{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P62826","secondaryAccessions":["A8K3Z8","P17080","P28746","P28747","Q6IPB2","Q86V08","Q8NI90","Q9CSP3","Q9CWI7","Q9CZA2","Q9UDJ5","Q9UEU9"],"uniProtkbId":"RAN_HUMAN","entryAudit":{"firstPublicDate":"2004-08-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":228,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"GTP-binding nuclear protein Ran"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"}],"value":"3.6.5.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10400640"}],"value":"Androgen receptor-associated protein 24"}},{"fullName":{"value":"GTPase Ran"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2108320"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8276887"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8421051"}],"value":"Ras-like protein TC4"}},{"fullName":{"value":"Ras-related nuclear protein"}}]},"genes":[{"geneName":{"value":"RAN"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10400640"}],"value":"ARA24"}],"orfNames":[{"value":"OK/SW-cl.81"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10408446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11336674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17209048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18617507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20485264"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27306458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7819259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8276887"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8421051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8692944"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8896452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9351834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9428644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26272610"}],"value":"GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"}],"value":"Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P62825"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P62827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10209022"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10400640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10679025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11336674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11425870"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11571268"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12808100"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14500717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14684163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15574331"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16428860"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18611384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18617507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19505478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1961752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19753112"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20485264"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23878195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26304119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29130391"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7819259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7891706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8896452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9351834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9428644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"value":"Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis (PubMed:7819259, PubMed:9428644). Interacts with KPNB1 (PubMed:10367892, PubMed:8896452, PubMed:9428644). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity (PubMed:9428644). Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP (PubMed:11336674, PubMed:12194828, PubMed:1961752, PubMed:7819259). Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP (PubMed:8896452). Interacts (GTP-bound form) with TNPO1; the interaction is direct (PubMed:9351834). Interacts (GTP-bound form) with TNPO3; the interaction is direct (PubMed:23878195, PubMed:24449914, PubMed:24915079). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity (PubMed:8896452, PubMed:9428644). Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity (PubMed:11832950, PubMed:7891706, PubMed:8896452, PubMed:9428644). Interacts with RANGRF, which promotes the release of bound guanine nucleotide (PubMed:29040603). RANGRF and RCC1 compete for an overlapping binding site on RAN (PubMed:29040603). Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:9428644). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1 (PubMed:9428644). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a nuclear export complex with XPO1 (PubMed:10209022, PubMed:15574331, PubMed:9323133). Found in a nuclear export complex with RANBP3 and XPO1 (PubMed:11425870, PubMed:11571268). Interacts with RANBP2/NUP358 (PubMed:10078529, PubMed:26272610). Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (PubMed:10209022, PubMed:19389996). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717). Interacts with RANBP9 and RANBP10 (PubMed:14684163). Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle (PubMed:18591255). Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus (PubMed:12808100). Interacts with MAD2L2 (PubMed:19753112). Interacts with VRK1 and VRK3 (PubMed:18617507). Interacts with isoform 1 and isoform 2 of VRK2 (PubMed:18617507). Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (PubMed:10679025, PubMed:18266911, PubMed:9822603). Interacts with CAPG; mediates CAPG nuclear import (PubMed:10679025, PubMed:18266911). Interacts with NUP153 (PubMed:18611384, PubMed:19505478). Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (PubMed:10400640). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (PubMed:26304119). Interacts with EPG5 (PubMed:29130391)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9837918"}],"value":"(Microbial infection) In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14612415"}],"value":"(Microbial infection) Found in a complex with HTLV-1 Rex, RANBP3 and XPO1"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25331866"}],"value":"(Microbial infection) Interacts with Mengo encephalomyocarditis virus Leader protein; the complex L-RAN recruits cellular kinases responsible for the L-induced nucleocytoplasmic trafficking inhibition"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9Y614","geneName":"ACTL7B","intActId":"EBI-25835070"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6DHV7-2","geneName":"ADAL","intActId":"EBI-18899653"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96MA6","geneName":"AK8","intActId":"EBI-8466265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96Q83-2","geneName":"ALKBH3","intActId":"EBI-9089544"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9Y303-2","geneName":"AMDHD2","intActId":"EBI-12323557"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8WVL7","geneName":"ANKRD49","intActId":"EBI-9381820"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P09525","geneName":"ANXA4","intActId":"EBI-2556852"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8WW27","geneName":"APOBEC4","intActId":"EBI-25836284"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q66PJ3-4","geneName":"ARL6IP4","intActId":"EBI-5280499"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6XD76","geneName":"ASCL4","intActId":"EBI-10254793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9H0Y0","geneName":"ATG10","intActId":"EBI-1048913"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q14032","geneName":"BAAT","intActId":"EBI-8994378"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P06276","geneName":"BCHE","intActId":"EBI-7936069"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O15392","geneName":"BIRC5","intActId":"EBI-518823"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9NSI6-4","geneName":"BRWD1","intActId":"EBI-10693038"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96Q07-2","geneName":"BTBD9","intActId":"EBI-22006737"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9H0W9-3","geneName":"C11orf54","intActId":"EBI-12108466"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q13901","geneName":"C1D","intActId":"EBI-3844053"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q3SXR2","geneName":"C3orf36","intActId":"EBI-18036948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P17655","geneName":"CAPN2","intActId":"EBI-1028956"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P20807-4","geneName":"CAPN3","intActId":"EBI-11532021"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O00257-3","geneName":"CBX4","intActId":"EBI-4392727"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9NNX6-10","geneName":"CD209","intActId":"EBI-12300031"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O95674","geneName":"CDS2","intActId":"EBI-3913685"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q494V2-2","geneName":"CFAP100","intActId":"EBI-11953200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8WUX9","geneName":"CHMP7","intActId":"EBI-749253"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9Y3D0","geneName":"CIAO2B","intActId":"EBI-744045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q3SX64","geneName":"CIMAP1D","intActId":"EBI-6660184"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6PJW8-3","geneName":"CNST","intActId":"EBI-25836090"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96BR5","geneName":"COA7","intActId":"EBI-6269632"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9UGL9","geneName":"CRCT1","intActId":"EBI-713677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9UKG9-2","geneName":"CROT","intActId":"EBI-25835363"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9H2U1-3","geneName":"DHX36","intActId":"EBI-25868628"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96EY1-3","geneName":"DNAJA3","intActId":"EBI-11526226"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q92782-2","geneName":"DPF1","intActId":"EBI-23669343"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9BPU6","geneName":"DPYSL5","intActId":"EBI-724653"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q658K8","geneName":"EEF1DP3","intActId":"EBI-10248874"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O00472","geneName":"ELL2","intActId":"EBI-395274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q49AJ0-4","geneName":"FAM135B","intActId":"EBI-25835236"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8IZU1","geneName":"FAM9A","intActId":"EBI-8468186"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6ZNL6","geneName":"FGD5","intActId":"EBI-7962481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P06241","geneName":"FYN","intActId":"EBI-515315"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q06547-3","geneName":"GABPB1","intActId":"EBI-9088619"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q49A26-4","geneName":"GLYR1","intActId":"EBI-12143817"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6NXT2","geneName":"H3-5","intActId":"EBI-2868501"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P62805","geneName":"H4C9","intActId":"EBI-302023"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9BT25","geneName":"HAUS8","intActId":"EBI-2558143"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9NRZ9-6","geneName":"HELLS","intActId":"EBI-12003732"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O94829","geneName":"IPO13","intActId":"EBI-747310"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P0C870","geneName":"JMJD7","intActId":"EBI-9090173"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9UK76","geneName":"JPT1","intActId":"EBI-720411"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8N5Z5","geneName":"KCTD17","intActId":"EBI-743960"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8TBB5-2","geneName":"KLHDC4","intActId":"EBI-21838933"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8N1A0","geneName":"KRT222","intActId":"EBI-8473062"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9H2C1","geneName":"LHX5","intActId":"EBI-25835523"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8N0U6","geneName":"LINC00518","intActId":"EBI-10264791"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q16609","geneName":"LPAL2","intActId":"EBI-10238012"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8IYG6","geneName":"LRRC56","intActId":"EBI-14752528"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P27338","geneName":"MAOB","intActId":"EBI-3911344"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"A6NJ78-4","geneName":"METTL15","intActId":"EBI-10174029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"A0A0A0MR05","geneName":"MLST8","intActId":"EBI-25835557"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6IN84-2","geneName":"MRM1","intActId":"EBI-25835707"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"A2RUH7","geneName":"MYBPHL","intActId":"EBI-9088235"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P36639-4","geneName":"NUDT1","intActId":"EBI-25834643"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q7Z3B4","geneName":"NUP54","intActId":"EBI-741048"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P61970","geneName