{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P37231","secondaryAccessions":["A8K3G6","B5BUA1","O00684","O00710","O14515","Q0QJH8","Q15178","Q15179","Q15180","Q15832","Q86U60","Q96J12"],"uniProtkbId":"PPARG_HUMAN","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-04-27","entryVersion":292,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Peroxisome proliferator-activated receptor gamma"},"shortNames":[{"value":"PPAR-gamma"}]},"alternativeNames":[{"fullName":{"value":"Nuclear receptor subfamily 1 group C member 3"}}]},"genes":[{"geneName":{"value":"PPARG"},"synonyms":[{"value":"NR1C3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16150867"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20829347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23525231"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8702406"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8706692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9065481"}],"value":"Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase (By similarity). Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses (PubMed:20829347). Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"}],"value":"Nuclear receptor that acts as the key factor controlling the development of adipocytes (By similarity). Specifically activated by 15-deoxy-delta12,14-prostaglandin J2 ligand during early adipogenesis, driving differentiation of all types of adipocytes (white, beige and brown) (By similarity). Acts together with retinoic acid receptor RXRA, forming the ARF6 complex, which acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity). Following recruitment of TLE3, promotes differentiation of white adipocytes (By similarity). Following recruitment of PRDM16, promotes differentiation of myoblastic precursors into brown adipose cells (BAT), which are specialized in dissipating energy in the form of heat in response to cold or excess feeding (By similarity). Also mediates diffentiation of white adipocytes into beige adipocytes by mediating recruitment of PRDM16 (By similarity)"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25504154"}],"value":"(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16150867"}],"value":"PDPK1 activates its transcriptional activity independently of its kinase activity"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10681503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11971969"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12039952"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15047147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15687259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15976031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16239304"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16919947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17101779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20078863"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21047783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22351778"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23525231"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9744270"}],"value":"Heterodimer with retinoic acid receptor, such as RXRA (By similarity). The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6 (By similarity). Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes (PubMed:10681503). Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes (By similarity). Interacts with NCOA7 in a ligand-inducible manner (PubMed:11971969). Interacts with NCOA1 and NCOA2 LXXLL motifs (PubMed:16919947, PubMed:9744270). Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRMT2 and TGFB1I1 (PubMed:12039952, PubMed:15047147, PubMed:15687259, PubMed:15976031, PubMed:17101779, PubMed:21047783). Interacts (when activated by agonist) with PPP5C (By similarity). Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG (PubMed:16239304, PubMed:23525231). Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters (By similarity). Interacts with NOCT (By similarity). Interacts with FOXO1 (acetylated form) (By similarity). Interacts with ACTN4 (PubMed:22351778). Interacts (when in the liganded conformation) with GPS2 (By similarity). Interacts with CRY1 and CRY2 in a ligand-dependent manner (By similarity). In the absence of hormonal ligand, interacts with TACC1 (PubMed:20078863). In macrophages, interacts with PAQR3 and STUB1; these interactions promote PPARG poylubiquitination and STUB1-mediated degradation (By similarity). Interacts with YTDC1 (via its intrinsically disordered region); the interaction prevents the ubiquitin-mediated proteasomal degradation of PPARG (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"}],"value":"Interacts with CEBPA; promoting activation of the adipogenic program (By similarity). Interacts with PRDM16; promoting activation of brown and beige adipocytes (By similarity)"}],"commentType":"SUBUNIT","molecule":"Isoform 2"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q8NFM4","geneName":"ADCY4","intActId":"EBI-2838710"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P10909","geneName":"CLU","intActId":"EBI-1104674"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"O60869","geneName":"EDF1","intActId":"EBI-781301"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q9BWX5","geneName":"GATA5","intActId":"EBI-12132270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P45984","geneName":"MAPK9","intActId":"EBI-713568"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"O75376","geneName":"NCOR1","intActId":"EBI-347233"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P55055-1","geneName":"NR1H2","intActId":"EBI-21458417"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q13133","geneName":"NR1H3","intActId":"EBI-781356"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P37231","geneName":"PPARG","intActId":"EBI-781384"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q9UBK2","geneName":"PPARGC1A","intActId":"EBI-765486"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P10276","geneName":"RARA","intActId":"EBI-413374"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P19793","geneName":"RXRA","intActId":"EBI-