{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q12913","secondaryAccessions":["Q15255","Q6P4H4","Q8NHM2","Q9UDA9"],"uniProtkbId":"PTPRJ_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-05","entryVersion":234,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Receptor-type tyrosine-protein phosphatase eta"},"shortNames":[{"value":"Protein-tyrosine phosphatase eta"},{"value":"R-PTP-eta"}],"ecNumbers":[{"value":"3.1.3.48"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14709717"}],"value":"Density-enhanced phosphatase 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10821867"}],"value":"DEP-1"}]},{"fullName":{"value":"HPTP eta"}},{"fullName":{"value":"Protein-tyrosine phosphatase receptor type J"},"shortNames":[{"value":"R-PTP-J"}]}],"cdAntigenNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9531590"}],"value":"CD148"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PTPRJ"},"synonyms":[{"value":"DEP1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q64455"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10821867"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11259588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12062403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12475979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12913111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14709717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16682945"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18348712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18936167"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19836242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19922411"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21091576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21262971"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30591527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9531590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9780142"}],"value":"Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052032"}],"value":"Activates angiogenesis and cell migration (PubMed:28052032). Down-regulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032)"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10684"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"}],"ecNumber":"3.1.3.48","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10044"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12475979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19246339"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21262971"}],"value":"Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P35222","geneName":"CTNNB1","intActId":"EBI-491549"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"O60716","geneName":"CTNND1","intActId":"EBI-701927"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P17948","geneName":"FLT1","intActId":"EBI-1026718"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"Q13480","geneName":"GAB1","intActId":"EBI-517684"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P10912","geneName":"GHR","intActId":"EBI-286316"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P35968","geneName":"KDR","intActId":"EBI-1005487"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P28482","geneName":"MAPK1","intActId":"EBI-959949"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P27361","geneName":"MAPK3","intActId":"EBI-73995"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P08581","geneName":"MET","intActId":"EBI-1039152"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"P09619","geneName":"PDGFRB","intActId":"EBI-641237"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q12913","intActId":"EBI-2264500"},"interactantTwo":{"uniProtKBAccession":"Q02763","geneName":"TEK","intActId":"EBI-2257090"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"After T-cell stimulation, it is temporarily excluded from immunological synapses"}]},"subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell projection, ruffle membrane","id":"SL-0301"}},{"location":{"value":"Cell junction","id":"SL-0038"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052032"}],"value":"Secreted, extracellular space","id":"SL-0112"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing","Alternative initiation"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q12913-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28052032"}],"value":"sPTPRJ"}],"isoformIds":["Q12913-2"],"sequenceIds":["VSP_043652","VSP_043653"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q12913-3"],"sequenceIds":["VSP_060928"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18603590"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33296397"}],"value":"Isoform 1 and isoform 3 result from alternative initiation of translation within the same 5' exon but produce the same functional protein following cleavage of their respective signal peptides (PubMed:18603590). Alternative initiation is probably a conserved mechanism in mammals to regulate the overall expression of that functional protein (PubMed:18603590, PubMed:33296397)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8483328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9531590"}],"value":"Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052032"}],"value":"Expressed in the brain"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9531590"}],"value":"N- and O-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052032"}],"value":"N-glycosylated"}],"commentType":"PTM","molecule":"Isoform 2"},{"commentType":"DISEASE","disease":{"diseaseId":"Thrombocytopenia 10","diseaseAccession":"DI-06750","acronym":"THC10","description":"A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC10 is an autosomal recessive form characterized by decreased numbers of platelets apparent from birth or early childhood.","diseaseCrossReference":{"database":"MIM","id":"620484"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30591527"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052032"}],"value":"Expressed in several normal and cancer cell lines, including A549, HUVEC, MCF7, HeLa, A172 and ADF cells (at protein level) (PubMed:28052032). Up-regulated in high-grade glioma samples (PubMed:28052032)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16778204"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30552125"}],"value":"Originally thought to dephosphorylate RET. However this paper was retracted due to manipulation of immunoblot data"}],"commentType":"CAUTION"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/41932/PTPRJ","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"Receptor-type tyrosine-protein phosphatase eta","featureId":"PRO_0000025444"},{"type":"Topological domain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":975,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":996,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":997,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Fibronectin type-III 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Fibronectin type-III 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Fibronectin type-III 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"Fibronectin type-III 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"Fibronectin type-III 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"Fibronectin type-III 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":720,"modifier":"EXACT"}},"description":"Fibronectin type-III 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":721,"modifier":"EXACT"},"end":{"value":817,"modifier":"EXACT"}},"description":"Fibronectin type-III 8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"Fibronectin type-III 9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1298,"modifier":"EXACT"}},"description":"Tyrosine-protein