{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O60733","secondaryAccessions":["A8K597","B0QYE8","O75645","Q8N452","Q9UG29","Q9UIT0","Q9Y671"],"uniProtkbId":"PLPL9_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-30","entryVersion":230,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"85/88 kDa calcium-independent phospholipase A2"},"shortNames":[{"value":"CaI-PLA2"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"value":"3.1.1.4"}]},"alternativeNames":[{"fullName":{"value":"2-lysophosphatidylcholine acylhydrolase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"value":"3.1.1.5"}]},{"fullName":{"value":"Group VI phospholipase A2"},"shortNames":[{"value":"GVI PLA2"}]},{"fullName":{"value":"Intracellular membrane-associated calcium-independent phospholipase A2 beta"},"shortNames":[{"value":"iPLA2-beta"}]},{"fullName":{"value":"Palmitoyl-CoA hydrolase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"value":"3.1.2.2"}]},{"fullName":{"value":"Patatin-like phospholipase domain-containing protein 9"},"shortNames":[{"value":"PNPLA9"}]}]},"genes":[{"geneName":{"value":"PLA2G6"},"synonyms":[{"value":"PLPLA9"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97570"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10092647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10336645"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23533611"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9417066"}],"value":"Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:10092647, PubMed:10336645, PubMed:20886109, PubMed:9417066). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position (PubMed:10092647, PubMed:10336645, PubMed:20886109). Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:20886109). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:23533611). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:20886109). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (PubMed:18208975). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9417066"}],"value":"Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms"}],"commentType":"FUNCTION","molecule":"Isoform Ankyrin-iPLA2-1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9417066"}],"value":"Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms"}],"commentType":"FUNCTION","molecule":"Isoform Ankyrin-iPLA2-2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886109"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36231"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:30909"},{"database":"ChEBI","id":"CHEBI:36702"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:36232"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41223"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:72999"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41224"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38779"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73001"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38780"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886109"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40811"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73002"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40812"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40427"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73003"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10092647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23533611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40428"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10092647"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23533611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40519"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:74965"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40520"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40431"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73004"},{"database":"ChEBI","id":"CHEBI:73009"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40432"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63304"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:72859"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63305"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15177"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15178"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886109"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40435"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:72998"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40436"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886109"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40831"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:74344"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40832"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40827"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:76079"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40828"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41067"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:55430"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41068"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40479"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:44811"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40480"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16645"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57379"}],"ecNumber":"3.1.2.2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16646"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20886109"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40463"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77253"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23533611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40464"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23533611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40467"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77256"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23533611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40468"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23533611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:52812"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:83580"},{"database":"ChEBI","id":"CHEBI:83581"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:52814"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63256"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:75036"},{"database":"ChEBI","id":"CHEBI:78832"},{"database":"ChEBI","id":"CHEBI:146277"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97570"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63257"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97570"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97570"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10092647"}],"value":"Activated by ATP (PubMed:10092647). Inhibited by calcium-activated calmodulin (By similarity). Inhibited by bromoenol lactone (BEL) (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}],"value":"Homodimer formed by catalytic domains tightly interacting through a large hydrophobic interface. The contact area involves 3 alpha helices, several loops and a part of the beta sheet from each monomer. Both active sites of the dimer are in close proximity adopting an open conformation that provide sufficient space for phospholipid access and favoring cooperativity in deacylation-reacylation reactions. Each monomer has 9 ankyrin repeats stacked side-by-side in an elongated structure oriented outwards from the catalytic core"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q8TAP6","geneName":"CEP76","intActId":"EBI-742887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q9NZL9","geneName":"MAT2B","intActId":"EBI-10317491"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q8N1F7","geneName":"NUP93","intActId":"EBI-1042703"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"O60733","geneName":"PLA2G6","intActId":"EBI-12089905"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"O95199","geneName":"RCBTB2","intActId":"EBI-742404"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q9BVN2","geneName":"RUSC1","intActId":"EBI-6257312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q14140","geneName":"SERTAD2","intActId":"EBI-2822051"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q86XT4","geneName":"TRIM50","intActId":"EBI-9867283"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"Q70EL1-9","geneName":"USP54","intActId":"EBI-11975223"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O60733","intActId":"EBI-12089905"},"interactantTwo":{"uniProtKBAccession":"B2RXF5","geneName":"ZBTB42","intActId":"EBI-12287587"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"}],"value":"Recruited to the membrane-enriched pseudopods upon MCP1/CCL2 stimulation in monocytes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97819"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"}],"value":"Cell projection, pseudopodium","id":"SL-0298"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"LH-iPLA2"},"isoformIds":["O60733-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"SH-iPLA2"},"isoformIds":["O60733-2"],"sequenceIds":["VSP_000278"],"isoformSequenceStatus":"Described"},{"name":{"value":"Ankyrin-iPLA2-1"},"isoformIds":["O60733-3"],"sequenceIds":["VSP_000281","VSP_000282"],"isoformSequenceStatus":"Described"},{"name":{"value":"Ankyrin-iPLA2-2"},"isoformIds":["O60733-4"],"sequenceIds":["VSP_000277","VSP_000279","VSP_000280"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Four different transcripts were found to be expressed in a distinct tissue distribution"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97570"}],"value":"Has two putative calmodulin binding domains, the 1-9-14 and IQ motifs. One calmodulin molecule interacts with PLA2G6 dimer, likely through 1-9-14 motif on each monomer (By similarity). Binds calmodulin in a calcium-dependent way (By similarity)"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Neurodegeneration with brain iron