{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P15151","secondaryAccessions":["B4DTS9","P15152","Q15267","Q15268","Q96BJ1"],"uniProtkbId":"PVR_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":244,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Poliovirus receptor"}},"alternativeNames":[{"fullName":{"value":"Nectin-like protein 5"},"shortNames":[{"value":"NECL-5"}]}],"cdAntigenNames":[{"value":"CD155"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PVR"},"synonyms":[{"value":"PVS"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15471548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15607800"}],"value":"Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2538245"}],"value":"(Microbial infection) Acts as a receptor for poliovirus. 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This interaction would drive the virus-containing vesicle to the axonal retrograde transport"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9616127"}],"value":"(Microbial infection) Acts as a receptor for Pseudorabies virus"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15640804"}],"value":"(Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells"}],"commentType":"FUNCTION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":72.0,"unit":"nM","substrate":"VTN"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11437656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11751937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12759359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15034010"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15039383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15194795"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16216929"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19011627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22421438"}],"value":"Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. 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