{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P04156","secondaryAccessions":["O60489","P78446","Q15216","Q15221","Q27H91","Q5QPB4","Q8TBG0","Q96E70","Q9UP19"],"uniProtkbId":"PRIO_HUMAN","entryAudit":{"firstPublicDate":"1986-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1986-11-01","entryVersion":282,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Major prion protein"},"shortNames":[{"value":"PrP"}]},"alternativeNames":[{"fullName":{"value":"ASCR"}},{"fullName":{"value":"PrP27-30"}},{"fullName":{"value":"PrP33-35C"}}],"cdAntigenNames":[{"value":"CD230"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"PRNP"},"synonyms":[{"value":"ALTPRP"},{"value":"PRIP"},{"value":"PRP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12732622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19936054"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20564047"},{"evidenceCode":"ECO:0000305"}],"value":"Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524679"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11900542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623188"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17468747"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19204296"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20375014"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20564047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21153684"}],"value":"Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization (PubMed:11524679, PubMed:11900542, PubMed:14623188, PubMed:17468747, PubMed:19204296, PubMed:19927125, PubMed:20375014, PubMed:20564047). Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with KIAA1191 (PubMed:21153684). Interacts with ADGRG6 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q9UL18","geneName":"AGO1","intActId":"EBI-527363"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q9UKV8","geneName":"AGO2","intActId":"EBI-528269"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P05067-4","geneName":"APP","intActId":"EBI-302641"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","chainId":"PRO_0000000092","intActId":"EBI-821758"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q8WXF7","geneName":"ATL1","intActId":"EBI-2410266"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P25311","geneName":"AZGP1","intActId":"EBI-2513837"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P55085","geneName":"F2RL1","intActId":"EBI-4303189"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q13642","geneName":"FHL1","intActId":"EBI-912547"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"O75084","geneName":"FZD7","intActId":"EBI-746917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P49639","geneName":"HOXA1","intActId":"EBI-740785"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":13,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P10636","geneName":"MAPT","intActId":"EBI-366182"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P29372","geneName":"MPG","intActId":"EBI-1043398"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q9BSJ6","geneName":"PIMREG","intActId":"EBI-2568609"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q9H4B4","geneName":"PLK3","intActId":"EBI-751877"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q06830","geneName":"PRDX1","intActId":"EBI-353193"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P04156","geneName":"PRNP","intActId":"EBI-977302"},"numberOfExperiments":33,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q8N6K7-2","geneName":"SAMD3","intActId":"EBI-11528848"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"Q8CJG0","geneName":"Ago2","intActId":"EBI-528299"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P04925","geneName":"Prnp","intActId":"EBI-768613"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P10279","geneName":"PRNP","intActId":"EBI-7430632"},"numberOfExperiments":5,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P04156","intActId":"EBI-977302"},"interactantTwo":{"uniProtKBAccession":"P23907","geneName":"PRNP","intActId":"EBI-7670302"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"chainId":"PRO_0000025675","intActId":"EBI-8830282"},"interactantTwo":{"uniProtKBAccession":"P31424-2","geneName":"Grm5","intActId":"EBI-8830305"},"numberOfExperiments":4,"organismDiffer":true},{"interactantOne":{"chainId":"PRO_0000025675","intActId":"EBI-8830282"},"interactantTwo":{"uniProtKBAccession":"P52480","geneName":"Pkm","intActId":"EBI-647785"},"numberOfExperiments":5,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19936054"}],"value":"Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis"}]},"subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19936054"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative initiation"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"PrP"}],"isoformIds":["P04156-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"3"},"synonyms":[{"value":"AltPrP"}],"isoformIds":["F7VJQ1-1"],"isoformSequenceStatus":"External"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17468747"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20564047"}],"value":"The normal, monomeric form, PRPN(C), has a mainly alpha-helical structure. Misfolding of this form produces a disease-associated, protease-resistant form, PRPN (Sc), accompanied by a large increase of the beta-sheet content and formation of amyloid fibrils. These fibrils consist of a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. In addition, the heparan-sulfate proteoglycan, GPC1, promotes the association of PRPN (C) to lipid rafts and appears to facilitate the conversion to PRPN (Sc)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11524679"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11900542"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20375014"}],"value":"Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12214108"}],"value":"The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1683708"}],"value":"The five tandem octapeptide repeats region is highly unstable. Insertions or deletions of octapeptide repeat units are associated to prion disease"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26061765"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9482303"}],"value":"A number of polymorphisms confer resistance to prion diseases (PubMed:1439789, PubMed:19923577, PubMed:26061765, PubMed:9482303). Val-127 has been selected for in response to the Kuru epidemic and confers resistance to prion disease by acting as a 'dominant negative' inhibitor of prion conversion (PubMed:26061765). Val-127 is not only itself resistant to conformational conversion, but also inhibits conversion of wild-type proteins. Confers protection against classical Creutzfeldt-Jakob disease (CJD) and Kuru in the heterozygous state, but can be infected with variant CJD prions, resulting from exposure to bovine spongiform encephalopathy prions. Confers complete resistance to all prion strains when homozygous (PubMed:26061765). Always associated with M-129 variant (PubMed:26061765). Val-129 confers relative protection against acquired, sporadic and some inherited prion diseases in the heterozygous state, possibly by preventing homodimerization (PubMed:1439789). Lys-219 confers relative protection against sporadic Creutzfeldt-Jakob disease (CJD) in the heterozygous state (PubMed:9482303)"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8105771"}],"value":"PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gerstmann-Straussler disease (GSD), Huntington disease-like type 1 (HDL1) and kuru in humans; scrapie in sheep and goat; bovine spongiform encephalopathy (BSE) in cattle; transmissible mink encephalopathy (TME); chronic wasting disease (CWD) of mule deer and elk; feline spongiform encephalopathy (FSE) in cats and exotic ungulate encephalopathy (EUE) in nyala and greater kudu. The prion diseases illustrate three manifestations of CNS degeneration: (1) infectious (2) sporadic and (3) dominantly inherited forms. TME, CWD, BSE, FSE, EUE are all thought to occur after consumption of prion-infected foodstuffs"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Creutzfeldt-Jakob disease","diseaseAccession":"DI-01448","acronym":"CJD","description":"Occurs primarily as a sporadic disorder (1 per million), while 10-15% are familial. Accidental transmission of CJD to humans appears to be iatrogenic (contaminated human growth hormone (HGH), corneal transplantation, electroencephalographic electrode implantation, etc.). Epidemiologic studies have failed to implicate the ingestion of infected animal meat in the pathogenesis of CJD in human. The triad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration of neurons, (2) severe astrocytic gliosis that often appears to be out of proportion to the degree of nerve cell loss, and (3) amyloid plaque formation. CJD is characterized by progressive dementia and myoclonic seizures, affecting adults in mid-life. Some patients present sleep disorders, abnormalities of high cortical function, cerebellar and corticospinal disturbances. The disease ends in death after a 3-12 months illness.","diseaseCrossReference":{"database":"MIM","id":"123400"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10790216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1671440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1975028"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902693"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7906019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7913755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8461023"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8909447"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Fatal familial insomnia","diseaseAccession":"DI-01607","acronym":"FFI","description":"Autosomal dominant disorder and is characterized by neuronal degeneration limited to selected thalamic nuclei and progressive insomnia.","diseaseCrossReference":{"database":"MIM","id":"600072"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1347910"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Gerstmann-Straussler disease","diseaseAccession":"DI-01656","acronym":"GSD","description":"A rare inherited prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain. GSD presents with progressive limb and truncal ataxia, dysarthria, and cognitive decline in the thirties and forties, and the average disease duration is 7 years.","diseaseCrossReference":{"database":"MIM","id":"137440"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581485"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11709001"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1363810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2564168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7699395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7783876"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902972"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8797472"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9786248"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Huntington disease-like 1","diseaseAccession":"DI-01755","acronym":"HDL1","description":"Autosomal dominant, early-onset neurodegenerative disorder with prominent psychiatric features.","diseaseCrossReference":{"database":"MIM","id":"603218"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9792871"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Kuru","diseaseAccession":"DI-01871","acronym":"KURU","description":"Kuru is transmitted during ritualistic cannibalism, among natives of the New Guinea highlands. Patients exhibit various movement disorders like cerebellar abnormalities, rigidity of the limbs, and clonus. Emotional lability is present, and dementia is conspicuously absent. Death usually occurs from 3 to 12 month after onset.","diseaseCrossReference":{"database":"MIM","id":"245300"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19923577"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26061765"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Spongiform encephalopathy with neuropsychiatric features","diseaseAccession":"DI-02210","acronym":"SENF","description":"Autosomal dominant presenile dementia with a rapidly progressive and protracted clinical course. The dementia was characterized clinically by frontotemporal features, including early personality changes. Some patients had memory loss, several showed aggressiveness, hyperorality and verbal stereotypy, others had parkinsonian symptoms.","diseaseCrossReference":{"database":"MIM","id":"606688"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12214108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9266722"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21478263"}],"value":"This protein is produced by a bicistronic gene which also produces the alternative prion protein/AltPrP (AC F7VJQ1) from an overlapping reading frame"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The alternative prion protein/AltPrP (AC F7VJQ1) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19059915"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29222195"}],"value":"An isoform was shown to be localized to both the cytoplasm and the nucleus and to be sumoylated with SUMO1 (PubMed:19059915). The article has later been withdrawn by the authors"}],"commentType":"CAUTION"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/PRNP","ftp":false,"note":"PRNP entry"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/179/","ftp":false,"note":"The shape of harm - Issue 179 of May 2016"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Major prion protein","featureId":"PRO_0000025675"},{"type":"Propeptide","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Removed in mature form","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04273"}],"featureId":"PRO_0000025676"},{"type":"Repeat","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"1"},{"type":"Repeat","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"2"},{"type":"Repeat","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"3"},{"type":"Repeat","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"4"},{"type":"Repeat","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"5"},{"type":"Region","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Interaction with GRB2, ERI3 and SYN1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"}]},{"type":"Region","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Interaction with ADGRG6","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04925"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q"},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"1"}},{"type":"Binding site","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"1"}},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"1"}},{"type":"Binding site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"2"}},{"type":"Binding site","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"2"}},{"type":"Binding site","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"2"}},{"type":"Binding site","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"3"}},{"type":"Binding site","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"3"}},{"type":"Binding site","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"3"}},{"type":"Binding site","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"4"}},{"type":"Binding site","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"4"}},{"type":"Binding site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29036"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11900542"}],"ligand":{"name":"Cu(2+)","id":"ChEBI:CHEBI:29036","label":"4"}},{"type":"Lipidation","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"GPI-anchor amidated serine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04273"}]},{"type":"Glycosylation","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12214108"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19349973"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623188"}]},{"type":"Natural