{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P53801","secondaryAccessions":["B2RDP7","D3DSL9","Q9NS09"],"uniProtkbId":"PTTG_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":195,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Pituitary tumor-transforming gene 1 protein-interacting protein"}},"alternativeNames":[{"fullName":{"value":"Pituitary tumor-transforming gene protein-binding factor"},"shortNames":[{"value":"PBF"},{"value":"PTTG-binding factor"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PTTG1IP"},"synonyms":[{"value":"C21orf1"},{"value":"C21orf3"}]}],"comments":[{"texts":[{"value":"May facilitate PTTG1 nuclear translocation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10781616"}],"value":"Interacts with PTTG1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q86WK6","geneName":"AMIGO1","intActId":"EBI-19125216"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q86V38","geneName":"ATN1","intActId":"EBI-11954292"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"O75787","geneName":"ATP6AP2","intActId":"EBI-2512037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2","geneName":"CLEC7A","intActId":"EBI-3939278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q9BXN2-6","geneName":"CLEC7A","intActId":"EBI-11989440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"P02489","geneName":"CRYAA","intActId":"EBI-6875961"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q92876","geneName":"KLK6","intActId":"EBI-2432309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q5T700","geneName":"LDLRAD1","intActId":"EBI-10173166"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"P23219","geneName":"PTGS1","intActId":"EBI-6655935"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q16585","geneName":"SGCB","intActId":"EBI-5663627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"A1A5C7-2","geneName":"SLC22A23","intActId":"EBI-12081840"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"Q9BVX2","geneName":"TMEM106C","intActId":"EBI-2821497"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"O15393-2","geneName":"TMPRSS2","intActId":"EBI-12345267"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P53801","intActId":"EBI-3906138"},"interactantTwo":{"uniProtKBAccession":"O43557","geneName":"TNFSF14","intActId":"EBI-524131"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"According to PubMed:10781616, it is found in the cytoplasm and the nucleus"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10781616"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10781616"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"value":"Ubiquitous"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15190888"}],"value":"By transcription factor RUNX2"}],"commentType":"INDUCTION"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/41944/PTTG1IP","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Pituitary tumor-transforming gene 1 protein-interacting protein","featureId":"PRO_0000022184"},{"type":"Topological domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI"},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8R143"}]},{"type":"Glycosylation","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"in Ref. 2; AAF73770","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"PTPYWRLRLGG","alternativeSequences":["ARRTGGCASV"]}},{"type":"Sequence conflict","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in Ref. 2; AAF73770","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"TLLLGIA","alternativeSequences":["NPPPGHC"]}}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9570958","citationType":"journal article","authors":["Yaspo M.-L.","Aaltonen J.","Horelli-Kuitunen N.","Peltonen L.","Lehrach H."],"citationCrossReferences":[{"database":"PubMed","id":"9570958"},{"database":"DOI","id":"10.1006/geno.1998.5217"}],"title":"Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3.","publicationDate":"1998","journal":"Genomics","firstPage":"133","lastPage":"136","volume":"49"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10781616","citationType":"journal article","authors":["Chien W.","Pei L."],"citationCrossReferences":[{"database":"PubMed","id":"10781616"},{"database":"DOI","id":"10.1074/jbc.m910105199"}],"title":"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"19422","lastPage":"19427","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","CHARACTERIZATION","SUBCELLULAR LOCATION","INTERACTION WITH PTTG1"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"10830953","citationType":"journal article","authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.-S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.-K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Shibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brandt P.","Scharfe M.","Schoen O.","Desario A.","Reichelt J.","Kauer G.","Bloecker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.-L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Muscle","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"15190888","citationType":"journal article","authors":["Stock M.","Schafer H.","Fliegauf M.","Otto F."],"citationCrossReferences":[{"database":"PubMed","id":"15190888"},{"database":"DOI","id":"10.1359/jbmr.2004.19.6.959"}],"title":"Identification of novel genes of the bone-specific transcription factor Runx2.","publicationDate":"2004","journal":"J. Bone Miner. Res.","firstPage":"959","lastPage":"972","volume":"19"},"referencePositions":["INDUCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z50022","properties":[{"key":"ProteinId","value":"CAA90325.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF149785","properties":[{"key":"ProteinId","value":"AAF73770.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK315626","properties":[{"key":"ProteinId","value":"BAG37994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL163300","properties":[{"key":"ProteinId","value":"CAB90552.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09386.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471079","properties":[{"key":"ProteinId","value":"EAX09388.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000415","properties":[{"key":"ProteinId","value":"AAH00415.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC012858","properties":[{"key":"ProteinId","value":"AAH12858.