phosphatase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00160"}]},{"type":"Region","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":1239,"modifier":"EXACT"},"end":{"value":1239,"modifier":"EXACT"}},"description":"Phosphocysteine intermediate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00160"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10044"}]},{"type":"Binding site","location":{"start":{"value":1205,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":1239,"modifier":"EXACT"},"end":{"value":1245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":1283,"modifier":"EXACT"},"end":{"value":1283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"substrate"}},{"type":"Modified residue","location":{"start":{"value":1009,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Glycosylation","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":525,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":637,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":761,"modifier":"EXACT"},"end":{"value":761,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":772,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":784,"modifier":"EXACT"},"end":{"value":784,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":937,"modifier":"EXACT"},"end":{"value":937,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 3","featureId":"VSP_060928","alternativeSequence":{"originalSequence":"M","alternativeSequences":["MSPGKPGAGGAGTRRTGWRRRRRRRRQEAATTVPGLGRTAGPDSRVRGTFQGARGM"]}},{"type":"Alternative sequence","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_043652","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Alternative sequence","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_043653","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in a colon cancer sample; somatic mutation; dbSNP:rs121434507","featureCrossReferences":[{"database":"dbSNP","id":"rs121434507"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089527"}],"featureId":"VAR_015905","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"in a colon cancer sample; somatic mutation; dbSNP:rs1566734","featureCrossReferences":[{"database":"dbSNP","id":"rs1566734"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15378013"}],"featureId":"VAR_015906","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"in dbSNP:rs2229701","featureCrossReferences":[{"database":"dbSNP","id":"rs2229701"}],"featureId":"VAR_038414","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"in dbSNP:rs1503185","featureCrossReferences":[{"database":"dbSNP","id":"rs1503185"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15378013"}],"featureId":"VAR_024582","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"in dbSNP:rs2229703","featureCrossReferences":[{"database":"dbSNP","id":"rs2229703"}],"featureId":"VAR_038415","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":872,"modifier":"EXACT"},"end":{"value":872,"modifier":"EXACT"}},"description":"in dbSNP:rs4752904","featureCrossReferences":[{"database":"dbSNP","id":"rs4752904"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12089527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15378013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7937872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7994032"}],"featureId":"VAR_038416","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1235,"modifier":"EXACT"},"end":{"value":1235,"modifier":"EXACT"}},"description":"in dbSNP:rs11039554","featureCrossReferences":[{"database":"dbSNP","id":"rs11039554"}],"featureId":"VAR_038417","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":1016,"modifier":"EXACT"},"end":{"value":1016,"modifier":"EXACT"}},"description":"80% decrease in interaction with MAPK1 and MAPK3.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494114"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1205,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"Substrate trapping with much higher affinity for substrate.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12475979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18348712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18936167"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19836242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21262971"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":1239,"modifier":"EXACT"},"end":{"value":1239,"modifier":"EXACT"}},"description":"Catalytically inactive and substrate trapping with higher affinity for substrate.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12475979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18936167"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19836242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21262971"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in Ref. 1; AAB36687","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"in Ref. 2; BAA07035","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"YNGKLEPLGSYR","alternativeSequences":["LQWEAGTSGLLP"]}},{"type":"Sequence conflict","location":{"start":{"value":1130,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"in Ref. 6; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1234,"modifier":"EXACT"}},"description":"in Ref. 6; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":1243,"modifier":"EXACT"},"end":{"value":1243,"modifier":"EXACT"}},"description":"in Ref. 6; no nucleotide entry","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Beta strand","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U08"}]},{"type":"Helix","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Helix","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7U01"}]},{"type":"Beta strand","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Beta strand","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Beta strand","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Beta strand","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Beta strand","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Beta strand","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Helix","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2DLE"}]},{"type":"Helix","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1047,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Turn","location":{"start":{"value":1048,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Turn","location":{"start":{"value":1058,"modifier":"EXACT"},"end":{"value":1061,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1063,"modifier":"EXACT"},"end":{"value":1068,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Turn","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1080,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1083,"modifier":"EXACT"},"end":{"value":1085,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1087,"modifier":"EXACT"},"end":{"value":1089,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1090,"modifier":"EXACT"},"end":{"value":1093,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1096,"modifier":"EXACT"},"end":{"value":1100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Turn","location":{"start":{"value":1117,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1120,"modifier":"EXACT"},"end":{"value":1129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1134,"modifier":"EXACT"},"end":{"value":1138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1159,"modifier":"EXACT"},"end":{"value":1161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1164,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1175,"modifier":"EXACT"},"end":{"value":1186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Turn","location":{"start":{"value":1187,"modifier":"EXACT"},"end":{"value":1189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1192,"modifier":"EXACT"},"end":{"value":1200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1212,"modifier":"EXACT"},"end":{"value":1225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1235,"modifier":"EXACT"},"end":{"value":1243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1244,"modifier":"EXACT"},"end":{"value":1261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Beta