":"NUTF2","intActId":"EBI-591778"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6N063-2","geneName":"OGFOD2","intActId":"EBI-22006224"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6GQQ9-2","geneName":"OTUD7B","intActId":"EBI-25830200"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9H8K7","geneName":"PAAT","intActId":"EBI-714785"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O15534","geneName":"PER1","intActId":"EBI-2557276"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9BUL5","geneName":"PHF23","intActId":"EBI-722852"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q14181","geneName":"POLA2","intActId":"EBI-712752"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P0DPB6","geneName":"POLR1D","intActId":"EBI-359498"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P36954","geneName":"POLR2I","intActId":"EBI-395202"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q07869","geneName":"PPARA","intActId":"EBI-78615"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O60927","geneName":"PPP1R11","intActId":"EBI-1048104"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8WUF5","geneName":"PPP1R13L","intActId":"EBI-5550163"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6ZMI0-5","geneName":"PPP1R21","intActId":"EBI-25835994"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8WUD1-2","geneName":"RAB2B","intActId":"EBI-25835884"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P49792","geneName":"RANBP2","intActId":"EBI-973138"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9HD47-3","geneName":"RANGRF","intActId":"EBI-9089733"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q09028","geneName":"RBBP4","intActId":"EBI-620823"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P18754","geneName":"RCC1","intActId":"EBI-992720"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q04206","geneName":"RELA","intActId":"EBI-73886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q99666","geneName":"RGPD6","intActId":"EBI-2511609"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P47804-3","geneName":"RGR","intActId":"EBI-25834767"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q15382","geneName":"RHEB","intActId":"EBI-1055287"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8N5U6","geneName":"RNF10","intActId":"EBI-714023"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P62701","geneName":"RPS4X","intActId":"EBI-354303"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96IZ7","geneName":"RSRC1","intActId":"EBI-712189"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q66K80","geneName":"RUSC1-AS1","intActId":"EBI-10248967"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P22307-3","geneName":"SCP2","intActId":"EBI-25834804"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9NTN9-3","geneName":"SEMA4G","intActId":"EBI-9089805"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8IYM2","geneName":"SLFN12","intActId":"EBI-2822550"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86US8","geneName":"SMG6","intActId":"EBI-3232100"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P37840","geneName":"SNCA","intActId":"EBI-985879"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96H20","geneName":"SNF8","intActId":"EBI-747719"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q13573","geneName":"SNW1","intActId":"EBI-632715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q496A3","geneName":"SPATS1","intActId":"EBI-3923692"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9C004","geneName":"SPRY4","intActId":"EBI-354861"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q5W111-2","geneName":"SPRYD7","intActId":"EBI-12408727"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96BD6","geneName":"SPSB1","intActId":"EBI-2659201"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q92797-2","geneName":"SYMPK","intActId":"EBI-21560407"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O60506-4","geneName":"SYNCRIP","intActId":"EBI-11123832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O15273","geneName":"TCAP","intActId":"EBI-954089"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86WV5","geneName":"TEN1","intActId":"EBI-2562799"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96A09","geneName":"TENT5B","intActId":"EBI-752030"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P54274-2","geneName":"TERF1","intActId":"EBI-711018"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9UIK5-2","geneName":"TMEFF2","intActId":"EBI-25835153"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q53NU3","geneName":"tmp_locus_54","intActId":"EBI-10242677"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q92973","geneName":"TNPO1","intActId":"EBI-286693"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O14787-2","geneName":"TNPO2","intActId":"EBI-12076664"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q12888","geneName":"TP53BP1","intActId":"EBI-396540"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q13625","geneName":"TP53BP2","intActId":"EBI-77642"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P36406","geneName":"TRIM23","intActId":"EBI-740098"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86WT6-2","geneName":"TRIM69","intActId":"EBI-11525489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P49459","geneName":"UBE2A","intActId":"EBI-2339348"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P09936","geneName":"UCHL1","intActId":"EBI-714860"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9P1Q0-4","geneName":"VPS54","intActId":"EBI-25835297"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q99986","geneName":"VRK1","intActId":"EBI-1769146"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86Y07-1","geneName":"VRK2","intActId":"EBI-1207633"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86Y07-5","geneName":"VRK2","intActId":"EBI-1207649"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9NX94","geneName":"WBP1L","intActId":"EBI-10316321"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9BQA1","geneName":"WDR77","intActId":"EBI-1237307"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q9UIA9","geneName":"XPO7","intActId":"EBI-286668"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O43592","geneName":"XPOT","intActId":"EBI-286683"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O95070","geneName":"YIF1A","intActId":"EBI-2799703"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"O43829","geneName":"ZBTB14","intActId":"EBI-10176632"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q8IWT0-2","geneName":"ZBTB8OS","intActId":"EBI-12956041"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q53FD0-2","geneName":"ZC2HC1C","intActId":"EBI-14104088"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q05CR2","geneName":"ZNF248","intActId":"EBI-25835471"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q96LX8","geneName":"ZNF597","intActId":"EBI-9091553"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q3KNS6-3","geneName":"ZNF829","intActId":"EBI-18036029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q5JTY5","geneName":"ZNG1C","intActId":"EBI-723434"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"A0A384MDV8","intActId":"EBI-25834468"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"B7Z3E8","intActId":"EBI-25831617"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q86V28","intActId":"EBI-10259496"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"P49791","geneName":"Nup153","intActId":"EBI-6140533"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P62826","intActId":"EBI-286642"},"interactantTwo":{"uniProtKBAccession":"Q6P5F9","geneName":"Xpo1","intActId":"EBI-2550236"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10679025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17081065"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8421051"}],"value":"Predominantly nuclear during interphase (PubMed:10679025, PubMed:12194828, PubMed:8421051). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:12194828, PubMed:8421051). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10679025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18617507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1961752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19753112"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31075303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8421051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8896452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9351834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8896452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"value":"Nucleus envelope","id":"SL-0178"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18617507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8276887"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10679025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17081065"}],"value":"Melanosome","id":"SL-0161"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2108320"}],"value":"Expressed in a variety of tissues"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31075303"}],"value":"Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding (PubMed:29040603). Acetylation at Lys-37 enhances the association with nuclear export components (PubMed:31075303). Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB93486.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"GTP-binding nuclear protein Ran","featureId":"PRO_0000208696"},{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Small GTPase Ran-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Interaction with RANBP1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7891706"}]},{"type":"Binding site","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10353245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18611384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19505478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26349033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7885480"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IBR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RRP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3CH5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ6"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3ZJY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10353245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26349033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7885480"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IBR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1QBK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RRP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3ZJY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JLJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10353245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18611384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19505478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26349033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7885480"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IBR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1QBK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RRP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3ZJY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JLJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10353245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18611384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19505478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26349033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7885480"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IBR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1QBK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1RRP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3CH5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ6"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3ZJY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CJ2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JLJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10078529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10353245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11832950"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18611384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19389996"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19505478"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24449914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26349033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28282025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7885480"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3CH5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ6"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ8"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NBZ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3NC1"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3ZJY"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CJ2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5JLJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Essential for GTP hydrolysis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31075303"}]},{"type":"Modified residue","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"}]},{"type":"Modified residue","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P62827"}]},{"type":"Cross-link","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"},{"type":"Cross-link","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Mutagenesis","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Blocks DNA replication; when associated with L-69.