variant","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1363802"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1678248"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7485229"}],"featureId":"VAR_013763","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in GSD and early-onset dementia; dbSNP:rs74315401","featureCrossReferences":[{"database":"dbSNP","id":"rs74315401"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10631141"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2564168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2783132"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7783876"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8797472"}],"featureId":"VAR_006464","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in GSD; dbSNP:rs11538758","featureCrossReferences":[{"database":"dbSNP","id":"rs11538758"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7699395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902972"}],"featureId":"VAR_006465","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"linked to development of dementing Gerstmann-Straussler disease; dbSNP:rs74315402","featureCrossReferences":[{"database":"dbSNP","id":"rs74315402"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2783132"}],"featureId":"VAR_006466","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"protective factor against Kuru; protective factor against prion disease; confers protection against classical Creutzfeldt-Jakob disease (CJD) and Kuru in the heterozygous state but can be infected with variant CJD prions resulting from exposure to bovine spongiform encephalopathy prions; confers complete resistance to all prion strains when homozygous; acts as a 'dominant negative' inhibitor of prion conversion; is not only itself resistant to conformational conversion, but also inhibits conversion of wild-type proteins; dbSNP:rs267606980","featureCrossReferences":[{"database":"dbSNP","id":"rs267606980"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19923577"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26061765"}],"featureId":"VAR_073722","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"protective factor against acquired, sporadic and some inherited prion diseases in the heterozygous state, possibly by preventing homodimerization; determines the disease phenotype in patients who have a PrP mutation at position 178; patients with M-129 develop FFI, those with V-129 develop CJD; dbSNP:rs1799990","featureCrossReferences":[{"database":"dbSNP","id":"rs1799990"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12690204"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2783132"}],"featureId":"VAR_006467","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in GSD; dbSNP:rs74315410","featureCrossReferences":[{"database":"dbSNP","id":"rs74315410"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11709001"}],"featureId":"VAR_014264","alternativeSequence":{"originalSequence":"G","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in schizoaffective disorder; dbSNP:rs16990018","featureCrossReferences":[{"database":"dbSNP","id":"rs16990018"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9384372"}],"featureId":"VAR_006468","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in FFI and CJD; dbSNP:rs74315403","featureCrossReferences":[{"database":"dbSNP","id":"rs74315403"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1347910"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1671440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"}],"featureId":"VAR_006469","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs74315408","featureCrossReferences":[{"database":"dbSNP","id":"rs74315408"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1439789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8461023"}],"featureId":"VAR_006470","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in SENF and early-onset dementia; induces loss of glycosylation at N-181; dbSNP:rs74315411","featureCrossReferences":[{"database":"dbSNP","id":"rs74315411"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10631141"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12214108"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9266722"}],"featureId":"VAR_006471","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in GSD; dbSNP:rs74315413","featureCrossReferences":[{"database":"dbSNP","id":"rs74315413"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10581485"}],"featureId":"VAR_008746","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in early-onset dementia and dementia due to prion diseases","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10631141"}],"featureId":"VAR_008748","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in dbSNP:rs372878791","featureCrossReferences":[{"database":"dbSNP","id":"rs372878791"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10987652"}],"featureId":"VAR_008747","alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in CJD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10790216"}],"featureId":"VAR_008749","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in GSD; atypical form with neurofibrillary tangles; dbSNP:rs74315405","featureCrossReferences":[{"database":"dbSNP","id":"rs74315405"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19927125"}],"featureId":"VAR_006472","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs28933385","featureCrossReferences":[{"database":"dbSNP","id":"rs28933385"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1975028"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7906019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7913755"}],"featureId":"VAR_006473","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in GSD; dbSNP:rs761807915","featureCrossReferences":[{"database":"dbSNP","id":"rs761807915"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9786248"}],"featureId":"VAR_008750","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in CJD; uncertain significance; dbSNP:rs776593792","featureCrossReferences":[{"database":"dbSNP","id":"rs776593792"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10790216"}],"featureId":"VAR_008751","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs74315412","featureCrossReferences":[{"database":"dbSNP","id":"rs74315412"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8909447"}],"featureId":"VAR_006474","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs74315407","featureCrossReferences":[{"database":"dbSNP","id":"rs74315407"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902693"}],"featureId":"VAR_006475","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs398122370","featureCrossReferences":[{"database":"dbSNP","id":"rs398122370"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10790216"}],"featureId":"VAR_008752","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in GSD; dbSNP:rs751882709","featureCrossReferences":[{"database":"dbSNP","id":"rs751882709"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9786248"}],"featureId":"VAR_008753","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in GSD; with neurofibrillary tangles; dbSNP:rs74315406","featureCrossReferences":[{"database":"dbSNP","id":"rs74315406"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1363810"}],"featureId":"VAR_006476","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"confers relative protection against sporadic Creutzfeldt-Jakob disease (CJD) in the heterozygous state; dbSNP:rs1800014","featureCrossReferences":[{"database":"dbSNP","id":"rs1800014"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8797472"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9482303"}],"featureId":"VAR_006477","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"in CJD; dbSNP:rs74315409","featureCrossReferences":[{"database":"dbSNP","id":"rs74315409"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8461023"}],"featureId":"VAR_006478","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10987652"}],"featureId":"VAR_008754","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in Ref. 9; AAA19664/BAA00011","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in Ref. 6; ABD63004","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in Ref. 8; AAH22532","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Beta strand","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1OEI"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1OEI"}]},{"type":"Turn","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1OEI"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1OEH"}]},{"type":"Beta strand","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UMQ"}]},{"type":"Beta strand","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UN5"}]},{"type":"Helix","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2KUN"}]},{"type":"Beta strand","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RL4"}]},{"type":"Turn","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RL4"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KML"}]},{"type":"Helix","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RL4"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3MD4"}]},{"type":"Beta strand","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RL4"}]},{"type":"Helix","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KML"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1E1S"}]},{"type":"Helix","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KML"}]},{"type":"Helix","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KML"}]},{"type":"Beta strand","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1E1U"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4KML"}]},{"type":"Turn","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1QM0"}]},{"type":"Beta strand","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1H"}]},{"type":"Beta strand","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LNI"}]},{"type":"Beta strand","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LNI"}]},{"type":"Turn","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3HAK"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LNI"}]},{"type":"Beta strand","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LNI"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4E1H"}]},{"type":"Helix","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LEJ"}]},{"type":"Turn","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3HER"}]},{"type":"Turn","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2LFT"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"id":"KW-1008","category":"Disease","name":"Amyloidosis"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0186","category":"Ligand","name":"Copper"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"id":"KW-0338","category":"Biological process","name":"Growth arrest"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0640","category":"Molecular function","name":"Prion"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"3755672","citationType":"journal article","authors":["Kretzschmar H.A.","Stowring L.E.","Westaway D.","Stubblebine W.H.","Prusiner S.B.","Dearmond S.J."],"citationCrossReferences":[{"database":"PubMed","id":"3755672"},{"database":"DOI","id":"10.1089/dna.1986.5.315"}],"title":"Molecular cloning of a human prion protein cDNA.","publicationDate":"1986","journal":"DNA","firstPage":"315","lastPage":"324","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"1678248","citationType":"journal article","authors":["Puckett C.","Concannon P.","Casey C.","Hood L.E."],"citationCrossReferences":[{"database":"PubMed","id":"1678248"}],"title":"Genomic structure of the human prion protein gene.","publicationDate":"1991","journal":"Am. J. Hum. Genet.","firstPage":"320","lastPage":"329","volume":"49"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT 56-GLY--GLY-63 DEL"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"9799790","citationType":"journal article","authors":["Lee I.Y.","Westaway D.","Smit A.F.A.","Wang K.","Seto J.","Chen L.","Acharya C.","Ankener M.","Baskin D.","Cooper C.","Yao H.","Prusiner S.B.","Hood L.E."],"citationCrossReferences":[{"database":"PubMed","id":"9799790"},{"database":"DOI","id":"10.1101/gr.8.10.1022"}],"title":"Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.","publicationDate":"1998","journal":"Genome Res.","firstPage":"1022","lastPage":"1037","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"10581485","citationType":"journal article","authors":["Cervenakova L.","Buetefisch C.","Lee H.S.","Taller I.","Stone G.","Gibbs C.J. Jr.","Brown P.","Hallett M.","Goldfarb L.G."],"citationCrossReferences":[{"database":"PubMed","id":"10581485"},{"database":"DOI","id":"10.1002/(sici)1096-8628(19991215)88:6<653::aid-ajmg14>3.0.co;2-e"}],"title":"Novel PRNP sequence variant associated with familial encephalopathy.","publicationDate":"1999","journal":"Am. J. Med. Genet.","firstPage":"653","lastPage":"656","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GSD ARG-187"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-LVJ46LLIUD8F","citationType":"submission","authors":["Hryb D.J.","Reynolds T.A.","Nakhla A.M.","Kahn S.M.","Khan S.M.","Romas N.A.","Rosner W."],"title":"Cloning of human prostate prion protein cDNA.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Prostate","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-DJKS178M4B05G","citationType":"submission","authors":["Zhang J.","Liu Y.","Chen H.","Jiang H.","Lu W.","Zhu X.","Xie Q.","Cai X.","Liu X."],"title":"Analysis and comparison of several mammalian prion protein genes Prnp.","publicationDate":"FEB-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"3014653","citationType":"journal article","authors":["Liao Y.