accumulation 2B","diseaseAccession":"DI-02043","acronym":"NBIA2B","description":"A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment.","diseaseCrossReference":{"database":"MIM","id":"610217"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Neurodegeneration with brain iron accumulation 2A","diseaseAccession":"DI-01819","acronym":"NBIA2A","description":"A neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years.","diseaseCrossReference":{"database":"MIM","id":"256600"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17033970"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23749988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39796207"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Parkinson disease 14","diseaseAccession":"DI-02500","acronym":"PARK14","description":"An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging.","diseaseCrossReference":{"database":"MIM","id":"612953"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18570303"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"Potential target for therapeutic intervention of Barth syndrome"}],"commentType":"PHARMACEUTICAL"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"85/88 kDa calcium-independent phospholipase A2","featureId":"PRO_0000067037"},{"type":"Transmembrane","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"ANK 4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"ANK 5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"ANK 6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"ANK 7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"ANK 9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},{"type":"Domain","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Region","location":{"start":{"value":677,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"Calmodulin-binding (1-9-14 motif)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},{"type":"Region","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":759,"modifier":"EXACT"}},"description":"Calmodulin-binding (IQ motif)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A3L7I2I8"}]},{"type":"Motif","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":652,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Alternative sequence","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in isoform Ankyrin-iPLA2-2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9417066"}],"featureId":"VSP_000277","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"in isoform SH-iPLA2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10092647"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_000278","alternativeSequence":{"originalSequence":"LVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLE","alternativeSequences":["Q"]}},{"type":"Alternative sequence","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"in isoform Ankyrin-iPLA2-2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9417066"}],"featureId":"VSP_000279","alternativeSequence":{"originalSequence":"ELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIA","alternativeSequences":["GSHPSQAGWWAWGAVSDGTTGSHAHLTGPEASVHPGLHEGREADMQNLSP"]}},{"type":"Alternative sequence","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"in isoform Ankyrin-iPLA2-1","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9417066"}],"featureId":"VSP_000281","alternativeSequence":{"originalSequence":"HDH","alternativeSequences":["CRT"]}},{"type":"Alternative sequence","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"in isoform Ankyrin-iPLA2-1","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9417066"}],"featureId":"VSP_000282","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"in isoform Ankyrin-iPLA2-2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9417066"}],"featureId":"VSP_000280","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in dbSNP:rs11570605","featureCrossReferences":[{"database":"dbSNP","id":"rs11570605"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}],"featureId":"VAR_018961","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in dbSNP:rs11570606","featureCrossReferences":[{"database":"dbSNP","id":"rs11570606"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}],"featureId":"VAR_018962","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"in dbSNP:rs11570607","featureCrossReferences":[{"database":"dbSNP","id":"rs11570607"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}],"featureId":"VAR_018963","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"in dbSNP:rs11570646","featureCrossReferences":[{"database":"dbSNP","id":"rs11570646"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}],"featureId":"VAR_018964","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"in NBIA2A; dbSNP:rs121908682","featureCrossReferences":[{"database":"dbSNP","id":"rs121908682"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"}],"featureId":"VAR_029371","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"in NBIA2A; complete loss of phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_083527","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"in dbSNP:rs11570680","featureCrossReferences":[{"database":"dbSNP","id":"rs11570680"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.6"}],"featureId":"VAR_018965","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"in NBIA2A; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39796207"}],"featureId":"VAR_091088","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"in NBIA2A","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23749988"}],"featureId":"VAR_070600","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":517,"modifier":"EXACT"}},"description":"in NBIA2A; complete loss of phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_083528","alternativeSequence":{"originalSequence":"G","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"in NBIA2B; dbSNP:rs121908681","featureCrossReferences":[{"database":"dbSNP","id":"rs121908681"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"}],"featureId":"VAR_029372","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"in dbSNP:rs1004616610","featureCrossReferences":[{"database":"dbSNP","id":"rs1004616610"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28887846"}],"featureId":"VAR_079753","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":632,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"in NBIA2B; increases phospholipase, lysophospholipase and thioesterase activities; dbSNP:rs121908683","featureCrossReferences":[{"database":"dbSNP","id":"rs121908683"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_029373","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":638,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"in NBIA2A; complete loss of phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_083529","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"in NBIA2A; dbSNP:rs767689496","featureCrossReferences":[{"database":"dbSNP","id":"rs767689496"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23749988"}],"featureId":"VAR_070601","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":691,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"in NBIA2A and NBIA2B; significantly reduces phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17033970"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_029374","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"in PARK14; has no effect on phospholipase, lysophospholipase and thioesterase activities; dbSNP:rs121908686","featureCrossReferences":[{"database":"dbSNP","id":"rs121908686"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18570303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_062530","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"in NBIA2A; significantly reduces phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_083530","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"in PARK14; has no effect on phospholipase, lysophospholipase and thioesterase activities; dbSNP:rs121908687","featureCrossReferences":[{"database":"dbSNP","id":"rs121908687"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18570303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_062531","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"in dbSNP:rs34184838","featureCrossReferences":[{"database":"dbSNP","id":"rs34184838"}],"featureId":"VAR_037903","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"in NBIA2A; complete loss of phospholipase and lysophospholipase activities","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16783378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"featureId":"VAR_083531","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"Abolishes phospholipase and lysophospholipase activities.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20886109"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"in Ref. 3; AAD30424","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in Ref. 2; AAD41722/AAD41723","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":579,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"in Ref. 3; AAD30424","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"in Ref. 3; AAD30424","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":801,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"in Ref. 1; AAC97486","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"id":"KW-0112","category":"Molecular function","name":"Calmodulin-binding"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0145","category":"Biological process","name":"Chemotaxis"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1023","category":"Disease","name":"Dystonia"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0523","category":"Disease","name":"Neurodegeneration"},{"id":"KW-0907","category":"Disease","name":"Parkinson disease"},{"id":"KW-0908","category":"Disease","name":"Parkinsonism"},{"id":"KW-0582","category":"Technical term","name":"Pharmaceutical"},{"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9417066","citationType":"journal article","authors":["Larsson P.K.A.","Claesson H.