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC019295","properties":[{"key":"ProteinId","value":"AAH19295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC020983","properties":[{"key":"ProteinId","value":"AAH20983.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC031097","properties":[{"key":"ProteinId","value":"AAH31097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC034250","properties":[{"key":"ProteinId","value":"AAH34250.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS13715.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001273751.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001286822.2"}]},{"database":"RefSeq","id":"NP_004330.1","properties":[{"key":"NucleotideSequenceId","value":"NM_004339.4"}]},{"database":"AlphaFoldDB","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"107210","properties":[{"key":"Interactions","value":"69"}]},{"database":"FunCoup","id":"P53801","properties":[{"key":"Number of interactors","value":"1262"}]},{"database":"IntAct","id":"P53801","properties":[{"key":"Interactions","value":"40"}]},{"database":"MINT","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PTTG1IP","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000328325","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P53801","properties":[{"key":"glycosylation","value":"5 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P53801","properties":[{"key":"glycosylation","value":"2 sites, 5 glycans"}]},{"database":"GlyGen","id":"P53801","properties":[{"key":"glycosylation","value":"4 sites, 26 N-linked glycans (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PTTG1IP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1711387","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000328325","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"56621","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24351","properties":[{"key":"antibodies","value":"170 antibodies from 32 providers"}]},{"database":"DNASU","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000330938.8","properties":[{"key":"ProteinId","value":"ENSP00000328325.3"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"GeneID","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:754","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000330938.8","properties":[{"key":"ProteinId","value":"ENSP00000328325.3"},{"key":"RefSeqNucleotideId","value":"NM_004339.4"},{"key":"RefSeqProteinId","value":"NP_004330.1"}]},{"database":"UCSC","id":"uc002zgb.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:13524","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34034","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PTTG1IP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"HPA","id":"ENSG00000183255","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"603784","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RYM1","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_109415_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CVEYPVR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5829916at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P53801","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P53801","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000183255","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"754","properties":[{"key":"hits","value":"11 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"PTTG1IP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PTTG1IP","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P53801","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P53801","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"RNAct","id":"P53801","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000183255","properties":[{"key":"ExpressionPatterns","value":"Expressed in visceral pleura and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P53801","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10781616"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10781616"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24506068"}]},{"database":"GO","id":"GO:0043518","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA damage response, signal transduction by p53 class mediator"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24506068"}]},{"database":"GO","id":"GO:1902254","properties":[{"key":"GoTerm","value":"P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24506068"}]},{"database":"GO","id":"GO:0031398","properties":[{"key":"GoTerm","value":"P:positive regulation of protein ubiquitination"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24506068"}]},{"database":"GO","id":"GO:0006606","properties":[{"key":"GoTerm","value":"P:protein import into nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10781616"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN","length":180,"molWeight":20324,"crc64":"F1E66014D49EC1DE","md5":"4AA47E83CC1471A11FE70A29EC7671EF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":14,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":1,"Region":1,"Coiled coil":1,"Modified residue":1,"Glycosylation":2,"Sequence conflict":2},"uniParcId":"UPI00000015F0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R1U4","uniProtkbId":"A0ACI8R1U4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051307784"},{"type":"Transmembrane","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"PTTG1IP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF30612"}]},{"type":"Domain","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"PTTG1IP C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF27838"}]},{"type":"Region","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R1U4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R1U4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568939.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898880.1","properties":[{"key":"ProteinId","value":"ENSP00000568939.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVLNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN","length":178,"molWeight":20048,"crc64":"58A5DA231391525F","md5":"B1CE81DD2660DFF1AC5A9BD8199385EA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2,"Region":1},"uniParcId":"UPI0040319333"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RQ58","uniProtkbId":"A0ACI8RQ58_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051495146"},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RQ58"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RQ58"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568940.