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8421051"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Has low binding affinity for GTP and GDP. Almost completely abolishes interaction with BIRC5.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Has low binding affinity for GTP and GDP. Decreases nuclear import of proteins and RNA. Stabilizes the interaction with RCC1. No effect on nuclear location during interphase. Loss of activity in triggering microtubule assembly at mitotic chromosomes.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10408446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7819259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9351834"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Minor effect on the interaction with the alpha phosphate group of bound GTP.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Mimics acetylation; enhances the nuclear export of RELA/p65.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31075303"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Decreased acetylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31075303"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Abolishes steric hindrance that traps the essential Q-69 in an unreactive position, and causes slow GTP hydrolysis in wild-type. Loss of one hydrogen bond with the gamma phosphate group of bound GTP.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26272610"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Strongly decreased GTPase activity. Probably locked in the GTP-bound form. Loss of interaction with NUTF2. Decreases nuclear location and leads to cytoplasmic location during interphase. Loss of function in importin-mediated protein nuclear import. High activity in triggering microtubule assembly at mitotic chromosomes. Blocks DNA replication; when associated with V-19.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10408446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12194828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17209048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7819259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8421051"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8636225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9351834"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Unable to hydrolyze GTP. Increases binding to BIRC5 and promotes exaggerated spindle formation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23878195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24915079"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Strongly decreases the relase of bound GDP.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11336674"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Probable loss of interaction with NUTF2. Loss of transport to the nucleus.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822603"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Loss of normal mitotic chromosome segregation and defective mitotic spindle orientation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Loss of normal mitotic chromosome segregation and formation of sister chromatid bridges.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29040603"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"No effect on GTPase activity. Abolishes interaction with RANBP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7891706"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"in Ref. 11; AAH72000","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"in Ref. 5; AAC99400","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["C"]}},{"type":"Turn","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MMG"}]},{"type":"Helix","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1QBK"}]},{"type":"Helix","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Turn","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8UX1"}]},{"type":"Helix","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Turn","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MO5"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1RRP"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5CJ2"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Turn","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Beta strand","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GJ0"}]},{"type":"Helix","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MNW"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"2108320","citationType":"journal article","authors":["Drivas G.T.","Shih A.","Coutavas E.","Rush M.G.","D'Eustachio P."],"citationCrossReferences":[{"database":"PubMed","id":"2108320"},{"database":"DOI","id":"10.1128/mcb.10.4.1793-1798.1990"}],"title":"Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.","publicationDate":"1990","journal":"Mol. Cell. Biol.","firstPage":"1793","lastPage":"1798","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"1855255","citationType":"journal article","authors":["Matsumoto T.","Beach D.H."],"citationCrossReferences":[{"database":"PubMed","id":"1855255"},{"database":"DOI","id":"10.1016/0092-8674(91)90624-8"}],"title":"Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.","publicationDate":"1991","journal":"Cell","firstPage":"347","lastPage":"360","volume":"66"},"referencePositions":["SEQUENCE REVISION TO C-TERMINUS"]},{"referenceNumber":3,"citation":{"id":"8421051","citationType":"journal article","authors":["Ren M.","Drivas G.T.","D'Eustachio P.","Rush M.G."],"citationCrossReferences":[{"database":"PubMed","id":"8421051"},{"database":"DOI","id":"10.1083/jcb.120.2.313"}],"title":"Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.","publicationDate":"1993","journal":"J. Cell Biol.","firstPage":"313","lastPage":"323","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","SUBCELLULAR LOCATION","MUTAGENESIS OF GLY-19 AND GLN-69"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"10400640","citationType":"journal article","authors":["Hsiao P.-W.","Lin D.-L.","Nakao R.","Chang C."],"citationCrossReferences":[{"database":"PubMed","id":"10400640"},{"database":"DOI","id":"10.1074/jbc.274.29.20229"}],"title":"The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"20229","lastPage":"20234","volume":"274"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","INTERACTION WITH AR","FUNCTION"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11042152","citationType":"journal article","authors":["Zhang Q.-H.","Ye M.","Wu X.-Y.","Ren S.-X.","Zhao M.","Zhao C.-J.","Fu G.","Shen Y.","Fan H.-Y.","Lu G.","Zhong M.","Xu X.-R.","Han Z.-G.","Zhang J.-W.","Tao J.","Huang Q.-H.","Zhou J.","Hu G.-X.","Gu J.","Chen S.-J.","Chen Z."],"citationCrossReferences":[{"database":"PubMed","id":"11042152"},{"database":"DOI","id":"10.1101/gr.140200"}],"title":"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.","publicationDate":"2000","journal":"Genome Res.","firstPage":"1546","lastPage":"1560","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Umbilical cord blood","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-A6VDT1KPT9651","citationType":"submission","authors":["Puhl H.L. III","Ikeda S.R.","Aronstam R.S."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":8,"citation":{"id":"CI-D49PLCHMKUIEL","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":9,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lymph","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"},{"value":"Skin","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"CI-1FNDAGPO7HQNP","citationType":"submission","authors":["Bienvenut W.V.","Claeys D."],"publicationDate":"FEB-2006","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 2-23 AND 143-166","CLEAVAGE OF INITIATOR METHIONINE","ACETYLATION AT ALA-2","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"CI-EJHB5D8BI36EI","citationType":"submission","authors":["Lubec G.","Afjehi-Sadat L."],"publicationDate":"MAR-2007","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 39-56 AND 153-166","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"CI-622I6T9164VV3","citationType":"submission","authors":["Shichijo S.","Itoh K."],"title":"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients.","publicationDate":"MAY-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-216"],"referenceComments":[{"value":"Colon adenocarcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"1961752","citationType":"journal article","authors":["Bischoff F.R.","Ponstingl H."],"citationCrossReferences":[{"database":"PubMed","id":"1961752"},{"database":"DOI","id":"10.1073/pnas.88.23.10830"}],"title":"Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10830","lastPage":"10834","volume":"88"},"referencePositions":["PROTEIN SEQUENCE OF 65-76; 90-125; 128-147 AND 154-216","INTERACTION WITH RCC1","SUBCELLULAR LOCATION"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"8276887","citationType":"journal article","authors":["Melchior F.","Paschal B.","Evans J.","Gerace L."],"citationCrossReferences":[{"database":"PubMed","id":"8276887"},{"database":"DOI","id":"10.1083/jcb.123.6.1649"}],"title":"Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.","publicationDate":"1993","journal":"J. Cell Biol.","firstPage":"1649","lastPage":"1659","volume":"123"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"7819259","citationType":"journal article","authors":["Klebe C.","Bischoff F.R.","Ponstingl H.","Wittinghofer A."],"citationCrossReferences":[{"database":"PubMed","id":"7819259"},{"database":"DOI","id":"10.1021/bi00002a031"}],"title":"Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.","publicationDate":"1995","journal":"Biochemistry","firstPage":"639","lastPage":"647","volume":"34"},"referencePositions":["FUNCTION","INTERACTION WITH RCC1","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":18,"citation":{"id":"7891706","citationType":"journal article","authors":["Ren M.","Villamarin A.","Shih A.","Coutavas E.","Moore M.S.","Locurcio M.","Clarke V.","Oppenheim J.D.","D'Eustachio P.","Rush M.G."],"citationCrossReferences":[{"database":"PubMed","id":"7891706"},{"database":"DOI","id":"10.1128/mcb.15.4.2117"}],"title":"Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.","publicationDate":"1995","journal":"Mol. Cell. Biol.","firstPage":"2117","lastPage":"2124","volume":"15"},"referencePositions":["INTERACTION WITH RANBP1","MUTAGENESIS OF 211-ASP--LEU-216"]},{"referenceNumber":19,"citation":{"id":"8896452","citationType":"journal article","authors":["Goerlich D.","Pante N.","Kutay U.","Aebi U.","Bischoff F.R."],"citationCrossReferences":[{"database":"PubMed","id":"8896452"},{"database":"DOI","id":"10.1002/j.1460-2075.1996.tb00943.x"}],"title":"Identification of different roles for RanGDP and RanGTP in nuclear protein import.","publicationDate":"1996","journal":"EMBO J.","firstPage":"5584","lastPage":"5594","volume":"15"},"referencePositions":["FUNCTION","INTERACTION WITH RANBP1 AND KPNB1","SUBCELLULAR LOCATION"]},{"referenceNumber":20,"citation":{"id":"8636225","citationType":"journal article","authors":["Palacios I.","Weis K.","Klebe C.","Mattaj I.W.","Dingwall C."],"citationCrossReferences":[{"database":"PubMed","id":"8636225"},{"database":"DOI","id":"10.1083/jcb.133.3.485"}],"title":"RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.","publicationDate":"1996","journal":"J. Cell Biol.","firstPage":"485","lastPage":"494","volume":"133"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":21,"citation":{"id":"8692944","citationType":"journal article","authors":["Moroianu J.","Blobel G.","Radu A."],"citationCrossReferences":[{"database":"PubMed","id":"8692944"},{"database":"DOI","id":"10.1073/pnas.93.14.7059"}],"title":"Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.","publicationDate":"1996","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7059","lastPage":"7062","volume":"93"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"9323133","citationType":"journal article","authors":["Fornerod M.","Ohno M.","Yoshida M.","Mattaj I.W."],"citationCrossReferences":[{"database":"PubMed","id":"9323133"},{"database":"DOI","id":"10.1016/s0092-8674(00)80371-2"}],"title":"CRM1 is an export receptor for leucine-rich nuclear export signals.","publicationDate":"1997","journal":"Cell","firstPage":"1051","lastPage":"1060","volume":"90"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH XPO1"]},{"referenceNumber":23,"citation":{"id":"9351834","citationType":"journal article","authors":["Izaurralde E.","Kutay U.","von Kobbe C.","Mattaj I.W.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"9351834"},{"database":"DOI","id":"10.1093/emboj/16.21.6535"}],"title":"The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.","publicationDate":"1997","journal":"EMBO J.","firstPage":"6535","lastPage":"6547","volume":"16"},"referencePositions":["FUNCTION","INTERACTION WITH TNPO1","SUBCELLULAR LOCATION","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":24,"citation":{"id":"9428644","citationType":"journal article","authors":["Bischoff F.R.