-E.","Kennedy B.P."],"citationCrossReferences":[{"database":"PubMed","id":"9417066"},{"database":"DOI","id":"10.1074/jbc.273.1.207"}],"title":"Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"207","lastPage":"214","volume":"273"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LH-IPLA2; ANKYRIN-IPLA2-1 AND ANKYRIN-IPLA2-2)","FUNCTION"],"referenceComments":[{"value":"B-cell","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10092647","citationType":"journal article","authors":["Ma Z.","Wang X.","Nowatzke W.","Ramanadham S.","Turk J."],"citationCrossReferences":[{"database":"PubMed","id":"10092647"},{"database":"DOI","id":"10.1074/jbc.274.14.9607"}],"title":"Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"9607","lastPage":"9616","volume":"274"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LH-IPLA2 AND SH-IPLA2)","FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION"],"referenceComments":[{"value":"Pancreatic islet","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"10336645","citationType":"journal article","authors":["Larsson Forsell P.K.A.","Kennedy B.P.","Claesson H.-E."],"citationCrossReferences":[{"database":"PubMed","id":"10336645"},{"database":"DOI","id":"10.1046/j.1432-1327.1999.00418.x"}],"title":"The human calcium-independent phospholipase A2 gene. Multiple enzymes with distinct properties from a single gene.","publicationDate":"1999","journal":"Eur. J. Biochem.","firstPage":"575","lastPage":"585","volume":"262"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","ALTERNATIVE SPLICING","FUNCTION"]},{"referenceNumber":4,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15461802","citationType":"journal article","authors":["Collins J.E.","Wright C.L.","Edwards C.A.","Davis M.P.","Grinham J.A.","Cole C.G.","Goward M.E.","Aguado B.","Mallya M.","Mokrab Y.","Huckle E.J.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15461802"},{"database":"DOI","id":"10.1186/gb-2004-5-10-r84"}],"title":"A genome annotation-driven approach to cloning the human ORFeome.","publicationDate":"2004","journal":"Genome Biol.","firstPage":"R84.1","lastPage":"R84.11","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)"]},{"referenceNumber":6,"citation":{"id":"CI-86AL9GH7VDJIK","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"JAN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ILE-58; GLY-63; GLN-70; ASN-183 AND THR-343"]},{"referenceNumber":7,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)"]},{"referenceNumber":8,"citation":{"id":"10591208","citationType":"journal article","authors":["Dunham I.","Hunt A.R.","Collins J.E.","Bruskiewich R.","Beare D.M.","Clamp M.","Smink L.J.","Ainscough R.","Almeida J.P.","Babbage A.K.","Bagguley C.","Bailey J.","Barlow K.F.","Bates K.N.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Buck D.","Burgess J.","Burrill W.D.","Burton J.","Carder C.","Carter N.P.","Chen Y.","Clark G.","Clegg S.M.","Cobley V.E.","Cole C.G.","Collier R.E.","Connor R.","Conroy D.","Corby N.R.","Coville G.J.","Cox A.V.","Davis J.","Dawson E.","Dhami P.D.","Dockree C.","Dodsworth S.J.","Durbin R.M.","Ellington A.G.","Evans K.L.","Fey J.M.","Fleming K.","French L.","Garner A.A.","Gilbert J.G.R.","Goward M.E.","Grafham D.V.","Griffiths M.N.D.","Hall C.","Hall R.E.","Hall-Tamlyn G.","Heathcott R.W.","Ho S.","Holmes S.","Hunt S.E.","Jones M.C.","Kershaw J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.F.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Martyn I.D.","Mashreghi-Mohammadi M.","Matthews L.H.","Mccann O.T.","Mcclay J.","Mclaren S.","McMurray A.A.","Milne S.A.","Mortimore B.J.","Odell C.N.","Pavitt R.","Pearce A.V.","Pearson D.","Phillimore B.J.C.T.","Phillips S.H.","Plumb R.W.","Ramsay H.","Ramsey Y.","Rogers L.","Ross M.T.","Scott C.E.","Sehra H.K.","Skuce C.D.","Smalley S.","Smith M.L.","Soderlund C.","Spragon L.","Steward C.A.","Sulston J.E.","Swann R.M.","Vaudin M.","Wall M.","Wallis J.M.","Whiteley M.N.","Willey D.L.","Williams L.","Williams S.A.","Williamson H.","Wilmer T.E.","Wilming L.","Wright C.L.","Hubbard T.","Bentley D.R.","Beck S.","Rogers J.","Shimizu N.","Minoshima S.","Kawasaki K.","Sasaki T.","Asakawa S.","Kudoh J.","Shintani A.","Shibuya K.","Yoshizaki Y.","Aoki N.","Mitsuyama S.","Roe B.A.","Chen F.","Chu L.","Crabtree J.","Deschamps S.","Do A.","Do T.","Dorman A.","Fang F.","Fu Y.","Hu P.","Hua A.","Kenton S.","Lai H.","Lao H.I.","Lewis J.","Lewis S.","Lin S.-P.","Loh P.","Malaj E.","Nguyen T.","Pan H.","Phan S.","Qi S.","Qian Y.","Ray L.","Ren Q.","Shaull S.","Sloan D.","Song L.","Wang Q.","Wang Y.","Wang Z.","White J.","Willingham D.","Wu H.","Yao Z.","Zhan M.","Zhang G.","Chissoe S.","Murray J.","Miller N.","Minx P.","Fulton R.","Johnson D.","Bemis G.","Bentley D.","Bradshaw H.","Bourne S.","Cordes M.","Du Z.","Fulton L.","Goela D.","Graves T.","Hawkins J.","Hinds K.","Kemp K.","Latreille P.","Layman D.","Ozersky P.","Rohlfing T.","Scheet P.","Walker C.","Wamsley A.","Wohldmann P.","Pepin K.","Nelson J.","Korf I.","Bedell J.A.","Hillier L.W.","Mardis E.","Waterston R.","Wilson R.","Emanuel B.S.","Shaikh T.","Kurahashi H.","Saitta S.","Budarf M.L.","McDermid H.E.","Johnson A.","Wong A.C.C.","Morrow B.E.","Edelmann L.","Kim U.J.","Shizuya H.","Simon M.I.","Dumanski J.P.","Peyrard M.","Kedra D.","Seroussi E.","Fransson I.","Tapia I.","Bruder C.E.","O'Brien K.P.","Wilkinson P.","Bodenteich A.","Hartman K.","Hu X.","Khan A.S.","Lane L.","Tilahun Y.","Wright H."],"citationCrossReferences":[{"database":"PubMed","id":"10591208"},{"database":"DOI","id":"10.1038/990031"}],"title":"The DNA sequence of human chromosome 22.","publicationDate":"1999","journal":"Nature","firstPage":"489","lastPage":"495","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LH-IPLA2 AND SH-IPLA2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"18208975","citationType":"journal article","authors":["Mishra R.S.","Carnevale K.A.","Cathcart M.K."],"citationCrossReferences":[{"database":"PubMed","id":"18208975"},{"database":"DOI","id":"10.1084/jem.20071243"}],"title":"iPLA2beta: front and center in human monocyte chemotaxis to MCP-1.","publicationDate":"2008","journal":"J. Exp. Med.","firstPage":"347","lastPage":"359","volume":"205"},"referencePositions":["FUNCTION IN CHEMOTAXIS","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"19029121","citationType":"journal article","authors":["Kienesberger P.C.","Oberer M.","Lass A.","Zechner R."],"citationCrossReferences":[{"database":"PubMed","id":"19029121"},{"database":"DOI","id":"10.1194/jlr.r800082-jlr200"}],"title":"Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions.","publicationDate":"2009","journal":"J. Lipid Res.","firstPage":"S63","lastPage":"S68","volume":"50"},"referencePositions":["REVIEW ON FAMILY"]},{"referenceNumber":13,"citation":{"id":"19164547","citationType":"journal article","authors":["Malhotra A.","Edelman-Novemsky I.","Xu Y.","Plesken H.","Ma J.","Schlame M.","Ren M."],"citationCrossReferences":[{"database":"PubMed","id":"19164547"},{"database":"DOI","id":"10.1073/pnas.0811224106"}],"title":"Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2337","lastPage":"2341","volume":"106"},"referencePositions":["FUNCTION","PHARMACEUTICAL USE"]},{"referenceNumber":14,"citation":{"id":"20886109","citationType":"journal article","authors":["Engel L.A.","Jing Z.","O'Brien D.E.","Sun M.","Kotzbauer P.T."],"citationCrossReferences":[{"database":"PubMed","id":"20886109"},{"database":"DOI","id":"10.1371/journal.pone.0012897"}],"title":"Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"e12897","lastPage":"e12897","volume":"5"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","VARIANTS THR-341; CYS-517; TRP-632; ARG-638; VAL-691 DEL; GLN-741; TRP-741; TRP-747 AND 790-TYR--PRO-806 DEL","MUTAGENESIS OF SER-519"]},{"referenceNumber":15,"citation":{"id":"23533611","citationType":"journal article","authors":["Hsu Y.H.","Dumlao D.S.","Cao J.","Dennis E.A."],"citationCrossReferences":[{"database":"PubMed","id":"23533611"},{"database":"DOI","id":"10.1371/journal.pone.0059267"}],"title":"Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E59267","lastPage":"E59267","volume":"8"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":16,"citation":{"id":"CI-F4PGUVU1EI11V","citationType":"journal article","authors":["Hsu Y.H.","Dumlao D.S.","Cao J.","Dennis E.A."],"citationCrossReferences":[{"database":"DOI","id":"10.1371/annotation/47607b18-ed69-4a08-8619-60c39bd83a13"}],"publicationDate":"2013","journal":"PLoS ONE","firstPage":"59267","lastPage":"59267","volume":"8"},"referencePositions":["ERRATUM OF PUBMED:23533611"]},{"referenceNumber":17,"citation":{"id":"17033970","citationType":"journal article","authors":["Khateeb S.","Flusser H.","Ofir R.","Shelef I.","Narkis G.","Vardi G.","Shorer Z.","Levy R.","Galil A.","Elbedour K.","Birk O.S."],"citationCrossReferences":[{"database":"PubMed","id":"17033970"},{"database":"DOI","id":"10.1086/508572"}],"title":"PLA2G6 mutation underlies infantile neuroaxonal dystrophy.","publicationDate":"2006","journal":"Am. J. Hum. Genet.","firstPage":"942","lastPage":"948","volume":"79"},"referencePositions":["VARIANT NBIA2A VAL-691 DEL"]},{"referenceNumber":18,"citation":{"id":"16783378","citationType":"journal article","authors":["Morgan N.V.","Westaway S.K.","Morton J.E.","Gregory A.","Gissen P.","Sonek S.","Cangul H.","Coryell J.","Canham N.","Nardocci N.","Zorzi G.","Pasha S.","Rodriguez D.","Desguerre I.","Mubaidin A.","Bertini E.","Trembath R.C.","Simonati A.","Schanen C.","Johnson C.A.","Levinson B.","Woods C.G.","Wilmot B.","Kramer P.","Gitschier J.","Maher E.R.","Hayflick S.J."],"citationCrossReferences":[{"database":"PubMed","id":"16783378"},{"database":"DOI","id":"10.1038/ng1826"}],"title":"PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron.","publicationDate":"2006","journal":"Nat. Genet.","firstPage":"752","lastPage":"754","volume":"38"},"referencePositions":["VARIANTS NBIA2B THR-545; TRP-632 AND VAL-691 DEL","VARIANTS NBIA2A GLU-310; THR-341; CYS-517; ARG-638; TRP-741 AND 790-TYR--PRO-806 DEL"]},{"referenceNumber":19,"citation":{"id":"CI-1SI61JGCGU3F9","citationType":"journal article","authors":["Morgan