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898881.1","properties":[{"key":"ProteinId","value":"ENSP00000568940.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYVYFVSGLFKEENPYARFENN","length":185,"molWeight":20919,"crc64":"9BEDE593D604E1F5","md5":"EB0184E886CC3938A7E74B6B121526BD"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1},"uniParcId":"UPI0040323DDF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UJ49","uniProtkbId":"A0ACI8UJ49_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051430604"},{"type":"Transmembrane","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]},{"type":"Region","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UJ49"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UJ49"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619515.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000949456.1","properties":[{"key":"ProteinId","value":"ENSP00000619515.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN","length":168,"molWeight":19005,"crc64":"F6CBAA0983E365AA","md5":"FE748753DAAA0528E54FD250886F0472"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1},"uniParcId":"UPI00403199CC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S4P7","uniProtkbId":"A0ACI8S4P7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051391515"},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S4P7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S4P7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568941.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898882.1","properties":[{"key":"ProteinId","value":"ENSP00000568941.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYAVCLSSPKTSGLEVCSCSAVVFGFLWARLRSRGLFKEENPYARFENN","length":212,"molWeight":23737,"crc64":"DD66890BE14DC092","md5":"CC4A02DDA2463FC3AB73CFB3631B662F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1},"uniParcId":"UPI00403214D4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A8MZH8","uniProtkbId":"A8MZH8_HUMAN","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-12-04","entryVersion":99,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002726837"},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A8MZH8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A8MZH8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380984.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A8MZH8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A8MZH8","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"A8MZH8","properties":[{"key":"Interactions","value":"1"}]},{"database":"SwissPalm","id":"A8MZH8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A8MZH8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"2481","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24351","properties":[{"key":"antibodies","value":"170 antibodies from 32 providers"}]},{"database":"Ensembl","id":"ENST00000397887.7","properties":[{"key":"ProteinId","value":"ENSP00000380984.3"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"UCSC","id":"uc062atq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5829916at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PTTG1IP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"Bgee","id":"ENSG00000183255","properties":[{"key":"ExpressionPatterns","value":"Expressed in visceral pleura and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A8MZH8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWGLFKEENPYARFENN","length":107,"molWeight":11598,"crc64":"585C3A650DCDD072","md5":"7777CA5B9443EFCE9E56C781B8185236"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI0000E5A40B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QQL0","uniProtkbId":"A0ACI8QQL0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"}],"value":"PTTG1IP"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051287529"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QQL0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QQL0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568936.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898877.1","properties":[{"key":"ProteinId","value":"ENSP00000568936.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAGLFKEENPYARFENN","length":53,"molWeight":5676,"crc64":"D5E553897A939151","md5":"776C2452DB40891F3127C0824FFCCD32"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0040320C2D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S3N4","uniProtkbId":"A0ACI8S3N4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051325473"},{"type":"Transmembrane","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"PTTG1IP C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF27838"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S3N4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S3N4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568938.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898879.1","properties":[{"key":"ProteinId","value":"ENSP00000568938.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN","length":126,"molWeight":14401,"crc64":"B76101A39896C423","md5":"6DA1D53BC8CA14B40912FC74F6A2FE9A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI00403176BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A8MXQ1","uniProtkbId":"A8MXQ1_HUMAN","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-12-04","entryVersion":98,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"PTTG1IP N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF30612"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"PTTG1IP C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF27838"}]},{"type":"Region","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A8MXQ1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A8MXQ1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000380983.