-C.J.","Lebo R.V.","Clawson G.A.","Smuckler E.A."],"citationCrossReferences":[{"database":"PubMed","id":"3014653"},{"database":"DOI","id":"10.1126/science.3014653"}],"title":"Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications.","publicationDate":"1986","journal":"Science","firstPage":"364","lastPage":"367","volume":"233"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 8-253"]},{"referenceNumber":10,"citation":{"id":"1363802","citationType":"journal article","authors":["Diedrich J.F.","Knopman D.S.","List J.F.","Olson K.","Frey W.H.","Emory C.R.","Sung J.H.","Haase A.T."],"citationCrossReferences":[{"database":"PubMed","id":"1363802"},{"database":"DOI","id":"10.1093/hmg/1.6.443"}],"title":"Deletion in the prion protein gene in a demented patient.","publicationDate":"1992","journal":"Hum. Mol. Genet.","firstPage":"443","lastPage":"444","volume":"1"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-232","VARIANT 56-GLY--GLY-63 DEL"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"9384372","citationType":"journal article","authors":["Samaia H.B.","Mari J.J.","Vallada H.P.","Moura R.P.","Simpson A.J.G.","Brentani R.R."],"citationCrossReferences":[{"database":"PubMed","id":"9384372"},{"database":"DOI","id":"10.1038/36757"}],"title":"A prion-linked psychiatric disorder.","publicationDate":"1997","journal":"Nature","firstPage":"241","lastPage":"241","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-253","VARIANT SCHIZOAFFECTIVE DISORDER SER-171"]},{"referenceNumber":12,"citation":{"id":"7485229","citationType":"journal article","authors":["Perry R.T.","Go R.C.","Harrell L.E.","Acton R.T."],"citationCrossReferences":[{"database":"PubMed","id":"7485229"},{"database":"DOI","id":"10.1002/ajmg.1320600104"}],"title":"SSCP analysis and sequencing of the human prion protein gene (PRNP) detects two different 24 bp deletions in an atypical Alzheimer's disease family.","publicationDate":"1995","journal":"Am. J. Med. Genet.","firstPage":"12","lastPage":"18","volume":"60"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-85","VARIANT 56-GLY--GLY-63 DEL"]},{"referenceNumber":13,"citation":{"id":"1672107","citationType":"journal article","authors":["Tagliavini F.","Prelli F.","Ghiso J.","Bugiani O.","Serban D.","Prusiner S.B.","Farlow M.R.","Ghetti B.","Frangione B."],"citationCrossReferences":[{"database":"PubMed","id":"1672107"},{"database":"DOI","id":"10.1002/j.1460-2075.1991.tb07977.x"}],"title":"Amyloid protein of Gerstmann-Straussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.","publicationDate":"1991","journal":"EMBO J.","firstPage":"513","lastPage":"519","volume":"10"},"referencePositions":["PROTEIN SEQUENCE OF 58-85 AND 111-150"]},{"referenceNumber":14,"citation":{"id":"1683708","citationType":"journal article","authors":["Goldfarb L.G.","Brown P.","McCombie W.R.","Goldgaber D.","Swergold G.D.","Wills P.R.","Cervenakova L.","Baron H.","Gibbs C.J. Jr.","Gajdusek D.C."],"citationCrossReferences":[{"database":"PubMed","id":"1683708"},{"database":"DOI","id":"10.1073/pnas.88.23.10926"}],"title":"Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10926","lastPage":"10930","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-91"]},{"referenceNumber":15,"citation":{"id":"9792871","citationType":"journal article","authors":["Xiang F.","Almqvist E.W.","Huq M.","Lundin A.","Hayden M.R.","Edstroem L.","Anvret M.","Zhang Z."],"citationCrossReferences":[{"database":"PubMed","id":"9792871"},{"database":"DOI","id":"10.1086/302093"}],"title":"A Huntington disease-like neurodegenerative disorder maps to chromosome 20p.","publicationDate":"1998","journal":"Am. J. Hum. Genet.","firstPage":"1431","lastPage":"1438","volume":"63"},"referencePositions":["INVOLVEMENT IN HDL1"]},{"referenceNumber":16,"citation":{"id":"12732622","citationType":"journal article","authors":["Mani K.","Cheng F.","Havsmark B.","Jonsson M.","Belting M.","Fransson L.A."],"citationCrossReferences":[{"database":"PubMed","id":"12732622"},{"database":"DOI","id":"10.1074/jbc.m300394200"}],"title":"Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"38956","lastPage":"38965","volume":"278"},"referencePositions":["COPPER-BINDING","FUNCTION"]},{"referenceNumber":17,"citation":{"id":"12214108","citationType":"journal article","authors":["Capellari S.","Zaidi S.I.","Long A.C.","Kwon E.E.","Petersen R.B."],"citationCrossReferences":[{"database":"PubMed","id":"12214108"},{"database":"DOI","id":"10.3233/jad-2000-2104"}],"title":"The Thr183Ala mutation, not the loss of the first glycosylation site, alters the physical properties of the prion protein.","publicationDate":"2000","journal":"J. Alzheimers Dis.","firstPage":"27","lastPage":"35","volume":"2"},"referencePositions":["GLYCOSYLATION AT ASN-181","VARIANT SENF ALA-183","CHARACTERIZATION OF VARIANT SENF ALA-183"]},{"referenceNumber":18,"citation":{"id":"16144413","citationType":"journal article","authors":["Chattopadhyay M.","Walter E.D.","Newell D.J.","Jackson P.J.","Aronoff-Spencer E.","Peisach J.","Gerfen G.J.","Bennett B.","Antholine W.E.","Millhauser G.L."],"citationCrossReferences":[{"database":"PubMed","id":"16144413"},{"database":"DOI","id":"10.1021/ja053254z"}],"title":"The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.","publicationDate":"2005","journal":"J. Am. Chem. Soc.","firstPage":"12647","lastPage":"12656","volume":"127"},"referencePositions":["COPPER-BINDING"]},{"referenceNumber":19,"citation":{"id":"18034490","citationType":"journal article","authors":["Walter E.D.","Stevens D.J.","Visconte M.P.","Millhauser G.L."],"citationCrossReferences":[{"database":"PubMed","id":"18034490"},{"database":"DOI","id":"10.1021/ja077146j"}],"title":"The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes.","publicationDate":"2007","journal":"J. Am. Chem. Soc.","firstPage":"15440","lastPage":"15441","volume":"129"},"referencePositions":["COPPER-BINDING","ZINC-BINDING"]},{"referenceNumber":20,"citation":{"id":"19059915","citationType":"journal article","authors":["Juanes M.E.","Elvira G.","Garcia-Grande A.","Calero M.","Gasset M."],"citationCrossReferences":[{"database":"PubMed","id":"19059915"},{"database":"DOI","id":"10.1074/jbc.m804051200"}],"title":"Biosynthesis of prion protein nucleocytoplasmic isoforms by alternative initiation of translation.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"2787","lastPage":"2794","volume":"284"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":21,"citation":{"id":"29222195","citationType":"journal article","authors":["Juanes M.E.","Elvira G.","Garcia-Grande A.","Calero M.","Gasset M."],"citationCrossReferences":[{"database":"PubMed","id":"29222195"},{"database":"DOI","id":"10.1074/jbc.w117.000658"}],"title":"Biosynthesis of prion protein nucleocytoplasmic isoforms by alternative initiation of translation.","publicationDate":"2017","journal":"J. Biol. Chem.","firstPage":"20044","lastPage":"20044","volume":"292"},"referencePositions":["RETRACTION NOTICE OF PUBMED:19059915"]},{"referenceNumber":22,"citation":{"id":"19349973","citationType":"journal article","authors":["Wollscheid B.","Bausch-Fluck D.","Henderson C.","O'Brien R.","Bibel M.","Schiess R.","Aebersold R.","Watts J.D."],"citationCrossReferences":[{"database":"PubMed","id":"19349973"},{"database":"DOI","id":"10.1038/nbt.1532"}],"title":"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.","publicationDate":"2009","journal":"Nat. Biotechnol.","firstPage":"378","lastPage":"386","volume":"27"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-197"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"19936054","citationType":"journal article","authors":["Taylor D.R.","Whitehouse I.J.","Hooper N.M."],"citationCrossReferences":[{"database":"PubMed","id":"19936054"},{"database":"DOI","id":"10.1371/journal.ppat.1000666"}],"title":"Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.","publicationDate":"2009","journal":"PLoS Pathog.","firstPage":"E1000666","lastPage":"E1000666","volume":"5"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISEASE ASSOCIATION"]},{"referenceNumber":24,"citation":{"id":"19381258","citationType":"journal article","authors":["Stevens D.J.","Walter E.D.","Rodriguez A.","Draper D.","Davies P.","Brown D.R.","Millhauser G.L."],"citationCrossReferences":[{"database":"PubMed","id":"19381258"},{"database":"DOI","id":"10.1371/journal.ppat.1000390"}],"title":"Early onset prion disease from octarepeat expansion correlates with copper or zinc binding properties.","publicationDate":"2009","journal":"PLoS Pathog.","firstPage":"E1000390","lastPage":"E1000390","volume":"5"},"referencePositions":["COPPER-BINDING"]},{"referenceNumber":25,"citation":{"id":"20375014","citationType":"journal article","authors":["Adrover M.","Pauwels K.","Prigent S.","de Chiara C.","Xu Z.","Chapuis C.","Pastore A.","Rezaei H."],"citationCrossReferences":[{"database":"PubMed","id":"20375014"},{"database":"DOI","id":"10.1074/jbc.m110.111815"}],"title":"Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"21004","lastPage":"21012","volume":"285"},"referencePositions":["SUBUNIT","DOMAIN"]},{"referenceNumber":26,"citation":{"id":"20564047","citationType":"journal article","authors":["Wu D.","Zhang W.","Luo Q.","Luo K.","Huang L.","Wang W.","Huang T.","Chen R.","Lin Y.","Pang D.","Xiao G."],"citationCrossReferences":[{"database":"PubMed","id":"20564047"},{"database":"DOI","id":"10.1002/jcb.22743"}],"title":"Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment.","publicationDate":"2010","journal":"J. Cell. Biochem.","firstPage":"627","lastPage":"633","volume":"111"},"referencePositions":["COPPER-BINDING","CIRCULAR DICHROISM","DOMAIN","FUNCTION","SUBUNIT"]},{"referenceNumber":27,"citation":{"id":"21478263","citationType":"journal article","authors":["Vanderperre B.","Staskevicius A.B.","Tremblay G.","McCoy M.","O'Neill M.A.","Cashman N.R.","Roucou X."],"citationCrossReferences":[{"database":"PubMed","id":"21478263"},{"database":"DOI","id":"10.1096/fj.10-173815"}],"title":"An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.","publicationDate":"2011","journal":"FASEB J.","firstPage":"2373","lastPage":"2386","volume":"25"},"referencePositions":["BICISTRONIC GENE"]},{"referenceNumber":28,"citation":{"id":"21153684","citationType":"journal article","authors":["Mishra M.","Inoue N.","Heese K."],"citationCrossReferences":[{"database":"PubMed","id":"21153684"},{"database":"DOI","id":"10.1007/s11010-010-0690-4"}],"title":"Characterizing the novel protein p33MONOX.","publicationDate":"2011","journal":"Mol. Cell. Biochem.","firstPage":"127","lastPage":"134","volume":"350"},"referencePositions":["INTERACTION WITH KIAA1191"]},{"referenceNumber":29,"citation":{"id":"10954699","citationType":"journal article","authors":["Zhang Y.","Swietnicki W.","Zagorski M.G.","Surewicz W.K.","Soennichsen F.D."],"citationCrossReferences":[{"database":"PubMed","id":"10954699"},{"database":"DOI","id":"10.1074/jbc.c000483200"}],"title":"Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"33650","lastPage":"33654","volume":"275"},"referencePositions":["STRUCTURE BY NMR OF 90-231 OF MUTANT LYS-200"]},{"referenceNumber":30,"citation":{"id":"10618385","citationType":"journal article","authors":["Zahn R.","Liu A.","Luhrs T.","Riek R.","von Schroetter C.","Lopez Garcia F.","Billeter M.","Calzolai L.","Wider G.","Wuethrich K."],"citationCrossReferences":[{"database":"PubMed","id":"10618385"},{"database":"DOI","id":"10.1073/pnas.97.1.145"}],"title":"NMR solution structure of the human prion protein.","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"145","lastPage":"150","volume":"97"},"referencePositions":["STRUCTURE BY NMR OF 23-230"]},{"referenceNumber":31,"citation":{"id":"10900000","citationType":"journal article","authors":["Calzolai L.","Lysek D.A.","Guntert P.","von Schroetter C.","Riek R.","Zahn R.","Wuethrich K."],"citationCrossReferences":[{"database":"PubMed","id":"10900000"},{"database":"DOI","id":"10.1073/pnas.97.15.8340"}],"title":"NMR structures of three single-residue variants of the human prion protein.","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8340","lastPage":"8345","volume":"97"},"referencePositions":["STRUCTURE BY NMR OF 118-221"]},{"referenceNumber":32,"citation":{"id":"11524679","citationType":"journal article","authors":["Knaus K.J.","Morillas M.","Swietnicki W.","Malone M.","Surewicz W.K.","Yee V.C."],"citationCrossReferences":[{"database":"PubMed","id":"11524679"},{"database":"DOI","id":"10.1038/nsb0901-770"}],"title":"Crystal structure of the human prion protein reveals a mechanism for oligomerization.","publicationDate":"2001","journal":"Nat. Struct. Biol.","firstPage":"770","lastPage":"774","volume":"8"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 119-226","DOMAIN","SUBUNIT"]},{"referenceNumber":33,"citation":{"id":"11900542","citationType":"journal article","authors":["Burns C.S.","Aronoff-Spencer E.","Dunham C.M.","Lario P.","Avdievich N.I.","Antholine W.E.","Olmstead M.M.","Vrielink A.","Gerfen G.J.","Peisach J.","Scott W.G.","Millhauser G.L."],"citationCrossReferences":[{"database":"PubMed","id":"11900542"},{"database":"DOI","id":"10.1021/bi011922x"}],"title":"Molecular features of the copper binding sites in the octarepeat domain of the prion protein.","publicationDate":"2002","journal":"Biochemistry","firstPage":"3991","lastPage":"4001","volume":"41"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (0.75 ANGSTROMS) OF 61-65 IN COMPLEX WITH COPPER ION","DOMAIN","SUBUNIT"]},{"referenceNumber":34,"citation":{"id":"14623188","citationType":"journal article","authors":["Zahn R."],"citationCrossReferences":[{"database":"PubMed","id":"14623188"},{"database":"DOI","id":"10.1016/j.jmb.2003.09.048"}],"title":"The octapeptide repeats in mammalian prion protein constitute a pH-dependent folding and aggregation site.","publicationDate":"2003","journal":"J. Mol. Biol.","firstPage":"477","lastPage":"488","volume":"334"},"referencePositions":["STRUCTURE BY NMR OF 61-68","DISULFIDE BOND","SUBUNIT"]},{"referenceNumber":35,"citation":{"id":"8364585","citationType":"journal article","authors":["Palmer M.S.","Collinge J."],"citationCrossReferences":[{"database":"PubMed","id":"8364585"},{"database":"DOI","id":"10.1002/humu.1380020303"}],"title":"Mutations and polymorphisms in the prion protein gene.","publicationDate":"1993","journal":"Hum. Mutat.","firstPage":"168","lastPage":"173","volume":"2"},"referencePositions":["REVIEW ON VARIANTS"]},{"referenceNumber":36,"citation":{"id":"8105771","citationType":"journal article","authors":["Prusiner S.B."],"citationCrossReferences":[{"database":"PubMed","id":"8105771"},{"database":"DOI","id":"10.1001/archneur.1993.00540110011002"}],"title":"Genetic and infectious prion diseases.","publicationDate":"1993","journal":"Arch. Neurol.","firstPage":"1129","lastPage":"1153","volume":"50"},"referencePositions":["REVIEW ON VARIANTS","INVOLVEMENT IN PRION DISEASES"]},{"referenceNumber":37,"citation":{"id":"17468747","citationType":"journal article","authors":["Sawaya M.R.","Sambashivan S.","Nelson R.","Ivanova M.I.","Sievers S.A.","Apostol M.I.","Thompson M.J.","Balbirnie M.","Wiltzius J.J.","McFarlane H.T.","Madsen A.O.","Riekel C.","Eisenberg D."],"citationCrossReferences":[{"database":"PubMed","id":"17468747"},{"database":"DOI","id":"10.1038/nature05695"}],"title":"Atomic structures of amyloid cross-beta spines reveal varied steric zippers.","publicationDate":"2007","journal":"Nature","firstPage":"453","lastPage":"457","volume":"447"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (0.85 ANGSTROMS) OF 170-175","SUBUNIT","DOMAIN"]},{"referenceNumber":38,"citation":{"id":"19204296","citationType":"journal article","authors":["Antonyuk S.V.","Trevitt C.R.","Strange R.W.","Jackson G.S.","Sangar D.","Batchelor M.","Cooper S.","Fraser C.","Jones S.","Georgiou T.","Khalili-Shirazi A.","Clarke A.R.","Hasnain S.S.","Collinge J."],"citationCrossReferences":[{"database":"PubMed","id":"19204296"},{"database":"DOI","id":"10.1073/pnas.0809170106"}],"title":"Crystal structure of human prion protein bound to a therapeutic antibody.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2554","lastPage":"2558","volume":"106"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 119-231 IN COMPLEX WITH FAB FRAGMENT OF MONOCLONAL ANTIBODY ICSM 18","SUBUNIT"]},{"referenceNumber":39,"citation":{"id":"19927125","citationType":"journal article","authors":["Lee S.","Antony L.","Hartmann R.","Knaus K.J.","Surewicz K.","Surewicz W.K.","Yee V.C."],"citationCrossReferences":[{"database":"PubMed","id":"19927125"},{"database":"DOI","id":"10.1038/emboj.2009.333"}],"title":"Conformational diversity in prion protein variants influences intermolecular beta-sheet formation.","publicationDate":"2010","journal":"EMBO J.","firstPage":"251","lastPage":"262","volume":"29"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 125-227 OF VARIANT VAL-129","VARIANT VAL-129","VARIANT CJD ASN-178","VARIANT FFI ASN-178","VARIANT GSD SER-198","SUBUNIT","DOMAIN"]},{"referenceNumber":40,"citation":{"id":"2564168","citationType":"journal article","authors":["Hsiao K.","Baker H.F.","Crow T.J.","Poulter M.","Owen F.","Terwilliger J.D.","Westaway D.","Ott J.","Pursiner S.B."],"citationCrossReferences":[{"database":"PubMed","id":"2564168"},{"database":"DOI","id":"10.1038/338342a0"}],"title":"Linkage of a prion protein missense variant to Gerstmann-Straussler syndrome.","publicationDate":"1989","journal":"Nature","firstPage":"342","lastPage":"345","volume":"338"},"referencePositions":["VARIANT GSD LEU-102"]},{"referenceNumber":41,"citation":{"id":"2783132","citationType":"journal article","authors":["Doh-Ura K.","Tateishi J.","Sasaki H.","Kitamoto T.