78598"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P28702","geneName":"RXRB","intActId":"EBI-748576"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q96EB6","geneName":"SIRT1","intActId":"EBI-1802965"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"P51532","geneName":"SMARCA4","intActId":"EBI-302489"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q6STE5-1","geneName":"SMARCD3","intActId":"EBI-488506"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231","intActId":"EBI-781384"},"interactantTwo":{"uniProtKBAccession":"Q6STE5-2","geneName":"SMARCD3","intActId":"EBI-488511"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231-1","intActId":"EBI-15664691"},"interactantTwo":{"uniProtKBAccession":"P37231-1","geneName":"PPARG","intActId":"EBI-15664691"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231-1","intActId":"EBI-15664691"},"interactantTwo":{"uniProtKBAccession":"P19793","geneName":"RXRA","intActId":"EBI-78598"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P37231-2","intActId":"EBI-781416"},"interactantTwo":{"uniProtKBAccession":"Q00535","geneName":"CDK5","intActId":"EBI-1041567"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17101779"}],"value":"Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (PubMed:17101779). NOCT enhances its nuclear translocation (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17101779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23525231"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17101779"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9144532"}],"value":"PPARgamma2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9144532"}],"value":"PPARgamma-2"}],"isoformIds":["P37231-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"1"},"synonyms":[{"value":"PPARgamma1(wt)"}],"isoformIds":["P37231-2"],"sequenceIds":["VSP_003645"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"PPARgamma1(tr)"}],"isoformIds":["P37231-3"],"sequenceIds":["VSP_003645","VSP_043906","VSP_043907"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9065481"}],"value":"Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25504154"}],"value":"(Microbial infection) Expression increases when incubated with M.tuberculosis or its lipoprotein LpqH; induction is TLR2-dependent (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30468856"}],"value":"The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"}],"value":"O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P37238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36737649"}],"value":"Ubiquitinated by E3 ubiquitin-protein ligase complex containing FBXO9; leading to proteasomal degradation (By similarity). Ubiquitinated at Lys-252 by TRIM55 leading to proteasomal degradation (PubMed:36737649). Ubiquitinated by E3 ubiquitin-protein ligase STUB1/CHIP; leading to proteasomal degradation (By similarity). Ubiquitinated by E3 ubiquitin-protein ligase ARIH2; leading to proteasomal degradation (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10523018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14569127"}],"value":"Genetic variations in PPARG define the body mass index quantitative trait locus 1 (BMIQ1) [MIM:606641]. The body max index (BMI) reflects the amount of fat, lean mass, and body build"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10394368"}],"value":"Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Obesity","diseaseAccession":"DI-01221","acronym":"OBESITY","description":"A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.","diseaseCrossReference":{"database":"MIM","id":"601665"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9753710"}]},"note":{"texts":[{"value":"Disease susceptibility may be associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Lipodystrophy, familial partial, 3","diseaseAccession":"DI-01596","acronym":"FPLD3","description":"An autosomal dominant form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.","diseaseCrossReference":{"database":"MIM","id":"604367"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11788685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12453919"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Glioma 1","diseaseAccession":"DI-01665","acronym":"GLM1","description":"Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.","diseaseCrossReference":{"database":"MIM","id":"137800"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10851250"}]},"note":{"texts":[{"value":"Disease susceptibility may be associated with variants affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Exhibits dominant negative activity over isoform 1"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the nuclear hormone receptor family. NR1 subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAN38992.2","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAA23354.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAF83270.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA62153.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/383/PPARG","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor","ftp":false,"note":"Peroxisome proliferator-activated receptor entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"Peroxisome proliferator-activated receptor gamma","featureId":"PRO_0000053492"},{"type":"Domain","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"NR LBD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01189"}]},{"type":"DNA binding","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Nuclear receptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Zinc finger","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"NR C4-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Zinc finger","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"NR C4-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00407"}]},{"type":"Region","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Interaction with FAM120B","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Motif","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"9aaTAD","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30468856"}]},{"type":"Binding 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