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"9428644"},{"database":"DOI","id":"10.1016/s0014-5793(97)01467-1"}],"title":"RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors.","publicationDate":"1997","journal":"FEBS Lett.","firstPage":"249","lastPage":"254","volume":"419"},"referencePositions":["FUNCTION","INTERACTION WITH RANBP1 AND KPNB1","SUBUNIT"]},{"referenceNumber":25,"citation":{"id":"9822603","citationType":"journal article","authors":["Ribbeck K.","Lipowsky G.","Kent H.M.","Stewart M.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"9822603"},{"database":"DOI","id":"10.1093/emboj/17.22.6587"}],"title":"NTF2 mediates nuclear import of Ran.","publicationDate":"1998","journal":"EMBO J.","firstPage":"6587","lastPage":"6598","volume":"17"},"referencePositions":["FUNCTION","INTERACTION WITH NUTF2","SUBCELLULAR LOCATION","MUTAGENESIS OF GLN-69 AND ARG-76"]},{"referenceNumber":26,"citation":{"id":"9837918","citationType":"journal article","authors":["Askjaer P.","Jensen T.H.","Nilsson J.","Englmeier L.","Kjems J."],"citationCrossReferences":[{"database":"PubMed","id":"9837918"},{"database":"DOI","id":"10.1074/jbc.273.50.33414"}],"title":"The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"33414","lastPage":"33422","volume":"273"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH HIV-1 REV; HIV-1 REV RESPONSE ELEMENT AND XPO1 (MICROBIAL INFECTION)"]},{"referenceNumber":27,"citation":{"id":"10209022","citationType":"journal article","authors":["Paraskeva E.","Izaurralde E.","Bischoff F.R.","Huber J.","Kutay U.","Hartmann E.","Luehrmann R.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"10209022"},{"database":"DOI","id":"10.1083/jcb.145.2.255"}],"title":"CRM1-mediated recycling of snurportin 1 to the cytoplasm.","publicationDate":"1999","journal":"J. Cell Biol.","firstPage":"255","lastPage":"264","volume":"145"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT RECEPTOR COMPLEX","IDENTIFICATION IN A TRIMERIC EXPORT COMPLEX WITH SNUPN AND XPO1"]},{"referenceNumber":28,"citation":{"id":"10408446","citationType":"journal article","authors":["Carazo-Salas R.E.","Guarguaglini G.","Gruss O.J.","Segref A.","Karsenti E.","Mattaj I.W."],"citationCrossReferences":[{"database":"PubMed","id":"10408446"},{"database":"DOI","id":"10.1038/22133"}],"title":"Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.","publicationDate":"1999","journal":"Nature","firstPage":"178","lastPage":"181","volume":"400"},"referencePositions":["FUNCTION","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":29,"citation":{"id":"10679025","citationType":"journal article","authors":["Steggerda S.M.","Black B.E.","Paschal B.M."],"citationCrossReferences":[{"database":"PubMed","id":"10679025"},{"database":"DOI","id":"10.1091/mbc.11.2.703"}],"title":"Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.","publicationDate":"2000","journal":"Mol. Biol. Cell","firstPage":"703","lastPage":"719","volume":"11"},"referencePositions":["INTERACTION WITH NUTF2","SUBCELLULAR LOCATION"]},{"referenceNumber":30,"citation":{"id":"11571268","citationType":"journal article","authors":["Englmeier L.","Fornerod M.","Bischoff F.R.","Petosa C.","Mattaj I.W.","Kutay U."],"citationCrossReferences":[{"database":"PubMed","id":"11571268"},{"database":"DOI","id":"10.1093/embo-reports/kve200"}],"title":"RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.","publicationDate":"2001","journal":"EMBO Rep.","firstPage":"926","lastPage":"932","volume":"2"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RANBP3 AND XPO1"]},{"referenceNumber":31,"citation":{"id":"11425870","citationType":"journal article","authors":["Lindsay M.E.","Holaska J.M.","Welch K.","Paschal B.M.","Macara I.G."],"citationCrossReferences":[{"database":"PubMed","id":"11425870"},{"database":"DOI","id":"10.1083/jcb.153.7.1391"}],"title":"Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.","publicationDate":"2001","journal":"J. Cell Biol.","firstPage":"1391","lastPage":"1402","volume":"153"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RANBP3 AND XPO1"]},{"referenceNumber":32,"citation":{"id":"14500717","citationType":"journal article","authors":["Zou Y.","Lim S.","Lee K.","Deng X.","Friedman E."],"citationCrossReferences":[{"database":"PubMed","id":"14500717"},{"database":"DOI","id":"10.1074/jbc.m307556200"}],"title":"Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"49573","lastPage":"49581","volume":"278"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH COPS5; RANBP9 AND DYRK1B"]},{"referenceNumber":33,"citation":{"id":"12194828","citationType":"journal article","authors":["Moore W.","Zhang C.","Clarke P.R."],"citationCrossReferences":[{"database":"PubMed","id":"12194828"},{"database":"DOI","id":"10.1016/s0960-9822(02)01076-x"}],"title":"Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.","publicationDate":"2002","journal":"Curr. Biol.","firstPage":"1442","lastPage":"1447","volume":"12"},"referencePositions":["INTERACTION WITH RCC1","FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":34,"citation":{"id":"12808100","citationType":"journal article","authors":["Haendeler J.","Hoffmann J.","Brandes R.P.","Zeiher A.M.","Dimmeler S."],"citationCrossReferences":[{"database":"PubMed","id":"12808100"},{"database":"DOI","id":"10.1128/mcb.23.13.4598-4610.2003"}],"title":"Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"4598","lastPage":"4610","volume":"23"},"referencePositions":["INTERACTION WITH TERT"]},{"referenceNumber":35,"citation":{"id":"14612415","citationType":"journal article","authors":["Hakata Y.","Yamada M.","Shida H."],"citationCrossReferences":[{"database":"PubMed","id":"14612415"},{"database":"DOI","id":"10.1128/mcb.23.23.8751-8761.2003"}],"title":"A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"8751","lastPage":"8761","volume":"23"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH HTLV-1 REX; RANBP3 AND XPO1 (MICROBIAL INFECTION)"]},{"referenceNumber":36,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":37,"citation":{"id":"14684163","citationType":"journal article","authors":["Wang D.","Li Z.","Schoen S.R.","Messing E.M.","Wu G."],"citationCrossReferences":[{"database":"PubMed","id":"14684163"},{"database":"DOI","id":"10.1016/j.bbrc.2003.11.124"}],"title":"A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"320","lastPage":"326","volume":"313"},"referencePositions":["INTERACTION WITH RANBP9 AND RANBP10"]},{"referenceNumber":38,"citation":{"id":"15574331","citationType":"journal article","authors":["Petosa C.","Schoehn G.","Askjaer P.","Bauer U.","Moulin M.","Steuerwald U.","Soler-Lopez M.","Baudin F.","Mattaj I.W.","Mueller C.W."],"citationCrossReferences":[{"database":"PubMed","id":"15574331"},{"database":"DOI","id":"10.1016/j.molcel.2004.11.018"}],"title":"Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.","publicationDate":"2004","journal":"Mol. Cell","firstPage":"761","lastPage":"775","volume":"16"},"referencePositions":["IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH XPO1"]},{"referenceNumber":39,"citation":{"id":"16428860","citationType":"journal article","authors":["Takeda E.","Hieda M.","Katahira J.","Yoneda Y."],"citationCrossReferences":[{"database":"PubMed","id":"16428860"},{"database":"DOI","id":"10.1247/csf.30.69"}],"title":"Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.","publicationDate":"2005","journal":"Cell Struct. Funct.","firstPage":"69","lastPage":"80","volume":"30"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH RANBP1 AND RANGAP1"]},{"referenceNumber":40,"citation":{"id":"17081065","citationType":"journal article","authors":["Chi A.","Valencia J.C.","Hu Z.-Z.","Watabe H.","Yamaguchi H.","Mangini N.J.","Huang H.","Canfield V.A.","Cheng K.C.","Yang F.","Abe R.","Yamagishi S.","Shabanowitz J.","Hearing V.J.","Wu C.","Appella E.","Hunt D.F."],"citationCrossReferences":[{"database":"PubMed","id":"17081065"},{"database":"DOI","id":"10.1021/pr060363j"}],"title":"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.","publicationDate":"2006","journal":"J. Proteome Res.","firstPage":"3135","lastPage":"3144","volume":"5"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Melanoma","type":"TISSUE"}]},{"referenceNumber":41,"citation":{"id":"17209048","citationType":"journal article","authors":["Yamashita D.","Komori H.","Higuchi Y.","Yamaguchi T.","Osumi T.","Hirose F."],"citationCrossReferences":[{"database":"PubMed","id":"17209048"},{"database":"DOI","id":"10.1074/jbc.m607180200"}],"title":"Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"7563","lastPage":"7575","volume":"282"},"referencePositions":["FUNCTION","MUTAGENESIS OF GLN-69"]},{"referenceNumber":42,"citation":{"id":"18591255","citationType":"journal article","authors":["Xia F.","Canovas P.M.","Guadagno T.M.","Altieri D.C."],"citationCrossReferences":[{"database":"PubMed","id":"18591255"},{"database":"DOI","id":"10.1128/mcb.02039-07"}],"title":"A survivin-ran complex regulates spindle formation in tumor cells.","publicationDate":"2008","journal":"Mol. Cell. Biol.","firstPage":"5299","lastPage":"5311","volume":"28"},"referencePositions":["FUNCTION","INTERACTION WITH BIRC5","MUTAGENESIS OF THR-24 AND GLN-69"]},{"referenceNumber":43,"citation":{"id":"18617507","citationType":"journal article","authors":["Sanz-Garcia M.","Lopez-Sanchez I.","Lazo P.A."],"citationCrossReferences":[{"database":"PubMed","id":"18617507"},{"database":"DOI","id":"10.1074/mcp.m700586-mcp200"}],"title":"Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.","publicationDate":"2008","journal":"Mol. Cell. Proteomics","firstPage":"2199","lastPage":"2214","volume":"7"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH VRK1; VRK2 AND VRK3"]},{"referenceNumber":44,"citation":{"id":"18266911","citationType":"journal article","authors":["Van Impe K.","Hubert T.","De Corte V.","Vanloo B.","Boucherie C.","Vandekerckhove J.","Gettemans J."],"citationCrossReferences":[{"database":"PubMed","id":"18266911"},{"database":"DOI","id":"10.1111/j.1600-0854.2008.00720.x"}],"title":"A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.","publicationDate":"2008","journal":"Traffic","firstPage":"695","lastPage":"707","volume":"9"},"referencePositions":["INTERACTION WITH CAPG AND NUTF2"]},{"referenceNumber":45,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":46,"citation":{"id":"19753112","citationType":"journal article","authors":["Medendorp K.","van Groningen J.J.","Vreede L.","Hetterschijt L.","van den Hurk W.H.","de Bruijn D.R.","Brugmans L.","van Kessel A.G."],"citationCrossReferences":[{"database":"PubMed","id":"19753112"},{"database":"DOI","id":"10.1371/journal.pone.0007020"}],"title":"The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E7020","lastPage":"E7020","volume":"4"},"referencePositions":["INTERACTION WITH MAD2L2","SUBCELLULAR LOCATION"]},{"referenceNumber":47,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-60; LYS-71; LYS-99 AND LYS-159","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":48,"citation":{"id":"20485264","citationType":"journal article","authors":["Koyama M.","Matsuura Y."],"citationCrossReferences":[{"database":"PubMed","id":"20485264"},{"database":"DOI","id":"10.1038/emboj.2010.89"}],"title":"An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.","publicationDate":"2010","journal":"EMBO J.","firstPage":"2002","lastPage":"2013","volume":"29"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":49,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":50,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":51,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":52,"citation":{"id":"23878195","citationType":"journal article","authors":["Taltynov O.","Demeulemeester J.","Christ F.","De Houwer S.","Tsirkone V.G.","Gerard M.","Weeks S.D.","Strelkov S.V.","Debyser Z."],"citationCrossReferences":[{"database":"PubMed","id":"23878195"},{"database":"DOI","id":"10.1074/jbc.m113.484345"}],"title":"Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"25603","lastPage":"25613","volume":"288"},"referencePositions":["INTERACTION WITH TNPO3","MUTAGENESIS OF GLN-69"]},{"referenceNumber":53,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":54,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":55,"citation":{"id":"25331866","citationType":"journal article","authors":["Bacot-Davis V.R.","Ciomperlik J.J.","Basta H.A.","Cornilescu C.C.","Palmenberg A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25331866"},{"database":"DOI","id":"10.1073/pnas.1411098111"}],"title":"Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15792","lastPage":"15797","volume":"111"},"referencePositions":["INTERACTION WITH MENGO ENCEPHALOMYOCARDITIS VIRUS LEADER PROTEIN (MICROBIAL INFECTION)"]},{"referenceNumber":56,"citation":{"id":"26304119","citationType":"journal article","authors":["Doerr A.","Pierre S.","Zhang D.D.","Henke M.","Holland S.","Scholich K."],"citationCrossReferences":[{"database":"PubMed","id":"26304119"},{"database":"DOI","id":"10.1074/jbc.m115.646901"}],"title":"MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia.","publicationDate":"2015","journal":"J. Biol. Chem.","firstPage":"25620","lastPage":"25635","volume":"290"},"referencePositions":["INTERACTION WITH MYCBP2"]},{"referenceNumber":57,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":58,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-71 AND LYS-152","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":59,"citation":{"id":"29130391","citationType":"journal article","authors":["Piano Mortari E.","Folgiero V.","Marcellini V.","Romania P.","Bellacchio E.","D'Alicandro V.","Bocci C.","Carrozzo R.","Martinelli D.","Petrini S.","Axiotis E.","Farroni C.","Locatelli F.","Schara U.","Pilz D.T.","Jungbluth H.","Dionisi-Vici C.","Carsetti R."],"citationCrossReferences":[{"database":"PubMed","id":"29130391"},{"database":"DOI","id":"10.1080/15548627.2017.1389356"}],"title":"The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity.","publicationDate":"2018","journal":"Autophagy","firstPage":"22","lastPage":"37","volume":"14"},"referencePositions":["INTERACTION WITH EPG5"]},{"referenceNumber":60,"citation":{"id":"29040603","citationType":"journal article","authors":["Bao X.","Liu H.","Liu X.","Ruan K.","Zhang Y.","Zhang Z.","Hu Q.","Liu Y.","Akram S.","Zhang J.","Gong Q.","Wang W.","Yuan X.","Li J.","Zhao L.","Dou Z.","Tian R.","Yao X.","Wu J.