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"2783132"},{"database":"DOI","id":"10.1016/0006-291x(89)92317-6"}],"title":"Pro-->Leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Straussler syndrome.","publicationDate":"1989","journal":"Biochem. Biophys. Res. Commun.","firstPage":"974","lastPage":"979","volume":"163"},"referencePositions":["VARIANTS LEU-102; VAL-117 AND VAL-129"]},{"referenceNumber":42,"citation":{"id":"1347910","citationType":"journal article","authors":["Medori R.","Montagna P.","Tritschler H.J.","Leblanc A.","Cortelli P.","Tinuper P.","Lugaresi E.","Gambetti P."],"citationCrossReferences":[{"database":"PubMed","id":"1347910"},{"database":"DOI","id":"10.1212/wnl.42.3.669"}],"title":"Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178.","publicationDate":"1992","journal":"Neurology","firstPage":"669","lastPage":"670","volume":"42"},"referencePositions":["VARIANT FFI ASN-178"]},{"referenceNumber":43,"citation":{"id":"1671440","citationType":"journal article","authors":["Goldfarb L.G.","Haltia M.","Brown P.","Nieto A.","Kovanen J.","McCombie W.R.","Trapp S.","Gajdusek D.C."],"citationCrossReferences":[{"database":"PubMed","id":"1671440"},{"database":"DOI","id":"10.1016/0140-6736(91)91198-4"}],"title":"New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred.","publicationDate":"1991","journal":"Lancet","firstPage":"425","lastPage":"425","volume":"337"},"referencePositions":["VARIANT CJD ASN-178"]},{"referenceNumber":44,"citation":{"id":"1975028","citationType":"journal article","authors":["Goldfarb L.","Mitrova E.","Brown P.","Toh B.K.","Gajdusek D.C."],"citationCrossReferences":[{"database":"PubMed","id":"1975028"},{"database":"DOI","id":"10.1016/0140-6736(90)92073-q"}],"title":"Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia.","publicationDate":"1990","journal":"Lancet","firstPage":"514","lastPage":"515","volume":"336"},"referencePositions":["VARIANT CJD LYS-200"]},{"referenceNumber":45,"citation":{"id":"1363810","citationType":"journal article","authors":["Hsiao K.","Dlouhy S.R.","Farlow M.R.","Cass C.","da Costa M.","Conneally P.M.","Hodes M.E.","Ghetti B.","Prusiner S.B."],"citationCrossReferences":[{"database":"PubMed","id":"1363810"},{"database":"DOI","id":"10.1038/ng0492-68"}],"title":"Mutant prion proteins in Gerstmann-Straussler-Scheinker disease with neurofibrillary tangles.","publicationDate":"1992","journal":"Nat. Genet.","firstPage":"68","lastPage":"71","volume":"1"},"referencePositions":["VARIANT GSD ARG-217"]},{"referenceNumber":46,"citation":{"id":"1439789","citationType":"journal article","authors":["Goldfarb L.G.","Petersen R.B.","Tabaton M.","Brown P.","LeBlanc A.C.","Montagna P.","Cortelli P.","Julien J.","Vital C.","Pendelbury W.W."],"citationCrossReferences":[{"database":"PubMed","id":"1439789"},{"database":"DOI","id":"10.1126/science.1439789"}],"title":"Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.","publicationDate":"1992","journal":"Science","firstPage":"806","lastPage":"808","volume":"258"},"referencePositions":["VARIANT VAL-129","VARIANT CJD ASN-178","VARIANT FFI ASN-178","CHARACTERIZATION OF VARIANT VAL-129","CHARACTERIZATION OF VARIANT CJD ASN-178","CHARACTERIZATION OF VARIANT FFI ASN-178","POLYMORPHISM"]},{"referenceNumber":47,"citation":{"id":"8461023","citationType":"journal article","authors":["Kitamoto T.","Ohta M.","Doh-Ura K.","Hitoshi S.","Terao Y.","Tateishi J."],"citationCrossReferences":[{"database":"PubMed","id":"8461023"},{"database":"DOI","id":"10.1006/bbrc.1993.1275"}],"title":"Novel missense variants of prion protein in Creutzfeldt-Jakob disease or Gerstmann-Straussler syndrome.","publicationDate":"1993","journal":"Biochem. Biophys. Res. Commun.","firstPage":"709","lastPage":"714","volume":"191"},"referencePositions":["VARIANTS CJD ILE-180 AND ARG-232"]},{"referenceNumber":48,"citation":{"id":"7902693","citationType":"journal article","authors":["Pocchiari M.","Salvatore M.","Cutruzzola F.","Genuardi M.","Allcatelli C.T.","Masullo C.","Macchi G.","Alema G.","Galgani S.","Xi Y.G.","Petraroli R.","Silvestrini M.C.","Brunori M."],"citationCrossReferences":[{"database":"PubMed","id":"7902693"},{"database":"DOI","id":"10.1002/ana.410340608"}],"title":"A new point mutation of the prion protein gene in Creutzfeldt-Jakob disease.","publicationDate":"1993","journal":"Ann. Neurol.","firstPage":"802","lastPage":"807","volume":"34"},"referencePositions":["VARIANT CJD ILE-210"]},{"referenceNumber":49,"citation":{"id":"7902972","citationType":"journal article","authors":["Yamada M.","Itoh Y.","Fujigasaki H.","Naruse S.","Kaneko K.","Kitamoto T.","Tateishi J.","Otomo E.","Hayakawa M.","Tanaka J.","Matsushita M.","Miyatake T."],"citationCrossReferences":[{"database":"PubMed","id":"7902972"},{"database":"DOI","id":"10.1212/wnl.43.12.2723-a"}],"title":"A missense mutation at codon 105 with codon 129 polymorphism of the prion protein gene in a new variant of Gerstmann-Straussler-Scheinker disease.","publicationDate":"1993","journal":"Neurology","firstPage":"2723","lastPage":"2724","volume":"43"},"referencePositions":["VARIANT GSD LEU-105"]},{"referenceNumber":50,"citation":{"id":"7699395","citationType":"journal article","authors":["Itoh Y.","Yamada M.","Hayakawa M.","Shozawa T.","Tanaka J.","Matsushita M.","Kitamoto T.","Tateishi J.","Otomo E."],"citationCrossReferences":[{"database":"PubMed","id":"7699395"},{"database":"DOI","id":"10.1016/0022-510x(94)90138-4"}],"title":"A variant of Gerstmann-Straussler-Scheinker disease carrying codon 105 mutation with codon 129 polymorphism of the prion protein gene: a clinicopathological study.","publicationDate":"1994","journal":"J. Neurol. Sci.","firstPage":"77","lastPage":"86","volume":"127"},"referencePositions":["VARIANT GSD LEU-105"]},{"referenceNumber":51,"citation":{"id":"7906019","citationType":"journal article","authors":["Inoue I.","Kitamoto T.","Doh-Ura K.","Shii H.","Goto I.","Tateishi J."],"citationCrossReferences":[{"database":"PubMed","id":"7906019"},{"database":"DOI","id":"10.1212/wnl.44.2.299"}],"title":"Japanese family with Creutzfeldt-Jakob disease with codon 200 point mutation of the prion protein gene.","publicationDate":"1994","journal":"Neurology","firstPage":"299","lastPage":"301","volume":"44"},"referencePositions":["VARIANT CJD LYS-200"]},{"referenceNumber":52,"citation":{"id":"7913755","citationType":"journal article","authors":["Gabizon R.","Rosenman H.","Meiner Z.","Kahana I.","Kahana E.","Shugart Y.","Ott J.","Prusiner S.B."],"citationCrossReferences":[{"database":"PubMed","id":"7913755"},{"database":"DOI","id":"10.1098/rstb.1994.0033"}],"title":"Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease.","publicationDate":"1994","journal":"Philos. Trans. R. Soc. Lond., B, Biol. Sci.","firstPage":"385","lastPage":"390","volume":"343"},"referencePositions":["VARIANT CJD LYS-200"]},{"referenceNumber":53,"citation":{"id":"7783876","citationType":"journal article","authors":["Young K.","Jones C.K.","Piccardo P.","Lazzarini A.","Golbe L.I.","Zimmerman T.R.","Dickson D.W.","McLachlan D.C.","St George-Hyslop P.H.","Lennox A."],"citationCrossReferences":[{"database":"PubMed","id":"7783876"},{"database":"DOI","id":"10.1212/wnl.45.6.1127"}],"title":"Gerstmann-Straussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients.","publicationDate":"1995","journal":"Neurology","firstPage":"1127","lastPage":"1134","volume":"45"},"referencePositions":["VARIANT GSD LEU-102"]},{"referenceNumber":54,"citation":{"id":"8797472","citationType":"journal article","authors":["Barbanti P.","Fabbrini G.","Salvatore M.","Petraroli R.","Cardone F.","Maras B.","Equestre M.","Macchi G.","Lenzi G.L.","Pocchiari M."],"citationCrossReferences":[{"database":"PubMed","id":"8797472"},{"database":"DOI","id":"10.1212/wnl.47.3.734"}],"title":"Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Straussler-Scheinker disease (PrP-P102L mutation).","publicationDate":"1996","journal":"Neurology","firstPage":"734","lastPage":"741","volume":"47"},"referencePositions":["VARIANT GSD LEU-102","VARIANT LYS-219"]},{"referenceNumber":55,"citation":{"id":"8909447","citationType":"journal article","authors":["Mastrianni J.A.","Iannicola C.","Myers R.M.","Dearmond S.","Prusiner S.B."],"citationCrossReferences":[{"database":"PubMed","id":"8909447"},{"database":"DOI","id":"10.1212/wnl.47.5.1305"}],"title":"Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease.","publicationDate":"1996","journal":"Neurology","firstPage":"1305","lastPage":"1312","volume":"47"},"referencePositions":["VARIANT CJD HIS-208"]},{"referenceNumber":56,"citation":{"id":"9266722","citationType":"journal article","authors":["Nitrini R.","Rosemberg S.","Passos-Bueno M.R.","da Silva L.S.","Iughetti P.","Papadopoulos M.","Carrilho P.M.","Caramelli P.","Albrecht S.","Zatz M.","Leblanc A."],"citationCrossReferences":[{"database":"PubMed","id":"9266722"},{"database":"DOI","id":"10.1002/ana.410420203"}],"title":"Familial spongiform encephalopathy associated with a novel prion protein gene mutation.","publicationDate":"1997","journal":"Ann. Neurol.","firstPage":"138","lastPage":"146","volume":"42"},"referencePositions":["VARIANT SENF ALA-183"]},{"referenceNumber":57,"citation":{"id":"9786248","citationType":"journal article","authors":["Piccardo P.","Dlouhy S.R.","Lievens P.M.","Young K.","Bird T.D.","Nochlin D.","Dickson D.W.","Vinters H.V.","Zimmerman T.R.","Mackenzie I.R.","Kish S.J.","Ang L.C.","De Carli C.","Pocchiari M.","Brown P.","Gibbs C.J. Jr.","Gajdusek D.C.","Bugiani O.","Ironside J.","Tagliavini F.","Ghetti B."],"citationCrossReferences":[{"database":"PubMed","id":"9786248"},{"database":"DOI","id":"10.1097/00005072-199810000-00010"}],"title":"Phenotypic variability of Gerstmann-Straussler-Scheinker disease is associated with prion protein heterogeneity.","publicationDate":"1998","journal":"J. Neuropathol. Exp. Neurol.","firstPage":"979","lastPage":"988","volume":"57"},"referencePositions":["VARIANTS GSD ASN-202 AND PRO-212"]},{"referenceNumber":58,"citation":{"id":"9482303","citationType":"journal article","authors":["Shibuya S.","Higuchi J.","Shin R.W.","Tateishi J.","Kitamoto T."],"citationCrossReferences":[{"database":"PubMed","id":"9482303"},{"database":"DOI","id":"10.1016/s0140-6736(05)78358-6"}],"title":"Protective prion protein polymorphisms against sporadic Creutzfeldt-Jakob disease.","publicationDate":"1998","journal":"Lancet","firstPage":"419","lastPage":"419","volume":"351"},"referencePositions":["VARIANT LYS-219","CHARACTERIZATION OF VARIANT LYS-219","POLYMORPHISM"]},{"referenceNumber":59,"citation":{"id":"10987652","citationType":"journal article","authors":["Windl O.","Giese A.","Schulz-Schaeffer W.","Zerr I.","Skworc K.","Arendt S.","Oberdieck C.","Bodemer M.","Poser S.","Kretzschmar H.A."],"citationCrossReferences":[{"database":"PubMed","id":"10987652"},{"database":"DOI","id":"10.1007/s004399900124"}],"title":"Molecular genetics of human prion diseases in Germany.","publicationDate":"1999","journal":"Hum. Genet.","firstPage":"244","lastPage":"252","volume":"105"},"referencePositions":["VARIANTS ARG-188 AND SER-238"]},{"referenceNumber":60,"citation":{"id":"10631141","citationType":"journal article","authors":["Finckh U.","Mueller-Thomsen T.","Mann U.","Eggers C.","Marksteiner J.","Meins W.","Binetti G.","Alberici A.","Hock C.","Nitsch R.M.","Gal A."],"citationCrossReferences":[{"database":"PubMed","id":"10631141"},{"database":"DOI","id":"10.1086/302702"}],"title":"High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.","publicationDate":"2000","journal":"Am. J. Hum. Genet.","firstPage":"110","lastPage":"117","volume":"66"},"referencePositions":["VARIANTS EARLY-ONSET DEMENTIA LEU-102; ALA-183 AND LYS-188"]},{"referenceNumber":61,"citation":{"id":"10790216","citationType":"journal article","authors":["Peoc'h K.","Manivet P.","Beaudry P.","Attane F.","Besson G.","Didier H.","Delasnerie-Laupretre N.","Laplanche J.-L."],"citationCrossReferences":[{"database":"PubMed","id":"10790216"},{"database":"DOI","id":"10.1002/(sici)1098-1004(200005)15:5<482::aid-humu16>3.0.co;2-1"}],"title":"Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype.","publicationDate":"2000","journal":"Hum. Mutat.","firstPage":"482","lastPage":"482","volume":"15"},"referencePositions":["VARIANTS CJD LYS-196; ILE-203 AND GLN-211"]},{"referenceNumber":62,"citation":{"id":"11709001","citationType":"journal article","authors":["Panegyres P.K.","Toufexis K.","Kakulas B.A.","Cernevakova L.","Brown P.","Ghetti B.","Piccardo P.","Dlouhy S.R."],"citationCrossReferences":[{"database":"PubMed","id":"11709001"},{"database":"DOI","id":"10.1001/archneur.58.11.1899"}],"title":"A new PRNP mutation (G131V) associated with Gerstmann-Straussler-Scheinker disease.","publicationDate":"2001","journal":"Arch. Neurol.","firstPage":"1899","lastPage":"1902","volume":"58"},"referencePositions":["VARIANT GSD VAL-131"]},{"referenceNumber":63,"citation":{"id":"12690204","citationType":"journal article","authors":["Mead S.","Stumpf M.P.","Whitfield J.","Beck J.A.","Poulter M.","Campbell T.","Uphill J.B.","Goldstein D.","Alpers M.","Fisher E.M.","Collinge J."],"citationCrossReferences":[{"database":"PubMed","id":"12690204"},{"database":"DOI","id":"10.1126/science.1083320"}],"title":"Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics.","publicationDate":"2003","journal":"Science","firstPage":"640","lastPage":"643","volume":"300"},"referencePositions":["VARIANT VAL-129","CHARACTERIZATION OF VARIANT VAL-129"]},{"referenceNumber":64,"citation":{"id":"19923577","citationType":"journal article","authors":["Mead S.","Whitfield J.","Poulter M.","Shah P.","Uphill J.","Campbell T.","Al-Dujaily H.","Hummerich H.","Beck J.","Mein C.A.","Verzilli C.","Whittaker J.","Alpers M.P.","Collinge J."],"citationCrossReferences":[{"database":"PubMed","id":"19923577"},{"database":"DOI","id":"10.1056/nejmoa0809716"}],"title":"A novel protective prion protein variant that colocalizes with kuru exposure.","publicationDate":"2009","journal":"N. Engl. J. Med.","firstPage":"2056","lastPage":"2065","volume":"361"},"referencePositions":["VARIANT VAL-127","INVOLVEMENT IN KURU"]},{"referenceNumber":65,"citation":{"id":"26061765","citationType":"journal article","authors":["Asante E.A.","Smidak M.","Grimshaw A.","Houghton R.","Tomlinson A.","Jeelani A.","Jakubcova T.","Hamdan S.","Richard-Londt A.","Linehan J.M.","Brandner S.","Alpers M.","Whitfield J.","Mead S.","Wadsworth J.D.","Collinge J."],"citationCrossReferences":[{"database":"PubMed","id":"26061765"},{"database":"DOI","id":"10.1038/nature14510"}],"title":"A naturally occurring variant of the human prion protein completely prevents prion disease.","publicationDate":"2015","journal":"Nature","firstPage":"478","lastPage":"481","volume":"522"},"referencePositions":["VARIANT VAL-127","CHARACTERIZATION OF VARIANT VAL-127","INVOLVEMENT IN KURU","POLYMORPHISM"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M13899","properties":[{"key":"ProteinId","value":"AAA60182.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X83416","properties":[{"key":"ProteinId","value":"CAA58442.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U29185","properties":[{"key":"ProteinId","value":"AAC78725.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF076976","properties":[{"key":"ProteinId","value":"AAD46098.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY008282","properties":[{"key":"ProteinId","value":"AAG21693.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ408531","properties":[{"key":"ProteinId","value":"ABD63004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL133396","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC012844","properties":[{"key":"ProteinId","value":"AAH12844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC022532","properties":[{"key":"ProteinId","value":"AAH22532.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D00015","properties":[{"key":"ProteinId","value":"BAA00011.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M13667","properties":[{"key":"ProteinId","value":"AAA19664.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M81929","properties":[{"key":"ProteinId","value":"AAB59442.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M81930","properties":[{"key":"ProteinId","value":"AAB59443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF030575","properties":[{"key":"ProteinId","value":"AAC05365.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S80732","properties":[{"key":"ProteinId","value":"AAB50648.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S80743","properties":[{"key":"ProteinId","value":"AAB50649.