{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NS23","secondaryAccessions":["B7ZLL1","O14571","O60539","O60710","Q0VGC6","Q5TZT2","Q9HB04","Q9HB18","Q9NS22","Q9UND4","Q9UND5"],"uniProtkbId":"RASF1_HUMAN","entryAudit":{"firstPublicDate":"2004-07-19","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-10-01","entryVersion":203,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ras association domain-containing protein 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF35128.2"}],"value":"RASSF1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAC16001.1"}],"value":"RDA32"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12024041"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14743218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15109305"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15949439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16510573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21199877"}],"value":"Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q99MK9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11857081"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14729613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14743218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15109305"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15205320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15753381"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15949439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16510573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21199877"}],"value":"Interacts with MAP1S (PubMed:15205320, PubMed:15753381). Interacts with XPA (PubMed:10888881). Binds to the N-terminal of CDC20 during prometaphase (PubMed:14743218). Binds to STK3/MST2 and STK4/MST1 (PubMed:15109305, PubMed:16510573, PubMed:21199877). Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (PubMed:15949439). Can self-associate (PubMed:11857081). Part of a complex with MDM2, DAXX, RASSF1 and USP7 (PubMed:18566590). Interacts with ECM2 (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q99MK9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11857081"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14729613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15949439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"}],"value":"Interacts with MOAP1 (PubMed:15949439). Interacts with E4F1 (PubMed:14729613). Interacts with RSSF5 and probably associates with HRAS via a RSSF1 isoform A-RSSF5 heterodimer (PubMed:11857081). Interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53 (PubMed:18566590). Interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53 (PubMed:18566590). Interacts with RAB39A (By similarity). Interacts with RAB39B; the interaction is weak (By similarity)"}],"commentType":"SUBUNIT","molecule":"Isoform A"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q99MK9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"}],"value":"Interacts (via N-terminus) with DAXX (PubMed:18566590). Interacts with RAB39B; the interaction is strong (By similarity). Does not interact with RAB39A (By similarity)"}],"commentType":"SUBUNIT","molecule":"Isoform C"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18566590"}],"value":"Interacts (via N-terminus) with DAXX"}],"commentType":"SUBUNIT","molecule":"Isoform H"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"P31749","geneName":"AKT1","intActId":"EBI-296087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"O95166","geneName":"GABARAP","intActId":"EBI-712001"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"P60520","geneName":"GABARAPL2","intActId":"EBI-720116"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"O60341","geneName":"KDM1A","intActId":"EBI-710124"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"Q9GZQ8","geneName":"MAP1LC3B","intActId":"EBI-373144"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"Q9BXW4","geneName":"MAP1LC3C","intActId":"EBI-2603996"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"Q00987","geneName":"MDM2","intActId":"EBI-389668"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23","intActId":"EBI-367363"},"interactantTwo":{"uniProtKBAccession":"O43463","geneName":"SUV39H1","intActId":"EBI-349968"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q12834","geneName":"CDC20","intActId":"EBI-367462"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q66K89","geneName":"E4F1","intActId":"EBI-1227043"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q01844","geneName":"EWSR1","intActId":"EBI-739737"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"P01112","geneName":"HRAS","intActId":"EBI-350145"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q9NS23-2","geneName":"RASSF1","intActId":"EBI-438698"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q13188","geneName":"STK3","intActId":"EBI-992580"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-2","intActId":"EBI-438698"},"interactantTwo":{"uniProtKBAccession":"Q13043","geneName":"STK4","intActId":"EBI-367376"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"P02649","geneName":"APOE","intActId":"EBI-1222467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"P54252","geneName":"ATXN3","intActId":"EBI-946046"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"Q9UER7","geneName":"DAXX","intActId":"EBI-77321"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"G5E9A7","geneName":"DMWD","intActId":"EBI-10976677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"P50570-2","geneName":"DNM2","intActId":"EBI-10968534"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"P41091","geneName":"EIF2S3","intActId":"EBI-1054228"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NS23-4","intActId":"EBI-438710"},"interactantTwo":{"uniProtKBAccession":"P22607","geneName":"FGFR3","intActId":"EBI-348399"},"numberOfExperiments":3,"organismD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Colocalizes with MDM2 in the nucleus"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"value":"Cytoplasm, cytoskeleton, spindle pole","id":"SL-0448"}},{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform C","note":{"texts":[{"value":"Predominantly nuclear"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing"],"isoforms":[{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"D"},"synonyms":[{"value":"RASSF1D"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"Cardiac-specific"}],"isoformIds":["Q9NS23-1"],"isoformSequenceStatus":"Displayed"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"A"},"synonyms":[{"value":"RASSF1A"}],"isoformIds":["Q9NS23-2"],"sequenceIds":["VSP_050771"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"}],"value":"B"},"synonyms":[{"value":"RASSF1B"}],"isoformIds":["Q9NS23-3"],"sequenceIds":["VSP_050770"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"C"},"synonyms":[{"value":"RASSF1C"}],"isoformIds":["Q9NS23-4"],"sequenceIds":["VSP_050773","VSP_050774"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"E"},"synonyms":[{"value":"RASSF1E"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"Pancreas-specific"}],"isoformIds":["Q9NS23-5"],"sequenceIds":["VSP_050771","VSP_050772"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"F"},"synonyms":[{"value":"RASSF1F"}],"isoformIds":["Q9NS23-6"],"sequenceIds":["VSP_050776","VSP_050777"],"isoformSequenceStatus":"Described"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"G"},"synonyms":[{"value":"RASSF1G"}],"isoformIds":["Q9NS23-7"],"sequenceIds":["VSP_050775","VSP_050778"],"isoformSequenceStatus":"Described"},{"name":{"value":"H"},"isoformIds":["Q9NS23-9"],"sequenceIds":["VSP_050773","VSP_050774","VSP_050778"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10888881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11333291"}],"value":"Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Produced by alternative promoter usage"}],"commentType":"MISCELLANEOUS","molecule":"Isoform D"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative splicing of isoform D"}],"commentType":"MISCELLANEOUS","molecule":"Isoform A"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative splicing of isoform D"}],"commentType":"MISCELLANEOUS","molecule":"Isoform B"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative promoter usage"}],"commentType":"MISCELLANEOUS","molecule":"Isoform C"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative splicing of isoform D"}],"commentType":"MISCELLANEOUS","molecule":"Isoform E"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative splicing of isoform 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