strand","location":{"start":{"value":1262,"modifier":"EXACT"},"end":{"value":1265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1267,"modifier":"EXACT"},"end":{"value":1275,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]},{"type":"Helix","location":{"start":{"value":1285,"modifier":"EXACT"},"end":{"value":1302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2NZ6"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0904","category":"Molecular function","name":"Protein phosphatase"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7937872","citationType":"journal article","authors":["Oestman A.","Yang Q.","Tonks N.K."],"citationCrossReferences":[{"database":"PubMed","id":"7937872"},{"database":"DOI","id":"10.1073/pnas.91.21.9680"}],"title":"Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9680","lastPage":"9684","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANT ASP-872"]},{"referenceNumber":2,"citation":{"id":"7994032","citationType":"journal article","authors":["Honda H.","Inazawa J.","Nishida J.","Yazaki Y.","Hirai H."],"citationCrossReferences":[{"database":"PubMed","id":"7994032"},{"database":"DOI","id":"10.1182/blood.v84.12.4186.bloodjournal84124186"}],"title":"Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta.","publicationDate":"1994","journal":"Blood","firstPage":"4186","lastPage":"4194","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANT ASP-872"]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Pancreas","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"12089527","citationType":"journal article","authors":["Ruivenkamp C.A.L.","van Wezel T.","Zanon C.","Stassen A.P.M.","Vlcek C.","Csikos T.","Klous A.M.","Tripodis N.","Perrakis A.","Boerrigter L.","Groot P.C.","Lindeman J.","Mooi W.J.","Meijjer G.A.","Scholten G.","Dauwerse H.","Paces V.","van Zandwijk N.","van Ommen G.J.B.","Demant P."],"citationCrossReferences":[{"database":"PubMed","id":"12089527"},{"database":"DOI","id":"10.1038/ng903"}],"title":"Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.","publicationDate":"2002","journal":"Nat. Genet.","firstPage":"295","lastPage":"300","volume":"31"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-1337","VARIANTS CYS-214; PRO-276 AND ASP-872"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"8483328","citationType":"journal article","authors":["Honda H.","Shibuya M.","Chiba S.","Yazaki Y.","Hirai H."],"citationCrossReferences":[{"database":"PubMed","id":"8483328"}],"title":"Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P.","publicationDate":"1993","journal":"Leukemia","firstPage":"742","lastPage":"746","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1124-1245 (ISOFORM 1)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Leukemia","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"9531590","citationType":"journal article","authors":["de la Fuente-Garcia M.A.","Nicolas J.M.","Freed J.H.","Palou E.","Thomas A.P.","Vilella R.","Vives J.","Gaya A."],"citationCrossReferences":[{"database":"PubMed","id":"9531590"},{"database":"DOI","id":"10.1182/blood.v91.8.2800.2800_2800_2809"}],"title":"CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes.","publicationDate":"1998","journal":"Blood","firstPage":"2800","lastPage":"2809","volume":"91"},"referencePositions":["PROTEIN SEQUENCE OF 36-49; 485-502 AND 723-739","FUNCTION","TISSUE SPECIFICITY","GLYCOSYLATION","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"9780142","citationType":"journal article","authors":["Tangye S.G.","Wu J.","Aversa G.","de Vries J.E.","Lanier L.L.","Phillips J.H."],"citationCrossReferences":[{"database":"PubMed","id":"9780142"}],"title":"Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148.","publicationDate":"1998","journal":"J. Immunol.","firstPage":"3803","lastPage":"3807","volume":"161"},"referencePositions":["FUNCTION"]},{"referenceNumber":9,"citation":{"id":"10821867","citationType":"journal article","authors":["Kovalenko M.","Denner K.","Sandstrom J.","Persson C.","Gross S.","Jandt E.","Vilella R.","Bohmer F.","Ostman A."],"citationCrossReferences":[{"database":"PubMed","id":"10821867"},{"database":"DOI","id":"10.1074/jbc.275.21.16219"}],"title":"Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"16219","lastPage":"16226","volume":"275"},"referencePositions":["FUNCTION"]},{"referenceNumber":10,"citation":{"id":"11259588","citationType":"journal article","authors":["Baker J.E.","Majeti R.","Tangye S.G.","Weiss A."],"citationCrossReferences":[{"database":"PubMed","id":"11259588"},{"database":"DOI","id":"10.1128/mcb.21.7.2393-2403.2001"}],"title":"Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.","publicationDate":"2001","journal":"Mol. Cell. Biol.","firstPage":"2393","lastPage":"2403","volume":"21"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"12062403","citationType":"journal article","authors":["Persson C.","Engstrom U.","Mowbray S.L.","Ostman A."],"citationCrossReferences":[{"database":"PubMed","id":"12062403"},{"database":"DOI","id":"10.1016/s0014-5793(02)02570-x"}],"title":"Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1.","publicationDate":"2002","journal":"FEBS Lett.","firstPage":"27","lastPage":"31","volume":"517"},"referencePositions":["FUNCTION"]},{"referenceNumber":12,"citation":{"id":"12370829","citationType":"journal article","authors":["Holsinger L.J.","Ward K.","Duffield B.","Zachwieja J.","Jallal B."],"citationCrossReferences":[{"database":"PubMed","id":"12370829"},{"database":"DOI","id":"10.1038/sj.onc.1205858"}],"title":"The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).","publicationDate":"2002","journal":"Oncogene","firstPage":"7067","lastPage":"7076","volume":"21"},"referencePositions":["FUNCTION","INTERACTION WITH CTNNB1 AND JUP","MUTAGENESIS OF ASP-1205 AND CYS-1239","TISSUE SPECIFICITY","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"12475979","citationType":"journal article","authors":["Palka H.L.","Park M.","Tonks N.K."],"citationCrossReferences":[{"database":"PubMed","id":"12475979"},{"database":"DOI","id":"10.1074/jbc.m210656200"}],"title":"Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"5728","lastPage":"5735","volume":"278"},"referencePositions":["FUNCTION","INTERACTION WITH CTNNB1; GRB2; GAB1 AND JUP","MUTAGENESIS OF ASP-1205 AND CYS-1239"]},{"referenceNumber":14,"citation":{"id":"12913111","citationType":"journal article","authors":["Lin J.","Weiss A."],"citationCrossReferences":[{"database":"PubMed","id":"12913111"},{"database":"DOI","id":"10.1083/jcb.200303040"}],"title":"The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.","publicationDate":"2003","journal":"J. Cell Biol.","firstPage":"673","lastPage":"682","volume":"162"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":15,"citation":{"id":"14709717","citationType":"journal article","authors":["Kellie S.","Craggs G.","Bird I.N.","Jones G.E."],"citationCrossReferences":[{"database":"PubMed","id":"14709717"},{"database":"DOI","id":"10.1242/jcs.00879"}],"title":"The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation.","publicationDate":"2004","journal":"J. Cell Sci.","firstPage":"609","lastPage":"618","volume":"117"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"16335952","citationType":"journal article","authors":["Liu T.","Qian W.