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S71208","properties":[{"key":"ProteinId","value":"AAB20521.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S71210","properties":[{"key":"ProteinId","value":"AAB20522.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"S71212","properties":[{"key":"ProteinId","value":"AAB20523.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS13080.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04156-1"},{"database":"PIR","id":"A24173","properties":[{"key":"EntryName","value":"UJHU"}]},{"database":"RefSeq","id":"NP_000302.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000311.5"}],"isoformId":"P04156-1"},{"database":"RefSeq","id":"NP_001073590.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080121.3"}],"isoformId":"P04156-1"},{"database":"RefSeq","id":"NP_001073591.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080122.3"}],"isoformId":"P04156-1"},{"database":"RefSeq","id":"NP_001073592.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080123.3"}],"isoformId":"P04156-1"},{"database":"RefSeq","id":"NP_001258490.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271561.3"}]},{"database":"RefSeq","id":"NP_898902.1","properties":[{"key":"NucleotideSequenceId","value":"NM_183079.4"}],"isoformId":"P04156-1"},{"database":"PDB","id":"1E1G","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1E1J","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1E1P","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1E1S","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1E1U","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1E1W","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1FKC","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"1FO7","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"1H0L","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=119-230"}]},{"database":"PDB","id":"1HJM","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1HJN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=125-228"}]},{"database":"PDB","id":"1I4M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=119-226"}]},{"database":"PDB","id":"1OEH","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=77-84"}]},{"database":"PDB","id":"1OEI","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=61-84"}]},{"database":"PDB","id":"1QLX","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=23-230"}]},{"database":"PDB","id":"1QLZ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=23-230"}]},{"database":"PDB","id":"1QM0","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-230"}]},{"database":"PDB","id":"1QM1","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-230"}]},{"database":"PDB","id":"1QM2","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=121-230"}]},{"database":"PDB","id":"1QM3","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=121-230"}]},{"database":"PDB","id":"2IV4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=180-195"}]},{"database":"PDB","id":"2IV5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=173-195"}]},{"database":"PDB","id":"2IV6","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=173-195"}]},{"database":"PDB","id":"2K1D","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2KUN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2LBG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=110-136"}]},{"database":"PDB","id":"2LEJ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2LFT","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2LSB","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2LV1","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2M8T","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"2OL9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"0.85 A"},{"key":"Chains","value":"A=170-175"}]},{"database":"PDB","id":"2W9E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=119-231"}]},{"database":"PDB","id":"3HAF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"3HAK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=125-227"}]},{"database":"PDB","id":"3HEQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=90-231"}]},{"database":"PDB","id":"3HER","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=90-231"}]},{"database":"PDB","id":"3HES","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=90-231"}]},{"database":"PDB","id":"3HJ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B=90-231"}]},{"database":"PDB","id":"3HJX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=126-231"}]},{"database":"PDB","id":"3MD4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.15 A"},{"key":"Chains","value":"A/B=127-132"}]},{"database":"PDB","id":"3MD5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=127-132"}]},{"database":"PDB","id":"3NHC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A/B=127-132"}]},{"database":"PDB","id":"3NHD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.92 A"},{"key":"Chains","value":"A/B=127-132"}]},{"database":"PDB","id":"3NVF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=138-143"}]},{"database":"PDB","id":"4DGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=120-230"}]},{"database":"PDB","id":"4E1H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/C/E/G/I/K=177-182, B/D/F/H/J/L=211-216"}]},{"database":"PDB","id":"4E1I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A/C/E/G/I/K=177-182, B/D/F/H/J/L=211-216"}]},{"database":"PDB","id":"4KML","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=24-231"}]},{"database":"PDB","id":"4N9O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=90-231"}]},{"database":"PDB","id":"5L6R","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=90-226"}]},{"database":"PDB","id":"5YJ4","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=91-231"}]},{"database":"PDB","id":"5YJ5","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=91-231"}]},{"database":"PDB","id":"6DU9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.33 A"},{"key":"Chains","value":"A=90-230"}]},{"database":"PDB","id":"6LNI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=23-231"}]},{"database":"PDB","id":"6PQ5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B=113-118"}]},{"database":"PDB","id":"6PQA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.46 A"},{"key":"Chains","value":"A=119-124"}]},{"database":"PDB","id":"6SUZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=125-223"}]},{"database":"PDB","id":"6SV2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=119-231"}]},{"database":"PDB","id":"6UUR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=94-178"}]},{"database":"PDB","id":"7DWV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.07 A"},{"key":"Chains","value":"A/B/C/D/E/F=23-231"}]},{"database":"PDB","id":"7FHQ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=91-231"}]},{"database":"PDB","id":"7RL4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.86 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=23-144"}]},{"database":"PDB","id":"7RVC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A=168-176"}]},{"database":"PDB","id":"7RVE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"0.85 A"},{"key":"Chains","value":"A=168-176"}]},{"database":"PDB","id":"7RVJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A/B=169-175"}]},{"database":"PDB","id":"7RVK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A=169-175"}]},{"database":"PDB","id":"7RVL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"1.00 A"},{"key":"Chains","value":"A=168-176"}]},{"database":"PDB","id":"7UMQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.29 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=80-141"}]},{"database":"PDB","id":"7UN5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.13 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J=80-141"}]},{"database":"PDBsum","id":"1E1G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1E1J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1E1P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1E1S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1E1U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1E1W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FKC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FO7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1H0L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HJM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HJN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1I4M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OEH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OEI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QLX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QLZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QM0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QM1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QM2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QM3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IV4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IV5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2IV6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2K1D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2KUN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LBG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LEJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LFT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LSB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2LV1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2M8T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2OL9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2W9E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HAF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HEQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HER","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HES","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HJX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MD4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3MD5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NHC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NHD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3NVF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4E1H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4E1I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4KML","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N9O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5L6R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YJ4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5YJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6DU9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LNI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PQ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PQA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SUZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6SV2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UUR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DWV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7FHQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RL4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RVC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RVE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RVJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RVK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RVL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UMQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UN5","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0931","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20900","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-24514","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26607","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26613","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30887","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111606","properties":[{"key":"Interactions","value":"2262"}]},{"database":"CORUM","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29933N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P04156","properties":[{"key":"Number of interactors","value":"501"}]},{"database":"IntAct","id":"P04156","properties":[{"key":"Interactions","value":"454"}]},{"database":"MINT","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PRNP","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000399376","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4869","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"DrugBank","id":"DB00759","properties":[{"key":"GenericName","value":"Tetracycline"}]},{"database":"DrugCentral","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"MoonDB","id":"P04156","properties":[{"key":"Type","value":"Predicted"}]},{"database":"TCDB","id":"1.C.48.1.2","properties":[{"key":"FamilyName","value":"the prion peptide (prp) family"}]},{"database":"GlyConnect","id":"P04156","properties":[{"key":"glycosylation","value":"31 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P04156","properties":[{"key":"glycosylation","value":"2 sites, 6 glycans"}]},{"database":"GlyGen","id":"P04156","properties":[{"key":"glycosylation","value":"5 sites, 12 N-linked glycans (2 sites), 4 O-linked glycans (3 sites)"}]},{"database":"iPTMnet","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"130912","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000399376","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51667","properties":[{"key":"Description","value":"-"}],"isoformId":"P04156-1"},{"database":"Pumba","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P04156","properties":[{"key":"antibodies","value":"3 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3351","properties":[{"key":"antibodies","value":"892 antibodies from 49 providers"}]},{"database":"DNASU","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000379440.9","properties":[{"key":"ProteinId","value":"ENSP00000368752.4"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000424424.2","properties":[{"key":"ProteinId","value":"ENSP00000411599.2"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000430350.2","properties":[{"key":"ProteinId","value":"ENSP00000399376.2"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000457586.2","properties":[{"key":"ProteinId","value":"ENSP00000415284.2"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000882184.1","properties":[{"key":"ProteinId","value":"ENSP00000552243.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000882185.1","properties":[{"key":"ProteinId","value":"ENSP00000552244.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000882186.1","properties":[{"key":"ProteinId","value":"ENSP00000552245.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000882187.1","properties":[{"key":"ProteinId","value":"ENSP00000552246.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000882188.1","properties":[{"key":"ProteinId","value":"ENSP00000552247.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000967833.1","properties":[{"key":"ProteinId","value":"ENSP00000637892.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000967834.1","properties":[{"key":"ProteinId","value":"ENSP00000637893.