N.V.","Westaway S.K.","Morton J.E.","Gregory A.","Gissen P.","Sonek S.","Cangul H.","Coryell J.","Canham N.","Nardocci N.","Zorzi G.","Pasha S.","Rodriguez D.","Desguerre I.","Mubaidin A.","Bertini E.","Trembath R.C.","Simonati A.","Schanen C.","Johnson C.A.","Levinson B.","Woods C.G.","Wilmot B.","Kramer P.","Gitschier J.","Maher E.R.","Hayflick S.J."],"publicationDate":"2006","journal":"Nat. Genet.","firstPage":"957","lastPage":"957","volume":"38"},"referencePositions":["ERRATUM OF PUBMED:16783378"]},{"referenceNumber":20,"citation":{"id":"18570303","citationType":"journal article","authors":["Paisan-Ruiz C.","Bhatia K.P.","Li A.","Hernandez D.","Davis M.","Wood N.W.","Hardy J.","Houlden H.","Singleton A.","Schneider S.A."],"citationCrossReferences":[{"database":"PubMed","id":"18570303"},{"database":"DOI","id":"10.1002/ana.21415"}],"title":"Characterization of PLA2G6 as a locus for dystonia-parkinsonism.","publicationDate":"2009","journal":"Ann. Neurol.","firstPage":"19","lastPage":"23","volume":"65"},"referencePositions":["VARIANTS PARK14 GLN-741 AND TRP-747"]},{"referenceNumber":21,"citation":{"id":"23749988","citationType":"journal article","authors":["Koeroglu C.","Seven M.","Tolun A."],"citationCrossReferences":[{"database":"PubMed","id":"23749988"},{"database":"DOI","id":"10.1136/jmedgenet-2013-101634"}],"title":"Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism.","publicationDate":"2013","journal":"J. Med. Genet.","firstPage":"515","lastPage":"520","volume":"50"},"referencePositions":["VARIANTS NBIA2A GLY-484 AND MET-661"]},{"referenceNumber":22,"citation":{"id":"28887846","citationType":"journal article","authors":["Zhou X.L.","He L.X.","Yu L.J.","Wang Y.","Wang X.J.","Wang E.D.","Yang T."],"citationCrossReferences":[{"database":"PubMed","id":"28887846"},{"database":"DOI","id":"10.1002/humu.23335"}],"title":"Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism.","publicationDate":"2017","journal":"Hum. Mutat.","firstPage":"1740","lastPage":"1750","volume":"38"},"referencePositions":["VARIANT TRP-550"]},{"referenceNumber":23,"citation":{"id":"39796207","citationType":"journal article","authors":["Cheema A.N.","Shi R.","Kamboh M.I."],"citationCrossReferences":[{"database":"PubMed","id":"39796207"},{"database":"DOI","id":"10.3390/ijms26010352"}],"title":"Association of Novel Pathogenic Variant (p. Ile366Asn) in PLA2G6 Gene with Infantile Neuroaxonal Dystrophy.","publicationDate":"2025","journal":"Int. J. Mol. Sci.","firstPage":"0","lastPage":"0","volume":"26"},"referencePositions":["VARIANT NBIA2A ASN-366"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF064594","properties":[{"key":"ProteinId","value":"AAC97486.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF102988","properties":[{"key":"ProteinId","value":"AAD41722.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF102989","properties":[{"key":"ProteinId","value":"AAD41723.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF117692","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117677","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117678","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117679","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117680","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117681","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117682","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117683","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117684","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117685","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117686","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117687","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117688","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117689","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117690","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF117691","properties":[{"key":"ProteinId","value":"AAD30424.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116267","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116252","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116253","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116254","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116255","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116256","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116257","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116258","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116259","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116260","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116261","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116262","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116263","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116264","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116265","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF116266","properties":[{"key":"ProteinId","value":"AAF34728.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL080187","properties":[{"key":"ProteinId","value":"CAB45768.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR456543","properties":[{"key":"ProteinId","value":"CAG30429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY522921","properties":[{"key":"ProteinId","value":"AAR92478.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK291212","properties":[{"key":"ProteinId","value":"BAF83901.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471095","properties":[{"key":"ProteinId","value":"EAW60219.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471095","properties":[{"key":"ProteinId","value":"EAW60220.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC036742","properties":[{"key":"ProteinId","value":"AAH36742.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051904","properties":[{"key":"ProteinId","value":"AAH51904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS13967.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-1"},{"database":"CCDS","id":"CCDS33645.1","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-2"},{"database":"RefSeq","id":"NP_001004426.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001004426.3"}],"isoformId":"O60733-2"},{"database":"RefSeq","id":"NP_001186491.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001199562.3"}],"isoformId":"O60733-2"},{"database":"RefSeq","id":"NP_001336793.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001349864.2"}],"isoformId":"O60733-1"},{"database":"RefSeq","id":"NP_001336794.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001349865.2"}],"isoformId":"O60733-2"},{"database":"RefSeq","id":"NP_001336795.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001349866.2"}],"isoformId":"O60733-2"},{"database":"RefSeq","id":"NP_003551.2","properties":[{"key":"NucleotideSequenceId","value":"NM_003560.4"}],"isoformId":"O60733-1"},{"database":"AlphaFoldDB","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113986","properties":[{"key":"Interactions","value":"32"}]},{"database":"FunCoup","id":"O60733","properties":[{"key":"Number of interactors","value":"1469"}]},{"database":"IntAct","id":"O60733","properties":[{"key":"Interactions","value":"16"}]},{"database":"MINT","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PLA2G6","properties":[{"key":"Evidences","value":"7 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000333142","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3213","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB01103","properties":[{"key":"GenericName","value":"Quinacrine"}]},{"database":"SwissLipids","id":"SLP:000000618","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PLA2G6","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000333142","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"49578","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-1"},{"database":"ProteomicsDB","id":"49579","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-2"},{"database":"ProteomicsDB","id":"49580","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-3"},{"database":"ProteomicsDB","id":"49581","properties":[{"key":"Description","value":"-"}],"isoformId":"O60733-4"},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"DNASU","id":"8398","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000332509.8","properties":[{"key":"ProteinId","value":"ENSP00000333142.3"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000335539.7","properties":[{"key":"ProteinId","value":"ENSP00000335149.3"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-2"},{"database":"Ensembl","id":"ENST00000402064.5","properties":[{"key":"ProteinId","value":"ENSP00000386100.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-2"},{"database":"Ensembl","id":"ENST00000660610.1","properties":[{"key":"ProteinId","value":"ENSP00000499555.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000663895.1","properties":[{"key":"ProteinId","value":"ENSP00000499712.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000667521.1","properties":[{"key":"ProteinId","value":"ENSP00000499665.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000885143.1","properties":[{"key":"ProteinId","value":"ENSP00000555202.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000885144.1","properties":[{"key":"ProteinId","value":"ENSP00000555203.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-2"},{"database":"Ensembl","id":"ENST00000885145.1","properties":[{"key":"ProteinId","value":"ENSP00000555204.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-2"},{"database":"Ensembl","id":"ENST00000885146.1","properties":[{"key":"ProteinId","value":"ENSP00000555205.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-1"},{"database":"Ensembl","id":"ENST00000955628.1","properties":[{"key":"ProteinId","value":"ENSP00000625687.1"},{"key":"GeneId","value":"ENSG00000184381.21"}],"isoformId":"O60733-2"},{"database":"GeneID","id":"8398","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8398","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000332509.8","properties":[{"key":"ProteinId","value":"ENSP00000333142.3"},{"key":"RefSeqNucleotideId","value":"NM_003560.4"},{"key":"RefSeqProteinId","value":"NP_003551.2"}]},{"database":"UCSC","id":"uc003auy.