-J.","Gritsenko M.A.","Camp D.G. II","Monroe M.E.","Moore R.J.","Smith R.D."],"citationCrossReferences":[{"database":"PubMed","id":"16335952"},{"database":"DOI","id":"10.1021/pr0502065"}],"title":"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.","publicationDate":"2005","journal":"J. Proteome Res.","firstPage":"2070","lastPage":"2080","volume":"4"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-342; ASN-351; ASN-391 AND ASN-396"],"referenceComments":[{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"16778204","citationType":"journal article","authors":["Iervolino A.","Iuliano R.","Trapasso F.","Viglietto G.","Melillo R.M.","Carlomagno F.","Santoro M.","Fusco A."],"citationCrossReferences":[{"database":"PubMed","id":"16778204"},{"database":"DOI","id":"10.1158/0008-5472.can-06-0228"}],"title":"The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins.","publicationDate":"2006","journal":"Cancer Res.","firstPage":"6280","lastPage":"6287","volume":"66"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":18,"citation":{"id":"30552125","citationType":"journal article","authors":["Iervolino A.","Iuliano R.","Trapasso F.","Viglietto G.","Melillo R.M.","Carlomagno F.","Santoro M.","Fusco A."],"citationCrossReferences":[{"database":"PubMed","id":"30552125"},{"database":"DOI","id":"10.1158/0008-5472.can-18-3456"}],"publicationDate":"2018","journal":"Cancer Res.","firstPage":"6907","lastPage":"6907","volume":"78"},"referencePositions":["RETRACTION NOTICE OF PUBMED:16778204"]},{"referenceNumber":19,"citation":{"id":"16682945","citationType":"journal article","authors":["Balavenkatraman K.K.","Jandt E.","Friedrich K.","Kautenburger T.","Pool-Zobel B.L.","Ostman A.","Bohmer F.D."],"citationCrossReferences":[{"database":"PubMed","id":"16682945"},{"database":"DOI","id":"10.1038/sj.onc.1209647"}],"title":"DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients.","publicationDate":"2006","journal":"Oncogene","firstPage":"6319","lastPage":"6324","volume":"25"},"referencePositions":["FUNCTION"]},{"referenceNumber":20,"citation":{"id":"18348712","citationType":"journal article","authors":["Tsuboi N.","Utsunomiya T.","Roberts R.L.","Ito H.","Takahashi K.","Noda M.","Takahashi T."],"citationCrossReferences":[{"database":"PubMed","id":"18348712"},{"database":"DOI","id":"10.1042/bj20071317"}],"title":"The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase.","publicationDate":"2008","journal":"Biochem. J.","firstPage":"193","lastPage":"200","volume":"413"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-1205","SUBCELLULAR LOCATION"]},{"referenceNumber":21,"citation":{"id":"18603590","citationType":"journal article","authors":["Karagyozov L.","Godfrey R.","Boehmer S.A.","Petermann A.","Hoelters S.","Ostman A.","Boehmer F.D."],"citationCrossReferences":[{"database":"PubMed","id":"18603590"},{"database":"DOI","id":"10.1093/nar/gkn391"}],"title":"The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"4443","lastPage":"4453","volume":"36"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)"]},{"referenceNumber":22,"citation":{"id":"19246339","citationType":"journal article","authors":["Senis Y.A.","Tomlinson M.G.","Ellison S.","Mazharian A.","Lim J.","Zhao Y.","Kornerup K.N.","Auger J.M.","Thomas S.G.","Dhanjal T.","Kalia N.","Zhu J.W.","Weiss A.","Watson S.P."],"citationCrossReferences":[{"database":"PubMed","id":"19246339"},{"database":"DOI","id":"10.1182/blood-2008-08-174318"}],"title":"The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.","publicationDate":"2009","journal":"Blood","firstPage":"4942","lastPage":"4954","volume":"113"},"referencePositions":["SUBUNIT"]},{"referenceNumber":23,"citation":{"id":"19836242","citationType":"journal article","authors":["Tarcic G.","Boguslavsky S.K.","Wakim J.","Kiuchi T.","Liu A.","Reinitz F.","Nathanson D.","Takahashi T.","Mischel P.S.","Ng T.","Yarden Y."],"citationCrossReferences":[{"database":"PubMed","id":"19836242"},{"database":"DOI","id":"10.1016/j.cub.2009.09.048"}],"title":"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.","publicationDate":"2009","journal":"Curr. Biol.","firstPage":"1788","lastPage":"1798","volume":"19"},"referencePositions":["FUNCTION IN EGFR REGULATION","MUTAGENESIS OF ASP-1205 AND CYS-1239","SUBCELLULAR LOCATION"]},{"referenceNumber":24,"citation":{"id":"19332538","citationType":"journal article","authors":["Sallee J.L.","Burridge K."],"citationCrossReferences":[{"database":"PubMed","id":"19332538"},{"database":"DOI","id":"10.1074/jbc.m901901200"}],"title":"Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"14997","lastPage":"15006","volume":"284"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-1205 AND CYS-1239","SUBCELLULAR LOCATION"]},{"referenceNumber":25,"citation":{"id":"19494114","citationType":"journal article","authors":["Sacco F.","Tinti M.","Palma A.","Ferrari E.","Nardozza A.P.","Hooft van Huijsduijnen R.","Takahashi T.","Castagnoli L.","Cesareni G."],"citationCrossReferences":[{"database":"PubMed","id":"19494114"},{"database":"DOI","id":"10.1074/jbc.m109.002758"}],"title":"Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"22048","lastPage":"22058","volume":"284"},"referencePositions":["FUNCTION","MUTAGENESIS OF LYS-1016 AND ASP-1205"]},{"referenceNumber":26,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-413 AND ASN-937"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"18936167","citationType":"journal article","authors":["Chabot C.","Spring K.","Gratton J.P.","Elchebly M.","Royal I."],"citationCrossReferences":[{"database":"PubMed","id":"18936167"},{"database":"DOI","id":"10.1128/mcb.01374-08"}],"title":"New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.","publicationDate":"2009","journal":"Mol. Cell. Biol.","firstPage":"241","lastPage":"253","volume":"29"},"referencePositions":["FUNCTION","MUTAGENESIS OF ASP-1205 AND CYS-1239"]},{"referenceNumber":28,"citation":{"id":"21091576","citationType":"journal article","authors":["Petermann A.","Haase D.","Wetzel A.","Balavenkatraman K.K.","Tenev T.","Guhrs K.H.","Friedrich S.","Nakamura M.","Mawrin C.","Bohmer F.D."],"citationCrossReferences":[{"database":"PubMed","id":"21091576"},{"database":"DOI","id":"10.1111/j.1750-3639.2010.00464.x"}],"title":"Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.","publicationDate":"2011","journal":"Brain Pathol.","firstPage":"405","lastPage":"418","volume":"21"},"referencePositions":["FUNCTION"]},{"referenceNumber":29,"citation":{"id":"19922411","citationType":"journal article","authors":["Omerovic J.","Clague M.J.","Prior I.A."],"citationCrossReferences":[{"database":"PubMed","id":"19922411"},{"database":"DOI","id":"10.1042/bj20091413"}],"title":"Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.","publicationDate":"2010","journal":"Biochem. J.","firstPage":"65","lastPage":"72","volume":"426"},"referencePositions":["FUNCTION"]},{"referenceNumber":30,"citation":{"id":"21262971","citationType":"journal article","authors":["Arora D.","Stopp S.","Bohmer S.A.","Schons J.","Godfrey R.","Masson K.","Razumovskaya E.","Ronnstrand L.","Tanzer S.","Bauer R.","Bohmer F.D.","Muller J.P."],"citationCrossReferences":[{"database":"PubMed","id":"21262971"},{"database":"DOI","id":"10.1074/jbc.m110.205021"}],"title":"Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"10918","lastPage":"10929","volume":"286"},"referencePositions":["FUNCTION","INTERACTION WITH FLT3","MUTAGENESIS OF ASP-1205 AND CYS-1239"]},{"referenceNumber":31,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1009","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"30591527","citationType":"journal article","authors":["Marconi C.","Di Buduo C.A.","LeVine K.","Barozzi S.","Faleschini M.","Bozzi V.","Palombo F.","McKinstry S.","Lassandro G.","Giordano P.","Noris P.","Balduini C.L.","Savoia A.","Balduini A.","Pippucci T.","Seri M.","Katsanis N.","Pecci A."],"citationCrossReferences":[{"database":"PubMed","id":"30591527"},{"database":"DOI","id":"10.1182/blood-2018-07-859496"}],"title":"Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia.","publicationDate":"2019","journal":"Blood","firstPage":"1346","lastPage":"1357","volume":"133"},"referencePositions":["INVOLVEMENT IN