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"Ensembl","id":"ENST00000967835.1","properties":[{"key":"ProteinId","value":"ENSP00000637894.1"},{"key":"GeneId","value":"ENSG00000171867.19"}]},{"database":"GeneID","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5621","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000379440.9","properties":[{"key":"ProteinId","value":"ENSP00000368752.4"},{"key":"RefSeqNucleotideId","value":"NM_000311.5"},{"key":"RefSeqProteinId","value":"NP_000302.1"}]},{"database":"AGR","id":"HGNC:9449","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33796","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9449","properties":[{"key":"GeneName","value":"PRNP"}]},{"database":"HPA","id":"ENSG00000171867","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (choroid)"}]},{"database":"MalaCards","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"123400","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"137440","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"176640","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"245300","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"600072","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"603218","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"606688","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"280397","properties":[{"key":"Disease","value":"Familial Alzheimer-like prion disease"}]},{"database":"Orphanet","id":"466","properties":[{"key":"Disease","value":"Fatal familial insomnia"}]},{"database":"Orphanet","id":"356","properties":[{"key":"Disease","value":"Gerstmann-Straussler-Scheinker syndrome"}]},{"database":"Orphanet","id":"157941","properties":[{"key":"Disease","value":"Huntington disease-like 1"}]},{"database":"Orphanet","id":"282166","properties":[{"key":"Disease","value":"Inherited Creutzfeldt-Jakob disease"}]},{"database":"Orphanet","id":"454745","properties":[{"key":"Disease","value":"Kuru"}]},{"database":"Orphanet","id":"397606","properties":[{"key":"Disease","value":"PrP systemic amyloidosis"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S2A8","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00510000049083","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QMCTTQY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P04156","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-419037","properties":[{"key":"PathwayName","value":"NCAM1 interactions"}]},{"database":"Reactome","id":"R-HSA-9609523","properties":[{"key":"PathwayName","value":"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"}]},{"database":"SignaLink","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000171867","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5621","properties":[{"key":"hits","value":"10 hits in 1169 CRISPR screens"}]},{"database":"CD-CODE","id":"7A2E2A6F","properties":[{"key":"EntryName","value":"Synthetic Condensate 000125"}]},{"database":"CD-CODE","id":"8188F968","properties":[{"key":"EntryName","value":"Tau-Prion Multiphasic condensate"}]},{"database":"CD-CODE","id":"9F779CC8","properties":[{"key":"EntryName","value":"Nuclear body"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P04156","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P04156","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"RNAct","id":"P04156","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000171867","properties":[{"key":"ExpressionPatterns","value":"Expressed in Brodmann (1909) area 23 and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P04156","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18419754"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16004966"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24012003"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22293988"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0019898","properties":[{"key":"GoTerm","value":"C:extrinsic component of membrane"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16004966"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016234","properties":[{"key":"GoTerm","value":"C:inclusion body"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20564047"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16254249"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18419754"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"26224839"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0043195","properties":[{"key":"GoTerm","value":"C:terminal bouton"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24012003"}]},{"database":"GO","id":"GO:0019828","properties":[{"key":"GoTerm","value":"F:aspartic-type endopeptidase inhibitor activity"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0043008","properties":[{"key":"GoTerm","value":"F:ATP-dependent protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11900542"}]},{"database":"GO","id":"GO:1903135","properties":[{"key":"GoTerm","value":"F:cupric ion binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903136","properties":[{"key":"GoTerm","value":"F:cuprous ion binding"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20564047"}]},{"database":"GO","id":"GO:0005539","properties":[{"key":"GoTerm","value":"F:glycosaminoglycan binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16286452"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18025469"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18436646"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19204296"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19278656"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19927125"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21920025"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"32284600"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"32514176"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"34516876"}]},{"database":"GO","id":"GO:0005521","properties":[{"key":"GoTerm","value":"F:lamin binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16004966"}]},{"database":"GO","id":"GO:0060090","properties":[{"key":"GoTerm","value":"F:molecular adaptor activity"},{"key":"GoEvidenceType","value":"IDA:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30401430"}]},{"database":"GO","id":"GO:0140693","properties":[{"key":"GoTerm","value":"F:molecular condensate scaffold activity"},{"key":"GoEvidenceType","value":"IDA:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30401430"}]},{"database":"GO","id":"GO:0140677","properties":[{"key":"GoTerm","value":"F:molecular function activator activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"23386614"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0044325","properties":[{"key":"GoTerm","value":"F:transmembrane transporter binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0015631","properties":[{"key":"GoTerm","value":"F:tubulin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16004966"}]},{"database":"GO","id":"GO:0031802","properties":[{"key":"GoTerm","value":"F:type 5 metabotropic glutamate receptor binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"24012003"}]},{"database":"GO","id":"GO:0071280","properties":[{"key":"GoTerm","value":"P:cellular response to copper ion"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16254249"}]},{"database":"GO","id":"GO:0097062","properties":[{"key":"GoTerm","value":"P:dendritic spine maintenance"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"25707991"}]},{"database":"GO","id":"GO:0006878","properties":[{"key":"GoTerm","value":"P:intracellular copper ion homeostasis"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16004966"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22820466"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0007616","properties":[{"key":"GoTerm","value":"P:long-term memory"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"19242475"}]},{"database":"GO","id":"GO:0046007","properties":[{"key":"GoTerm","value":"P:negative regulation of activated T cell proliferation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1902992","properties":[{"key":"GoTerm","value":"P:negative regulation of amyloid precursor protein catabolic process"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1902430","properties":[{"key":"GoTerm","value":"P:negative regulation of amyloid-beta formation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070885","properties":[{"key":"GoTerm","value":"P:negative regulation of calcineurin-NFAT signaling cascade"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1902951","properties":[{"key":"GoTerm","value":"P:negative regulation of dendritic spine maintenance"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0032700","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-17 production"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0032703","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-2 production"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010955","properties":[{"key":"GoTerm","value":"P:negative regulation of protein processing"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"23386614"}]},{"database":"GO","id":"GO:0050860","properties":[{"key":"GoTerm","value":"P:negative regulation of T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0032689","properties":[{"key":"GoTerm","value":"P:negative regulation of type II interferon production"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:1990535","properties":[{"key":"GoTerm","value":"P:neuron projection maintenance"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0050850","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"24012003"}]},{"database":"GO","id":"GO:1900451","properties":[{"key":"GoTerm","value":"P:positive regulation of glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"24012003"}]},{"database":"GO","id":"GO:0043525","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20564047"}]},{"database":"GO","id":"GO:1903078","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090314","properties":[{"key":"GoTerm","value":"P:positive regulation of protein targeting to membrane"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0031648","properties":[{"key":"GoTerm","value":"P:protein destabilization"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20564047"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1905664","properties":[{"key":"GoTerm","value":"P:regulation of calcium ion import across plasma membrane"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1900449","properties":[{"key":"GoTerm","value":"P:regulation of glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:1904645","properties":[{"key":"GoTerm","value":"P:response to amyloid-beta"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0046686","properties":[{"key":"GoTerm","value":"P:response to cadmium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006979","properties":[{"key":"GoTerm","value":"P:response to oxidative stress"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"DisProt","id":"DP00466","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":253,"molWeight":27661,"crc64":"43DB596BAAA66484","md5":"EB1D83712198163C78DBDE49879A267B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":25,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":2,"PTM":1,"POLYMORPHISM":2,"DISEASE":7,"MISCELLANEOUS":2,"SIMILARITY":1,"CAUTION":1,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":1,"Propeptide":1,"Repeat":5,"Region":4,"Compositional bias":1,"Binding site":12,"Lipidation":1,"Glycosylation":2,"Disulfide bond":1,"Natural variant":27,"Sequence conflict":3,"Beta strand":17,"Turn":6,"Helix":7},"uniParcId":"UPI0000033C27"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"F7VJQ1","uniProtkbId":"APRIO_HUMAN","entryAudit":{"firstPublicDate":"2012-11-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":67,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Alternative prion protein"}},"alternativeNames":[{"fullName":{"value":"AltPrP"}}]},"genes":[{"geneName":{"value":"PRNP"},"synonyms":[{"value":"ALTPRP"},{"value":"PRIP"},{"value":"PRP"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21478263"}],"value":"Mitochondrion outer membrane","id":"SL-0172"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21478263"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative initiation"],"isoforms":[{"name":{"value":"3"},"synonyms":[{"value":"AltPrP"}],"isoformIds":["F7VJQ1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"1"},"synonyms":[{"value":"PrP"}],"isoformIds":["P04156-1"],"isoformSequenceStatus":"External"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21478263"}],"value":"Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21478263"}],"value":"Up-regulated by endoplasmic reticulum stress and proteasomal inhibition"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21478263"}],"value":"This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21478263"}],"value":"The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263)"}],"commentType":"MISCELLANEOUS"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Alternative prion protein","featureId":"PRO_0000420424"},{"type":"Transmembrane","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0024","category":"Coding sequence diversity","name":"Alternative initiation"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1000","category":"Cellular component","name":"Mitochondrion outer membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"21478263","citationType":"journal article","authors":["Vanderperre B.","Staskevicius A.B.","Tremblay G.","McCoy M.","O'Neill M.A.","Cashman N.R.","Roucou X."],"citationCrossReferences":[{"database":"PubMed","id":"21478263"},{"database":"DOI","id":"10.1096/fj.10-173815"}],"title":"An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.","publicationDate":"2011","journal":"FASEB J.","firstPage":"2373","lastPage":"2386","volume":"25"},"referencePositions":["IDENTIFICATION","SUBCELLULAR LOCATION","INDUCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133396","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK007887","properties":[{"key":"ProteinId","value":"DAA34790.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001258490.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271561.3"}],"isoformId":"F7VJQ1-1"},{"database":"AlphaFoldDB","id":"F7VJQ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111606","properties":[{"key":"Interactions","value":"2262"}]},{"database":"NDEx","id":"IQUERY-CP-PRNP","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"SwissPalm","id":"F7VJQ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"HGNC:9449","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9449","properties":[{"key":"GeneName","value":"PRNP"}]},{"database":"MalaCards","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"F7VJQ1","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"F7VJQ1","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"F7VJQ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"5621","properties":[{"key":"hits","value":"10 hits in 1169 CRISPR screens"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PRNP","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"F7VJQ1","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0005741","properties":[{"key":"GoTerm","value":"C:mitochondrial outer membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21478263"}]}],"sequence":{"value":"MEHWGQPIPGAGQPWRQPLPTSGRWWLGAASWWWLGAASWWWLGAAPWWWLGTASWWWLGSRRWHPQSVEQAE","length":73,"molWeight":8691,"crc64":"4360C28341A4CA52","md5":"03DE93EEA9F5392582C1837BD750232C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"MISCELLANEOUS":2},"countByFeatureType":{"Chain":1,"Transmembrane":1},"uniParcId":"UPI00021294CE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q53YK7","uniProtkbId":"Q53YK7_HUMAN","entryAudit":{"firstPublicDate":"2005-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-24","entryVersion":175,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAS80162.