[{"value":"G0S8"}],"orfNames":[{"value":"GIG31"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O08849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11063746"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11278586"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17901199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19736320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28784619"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7643615"}],"value":"Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14608379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18434541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19478087"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19736320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25970626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28784619"}],"value":"Interacts with GNAQ (PubMed:18434541, PubMed:19478087, PubMed:28784619). Does not interact with GNAI1 and GNAI3 (PubMed:18434541, PubMed:19478087). Interacts with EIF2B5 (PubMed:19736320). Interacts with PRKG1 (isoform alpha) (PubMed:14608379). 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Phosphorylation by PRKG1 leads to activation of RGS2 activity. Phosphorylation of Ser-3 protects RGS2 from FBXO44-mediated proteasomal degradation (PubMed:33008920)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25970626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33008920"}],"value":"Ubiquitinated by the cullin-RING ligase (CRL) complex composed of CUL4B, DDB1 and FBXO44; ubiquitination leads to RGS2 proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Lacks type V adenylyl cyclase (AC) inhibitory function"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Lacks type V adenylyl cyclase (AC) inhibitory function"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 4"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42102/RGS2","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Regulator of G protein signaling 2","featureId":"PRO_0000204178"},{"type":"Domain","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"RGS","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00171"}]},{"type":"Region","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Necessary for membrane association","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11278586"}]},{"type":"Region","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Necessary to inhibit protein synthesis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19736320"}]},{"type":"Modified residue","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33008920"}]},{"type":"Cross-link","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33008920"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17901199"}],"featureId":"VSP_041298","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17901199"}],"featureId":"VSP_041297","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17901199"}],"featureId":"VSP_041296","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"found in hypertensive patients; 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