THC10","FUNCTION"]},{"referenceNumber":33,"citation":{"id":"33296397","citationType":"journal article","authors":["Karagyozov L.","Grozdanov P.N.","Boehmer F.D."],"citationCrossReferences":[{"database":"PubMed","id":"33296397"},{"database":"DOI","id":"10.1371/journal.pone.0240498"}],"title":"The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals.","publicationDate":"2020","journal":"PLoS ONE","firstPage":"e0240498","lastPage":"e0240498","volume":"15"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 3)"]},{"referenceNumber":34,"citation":{"id":"CI-CNCR4HCF8O9E1","citationType":"submission","authoringGroup":["RIKEN structural genomics initiative (RSGI)"],"title":"Solution structure of the fourth FN3 domain of human receptor-type tyrosine-protein phosphatase eta.","publicationDate":"OCT-2006","submissionDatabase":"PDB data bank"},"referencePositions":["STRUCTURE BY NMR OF 366-456"]},{"referenceNumber":35,"citation":{"id":"15378013","citationType":"journal article","authors":["Iuliano R.","Le Pera I.","Cristofaro C.","Baudi F.","Arturi F.","Pallante P.","Martelli M.L.","Trapasso F.","Chiariotti L.","Fusco A."],"citationCrossReferences":[{"database":"PubMed","id":"15378013"},{"database":"DOI","id":"10.1038/sj.onc.1207766"}],"title":"The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.","publicationDate":"2004","journal":"Oncogene","firstPage":"8432","lastPage":"8438","volume":"23"},"referencePositions":["VARIANTS PRO-276; GLN-326 AND ASP-872"]},{"referenceNumber":36,"citation":{"id":"28052032","citationType":"journal article","authors":["Bilotta A.","Dattilo V.","D'Agostino S.","Belviso S.","Scalise S.","Bilotta M.","Gaudio E.","Paduano F.","Perrotti N.","Florio T.","Fusco A.","Iuliano R.","Trapasso F."],"citationCrossReferences":[{"database":"PubMed","id":"28052032"},{"database":"DOI","id":"10.18632/oncotarget.14350"}],"title":"A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.","publicationDate":"2017","journal":"Oncotarget","firstPage":"10091","lastPage":"10102","volume":"8"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORM 2)","FUNCTION (ISOFORM 2)","SUBCELLULAR LOCATION (ISOFORM 2)","TISSUE SPECIFICITY (ISOFORM 2)","GLYCOSYLATION (ISOFORM 2)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U10886","properties":[{"key":"ProteinId","value":"AAB36687.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D37781","properties":[{"key":"ProteinId","value":"BAA07035.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC026975","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC103828","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC063417","properties":[{"key":"ProteinId","value":"AAH63417.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AH011675","properties":[{"key":"ProteinId","value":"AAM69432.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS44596.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q12913-2"},{"database":"CCDS","id":"CCDS7945.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q12913-1"},{"database":"PIR","id":"I38670","properties":[{"key":"EntryName","value":"I38670"}]},{"database":"RefSeq","id":"NP_001091973.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001098503.2"}],"isoformId":"Q12913-2"},{"database":"RefSeq","id":"NP_002834.3","properties":[{"key":"NucleotideSequenceId","value":"NM_002843.4"}],"isoformId":"Q12913-1"},{"database":"PDB","id":"2CFV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1016-1311"}]},{"database":"PDB","id":"2DLE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=366-456"}]},{"database":"PDB","id":"2NZ6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1019-1311"}]},{"database":"PDB","id":"7U01","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A/B/C/D=206-364"}]},{"database":"PDB","id":"7U08","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"A=37-374"}]},{"database":"PDBsum","id":"2CFV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2DLE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2NZ6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U01","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U08","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111759","properties":[{"key":"Interactions","value":"104"}]},{"database":"FunCoup","id":"Q12913","properties":[{"key":"Number of interactors","value":"557"}]},{"database":"IntAct","id":"Q12913","properties":[{"key":"Interactions","value":"95"}]},{"database":"MINT","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PTPRJ","properties":[{"key":"Evidences","value":"8 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000400010","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3692","properties":[{"key":"Description","value":"-"}]},{"database":"DEPOD","id":"PTPRJ","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"Q12913","properties":[{"key":"glycosylation","value":"8 N-Linked glycans (4 sites)"}]},{"database":"GlyCosmos","id":"Q12913","properties":[{"key":"glycosylation","value":"36 sites, 8 glycans"}]},{"database":"GlyGen","id":"Q12913","properties":[{"key":"glycosylation","value":"45 sites, 41 N-linked glycans (18 sites), 3 O-linked glycans (7 sites)"}]},{"database":"iPTMnet","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PTPRJ","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"166899088","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000400010","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"59024","properties":[{"key":"Description","value":"-"}],"isoformId":"Q12913-1"},{"database":"ProteomicsDB","id":"59025","properties":[{"key":"Description","value":"-"}],"isoformId":"Q12913-2"},{"database":"Pumba","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1162","properties":[{"key":"antibodies","value":"536 antibodies from 37 providers"}]},{"database":"DNASU","id":"5795","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000418331.7","properties":[{"key":"ProteinId","value":"ENSP00000400010.2"},{"key":"GeneId","value":"ENSG00000149177.15"}],"isoformId":"Q12913-1"},{"database":"Ensembl","id":"ENST00000440289.6","properties":[{"key":"ProteinId","value":"ENSP00000409733.2"},{"key":"GeneId","value":"ENSG00000149177.15"}],"isoformId":"Q12913-2"},{"database":"GeneID","id":"5795","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5795","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000418331.7","properties":[{"key":"ProteinId","value":"ENSP00000400010.2"},{"key":"RefSeqNucleotideId","value":"NM_002843.4"},{"key":"RefSeqProteinId","value":"NP_002834.3"}]},{"database":"UCSC","id":"uc001ngo.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q12913-1"},{"database":"AGR","id":"HGNC:9673","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34018","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5795","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5795","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PTPRJ","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9673","properties":[{"key":"GeneName","value":"PTPRJ"}]},{"database":"HPA","id":"ENSG00000149177","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"PTPRJ","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600925","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"620484","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"566192","properties":[{"key":"Disease","value":"Congenital autosomal recessive small-platelet thrombocytopenia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0791","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156870","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001541_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PGMMYSF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10253954at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q12913","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.1.3.48","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-202427","properties":[{"key":"PathwayName","value":"Phosphorylation