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAS80162.1"}],"value":"PRNP"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10449.1"}],"value":"hCG_1785425"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014309518"},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10449.1"}]},{"referenceNumber":2,"citation":{"id":"CI-50MMCIBS43A69","citationType":"submission","authors":["Cui X.","Wang Z.","Chen J."],"title":"Analysis of the Sequence and Polymorphism of Human PrPc Mature Protein Gene.","publicationDate":"MAR-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAS80162.1"}]},{"referenceNumber":3,"citation":{"id":"CI-8KUJ66VCE3DJO","citationType":"submission","authors":["Cui X.","Wang Z.","Chen J."],"title":"Cloning, Prokaryotic Expression and Antigenic Analysis of Resistant Core of Human PrP in E. coli.","publicationDate":"MAR-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAS80162.1"}]},{"referenceNumber":4,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX10449.1"}]},{"referenceNumber":5,"citation":{"id":"18445040","citationType":"journal article","authors":["Kikuchi Y.","Kakeya T.","Nakajima O.","Sakai A.","Ikeda K.","Yamaguchi N.","Yamazaki T.","Tanamoto K.","Matsuda H.","Sawada J.","Takatori K."],"citationCrossReferences":[{"database":"PubMed","id":"18445040"},{"database":"DOI","id":"10.1111/j.1742-4658.2008.06452.x"}],"title":"Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.","publicationDate":"2008","journal":"FEBS J.","firstPage":"2965","lastPage":"2976","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32276.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY569456","properties":[{"key":"ProteinId","value":"AAS80162.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB300823","properties":[{"key":"ProteinId","value":"BAG32276.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471133","properties":[{"key":"ProteinId","value":"EAX10449.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_000302.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000311.5"}]},{"database":"RefSeq","id":"NP_001073590.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080121.3"}]},{"database":"RefSeq","id":"NP_001073591.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080122.3"}]},{"database":"RefSeq","id":"NP_001073592.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001080123.3"}]},{"database":"RefSeq","id":"NP_898902.1","properties":[{"key":"NucleotideSequenceId","value":"NM_183079.4"}]},{"database":"AlphaFoldDB","id":"Q53YK7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q53YK7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3351","properties":[{"key":"antibodies","value":"892 antibodies from 49 providers"}]},{"database":"DNASU","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5621","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc002wkx.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA33796","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5621","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QMCTTQY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"5621","properties":[{"key":"hits","value":"10 hits in 1169 CRISPR screens"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043195","properties":[{"key":"GoTerm","value":"C:terminal bouton"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019828","properties":[{"key":"GoTerm","value":"F:aspartic-type endopeptidase inhibitor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043008","properties":[{"key":"GoTerm","value":"F:ATP-dependent protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903135","properties":[{"key":"GoTerm","value":"F:cupric ion binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005539","properties":[{"key":"GoTerm","value":"F:glycosaminoglycan binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005521","properties":[{"key":"GoTerm","value":"F:lamin binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140693","properties":[{"key":"GoTerm","value":"F:molecular condensate scaffold activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140677","properties":[{"key":"GoTerm","value":"F:molecular function activator activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0044325","properties":[{"key":"GoTerm","value":"F:transmembrane transporter binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031802","properties":[{"key":"GoTerm","value":"F:type 5 metabotropic glutamate receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046007","properties":[{"key":"GoTerm","value":"P:negative regulation of activated T cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902430","properties":[{"key":"GoTerm","value":"P:negative regulation of amyloid-beta formation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070885","properties":[{"key":"GoTerm","value":"P:negative regulation of calcineurin-NFAT signaling cascade"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1902951","properties":[{"key":"GoTerm","value":"P:negative regulation of dendritic spine maintenance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032700","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-17 production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032703","properties":[{"key":"GoTerm","value":"P:negative regulation of interleukin-2 production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1900272","properties":[{"key":"GoTerm","value":"P:negative regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050860","properties":[{"key":"GoTerm","value":"P:negative regulation of T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032689","properties":[{"key":"GoTerm","value":"P:negative regulation of type II interferon production"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1990535","properties":[{"key":"GoTerm","value":"P:neuron projection maintenance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0050850","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903078","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090314","properties":[{"key":"GoTerm","value":"P:positive regulation of protein targeting to membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:1905664","properties":[{"key":"GoTerm","value":"P:regulation of calcium ion import across plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1900449","properties":[{"key":"GoTerm","value":"P:regulation of glutamate receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046686","properties":[{"key":"GoTerm","value":"P:response to cadmium ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046688","properties":[{"key":"GoTerm","value":"P:response to copper ion"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":253,"molWeight":27661,"crc64":"43DB596BAAA66484","md5":"EB1D83712198163C78DBDE49879A267B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000033C27"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2NI05","uniProtkbId":"B2NI05_HUMAN","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-07-01","entryVersion":82,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32279.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32279.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002781148"},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"18445040","citationType":"journal article","authors":["Kikuchi Y.","Kakeya T.","Nakajima O.","Sakai A.","Ikeda K.","Yamaguchi N.","Yamazaki T.","Tanamoto K.","Matsuda H.","Sawada J.","Takatori K."],"citationCrossReferences":[{"database":"PubMed","id":"18445040"},{"database":"DOI","id":"10.1111/j.1742-4658.2008.06452.x"}],"title":"Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.","publicationDate":"2008","journal":"FEBS J.","firstPage":"2965","lastPage":"2976","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32279.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB300826","properties":[{"key":"ProteinId","value":"BAG32279.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"B2NI05","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B2NI05","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B2NI05","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYVLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQLINTLGTDGHWKT","length":230,"molWeight":24960,"crc64":"CB2709E11BBD50F5","md5":"77D92B303B8BEFC4B0324B8E550601F7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000174C0AC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6FGN5","uniProtkbId":"Q6FGN5_HUMAN","entryAudit":{"firstPublicDate":"2005-05-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-10","entryVersion":130,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46869.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46869.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014310440"},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46869.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-65UA89QGSSD50","citationType":"submission","authors":["Halleck A.","Ebert L.","Mkoundinya M.","Schick M.","Eisenstein S.","Neubert P.","Kstrang K.","Schatten R.","Shen B.","Henze S.","Mar W.","Korn B.","Zuo D.","Hu Y.","LaBaer J."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46869.1"}]},{"referenceNumber":2,"citation":{"id":"18445040","citationType":"journal article","authors":["Kikuchi Y.","Kakeya T.","Nakajima O.","Sakai A.","Ikeda K.","Yamaguchi N.","Yamazaki T.","Tanamoto K.","Matsuda H.","Sawada J.","Takatori K."],"citationCrossReferences":[{"database":"PubMed","id":"18445040"},{"database":"DOI","id":"10.1111/j.1742-4658.2008.06452.x"}],"title":"Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.","publicationDate":"2008","journal":"FEBS J.","firstPage":"2965","lastPage":"2976","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32277.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB300824","properties":[{"key":"ProteinId","value":"BAG32277.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR542072","properties":[{"key":"ProteinId","value":"CAG46869.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6FGN5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6FGN5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6FGN5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYVLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":253,"molWeight":27629,"crc64":"43DB4D3BA5F67F84","md5":"A7785C08421CE64CF4D1787295264E15"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0000169F33"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q86XR1","uniProtkbId":"Q86XR1_HUMAN","entryAudit":{"firstPublicDate":"2003-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-06-01","entryVersion":119,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5012881304"},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"15148589","citationType":"journal article","authors":["Jeong B.H.","Nam J.H.","Lee Y.J.","Lee K.H.","Jang M.K.","Carp R.I.","Lee H.D.","Ju Y.R.","Ahn Jo S.","Park K.Y.","Kim Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"15148589"},{"database":"DOI","id":"10.1007/s10038-004-0150-7"}],"title":"Polymorphisms of the prion protein gene (PRNP) in a Korean population.","publicationDate":"2004","journal":"J. Hum. Genet.","firstPage":"319","lastPage":"324","volume":"49"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}]},{"referenceNumber":2,"citation":{"id":"16217673","citationType":"journal article","authors":["Jeong B.H.","Lee K.H.","Kim N.H.","Jin J.K.","Kim J.I.","Carp R.I.","Kim Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"16217673"},{"database":"DOI","id":"10.1007/s10048-005-0016-y"}],"title":"Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population.","publicationDate":"2005","journal":"Neurogenetics","firstPage":"229","lastPage":"232","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83635.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY219882","properties":[{"key":"ProteinId","value":"AAO83635.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q86XR1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q86XR1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q86XR1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":238,"molWeight":26108,"crc64":"EC9FA42623F3BBAE","md5":"950114997C4448F8B587701C34B1BC81"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI0000183D5C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6J4EE43","uniProtkbId":"A0A6J4EE43_HUMAN","entryAudit":{"firstPublicDate":"2020-10-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-10-07","entryVersion":21,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCK59655.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCK59655.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5047881102"},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3T970EM3CCDQ4","citationType":"journal article","authors":["Omae Y.","Ito S.","Takeuchi M.","Isa K.","Ogasawara K.","Kawabata K.","Oda A.","Kaito S.","Tsuneyama H.","Uchikawa M.","Wada I.","Ohto H.","Tokunaga K."],"title":"Integrative genome analysis identified the KANNO blood group antigen as prion protein.","publicationDate":"2019","journal":"Transfusion","firstPage":"2429","lastPage":"2435","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCK59655.1"}]},{"referenceNumber":2,"citation":{"id":"CI-6D066IFJ6TPFS","citationType":"submission","authors":["Isa K.","Ogasawara K."],"publicationDate":"AUG-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCK59655.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"LC574065","properties":[{"key":"ProteinId","value":"BCK59655.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A6J4EE43","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6J4EE43","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYKRESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":253,"molWeight":27660,"crc64":"43DB51C920866484","md5":"7ECEB5475B945CB3283C5FDBD3C984C3"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI00159AE671"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A2A2V1","uniProtkbId":"A2A2V1_HUMAN","entryAudit":{"firstPublicDate":"2007-02-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-02-20","entryVersion":129,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411599"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411599"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002641817"},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411599"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A2A2V1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A2A2V1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411599"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-V6MDPQG5Q163","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"AUG-2012","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411599"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133396","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A2A2V1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A2A2V1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A2A2V1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3351","properties":[{"key":"antibodies","value":"892 antibodies from 49 providers"}]},{"database":"Ensembl","id":"ENST00000424424","properties":[{"key":"ProteinId","value":"ENSP00000411599"},{"key":"GeneId","value":"ENSG00000171867"}]},{"database":"UCSC","id":"uc061vez.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9449","properties":[{"key":"GeneName","value":"PRNP"}]},{"database":"OpenTargets","id":"ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00510000049083","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QMCTTQY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"Bgee","id":"ENSG00000171867","properties":[{"key":"ExpressionPatterns","value":"Expressed in Brodmann (1909) area 23 and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A2A2V1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIF","length":249,"molWeight":27279,"crc64":"FAA66484345A5A87","md5":"3825150D72F785E45A01A1D3E067EE82"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0000206974"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q540C4","uniProtkbId":"Q540C4_HUMAN","entryAudit":{"firstPublicDate":"2005-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-24","entryVersion":97,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5012926517"},{"type":"Transmembrane","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"15148589","citationType":"journal article","authors":["Jeong B.H.","Nam J.H.","Lee Y.J.","Lee K.H.","Jang M.K.","Carp R.I.","Lee H.D.","Ju Y.R.","Ahn Jo S.","Park K.Y.","Kim Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"15148589"},{"database":"DOI","id":"10.1007/s10038-004-0150-7"}],"title":"Polymorphisms of the prion protein gene (PRNP) in a Korean population.","publicationDate":"2004","journal":"J. Hum. Genet.","firstPage":"319","lastPage":"324","volume":"49"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}]},{"referenceNumber":2,"citation":{"id":"16217673","citationType":"journal article","authors":["Jeong B.H.","Lee K.H.","Kim N.H.","Jin J.K.","Kim J.I.","Carp R.I.","Kim Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"16217673"},{"database":"DOI","id":"10.1007/s10048-005-0016-y"}],"title":"Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population.","publicationDate":"2005","journal":"Neurogenetics","firstPage":"229","lastPage":"232","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO83636.