{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O60894","secondaryAccessions":["Q6FGS5"],"uniProtkbId":"RAMP1_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1998-08-01","entryVersion":196,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Receptor activity-modifying protein 1"}},"alternativeNames":[{"fullName":{"value":"Calcitonin-receptor-like receptor activity-modifying protein 1"},"shortNames":[{"value":"CRLR activity-modifying protein 1"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:9843"}],"value":"RAMP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33602864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35324283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38603770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9620797"}],"value":"Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB (PubMed:33602864, PubMed:9620797). Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (PubMed:35324283, PubMed:38603770)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18725456"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20826335"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33602864"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35324283"}],"value":"Heterodimer of CALCRL and RAMP1; the interaction induces allosteric modulation of CALCRL function and CGRP1/CALCA and CGRP2/CALCB ligand specificity (PubMed:18725456, PubMed:20826335, PubMed:33602864). Heterodimer of CALCR and RAMP1; interaction forms the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA ligands (PubMed:35324283, PubMed:38603770)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P48960","geneName":"ADGRE5","intActId":"EBI-1756009"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"Q86Y34","geneName":"ADGRG3","chainId":"PRO_0000012889","intActId":"EBI-67109479"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"Q8IZF4","geneName":"ADGRG5","intActId":"EBI-6658275"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P30542","geneName":"ADORA1","intActId":"EBI-2903663"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P29274","geneName":"ADORA2A","intActId":"EBI-2902702"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P29275","geneName":"ADORA2B","intActId":"EBI-3904751"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P18089","geneName":"ADRA2B","intActId":"EBI-9077302"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P08588","geneName":"ADRB1","intActId":"EBI-991009"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P07550","geneName":"ADRB2","intActId":"EBI-491169"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P47901","geneName":"AVPR1B","intActId":"EBI-54518482"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P46663","geneName":"BDKRB1","intActId":"EBI-6623218"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"Q16581","geneName":"C3AR1","intActId":"EBI-21515121"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P21730","geneName":"C5AR1","intActId":"EBI-6595751"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"Q9P296","geneName":"C5AR2","intActId":"EBI-2874691"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"Q16602","geneName":"CALCRL","intActId":"EBI-962878"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P32238","geneName":"CCKAR","intActId":"EBI-6623485"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P32239","geneName":"CCKBR","intActId":"EBI-1753137"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P51677","geneName":"CCR3","intActId":"EBI-6625120"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P51679","geneName":"CCR4","intActId":"EBI-7847466"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P32248","geneName":"CCR7","intActId":"EBI-3401578"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P51685","geneName":"CCR8","intActId":"EBI-20804763"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P08172","geneName":"CHRM2","intActId":"EBI-2624832"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60894","intActId":"EBI-962893"},"interactantTwo":{"uniProtKBAccession":"P08173","geneName":"CHRM4","in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