of CD3 and TCR zeta chains"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-6807004","properties":[{"key":"PathwayName","value":"Negative regulation of MET activity"}]},{"database":"Reactome","id":"R-HSA-9706369","properties":[{"key":"PathwayName","value":"Negative regulation of FLT3"}]},{"database":"SignaLink","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000149177","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5795","properties":[{"key":"hits","value":"18 hits in 1177 CRISPR screens"}]},{"database":"ChiTaRS","id":"PTPRJ","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"PTPRJ","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5795","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q12913","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q12913","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q12913","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000149177","properties":[{"key":"ExpressionPatterns","value":"Expressed in ileal mucosa and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q12913","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12913111"}]},{"database":"GO","id":"GO:0005911","properties":[{"key":"GoTerm","value":"C:cell-cell junction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19332538"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0001772","properties":[{"key":"GoTerm","value":"C:immunological synapse"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12913111"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18348712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19836242"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9531590"}]},{"database":"GO","id":"GO:0032587","properties":[{"key":"GoTerm","value":"C:ruffle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0035579","properties":[{"key":"GoTerm","value":"C:specific granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0008013","properties":[{"key":"GoTerm","value":"F:beta-catenin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12370829"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"28926625"}]},{"database":"GO","id":"GO:0070097","properties":[{"key":"GoTerm","value":"F:delta-catenin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19332538"}]},{"database":"GO","id":"GO:0045295","properties":[{"key":"GoTerm","value":"F:gamma-catenin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"12370829"}]},{"database":"GO","id":"GO:0051019","properties":[{"key":"GoTerm","value":"F:mitogen-activated protein kinase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19494114"}]},{"database":"GO","id":"GO:0016791","properties":[{"key":"GoTerm","value":"F:phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12062403"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19494114"}]},{"database":"GO","id":"GO:0005161","properties":[{"key":"GoTerm","value":"F:platelet-derived growth factor receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10821867"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19332538"}]},{"database":"GO","id":"GO:0004725","properties":[{"key":"GoTerm","value":"F:protein tyrosine phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10821867"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12913111"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18348712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18936167"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19332538"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9531590"}]},{"database":"GO","id":"GO:0007411","properties":[{"key":"GoTerm","value":"P:axon guidance"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030183","properties":[{"key":"GoTerm","value":"P:B cell differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0060242","properties":[{"key":"GoTerm","value":"P:contact inhibition"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7937872"}]},{"database":"GO","id":"GO:0019221","properties":[{"key":"GoTerm","value":"P:cytokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030308","properties":[{"key":"GoTerm","value":"P:negative regulation of cell growth"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14709717"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16682945"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14709717"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16682945"}]},{"database":"GO","id":"GO:0042059","properties":[{"key":"GoTerm","value":"P:negative regulation of epidermal growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19836242"}]},{"database":"GO","id":"GO:0043407","properties":[{"key":"GoTerm","value":"P:negative regulation of MAP kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19494114"}]},{"database":"GO","id":"GO:0051898","properties":[{"key":"GoTerm","value":"P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19922411"}]},{"database":"GO","id":"GO:0010642","properties":[{"key":"GoTerm","value":"P:negative regulation of platelet-derived growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14709717"}]},{"database":"GO","id":"GO:0050860","properties":[{"key":"GoTerm","value":"P:negative regulation of T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12913111"}]},{"database":"GO","id":"GO:0043116","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular permeability"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19332538"}]},{"database":"GO","id":"GO:0035335","properties":[{"key":"GoTerm","value":"P:peptidyl-tyrosine dephosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10821867"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12913111"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18348712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18936167"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19332538"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9531590"}]},{"database":"GO","id":"GO:0030220","properties":[{"key":"GoTerm","value":"P:platelet formation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30591527"}]},{"database":"GO","id":"GO:0048008","properties":[{"key":"GoTerm","value":"P:platelet-derived growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21091576"}]},{"database":"GO","id":"GO:0050918","properties":[{"key":"GoTerm","value":"P:positive chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14709717"}]},{"database":"GO","id":"GO:0050850","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium-mediated signaling"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21091576"}]},{"database":"GO","id":"GO:0060369","properties":[{"key":"GoTerm","value":"P:positive regulation of Fc receptor mediated stimulatory signaling pathway"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"18249142"}]},{"database":"GO","id":"GO:0051894","properties":[{"key":"GoTerm","value":"P:positive regulation of focal adhesion assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21091576"}]},{"database":"GO","id":"GO:0043410","properties":[{"key":"GoTerm","value":"P:positive regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0050766","properties":[{"key":"GoTerm","value":"P:positive regulation of phagocytosis"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18936167"}]},{"database":"GO","id":"GO:0032760","properties":[{"key":"GoTerm","value":"P:positive regulation of tumor necrosis factor production"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12370829"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050852","properties":[{"key":"GoTerm","value":"P:T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"5"}]},{"database":"CDD","id":"cd14615","properties":[{"key":"EntryName","value":"R-PTPc-J"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.190.10:FF:000009","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000362","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase eta"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:001417","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase eta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"7"}]},{"database":"Gene3D","id":"3.90.190.10","properties":[{"key":"EntryName","value":"Protein tyrosine phosphatase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00665","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR029021","properties":[{"key":"EntryName","value":"Prot-tyrosine_phosphatase-like"}]},{"database":"InterPro","id":"IPR000242","properties":[{"key":"EntryName","value":"PTP_cat"}]},{"database":"InterPro","id":"IPR041201","properties":[{"key":"EntryName","value":"PTPRJ_TM"}]},{"database":"InterPro","id":"IPR050713","properties":[{"key":"EntryName","value":"RTP_Phos/Ushers"}]},{"database":"InterPro","id":"IPR016130","properties":[{"key":"EntryName","value":"Tyr_Pase_AS"}]},{"database":"InterPro","id":"IPR003595","properties":[{"key":"EntryName","value":"Tyr_Pase_cat"}]},{"database":"InterPro","id":"IPR000387","properties":[{"key":"EntryName","value":"Tyr_Pase_dom"}]},{"database":"PANTHER","id":"PTHR46957","properties":[{"key":"EntryName","value":"CYTOKINE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46957:SF5","properties":[{"key":"EntryName","value":"PROTEIN-TYROSINE-PHOSPHATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF18861","properties":[{"key":"EntryName","value":"PTP_tm"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00102","properties":[{"key":"EntryName","value":"Y_phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00700","properties":[{"key":"EntryName","value":"PRTYPHPHTASE"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]},{"database":"SMART","id":"SM00194","properties":[{"key":"EntryName","value":"PTPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00404","properties":[{"key":"EntryName","value":"PTPc_motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52799","properties":[{"key":"EntryName","value":"(Phosphotyrosine protein) phosphatases II"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS00383","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50056","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50055","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_PTP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA","length":1337,"molWeight":145941,"crc64":"B44F4343FC8FD1B4","md5":"449FFA988B52EEFBC7D605CEDFE35D02"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":12,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":2,"PTM":2,"DISEASE":1,"MISCELLANEOUS":1,"SIMILARITY":1,"CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":10,"Region":2,"Compositional bias":2,"Active site":1,"Binding site":3,"Modified residue":1,"Glycosylation":34,"Alternative sequence":3,"Natural variant":7,"Mutagenesis":3,"Sequence conflict":5,"Helix":14,"Beta strand":33,"Turn":5},"uniParcId":"UPI00004564C8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8V8TP51","uniProtkbId":"A0A8V8TP51_HUMAN","entryAudit":{"firstPublicDate":"2022-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-12-14","entryVersion":19,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10044"}],"value":"Protein-tyrosine-phosphatase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10044"}],"value":"3.1.3.48"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"}],"value":"PTPRJ"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10684"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"}],"ecNumber":"3.1.3.48","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051722"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10044"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064171"}],"value":"Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with FLT3 (phosphorylated). Interacts with GAB1 and GRB2"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004282"}],"value":"Cell junction","id":"SL-0038"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004632"}],"value":"Cell projection, ruffle membrane","id":"SL-0301"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025789"}],"value":"Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":1089,"modifier":"EXACT"},"end":{"value":1110,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":834,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1412,"modifier":"EXACT"}},"description":"Tyrosine-protein phosphatase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50055"}]},{"type":"Domain","location":{"start":{"value":1330,"modifier":"EXACT"},"end":{"value":1403,"modifier":"EXACT"}},"description":"Tyrosine specific protein phosphatases","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50056"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":1353,"modifier":"EXACT"},"end":{"value":1353,"modifier":"EXACT"}},"description":"Phosphocysteine intermediate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00160"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022949"}],"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00160"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022912"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00160"}],"id":"KW-0904","category":"Molecular function","name":"Protein phosphatase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A8V8TP51"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A8V8TP51"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000514003.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC026975","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC103828","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"A0A8V8TP51","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000698881.1","properties":[{"key":"ProteinId","value":"ENSP00000514003.1"},{"key":"GeneId","value":"ENSG00000149177.15"}]},{"database":"HGNC","id":"HGNC:9673","properties":[{"key":"GeneName","value":"PTPRJ"}]},{"database":"OpenTargets","id":"ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000156870","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10253954at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"ExpressionAtlas","id":"A0A8V8TP51","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070161","properties":[{"key":"GoTerm","value":"C:anchoring junction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001772","properties":[{"key":"GoTerm","value":"C:immunological synapse"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0032587","properties":[{"key":"GoTerm","value":"C:ruffle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045296","properties":[{"key":"GoTerm","value":"F:cadherin binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004725","properties":[{"key":"GoTerm","value":"F:protein tyrosine phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009653","properties":[{"key":"GoTerm","value":"P:anatomical structure morphogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030097","properties":[{"key":"GoTerm","value":"P:hemopoiesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0002376","properties":[{"key":"GoTerm","value":"P:immune system process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010642","properties":[{"key":"GoTerm","value":"P:negative regulation of platelet-derived growth factor receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0050860","properties":[{"key":"GoTerm","value":"P:negative regulation of T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0001954","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-matrix adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051130","properties":[{"key":"GoTerm","value":"P:positive regulation of cellular component organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0050778","properties":[{"key":"GoTerm","value":"P:positive regulation of immune response"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1902533","properties":[{"key":"GoTerm","value":"P:positive regulation of intracellular