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY219883","properties":[{"key":"ProteinId","value":"AAO83636.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q540C4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q540C4","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q540C4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYKRESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":246,"molWeight":26884,"crc64":"309B1B13C8841566","md5":"C65FCBDC27B4F9EB5B35364837067813"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI0000183D5D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2NI04","uniProtkbId":"B2NI04_HUMAN","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-07-01","entryVersion":94,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32278.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32278.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002781340"},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"18445040","citationType":"journal article","authors":["Kikuchi Y.","Kakeya T.","Nakajima O.","Sakai A.","Ikeda K.","Yamaguchi N.","Yamazaki T.","Tanamoto K.","Matsuda H.","Sawada J.","Takatori K."],"citationCrossReferences":[{"database":"PubMed","id":"18445040"},{"database":"DOI","id":"10.1111/j.1742-4658.2008.06452.x"}],"title":"Hypoxia induces expression of a GPI-anchorless splice variant of the prion protein.","publicationDate":"2008","journal":"FEBS J.","firstPage":"2965","lastPage":"2976","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG32278.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB300825","properties":[{"key":"ProteinId","value":"BAG32278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"B2NI04","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B2NI04","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B2NI04","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQLINTLGTDGHWKT","length":230,"molWeight":24992,"crc64":"D691D290DCA851B0","md5":"7F9EFF6404AFD36F29370DD9E22644CE"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000174C0AB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6FGR8","uniProtkbId":"Q6FGR8_HUMAN","entryAudit":{"firstPublicDate":"2004-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-19","entryVersion":105,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46836.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46836.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004273977"},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-65UA89QGSSD50","citationType":"submission","authors":["Halleck A.","Ebert L.","Mkoundinya M.","Schick M.","Eisenstein S.","Neubert P.","Kstrang K.","Schatten R.","Shen B.","Henze S.","Mar W.","Korn B.","Zuo D.","Hu Y.","LaBaer J."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG46836.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CR542039","properties":[{"key":"ProteinId","value":"CAG46836.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q6FGR8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6FGR8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQRNKPSKPKTNMKHMAGAAAAGAVVGGLGGYVLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":253,"molWeight":27599,"crc64":"44DC3F1C85D62A84","md5":"CA0C4FE038C730BE807D3E1C0B203CDA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":2},"uniParcId":"UPI00003B5D21"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6SES1","uniProtkbId":"Q6SES1_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":118,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004279822"},{"type":"Transmembrane","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Domain","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00706"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8AVP3LBHDFN3M","citationType":"submission","authors":["Yu S.","Jing L.","Sy M.","Kang S.","Mei F.","Sun G.","Tien P.","Wang F.","Xiao G."],"publicationDate":"NOV-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}]},{"referenceNumber":2,"citation":{"id":"15266305","citationType":"journal article","authors":["Yu S.L.","Jin L.","Sy M.S.","Mei F.H.","Kang S.L.","Sun G.H.","Tien P.","Wang F.S.","Xiao G.F."],"citationCrossReferences":[{"database":"PubMed","id":"15266305"},{"database":"DOI","id":"10.1038/sj.ejhg.5201245"}],"title":"Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation.","publicationDate":"2004","journal":"Eur. J. Hum. Genet.","firstPage":"867","lastPage":"870","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAR21603.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY458651","properties":[{"key":"ProteinId","value":"AAR21603.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6SES1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6SES1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6SES1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00706","properties":[{"key":"EntryName","value":"PRION_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG","length":277,"molWeight":29992,"crc64":"5B027A1319640F1E","md5":"6EC09BCA69D3C9076E0B0BE7D7560805"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":2,"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000223FDC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"X6RKS3","uniProtkbId":"X6RKS3_HUMAN","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-06-11","entryVersion":71,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415284"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Major prion protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415284"}],"value":"PRNP"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004609"}],"value":"Lipid-anchor, GPI-anchor","id":"SL-9902"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009910"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"value":"Belongs to the prion family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Major prion protein","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004976246"},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Prion/Doppel protein beta-ribbon","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00291"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415284"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023087"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022622"}],"id":"KW-0336","category":"PTM","name":"GPI-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022678"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003882"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"X6RKS3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"X6RKS3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.","Burton J.","Gilbert J.G.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaslaiho M.H.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.","Mistry D.","Moore M.J.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.","Peck A.I.","Phillimore B.J.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415284"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-V6MGFTU5M555","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"APR-2014","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415284"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL133396","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"X6RKS3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"X6RKS3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"X6RKS3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"X6RKS3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3351","properties":[{"key":"antibodies","value":"892 antibodies from 49 providers"}]},{"database":"Ensembl","id":"ENST00000457586","properties":[{"key":"ProteinId","value":"ENSP00000415284"},{"key":"GeneId","value":"ENSG00000171867"}]},{"database":"UCSC","id":"uc061vfa.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9449","properties":[{"key":"GeneName","value":"PRNP"}]},{"database":"OpenTargets","id":"ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171867","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00510000049083","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_094631_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QMCTTQY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"Bgee","id":"ENSG00000171867","properties":[{"key":"ExpressionPatterns","value":"Expressed in Brodmann (1909) area 23 and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"X6RKS3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.790.10:FF:000001","properties":[{"key":"EntryName","value":"Major prion protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.790.10","properties":[{"key":"EntryName","value":"Prion/Doppel protein, beta-ribbon domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000817","properties":[{"key":"EntryName","value":"Prion"}]},{"database":"InterPro","id":"IPR036924","properties":[{"key":"EntryName","value":"Prion/Doppel_b-ribbon_dom_sf"}]},{"database":"InterPro","id":"IPR022416","properties":[{"key":"EntryName","value":"Prion/Doppel_prot_b-ribbon_dom"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"InterPro","id":"IPR025860","properties":[{"key":"EntryName","value":"Prion_N"}]},{"database":"PANTHER","id":"PTHR15506","properties":[{"key":"EntryName","value":"DOPPEL PRION"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15506:SF2","properties":[{"key":"EntryName","value":"MAJOR PRION PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00377","properties":[{"key":"EntryName","value":"Prion"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11587","properties":[{"key":"EntryName","value":"Prion_bPrPp"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00341","properties":[{"key":"EntryName","value":"PRION"}]},{"database":"SMART","id":"SM00157","properties":[{"key":"EntryName","value":"PRP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54098","properties":[{"key":"EntryName","value":"Prion-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00291","properties":[{"key":"EntryName","value":"PRION_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQ","length":217,"molWeight":23554,"crc64":"AD1C635A98400EC2","md5":"EB74EFC35B19953BD88F33F99976E3C4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0000470B04"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"K0P2W7","uniProtkbId":"K0P2W7_HUMAN","entryAudit":{"firstPublicDate":"2012-11-28","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2012-11-28","entryVersion":12,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"value":"Alternative prion protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"value":"PRNP"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}],"id":"KW-0640","category":"Molecular function","name":"Prion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"21478263","citationType":"journal article","authors":["Vanderperre B.","Staskevicius A.B.","Tremblay G.","McCoy M.","O'Neill M.A.","Cashman N.R.","Roucou X."],"citationCrossReferences":[{"database":"PubMed","id":"21478263"},{"database":"DOI","id":"10.1096/fj.10-173815"}],"title":"An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.","publicationDate":"2011","journal":"FASEB J.","firstPage":"2373","lastPage":"2386","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}]},{"referenceNumber":2,"citation":{"id":"CI-FDMV33D89DU28","citationType":"submission","authors":["Roucou X."],"publicationDate":"SEP-2012","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCM44249.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HE993880","properties":[{"key":"ProteinId","value":"CCM44249.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"K0P2W7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"MEHWGQPMPGAGQPWRQPLPTSGRWWLGAASWWWLGAASWWWLGAAPWWWLGTASWWWLGSRRWHPQSVEQAE","length":73,"molWeight":8709,"crc64":"4366044347620A52","md5":"E07DEEF7C56265F9A939C4C5DC734412"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI00027EA1AD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q16409","secondaryAccessions":["Q16407"],"uniProtkbId":"Q16409_HUMAN","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1996-11-01","entryVersion":71,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB21334.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB21334.1"}],"value":"PrP amyloid"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB21334.1"}],"value":"PRNP"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB21334.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"1736177","citationType":"journal article","authors":["Brown P.","Goldfarb L.G.","McCombie W.R.","Nieto A.","Squillacote D.","Sheremata W.","Little B.W.","Godec M.S.","Gibbs C.J. Jr","Gajdusek D.C."],"citationCrossReferences":[{"database":"PubMed","id":"1736177"}],"title":"Atypical Creutzfeldt-Jakob disease in an American family with an insert mutation in the PRNP amyloid precursor gene.","publicationDate":"1992","journal":"Neurology","firstPage":"422","lastPage":"427","volume":"42"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB21334.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S80539","properties":[{"key":"ProteinId","value":"AAB21334.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q16409","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q16409","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"PQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQ","length":97,"molWeight":9388,"crc64":"D2A9F370DD10511D","md5":"F175C8020A53BFC17D59A681850DCE5C"},"extraAttributes":{"countByFeatureType":{"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000006D5D2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q7KYY8","uniProtkbId":"Q7KYY8_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2004-07-05","entryVersion":60,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}],"value":"Prion protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}],"value":"PRNP"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}],"id":"KW-0034","category":"Cellular component","name":"Amyloid"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}],"id":"KW-0640","category":"Molecular function","name":"Prion"}],"references":[{"referenceNumber":1,"citation":{"id":"8797471","citationType":"journal article","authors":["Cochran E.J.","Bennett D.A.","Cervenakova L.","Kenney K.","Bernard B.","Foster N.L.","Benson D.F.","Goldfarb L.G.","Brown P."],"citationCrossReferences":[{"database":"PubMed","id":"8797471"}],"title":"Familial Creutzfeldt-Jakob disease with a five-repeat octapeptide insert mutation.","publicationDate":"1996","journal":"Neurology","firstPage":"727","lastPage":"733","volume":"47"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB50777.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S83341","properties":[{"key":"ProteinId","value":"AAB50777.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q7KYY8","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7KYY8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9048788at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PRNP","properties":[{"key":"OrganismName","value":"human"}]},{"database":"InterPro","id":"IPR020949","properties":[{"key":"EntryName","value":"Prion_copper_b_octapeptide"}]},{"database":"Pfam","id":"PF03991","properties":[{"key":"EntryName","value":"Prion_octapep"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"PQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQ","length":81,"molWeight":7834,"crc64":"9CCF62CE19B60D9A","md5":"D1B85F191AF63A64578C121555556E24"},"extraAttributes":{"countByFeatureType":{"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000016B4CC"}}]}