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"O60733-1"},{"database":"AGR","id":"HGNC:9039","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA33367","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8398","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8398","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PLA2G6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"PLA2G6","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"HPA","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"PLA2G6","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"256600","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"603604","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"610217","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"612953","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"199351","properties":[{"key":"Disease","value":"Adult-onset PLA2G6-associated neurodegeneration"}]},{"database":"Orphanet","id":"35069","properties":[{"key":"Disease","value":"Infantile-onset PLA2G6-associated neurodegeneration"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0513","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_010817_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VVYSHTH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O60733","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.1.1.4","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1482788","properties":[{"key":"PathwayName","value":"Acyl chain remodelling of PC"}]},{"database":"Reactome","id":"R-HSA-1482798","properties":[{"key":"PathwayName","value":"Acyl chain remodeling of CL"}]},{"database":"Reactome","id":"R-HSA-1482839","properties":[{"key":"PathwayName","value":"Acyl chain remodelling of PE"}]},{"database":"Reactome","id":"R-HSA-2029485","properties":[{"key":"PathwayName","value":"Role of phospholipids in phagocytosis"}]},{"database":"Reactome","id":"R-HSA-6811436","properties":[{"key":"PathwayName","value":"COPI-independent Golgi-to-ER retrograde traffic"}]},{"database":"SignaLink","id":"O60733","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000184381","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8398","properties":[{"key":"hits","value":"8 hits in 1163 CRISPR screens"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PLA2G6","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8398","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O60733","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:O60733","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"RNAct","id":"O60733","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O60733","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18208975"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18714013"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38322995"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0031143","properties":[{"key":"GoTerm","value":"C:pseudopodium"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003847","properties":[{"key":"GoTerm","value":"F:1-alkyl-2-acetylglycerophosphocholine esterase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004623","properties":[{"key":"GoTerm","value":"F:A2-type glycerophospholipase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15908428"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20886109"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23533611"}]},{"database":"GO","id":"GO:0016787","properties":[{"key":"GoTerm","value":"F:hydrolase activity"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"32296183"}]},{"database":"GO","id":"GO:0052816","properties":[{"key":"GoTerm","value":"F:long-chain fatty acyl-CoA hydrolase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20886109"}]},{"database":"GO","id":"GO:0004622","properties":[{"key":"GoTerm","value":"F:phosphatidylcholine lysophospholipase A1 activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20886109"}]},{"database":"GO","id":"GO:0017171","properties":[{"key":"GoTerm","value":"F:serine hydrolase activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019731","properties":[{"key":"GoTerm","value":"P:antibacterial humoral response"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18714013"}]},{"database":"GO","id":"GO:0035965","properties":[{"key":"GoTerm","value":"P:cardiolipin acyl-chain remodeling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23533611"}]},{"database":"GO","id":"GO:0038096","properties":[{"key":"GoTerm","value":"P:Fc-gamma receptor signaling pathway involved in phagocytosis"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0046473","properties":[{"key":"GoTerm","value":"P:phosphatidic acid metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034638","properties":[{"key":"GoTerm","value":"P:phosphatidylcholine catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20886109"}]},{"database":"GO","id":"GO:0046338","properties":[{"key":"GoTerm","value":"P:phosphatidylethanolamine catabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046469","properties":[{"key":"GoTerm","value":"P:platelet activating factor metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000304","properties":[{"key":"GoTerm","value":"P:positive regulation of ceramide biosynthetic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035774","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":806,"molWeight":89903,"crc64":"8E55CD4EB9ACAD8B","md5":"53CC5912BF872AA9AC7B8991DB9D0DE1"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"CATALYTIC ACTIVITY":20,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":10,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"DOMAIN":1,"DISEASE":3,"PHARMACEUTICAL":1},"countByFeatureType":{"Chain":1,"Transmembrane":2,"Repeat":9,"Domain":1,"Region":2,"Motif":3,"Active site":2,"Alternative sequence":6,"Natural variant":21,"Mutagenesis":1,"Sequence conflict":5},"uniParcId":"UPI00001310F3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A590UJC7","uniProtkbId":"A0A590UJC7_HUMAN","entryAudit":{"firstPublicDate":"2019-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":31,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067994"}],"value":"85/88 kDa calcium-independent phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013274"}],"value":"3.1.1.5"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038848"}],"value":"3.1.2.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079203"}],"value":"2-lysophosphatidylcholine acylhydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00081750"}],"value":"Group VI phospholipase A2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080530"}],"value":"Intracellular membrane-associated calcium-independent phospholipase A2 beta"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075657"}],"value":"Palmitoyl-CoA hydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078895"}],"value":"Patatin-like phospholipase domain-containing protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:52812"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:83580"},{"database":"ChEBI","id":"CHEBI:83581"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:52814"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40463"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77253"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40464"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40467"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77256"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40468"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63304"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:72859"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63305"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41223"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:72999"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41224"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40831"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:74344"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40832"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41067"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:55430"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41068"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40479"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:44811"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40480"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40427"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73003"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40428"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40431"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73004"},{"database":"ChEBI","id":"CHEBI:73009"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40432"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40811"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73002"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40812"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38779"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38780"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40435"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:72998"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40436"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63256"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:75036"},{"database":"ChEBI","id":"CHEBI:78832"},{"database":"ChEBI","id":"CHEBI:146277"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40519"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:74965"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40520"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40827"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:76079"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40828"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36231"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:30909"},{"database":"ChEBI","id":"CHEBI:36702"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:36232"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15177"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15178"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16645"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57379"}],"ecNumber":"3.1.