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"29040603"},{"database":"DOI","id":"10.1093/jmcb/mjx045"}],"title":"Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation.","publicationDate":"2018","journal":"J. Mol. Cell Biol.","firstPage":"18","lastPage":"32","volume":"10"},"referencePositions":["FUNCTION","INTERACTION WITH RANGRF AND RCC1","ACETYLATION AT LYS-134","IDENTIFICATION BY MASS SPECTROMETRY","MUTAGENESIS OF LYS-134"]},{"referenceNumber":61,"citation":{"id":"31075303","citationType":"journal article","authors":["Sobuz S.U.","Sato Y.","Yoshizawa T.","Karim F.","Ono K.","Sawa T.","Miyamoto Y.","Oka M.","Yamagata K."],"citationCrossReferences":[{"database":"PubMed","id":"31075303"},{"database":"DOI","id":"10.1016/j.bbamcr.2019.05.001"}],"title":"SIRT7 regulates the nuclear export of NF-kappaB p65 by deacetylating Ran.","publicationDate":"2019","journal":"Biochim. Biophys. Acta","firstPage":"1355","lastPage":"1367","volume":"1866"},"referencePositions":["ACETYLATION AT LYS-37","DEACETYLATION","SUBCELLULAR LOCATION","MUTAGENESIS OF LYS-37"]},{"referenceNumber":62,"citation":{"id":"7885480","citationType":"journal article","authors":["Scheffzek K.","Klebe C.","Fritz-Wolf K.","Kabsch W.","Wittinghofer A."],"citationCrossReferences":[{"database":"PubMed","id":"7885480"},{"database":"DOI","id":"10.1038/374378a0"}],"title":"Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.","publicationDate":"1995","journal":"Nature","firstPage":"378","lastPage":"381","volume":"374"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH GDP"]},{"referenceNumber":63,"citation":{"id":"10367892","citationType":"journal article","authors":["Vetter I.R.","Arndt A.","Kutay U.","Goerlich D.","Wittinghofer A."],"citationCrossReferences":[{"database":"PubMed","id":"10367892"},{"database":"DOI","id":"10.1016/s0092-8674(00)80774-6"}],"title":"Structural view of the Ran-Importin beta interaction at 2.3 A resolution.","publicationDate":"1999","journal":"Cell","firstPage":"635","lastPage":"646","volume":"97"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH GTP ANALOG AND KPNB1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1IBR"}]},{"referenceNumber":64,"citation":{"id":"10353245","citationType":"journal article","authors":["Chook Y.M.","Blobel G."],"citationCrossReferences":[{"database":"PubMed","id":"10353245"},{"database":"DOI","id":"10.1038/20375"}],"title":"Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.","publicationDate":"1999","journal":"Nature","firstPage":"230","lastPage":"237","volume":"399"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH GTP ANALOG AND KPNB2"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1QBK"}]},{"referenceNumber":65,"citation":{"id":"10078529","citationType":"journal article","authors":["Vetter I.R.","Nowak C.","Nishimoto T.","Kuhlmann J.","Wittinghofer A."],"citationCrossReferences":[{"database":"PubMed","id":"10078529"},{"database":"DOI","id":"10.1038/17969"}],"title":"Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.","publicationDate":"1999","journal":"Nature","firstPage":"39","lastPage":"46","volume":"398"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.96 ANGSTROMS) IN COMPLEX WITH GTP ANALOG AND RANBP2"]},{"referenceNumber":66,"citation":{"id":"11336674","citationType":"journal article","authors":["Renault L.","Kuhlmann J.","Henkel A.","Wittinghofer A."],"citationCrossReferences":[{"database":"PubMed","id":"11336674"},{"database":"DOI","id":"10.1016/s0092-8674(01)00315-4"}],"title":"Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).","publicationDate":"2001","journal":"Cell","firstPage":"245","lastPage":"255","volume":"105"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH RCC1","FUNCTION","INTERACTION WITH RCC1","MUTAGENESIS OF GLU-70"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1I2M"}]},{"referenceNumber":67,"citation":{"id":"11832950","citationType":"journal article","authors":["Seewald M.J.","Korner C.","Wittinghofer A.","Vetter I.R."],"citationCrossReferences":[{"database":"PubMed","id":"11832950"},{"database":"DOI","id":"10.1038/415662a"}],"title":"RanGAP mediates GTP hydrolysis without an arginine finger.","publicationDate":"2002","journal":"Nature","firstPage":"662","lastPage":"666","volume":"415"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEXES WITH GTP ANALOGS; RANBP1 AND FISSION YEAST RANGAP1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"1K5G"}]},{"referenceNumber":68,"citation":{"id":"18611384","citationType":"journal article","authors":["Schrader N.","Koerner C.","Koessmeier K.","Bangert J.A.","Wittinghofer A.","Stoll R.","Vetter I.R."],"citationCrossReferences":[{"database":"PubMed","id":"18611384"},{"database":"DOI","id":"10.1016/j.str.2008.03.014"}],"title":"The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex.","publicationDate":"2008","journal":"Structure","firstPage":"1116","lastPage":"1125","volume":"16"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH GDP ANALOG AND NUP153"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3CH5"}]},{"referenceNumber":69,"citation":{"id":"19505478","citationType":"journal article","authors":["Partridge J.R.","Schwartz T.U."],"citationCrossReferences":[{"database":"PubMed","id":"19505478"},{"database":"DOI","id":"10.1016/j.jmb.2009.06.011"}],"title":"Crystallographic and biochemical analysis of the Ran-binding zinc finger domain.","publicationDate":"2009","journal":"J. Mol. Biol.","firstPage":"375","lastPage":"389","volume":"391"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 2-216 IN COMPLEX WITH GDP ANALOG AND NUP153"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ0"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ3"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ4"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ6"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ7"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJ8"}]},{"referenceNumber":70,"citation":{"id":"19389996","citationType":"journal article","authors":["Monecke T.","Guttler T.","Neumann P.","Dickmanns A.","Gorlich D.","Ficner R."],"citationCrossReferences":[{"database":"PubMed","id":"19389996"},{"database":"DOI","id":"10.1126/science.1173388"}],"title":"Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.","publicationDate":"2009","journal":"Science","firstPage":"1087","lastPage":"1091","volume":"324"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH GTP; XPO1 AND SNUPN","IDENTIFICATION IN A COMPLEX WITH XPO1 AND SNUPN"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"3GJX"}]},{"referenceNumber":71,"citation":{"id":"24915079","citationType":"journal article","authors":["Tsirkone V.G.","Beutels K.G.","Demeulemeester J.","Debyser Z.","Christ F.","Strelkov S.V."],"citationCrossReferences":[{"database":"PubMed","id":"24915079"},{"database":"DOI","id":"10.1107/s2053230x14009492"}],"title":"Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.","publicationDate":"2014","journal":"Acta Crystallogr. F","firstPage":"723","lastPage":"729","volume":"70"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF MUTANT ASN-69 IN COMPLEX WITH GTP AND TNPO3","MUTAGENESIS OF GLN-69"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4OL0"}]},{"referenceNumber":72,"citation":{"id":"24449914","citationType":"journal article","authors":["Maertens G.N.","Cook N.J.","Wang W.","Hare S.","Gupta S.S.","Oztop I.","Lee K.","Pye V.E.","Cosnefroy O.","Snijders A.P.","KewalRamani V.N.","Fassati A.","Engelman A.","Cherepanov P."],"citationCrossReferences":[{"database":"PubMed","id":"24449914"},{"database":"DOI","id":"10.1073/pnas.1320755111"}],"title":"Structural basis for nuclear import of splicing factors by human Transportin 3.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2728","lastPage":"2733","volume":"111"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.42 ANGSTROMS) OF 2-216 IN COMPLEX WITH GTP AND TNPO3"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4C0Q"}]},{"referenceNumber":73,"citation":{"id":"26349033","citationType":"journal article","authors":["Fung H.Y.","Fu S.C.","Brautigam C.A.","Chook Y.M."],"citationCrossReferences":[{"database":"PubMed","id":"26349033"},{"database":"DOI","id":"10.7554/elife.10034"}],"title":"Structural determinants of nuclear export signal orientation in binding to exportin CRM1.","publicationDate":"2015","journal":"Elife","firstPage":"0","lastPage":"0","volume":"4"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) IN COMPLEX WITH GTP ANALOG; CPEB4 NUCLEAR EXPORT SIGNAL AND YEAST HOMOLOGS OF XPO1 AND RANGAP1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DH9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DHF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DI9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DIF"}]},{"referenceNumber":74,"citation":{"id":"26272610","citationType":"journal article","authors":["Rudack T.","Jenrich S.","Brucker S.","Vetter I.R.","Gerwert K.","Kotting C."],"citationCrossReferences":[{"database":"PubMed","id":"26272610"},{"database":"DOI","id":"10.1074/jbc.m115.648071"}],"title":"Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy.","publicationDate":"2015","journal":"J. Biol. Chem.","firstPage":"24079","lastPage":"24090","volume":"290"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEXES WITH GTP ANALOGS AND RANBP2","FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH RANBP2","COFACTOR","MUTAGENESIS OF THR-25 AND TYR-39"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CIW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CJ2"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5CLQ"}]},{"referenceNumber":75,"citation":{"id":"27306458","citationType":"journal article","authors":["Aksu M.","Trakhanov S.","Goerlich D."],"citationCrossReferences":[{"database":"PubMed","id":"27306458"},{"database":"DOI","id":"10.1038/ncomms11952"}],"title":"Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A.","publicationDate":"2016","journal":"Nat. Commun.","firstPage":"11952","lastPage":"11952","volume":"7"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 5-180 IN COMPLEX WITH XPO4 AND EIF5A","FUNCTION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5DLQ"}]},{"referenceNumber":76,"citation":{"id":"28282025","citationType":"journal article","authors":["Fung H.Y.","Fu S.C.","Chook Y.M."],"citationCrossReferences":[{"database":"PubMed","id":"28282025"},{"database":"DOI","id":"10.7554/elife.23961"}],"title":"Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.","publicationDate":"2017","journal":"Elife","firstPage":"0","lastPage":"0","volume":"6"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) IN COMPLEX WITH GTP ANALOG AND THE YEAST HOMOLOGS OF XPO1 AND RANGAP1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWO"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWP"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWQ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWU"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UWW"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M31469","properties":[{"key":"ProteinId","value":"AAA36546.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF052578","properties":[{"key":"ProteinId","value":"AAC05840.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF054183","properties":[{"key":"ProteinId","value":"AAC99400.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF501887","properties":[{"key":"ProteinId","value":"AAM15923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT007271","properties":[{"key":"ProteinId","value":"AAP35935.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR450347","properties":[{"key":"ProteinId","value":"CAG29343.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290763","properties":[{"key":"ProteinId","value":"BAF83452.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK312466","properties":[{"key":"ProteinId","value":"BAG35373.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471054","properties":[{"key":"ProteinId","value":"EAW98516.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC004272","properties":[{"key":"ProteinId","value":"AAH04272.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC014518","properties":[{"key":"ProteinId","value":"AAH14518.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC014901","properties":[{"key":"ProteinId","value":"AAH14901.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016654","properties":[{"key":"ProteinId","value":"AAH16654.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051908","properties":[{"key":"ProteinId","value":"AAH51908.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC072000","properties":[{"key":"ProteinId","value":"AAH72000.