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A8MXQ1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A8MXQ1","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"A8MXQ1","properties":[{"key":"Interactions","value":"1"}]},{"database":"MassIVE","id":"A8MXQ1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"2341","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24351","properties":[{"key":"antibodies","value":"170 antibodies from 32 providers"}]},{"database":"Ensembl","id":"ENST00000397886.3","properties":[{"key":"ProteinId","value":"ENSP00000380983.3"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"UCSC","id":"uc062atr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5829916at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PTTG1IP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"Bgee","id":"ENSG00000183255","properties":[{"key":"ExpressionPatterns","value":"Expressed in visceral pleura and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A8MXQ1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGQAVSCVLGRLQPVKCTGARRVGRRGLRKQTSQECLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN","length":159,"molWeight":18331,"crc64":"F1DB17BC4A0BE2ED","md5":"204EDA9A33E779D87D8AD4EF58A58DAA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":1},"uniParcId":"UPI0000E5A40A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UJ23","uniProtkbId":"A0ACI8UJ23_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051357854"},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UJ23"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UJ23"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000619514.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000949455.1","properties":[{"key":"ProteinId","value":"ENSP00000619514.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYEENPYARFENN","length":176,"molWeight":19878,"crc64":"E9F42E0A49BA9509","md5":"DBE113E8879D0FC529599868CD16F3B8"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1},"uniParcId":"UPI0040325E21"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6ST71","uniProtkbId":"F6ST71_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"}],"value":"PTTG1IP"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051196024"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395374.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001273751.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001286822.2"}]},{"database":"DNASU","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000445724.3","properties":[{"key":"ProteinId","value":"ENSP00000395374.2"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"GeneID","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"754","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1815171_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5829916at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"754","properties":[{"key":"hits","value":"11 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"PTTG1IP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"Bgee","id":"ENSG00000183255","properties":[{"key":"ExpressionPatterns","value":"Expressed in visceral pleura and 209 other cell types or tissues"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSACLKKKTRMLDLKTTKALQHISPDASCEVHAPQPSPAGRPRGHCGLLTLASEPASLPGQAAGELPLKDSPLVLQTGDLLFPVHLCF","length":142,"molWeight":14893,"crc64":"641913C193A0E8C8","md5":"2573120E96192682FBFE39F09C909B91"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00017A782D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SAK4","uniProtkbId":"A0ACI8SAK4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"}],"value":"PTTG1 interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"}],"value":"PTTG1IP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051206812"},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"PSI","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00423"}]},{"type":"Region","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SAK4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SAK4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10830953","citationType":"journal article","authoringGroup":["Chromosome 21 mapping and sequencing consortium"],"authors":["Hattori M.","Fujiyama A.","Taylor T.D.","Watanabe H.","Yada T.","Park H.S.","Toyoda A.","Ishii K.","Totoki Y.","Choi D.K.","Groner Y.","Soeda E.","Ohki M.","Takagi T.","Sakaki Y.","Taudien S.","Blechschmidt K.","Polley A.","Menzel U.","Delabar J.","Kumpf K.","Lehmann R.","Patterson D.","Reichwald K.","Rump A.","Schillhabel M.","Schudy A.","Zimmermann W.","Rosenthal A.","Kudoh J.","Schibuya K.","Kawasaki K.","Asakawa S.","Shintani A.","Sasaki T.","Nagamine K.","Mitsuyama S.","Antonarakis S.E.","Minoshima S.","Shimizu N.","Nordsiek G.","Hornischer K.","Brant P.","Scharfe M.","Schon O.","Desario A.","Reichelt J.","Kauer G.","Blocker H.","Ramser J.","Beck A.","Klages S.","Hennig S.","Riesselmann L.","Dagand E.","Haaf T.","Wehrmeyer S.","Borzym K.","Gardiner K.","Nizetic D.","Francis F.","Lehrach H.","Reinhardt R.","Yaspo M.L."],"citationCrossReferences":[{"database":"PubMed","id":"10830953"},{"database":"DOI","id":"10.1038/35012518"}],"title":"The DNA sequence of human chromosome 21.","publicationDate":"2000","journal":"Nature","firstPage":"311","lastPage":"319","volume":"405"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000568937.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL773603","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000898878.1","properties":[{"key":"ProteinId","value":"ENSP00000568937.1"},{"key":"GeneId","value":"ENSG00000183255.13"}]},{"database":"HGNC","id":"HGNC:13524","properties":[{"key":"GeneName","value":"PTTG1IP"}]},{"database":"OpenTargets","id":"ENSG00000183255","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000004977","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 21"}]},{"database":"InterPro","id":"IPR016201","properties":[{"key":"EntryName","value":"PSI"}]},{"database":"InterPro","id":"IPR063687","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"}]},{"database":"InterPro","id":"IPR052304","properties":[{"key":"EntryName","value":"PTTG1IP"}]},{"database":"InterPro","id":"IPR060449","properties":[{"key":"EntryName","value":"PTTG1IP_C"}]},{"database":"PANTHER","id":"PTHR15191:SF14","properties":[{"key":"EntryName","value":"PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15191","properties":[{"key":"EntryName","value":"PROTEIN CBG20567"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30612","properties":[{"key":"EntryName","value":"PSI_PTTG1IP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27838","properties":[{"key":"EntryName","value":"PTTG1IP_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00423","properties":[{"key":"EntryName","value":"PSI"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERAEMKTRHDEIRKKYGLFKEENPYARFENN","length":179,"molWeight":20168,"crc64":"8CEB6ABB4B4B59B4","md5":"960B98E2FC27ED61DFEC16E7BD776015"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1},"uniParcId":"UPI00403192D4"}}]}