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16646"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037818"}],"value":"Cell projection, pseudopodium","id":"SL-0298"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":606,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":606,"modifier":"EXACT"},"end":{"value":606,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A590UJC7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A590UJC7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499394.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A590UJC7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A590UJC7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A590UJC7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000664587.1","properties":[{"key":"ProteinId","value":"ENSP00000499394.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A590UJC7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0031143","properties":[{"key":"GoTerm","value":"C:pseudopodium"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004623","properties":[{"key":"GoTerm","value":"F:A2-type glycerophospholipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004622","properties":[{"key":"GoTerm","value":"F:phosphatidylcholine lysophospholipase A1 activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRPCPALCLTELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":760,"molWeight":84893,"crc64":"0D35B23545A37B61","md5":"734A9BC786E883378D1F6447B7C9EBFB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":20,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Repeat":4,"Domain":1,"Motif":3,"Active site":2},"uniParcId":"UPI00114B1C64"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S667","uniProtkbId":"A0ACI8S667_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067994"}],"value":"85/88 kDa calcium-independent phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013274"}],"value":"3.1.1.5"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038848"}],"value":"3.1.2.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079203"}],"value":"2-lysophosphatidylcholine acylhydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00081750"}],"value":"Group VI phospholipase A2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080530"}],"value":"Intracellular membrane-associated calcium-independent phospholipase A2 beta"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075657"}],"value":"Palmitoyl-CoA hydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078895"}],"value":"Patatin-like phospholipase domain-containing protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:52812"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:83580"},{"database":"ChEBI","id":"CHEBI:83581"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:52814"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40463"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77253"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40464"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40467"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77256"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40468"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63304"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:72859"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63305"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41223"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:72999"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41224"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40831"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:74344"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40832"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41067"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:55430"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41068"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40479"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:44811"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40480"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40427"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73003"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40428"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40431"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73004"},{"database":"ChEBI","id":"CHEBI:73009"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40432"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40811"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73002"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40812"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38779"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38780"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40435"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:72998"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40436"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63256"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:75036"},{"database":"ChEBI","id":"CHEBI:78832"},{"database":"ChEBI","id":"CHEBI:146277"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40519"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:74965"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40520"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40827"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:76079"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40828"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36231"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:30909"},{"database":"ChEBI","id":"CHEBI:36702"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:36232"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15177"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15178"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16645"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57379"}],"ecNumber":"3.1.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16646"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037818"}],"value":"Cell projection, pseudopodium","id":"SL-0298"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S667"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S667"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555206.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000885147.1","properties":[{"key":"ProteinId","value":"ENSP00000555206.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":691,"molWeight":77637,"crc64":"684AD28194B0CC98","md5":"E9ECBA87CE266214FB9ED577730BD5C0"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":20,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Repeat":3,"Domain":1,"Motif":3,"Active site":2},"uniParcId":"UPI00403269AF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QNK0","uniProtkbId":"A0ACI8QNK0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00067994"}],"value":"85/88 kDa calcium-independent phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013274"}],"value":"3.1.1.5"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038848"}],"value":"3.1.2.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079203"}],"value":"2-lysophosphatidylcholine acylhydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00081750"}],"value":"Group VI phospholipase A2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080530"}],"value":"Intracellular membrane-associated calcium-independent phospholipase A2 beta"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00075657"}],"value":"Palmitoyl-CoA hydrolase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078895"}],"value":"Patatin-like phospholipase domain-containing protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:52812"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:83580"},{"database":"ChEBI","id":"CHEBI:83581"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:52814"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40463"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77253"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40464"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40467"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:77256"},{"database":"ChEBI","id":"CHEBI:77259"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40468"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050571"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63304"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57518"},{"database":"ChEBI","id":"CHEBI:72859"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63305"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052243"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41223"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:72999"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41224"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048227"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40831"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:74344"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40832"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052127"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41067"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:55430"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41068"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048903"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40479"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:44811"},{"database":"ChEBI","id":"CHEBI:64496"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40480"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023721"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40427"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73003"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40428"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048373"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