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB062399","properties":[{"key":"ProteinId","value":"BAB93486.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9271.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A44393","properties":[{"key":"EntryName","value":"TVHUC3"}]},{"database":"RefSeq","id":"NP_001287725.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300796.2"}]},{"database":"RefSeq","id":"NP_001287726.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300797.2"}]},{"database":"RefSeq","id":"NP_006316.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006325.5"}]},{"database":"PDB","id":"1I2M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.76 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"1IBR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"1K5D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/D/G/J=1-216"}]},{"database":"PDB","id":"1K5G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/D/G/J=1-216"}]},{"database":"PDB","id":"1QBK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C=1-216"}]},{"database":"PDB","id":"1RRP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.96 A"},{"key":"Chains","value":"A/C=8-211"}]},{"database":"PDB","id":"2MMC","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"2MMG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"2N1B","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"3CH5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"3EA5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"3GJ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A/B=2-216"}]},{"database":"PDB","id":"3GJ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=2-216"}]},{"database":"PDB","id":"3GJ4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/C=2-216"}]},{"database":"PDB","id":"3GJ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A/C=2-216"}]},{"database":"PDB","id":"3GJ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=2-216"}]},{"database":"PDB","id":"3GJ7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A/C=2-216"}]},{"database":"PDB","id":"3GJ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.82 A"},{"key":"Chains","value":"A/C=2-216"}]},{"database":"PDB","id":"3GJX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"C/F=1-216"}]},{"database":"PDB","id":"3NBY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.42 A"},{"key":"Chains","value":"C/F=5-180"}]},{"database":"PDB","id":"3NBZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"C/F=5-180"}]},{"database":"PDB","id":"3NC0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"C/F=5-180"}]},{"database":"PDB","id":"3NC1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.35 A"},{"key":"Chains","value":"C=1-180"}]},{"database":"PDB","id":"3ZJY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A/D/F=1-180"}]},{"database":"PDB","id":"4C0Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.42 A"},{"key":"Chains","value":"C/D=2-216"}]},{"database":"PDB","id":"4GMX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4GPT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.78 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HAZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HB0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HB2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HB3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4HB4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4OL0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"4WVF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5CIQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/B=1-216"}]},{"database":"PDB","id":"5CIT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=1-216"}]},{"database":"PDB","id":"5CIW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=1-216"}]},{"database":"PDB","id":"5CJ2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H=1-216"}]},{"database":"PDB","id":"5CLL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/C=1-191"}]},{"database":"PDB","id":"5CLQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"5DH9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5DHA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5DHF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.29 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5DI9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5DIF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5DIS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B=8-179"}]},{"database":"PDB","id":"5DLQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"C/D=5-180"}]},{"database":"PDB","id":"5FYQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"C/D=31-43"}]},{"database":"PDB","id":"5JLJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.14 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.28 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5UWW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5YRO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5YST","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.04 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5YSU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5YTB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"5ZPU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6A38","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6A3A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6A3B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6A3C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6A3E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6CIT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6LQ9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6M60","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6M6X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6NIF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=167-185, A=189-194"}]},{"database":"PDB","id":"6Q82","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.99 A"},{"key":"Chains","value":"B=5-180"}]},{"database":"PDB","id":"6Q84","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"B/E=5-180"}]},{"database":"PDB","id":"6TVO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B=1-180"}]},{"database":"PDB","id":"6X2M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.82 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.46 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6X2Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6XJP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6XJR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6XJS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6XJT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"6XJU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.19 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7B51","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.58 A"},{"key":"Chains","value":"B=1-180"}]},{"database":"PDB","id":"7CND","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7DBG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7L5E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MNQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MNU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MNW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/C/E/G=1-216"}]},{"database":"PDB","id":"7MNX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/C/E/G/I/K=1-216"}]},{"database":"PDB","id":"7MNY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/C/E/G/I/K=1-216"}]},{"database":"PDB","id":"7MNZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"A/C/E/G/I/K=1-215"}]},{"database":"PDB","id":"7MO0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MO1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7MO2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.65 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MO3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MO4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/C=1-216"}]},{"database":"PDB","id":"7MO5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"7YPZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HQ3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HQ4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HQ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HQ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HUF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.29 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8HUG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8ITV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"8URJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.25 A"},{"key":"Chains","value":"D/H=3-179"}]},{"database":"PDB","id":"8UX1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"K=1-216"}]},{"database":"PDB","id":"9B62","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/F=1-216"}]},{"database":"PDB","id":"9BAW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"B=9-178"}]},{"database":"PDB","id":"9HFL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"B=1-216"}]},{"database":"PDB","id":"9N85","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"C=6-213"}]},{"database":"PDB","id":"9OGN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"9OGO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"9VM1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.45 A"},{"key":"Chains","value":"A=1-216"}]},{"database":"PDB","id":"9YB5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"D=8-213"}]},{"database":"PDBsum","id":"1I2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IBR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1K5D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1K5G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QBK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1RRP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MMC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MMG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2N1B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3CH5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3EA5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GJX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NBY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NBZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NC0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NC1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ZJY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4C0Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4GMX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4GPT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HAZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HB0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HB2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HB3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4HB4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4OL0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4WVF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CIQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CIT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CIW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CJ2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CLL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5CLQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DH9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DHA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DHF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DI9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DIF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DIS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5DLQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FYQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JLJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5UWW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YRO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YST","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YSU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YTB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ZPU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6A38","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6A3A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6A3B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6A3C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6A3E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CIT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LQ9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M60","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6M6X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NIF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Q82","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Q84","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TVO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X2Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XJP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XJR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XJS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XJT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6XJU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7B51","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7CND","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DBG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7L