signal transduction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"5"}]},{"database":"CDD","id":"cd14615","properties":[{"key":"EntryName","value":"R-PTPc-J"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.190.10:FF:000009","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000362","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase eta"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:001417","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase eta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"7"}]},{"database":"Gene3D","id":"3.90.190.10","properties":[{"key":"EntryName","value":"Protein tyrosine phosphatase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR029021","properties":[{"key":"EntryName","value":"Prot-tyrosine_phosphatase-like"}]},{"database":"InterPro","id":"IPR000242","properties":[{"key":"EntryName","value":"PTP_cat"}]},{"database":"InterPro","id":"IPR041201","properties":[{"key":"EntryName","value":"PTPRJ_TM"}]},{"database":"InterPro","id":"IPR050713","properties":[{"key":"EntryName","value":"RTP_Phos/Ushers"}]},{"database":"InterPro","id":"IPR016130","properties":[{"key":"EntryName","value":"Tyr_Pase_AS"}]},{"database":"InterPro","id":"IPR003595","properties":[{"key":"EntryName","value":"Tyr_Pase_cat"}]},{"database":"InterPro","id":"IPR000387","properties":[{"key":"EntryName","value":"Tyr_Pase_dom"}]},{"database":"PANTHER","id":"PTHR46957","properties":[{"key":"EntryName","value":"CYTOKINE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46957:SF5","properties":[{"key":"EntryName","value":"PROTEIN-TYROSINE-PHOSPHATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF18861","properties":[{"key":"EntryName","value":"PTP_tm"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00102","properties":[{"key":"EntryName","value":"Y_phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00700","properties":[{"key":"EntryName","value":"PRTYPHPHTASE"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]},{"database":"SMART","id":"SM00194","properties":[{"key":"EntryName","value":"PTPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00404","properties":[{"key":"EntryName","value":"PTPc_motif"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52799","properties":[{"key":"EntryName","value":"(Phosphotyrosine protein) phosphatases II"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00383","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50056","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50055","properties":[{"key":"EntryName","value":"TYR_PHOSPHATASE_PTP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTRGGGSGSSRGSRDRVAARWGWAPLAPPREAPARSGTRPPRGSRARLRRVAAAAAAAAMSPGKPGAGGAGTRRTGWRRRRRRRRQEAATTVPGLGRTAGPDSRVRGTFQGARGMKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA","length":1451,"molWeight":157846,"crc64":"83FC268BE51C6E4E","md5":"6A9B6780A5DE369E14BE1ADEE46ABEE6"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1,"Domain":5,"Region":3,"Compositional bias":4,"Active site":1},"uniParcId":"UPI000013DB76"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PPH3","uniProtkbId":"E9PPH3_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":87,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"}],"value":"Protein tyrosine phosphatase receptor type J"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"}],"value":"PTPRJ"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025789"}],"value":"Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003242895"},{"type":"Domain","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Non-terminal residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PPH3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PPH3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432686.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC026975","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC103828","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PPH3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PPH3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PPH3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22718","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1162","properties":[{"key":"antibodies","value":"536 antibodies from 37 providers"}]},{"database":"Ensembl","id":"ENST00000534219.5","properties":[{"key":"ProteinId","value":"ENSP00000432686.1"},{"key":"GeneId","value":"ENSG00000149177.15"}]},{"database":"UCSC","id":"uc058biq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9673","properties":[{"key":"GeneName","value":"PTPRJ"}]},{"database":"OpenTargets","id":"ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000156870","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2054972_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10253954at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PTPRJ","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000149177","properties":[{"key":"ExpressionPatterns","value":"Expressed in ileal mucosa and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PPH3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000362","properties":[{"key":"EntryName","value":"Receptor-type tyrosine-protein phosphatase eta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGRPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPR","length":120,"molWeight":13292,"crc64":"47EB68519BF95A76","md5":"22E304ED2ADE3E90183FC2EA4AF10BB9"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F77F48"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PJ83","uniProtkbId":"E9PJ83_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":89,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"}],"value":"Protein tyrosine phosphatase receptor type J"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"}],"value":"PTPRJ"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5008413945"},{"type":"Region","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PJ83"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PJ83"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435618.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC026975","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC103828","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PJ83","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PJ83","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PJ83","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"21053","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1162","properties":[{"key":"antibodies","value":"536 antibodies from 37 providers"}]},{"database":"Ensembl","id":"ENST00000527952.1","properties":[{"key":"ProteinId","value":"ENSP00000435618.1"},{"key":"GeneId","value":"ENSG00000149177.15"}]},{"database":"UCSC","id":"uc058bir.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9673","properties":[{"key":"GeneName","value":"PTPRJ"}]},{"database":"OpenTargets","id":"ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149177","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000156870","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1781668_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10253954at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PTPRJ","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSG00000149177","properties":[{"key":"ExpressionPatterns","value":"Expressed in ileal mucosa and 182 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PJ83","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030054","properties":[{"key":"GoTerm","value":"C:cell junction"},{"key":"GoEvidenceType","value":"IDA:HPA"}]}],"sequence":{"value":"MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTEPIPVSDLRVALTGVRKAALSWSNGNGTA","length":146,"molWeight":14970,"crc64":"DE636FFE8FD85022","md5":"B0436B9ACD55D2D5DB065E8610D8263E"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":2,"Non-terminal residue":1},"uniParcId":"UPI0003F47BEC"}}]}