40431"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73004"},{"database":"ChEBI","id":"CHEBI:73009"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40432"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048541"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40811"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30245"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73002"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40812"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023408"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38779"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30823"},{"database":"ChEBI","id":"CHEBI:72998"},{"database":"ChEBI","id":"CHEBI:73001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:38780"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048699"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40435"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:72998"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40436"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048656"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63256"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:75036"},{"database":"ChEBI","id":"CHEBI:78832"},{"database":"ChEBI","id":"CHEBI:146277"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:63257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052553"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40519"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:73858"},{"database":"ChEBI","id":"CHEBI:74965"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40520"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049468"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:40827"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:32395"},{"database":"ChEBI","id":"CHEBI:76079"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:40828"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052937"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36231"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:30909"},{"database":"ChEBI","id":"CHEBI:36702"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:36232"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048049"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15177"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16870"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15178"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048454"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16645"},{"database":"ChEBI","id":"CHEBI:7896"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57379"}],"ecNumber":"3.1.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16646"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047734"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037818"}],"value":"Cell projection, pseudopodium","id":"SL-0298"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]}],"features":[{"type":"Repeat","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QNK0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QNK0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000555207.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000885148.1","properties":[{"key":"ProteinId","value":"ENSP00000555207.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"Ensembl","id":"ENST00000885149.1","properties":[{"key":"ProteinId","value":"ENSP00000555208.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":734,"molWeight":81559,"crc64":"0D5C12FFE9762405","md5":"856B590682BECC6F65CDA113FF9839EB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":20,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Repeat":4,"Domain":1,"Motif":3,"Active site":2},"uniParcId":"UPI000387D5CF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TKS7","uniProtkbId":"A0ACI8TKS7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":571,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TKS7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TKS7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601392.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000931333.1","properties":[{"key":"ProteinId","value":"ENSP00000601392.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLGKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":725,"molWeight":81160,"crc64":"24CD7E0057515F1E","md5":"C15E56A77963A5BE66A98C7B0162EDA1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"CAUTION":1},"countByFeatureType":{"Repeat":4,"Domain":1,"Motif":1},"uniParcId":"UPI004031BEF1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UYN9","uniProtkbId":"A0ACI8UYN9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Region","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":588,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Compositional bias","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":588,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UYN9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UYN9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625691.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000955632.1","properties":[{"key":"ProteinId","value":"ENSP00000625691.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQVCGDDHQHGQQPDPQQRPPLRSQPPPLGQERRDGPHAAETGLQREQHQLRGEHGPARGGDAQPLRLCHSAADPRGQRGCPRRARQHPAAPGHKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":742,"molWeight":83153,"crc64":"75D1F4A655422298","md5":"CDA45C68710AE3468710878DB9B53A92"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Repeat":1,"Domain":1,"Region":2,"Motif":3,"Compositional bias":1,"Active site":2},"uniParcId":"UPI004031CEE2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UYZ7","uniProtkbId":"A0ACI8UYZ7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]}],"features":[{"type":"Repeat","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UYZ7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UYZ7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625690.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000955630.1","properties":[{"key":"ProteinId","value":"ENSP00000625689.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"Ensembl","id":"ENST00000955631.1","properties":[{"key":"ProteinId","value":"ENSP00000625690.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1090.10:FF:000006","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13857","properties":[{"key":"EntryName","value":"Ank_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIIRCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":628,"molWeight":70620,"crc64":"6A8A34D5207D49D9","md5":"D973AA6B85731E9A4566B0EA8AF81EA7"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Repeat":2,"Domain":1,"Motif":3,"Active site":2},"uniParcId":"UPI0040325B2D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A590UK51","uniProtkbId":"A0A590UK51_HUMAN","entryAudit":{"firstPublicDate":"2019-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":31,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":611,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":465,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A590UK51"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A590UK51"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499711.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A590UK51","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A590UK51","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A590UK51","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000668949.1","properties":[{"key":"ProteinId","value":"ENSP00000499711.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A590UK51","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0004623","properties":[{"key":"GoTerm","value":"F:A2-type glycerophospholipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKAAETVRLSDTSQSNSPIACGWGAWDPEWEASPKIIQQIGSRACSEANKRGSGRAQRLTPVIPALWEAEGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":820,"molWeight":91412,"crc64":"E2F0107E495E208E","md5":"A21AE6052638D02D646CF05A1A1130F9"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Repeat":4,"Domain":1,"Motif":3,"Active site":2},"uniParcId":"UPI00114982E8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UZU8","uniProtkbId":"A0ACI8UZU8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UZU8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UZU8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000625688.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000955629.1","properties":[{"key":"ProteinId","value":"ENSP00000625688.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"CDD","id":"cd07212","properties":[{"key":"EntryName","value":"Pat_PNPLA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRRKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP","length":671,"molWeight":75450,"crc64":"9E052F9FE339470C","md5":"3F72BFB83896D9F4C056B3841BA2B8B2"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"CAUTION":1},"countByFeatureType":{"Repeat":4,"Domain":1,"Motif":1},"uniParcId":"UPI0040324BBF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0Y6T3","uniProtkbId":"H0Y6T3_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":79,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"phospholipase A2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013278"}],"value":"3.1.1.4"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"}],"value":"PLA2G6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15801"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:28868"},{"database":"ChEBI","id":"CHEBI:57643"},{"database":"ChEBI","id":"CHEBI:58168"}],"ecNumber":"3.1.1.4","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15802"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023422"}]}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Repeat","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Domain","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"DGA/G","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Active site","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Non-terminal residue","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0Y6T3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0Y6T3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407743.