5E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MNZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MO5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YPZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HQ3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HQ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HQ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HUF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HUG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ITV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8URJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UX1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B62","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BAW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HFL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N85","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OGO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9VM1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YB5","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42494","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42685","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44235","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44236","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44237","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44238","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44239","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44240","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44241","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44242","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44243","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44412","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-49114","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52115","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-6231","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-72749","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111837","properties":[{"key":"Interactions","value":"518"}]},{"database":"CORUM","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-5929N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P62826","properties":[{"key":"Number of interactors","value":"3358"}]},{"database":"IntAct","id":"P62826","properties":[{"key":"Interactions","value":"352"}]},{"database":"MINT","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-RAN","properties":[{"key":"Evidences","value":"10 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000446215","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1741190","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB04315","properties":[{"key":"GenericName","value":"Guanosine-5'-Diphosphate"}]},{"database":"DrugCentral","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.A.60.1.1","properties":[{"key":"FamilyName","value":"the small nuclear rna exporter (snrna-e) family"}]},{"database":"GlyGen","id":"P62826","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RAN","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"51338598","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000446215","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57429","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19412","properties":[{"key":"antibodies","value":"610 antibodies from 44 providers"}]},{"database":"DNASU","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000392369.6","properties":[{"key":"ProteinId","value":"ENSP00000376176.2"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"Ensembl","id":"ENST00000543796.6","properties":[{"key":"ProteinId","value":"ENSP00000446215.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"Ensembl","id":"ENST00000857526.1","properties":[{"key":"ProteinId","value":"ENSP00000527585.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"Ensembl","id":"ENST00000857528.1","properties":[{"key":"ProteinId","value":"ENSP00000527587.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"GeneID","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5901","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000543796.6","properties":[{"key":"ProteinId","value":"ENSP00000446215.1"},{"key":"RefSeqNucleotideId","value":"NM_006325.5"},{"key":"RefSeqProteinId","value":"NP_006316.1"}]},{"database":"UCSC","id":"uc001uir.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:9846","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34205","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RAN","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"HPA","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"601179","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0096","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FNAWDTA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P62826","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.6.5.2","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-165054","properties":[{"key":"PathwayName","value":"Rev-mediated nuclear export of HIV RNA"}]},{"database":"Reactome","id":"R-HSA-1655829","properties":[{"key":"PathwayName","value":"Regulation of cholesterol biosynthesis by SREBP (SREBF)"}]},{"database":"Reactome","id":"R-HSA-168333","properties":[{"key":"PathwayName","value":"NEP/NS2 Interacts with the Cellular Export Machinery"}]},{"database":"Reactome","id":"R-HSA-180746","properties":[{"key":"PathwayName","value":"Nuclear import of Rev protein"}]},{"database":"Reactome","id":"R-HSA-203927","properties":[{"key":"PathwayName","value":"MicroRNA (miRNA) biogenesis"}]},{"database":"Reactome","id":"R-HSA-5578749","properties":[{"key":"PathwayName","value":"Transcriptional regulation by small RNAs"}]},{"database":"Reactome","id":"R-HSA-6784531","properties":[{"key":"PathwayName","value":"tRNA processing in the nucleus"}]},{"database":"Reactome","id":"R-HSA-9615933","properties":[{"key":"PathwayName","value":"Postmitotic nuclear pore complex (NPC) reformation"}]},{"database":"SignaLink","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000132341","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5901","properties":[{"key":"hits","value":"855 hits in 1140 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P62826","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Ran_(biology)","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P62826","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P62826","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"P62826","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P62826","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005814","properties":[{"key":"GoTerm","value":"C:centriole"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19166812"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1961752"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1961752"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0042470","properties":[{"key":"GoTerm","value":"C:melanosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17081065"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0030496","properties":[{"key":"GoTerm","value":"C:midbody"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19166812"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27541860"}]},{"database":"GO","id":"GO:0005643","properties":[{"key":"GoTerm","value":"C:nuclear pore"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8421051"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18938132"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18938132"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31075303"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9822603"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11336674"}]},{"database":"GO","id":"GO:0055037","properties":[{"key":"GoTerm","value":"C:recycling endosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24561039"}]},{"database":"GO","id":"GO:0042565","properties":[{"key":"GoTerm","value":"C:RNA nuclear export complex"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14681208"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"HDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25468996"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1961752"}]},{"database":"GO","id":"GO:0003925","properties":[{"key":"GoTerm","value":"F:G protein activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11336674"}]},{"database":"GO","id":"GO:0019003","properties":[{"key":"GoTerm","value":"F:GDP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27541860"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"1961752"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27541860"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29040603"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26272610"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8636225"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26272610"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IPI:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11336674"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0006259","properties":[{"key":"GoTerm","value":"P:DNA metabolic process"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8421051"}]},{"database":"GO","id":"GO:0046039","properties":[{"key":"GoTerm","value":"P:GTP metabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26272610"}]},{"database":"GO","id":"GO:0000278","properties":[{"key":"GoTerm","value":"P:mitotic cell cycle"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8421051"}]},{"database":"GO","id":"GO:0000070","properties":[{"key":"GoTerm","value":"P:mitotic sister chromatid segregation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"29040603"}]},{"database":"GO","id":"GO:0007052","properties":[{"key":"GoTerm","value":"P:mitotic spindle organization"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10408446"}]},{"database":"GO","id":"GO:0042307","properties":[{"key":"GoTerm","value":"P:positive regulation of protein import into nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18691641"}]},{"database":"GO","id":"GO:0035281","properties":[{"key":"GoTerm","value":"P:pre-miRNA export from nucleus"},{"key":"GoEvidenceType","value":"IC:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14681208"}]},{"database":"GO","id":"GO:0006611","properties":[{"key":"GoTerm","value":"P:protein export from nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31075303"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9822603"}]},{"database":"GO","id":"GO:1902570","properties":[{"key":"GoTerm","value":"P:protein localization to nucleolus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18938132"}]},{"database":"GO","id":"GO:0000055","properties":[{"key":"GoTerm","value":"P:ribosomal large subunit export from nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12773398"}]},{"database":"GO","id":"GO:0000056","properties":[{"key":"GoTerm","value":"P:ribosomal small subunit export from nucleus"},{"key":"GoEvidenceType","value":"IMP:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12773398"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0061015","properties":[{"key":"GoTerm","value":"P:snRNA import into nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"8636225"}]},{"database":"GO","id":"GO:0016032","properties":[{"key":"GoTerm","value":"P:viral process"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"CDD","id":"cd00877","properties":[{"key":"EntryName","value":"Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01364","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.40.50.300:FF:000131","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00162","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL","length":216,"molWeight":24423,"crc64":"D5C9B7275C34BCE0","md5":"47FDBE2A237C269EDFA2519CCDE0994D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":4,"INTERACTION":143,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":1,"Region":3,"Binding site":5,"Site":1,"Modified residue":9,"Cross-link":3,"Mutagenesis":14,"Sequence conflict":2,"Turn":4,"Helix":17,"Beta strand":12},"uniParcId":"UPI0000000DE2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B5MDF5","uniProtkbId":"B5MDF5_HUMAN","entryAudit":{"firstPublicDate":"2008-10-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-10-14","entryVersion":139,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding nuclear protein Ran"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"}],"value":"RAN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008028"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Region","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"B5MDF5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"B5MDF5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":5,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":6,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":7,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.M111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22223895"}]},{"referenceNumber":8,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22814378"}]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":10,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":11,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":12,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"28112733"}]},{"referenceNumber":13,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000376174.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B5MDF5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B5MDF5","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"B5MDF5","properties":[{"key":"Interactions","value":"2"}]},{"database":"ProteomicsDB","id":"6173","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19412","properties":[{"key":"antibodies","value":"610 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000392367.4","properties":[{"key":"ProteinId","value":"ENSP00000376174.3"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"UCSC","id":"uc058ves.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"OpenTargets","id":"ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00877","properties":[{"key":"EntryName","value":"Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000131","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08477","properties":[{"key":"EntryName","value":"Roc"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQEMGIHHVAHAGLELMSSAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL","length":233,"molWeight":26224,"crc64":"2B1EDBC3550137B5","md5":"0D8B252A88FC12C1392B5D517BD79073"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Region":3},"uniParcId":"UPI0000E59AAF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J3KQE5","uniProtkbId":"J3KQE5_HUMAN","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":84,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding nuclear protein Ran"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"}],"value":"RAN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008028"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"J3KQE5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"J3KQE5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":7,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":8,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":9,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"28112733"}]},{"referenceNumber":10,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000396127.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J3KQE5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"J3KQE5","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"J3KQE5","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"J3KQE5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"J3KQE5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19412","properties":[{"key":"antibodies","value":"610 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000448750.7","properties":[{"key":"ProteinId","value":"ENSP00000396127.3"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"UCSC","id":"uc010tbk.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"J3KQE5","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"J3KQE5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00877","properties":[{"key":"EntryName","value":"Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000131","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51421","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RRRRLRLRRLNCASAIFPASVGRARRRFWKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL","length":234,"molWeight":26816,"crc64":"24599D5EE79636EE","md5":"2CBE17D9CC1FE1422D02C1D7349B1FC4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Region":4,"Non-terminal residue":1},"uniParcId":"UPI0000E59AAE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F5H018","uniProtkbId":"F5H018_HUMAN","entryAudit":{"firstPublicDate":"2011-06-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":93,"sequenceVersion":8},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding nuclear protein Ran"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"}],"value":"RAN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008028"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Non-terminal residue","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F5H018"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F5H018"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":7,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":8,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":9,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"28112733"}]},{"referenceNumber":10,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000444042.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F5H018","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F5H018","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"F5H018","properties":[{"key":"Interactions","value":"2"}]},{"database":"SwissPalm","id":"F5H018","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F5H018","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"25198","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19412","properties":[{"key":"antibodies","value":"610 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000535090.5","properties":[{"key":"ProteinId","value":"ENSP00000444042.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"UCSC","id":"uc058vep.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_041217_13_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F5H018","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00877","properties":[{"key":"EntryName","value":"Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000131","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51421","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAQGEPQLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLE","length":198,"molWeight":22436,"crc64":"2C4020E313A9EBAA","md5":"9DE1F7E55EF08FE2EBDEB29454FEF08B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Region":4,"Non-terminal residue":1},"uniParcId":"UPI0003F480D1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6VP10","uniProtkbId":"F6VP10_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding nuclear protein Ran"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"}],"value":"RAN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F6VP10"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F6VP10"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"28112733"}]},{"referenceNumber":8,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000441210.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001287725.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300796.2"}]},{"database":"RefSeq","id":"NP_001287726.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300797.2"}]},{"database":"DNASU","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000541630.5","properties":[{"key":"ProteinId","value":"ENSP00000441210.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"GeneID","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5901","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"OpenTargets","id":"ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"5901","properties":[{"key":"hits","value":"855 hits in 1140 CRISPR screens"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"FunFam","id":"3.40.50.300:FF:003472","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL","length":128,"molWeight":14731,"crc64":"6F87C0AC20E185EF","md5":"28677A6046D69A50F35BF027D1CC1FE9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"uniParcId":"UPI000006EF00"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PYF8","uniProtkbId":"A0ACI8PYF8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding nuclear protein Ran"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"}],"value":"RAN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008028"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363057"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PYF8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PYF8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000527586.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000857527.1","properties":[{"key":"ProteinId","value":"ENSP00000527586.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"OpenTargets","id":"ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"CDD","id":"cd00877","properties":[{"key":"EntryName","value":"Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000131","properties":[{"key":"EntryName","value":"GTP-binding nuclear protein Ran"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00627","properties":[{"key":"EntryName","value":"GTPRANTC4"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51421","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLETTALPDEDDDL","length":213,"molWeight":24125,"crc64":"069D872B2CF34C68","md5":"1BC7594C7D3D3BA9776092C929831D26"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Region":4},"uniParcId":"UPI00403236AA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YFC6","uniProtkbId":"H0YFC6_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":81,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040533"}],"value":"GTP-binding nuclear protein Ran"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042268"}],"value":"GTPase Ran"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041239"}],"value":"Ras-related nuclear protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"}],"value":"RAN"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = GDP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19669"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19670"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049117"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008028"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"value":"Belongs to the small GTPase superfamily. Ran family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YFC6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YFC6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00752"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":7,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":8,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"28112733"}]},{"referenceNumber":9,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437950.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YFC6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"38027","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000536606.5","properties":[{"key":"ProteinId","value":"ENSP00000437950.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"UCSC","id":"uc058vem.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2283774_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YFC6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000054","properties":[{"key":"GoTerm","value":"P:ribosomal subunit export from nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR002041","properties":[{"key":"EntryName","value":"Ran_GTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071:SF0","properties":[{"key":"EntryName","value":"GTP-BINDING NUCLEAR PROTEIN RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24071","properties":[{"key":"EntryName","value":"RAN GTPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00449","properties":[{"key":"EntryName","value":"RASTRNSFRMNG"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51418","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XLRLRRLNCASAIFPASVGRARRRFWKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQVCHHNV","length":103,"molWeight":11680,"crc64":"B129A2FB6E98B3AD","md5":"ABDADBC31451E1E49B2A5D2EDD0996A3"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Region":4,"Non-terminal residue":1},"uniParcId":"UPI000204AB23"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A087X0W0","uniProtkbId":"A0A087X0W0_HUMAN","entryAudit":{"firstPublicDate":"2014-10-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-10-29","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"}],"value":"RAN, member RAS oncogene family"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"}],"value":"RAN"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A087X0W0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A087X0W0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19413330"}]},{"referenceNumber":5,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.M111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"22223895"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000483687.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC073912","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A087X0W0","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A087X0W0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"19412","properties":[{"key":"antibodies","value":"610 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000541679.7","properties":[{"key":"ProteinId","value":"ENSP00000483687.1"},{"key":"GeneId","value":"ENSG00000132341.13"}]},{"database":"UCSC","id":"uc058veq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9846","properties":[{"key":"GeneName","value":"RAN"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000132341","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153786","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3067941_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"48625at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"RAN","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000132341","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A087X0W0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]}],"sequence":{"value":"MAAQGEPQVQFKPSSGLLGSSLETLTWNLLPCLLSPHQKLSWTQLWQHSMSTT","length":53,"molWeight":5896,"crc64":"63ACA3577D601A05","md5":"CC190CBA5A187F2243DA379DEF3BD6E2"},"extraAttributes":{"uniParcId":"UPI0004620D27"}}]}