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0Y6T3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0Y6T3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0Y6T3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35280","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000427114.6","properties":[{"key":"ProteinId","value":"ENSP00000407743.2"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062eds.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1217163_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0Y6T3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0004623","properties":[{"key":"GoTerm","value":"F:A2-type glycerophospholipase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEY","length":439,"molWeight":48544,"crc64":"BF8731EEC497EBFE","md5":"EF0ED5E9B09CEB575315AF165BEA997A"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Transmembrane":2,"Repeat":3,"Domain":1,"Motif":3,"Active site":2,"Non-terminal residue":1},"uniParcId":"UPI001149F94D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A590UJZ2","uniProtkbId":"A0A590UJZ2_HUMAN","entryAudit":{"firstPublicDate":"2019-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"}],"value":"Phospholipase A2 group VI"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"}],"value":"PLA2G6"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A590UJZ2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A590UJZ2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499626.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A590UJZ2","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000668499.1","properties":[{"key":"ProteinId","value":"ENSP00000499626.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"Ensembl","id":"ENST00000673413.1","properties":[{"key":"ProteinId","value":"ENSP00000500600.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"OpenTargets","id":"ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRRLGSSPCVLSPMRLLLVLLVCPSSPVTAT","length":99,"molWeight":11052,"crc64":"CE935588EDFE1B98","md5":"8BDE291663EC98BBADF9B851D3CF612C"},"extraAttributes":{"uniParcId":"UPI000173A307"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F8WEN3","uniProtkbId":"F8WEN3_HUMAN","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":70,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"}],"value":"Phospholipase A2 group VI"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"}],"value":"PLA2G6"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F8WEN3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F8WEN3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000401242.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F8WEN3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F8WEN3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F8WEN3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"31900","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000436218.6","properties":[{"key":"ProteinId","value":"ENSP00000401242.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edz.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_084376_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F8WEN3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISSLEGTQWLA","length":151,"molWeight":17390,"crc64":"E9B1B429C49A0812","md5":"6B76E4515366790ABFE9D12131251BBA"},"extraAttributes":{"uniParcId":"UPI000173A30F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F8WEQ9","uniProtkbId":"F8WEQ9_HUMAN","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":84,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"}],"value":"PLA2G6"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F8WEQ9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F8WEQ9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000393761.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F8WEQ9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F8WEQ9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"31926","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000455341.2","properties":[{"key":"ProteinId","value":"ENSP00000393761.2"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062eef.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2612214_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VVYSHTH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F8WEQ9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEAD","length":79,"molWeight":9118,"crc64":"5107A0802B50C81B","md5":"E6619B38BCC21BCCAB118C0A57A79B4B"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0003F483F9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R1Q9","uniProtkbId":"M0R1Q9_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":72,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"}],"value":"PLA2G6"}}],"features":[{"type":"Repeat","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Non-terminal residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0R1Q9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0R1Q9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000472058.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0R1Q9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0R1Q9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R1Q9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000498338.1","properties":[{"key":"ProteinId","value":"ENSP00000472058.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edw.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2055008_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VVYSHTH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R1Q9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAE","length":120,"molWeight":13186,"crc64":"AD9727D71399AF08","md5":"9A91E5C28C84A04D50D7FC8A5F79EBF5"},"extraAttributes":{"countByFeatureType":{"Repeat":1,"Non-terminal residue":1},"uniParcId":"UPI0002A474A4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R3D9","uniProtkbId":"M0R3D9_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":68,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"}],"value":"PLA2G6"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"M0R3D9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"M0R3D9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473160.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"M0R3D9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"M0R3D9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R3D9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000594306.1","properties":[{"key":"ProteinId","value":"ENSP00000473160.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062eei.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3129473_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VVYSHTH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R3D9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNT","length":50,"molWeight":5730,"crc64":"0D049B52A33EAC63","md5":"B7AEE5170D7030E748A929CA58807257"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0003F48164"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A590UK67","uniProtkbId":"A0A590UK67_HUMAN","entryAudit":{"firstPublicDate":"2019-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":28,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"}],"value":"Phospholipase A2 group VI"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"}],"value":"PLA2G6"}}],"features":[{"type":"Repeat","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Region","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A590UK67"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A590UK67"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499715.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A590UK67","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A590UK67","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A590UK67","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000655142.1","properties":[{"key":"ProteinId","value":"ENSP00000499715.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A590UK67","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQVCGDDHQHGQQPDPQQRPPLRSQPPPLGQERRDGPHAAETGLQREQHQLRGEHGPARGGDAQPLRLCHSAADPRGQRGCPRRARQHPAAPGHVERQRGDDQGPHRVRSRSGHPE","length":317,"molWeight":35746,"crc64":"DB18DE6D0C313522","md5":"D3DF555957FE785C7E358089FB1BC129"},"extraAttributes":{"countByFeatureType":{"Repeat":1,"Region":1,"Compositional bias":4},"uniParcId":"UPI00114B8412"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0QYE9","uniProtkbId":"B0QYE9_HUMAN","entryAudit":{"firstPublicDate":"2008-04-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-04-08","entryVersion":105,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"}],"value":"PLA2G6"}}],"features":[{"type":"Repeat","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Non-terminal residue","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"B0QYE9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"B0QYE9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000395464.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0QYE9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B0QYE9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"B0QYE9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"2634","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000430886.5","properties":[{"key":"ProteinId","value":"ENSP00000395464.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edx.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1606445_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"B0QYE9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV","length":166,"molWeight":18555,"crc64":"221F261B628FCA6D","md5":"50B265C8842272C974159F63083CA4CF"},"extraAttributes":{"countByFeatureType":{"Repeat":2,"Non-terminal residue":1},"uniParcId":"UPI000165DBCC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0Y7G5","uniProtkbId":"H0Y7G5_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":73,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"}],"value":"PLA2G6"}}],"features":[{"type":"Repeat","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0Y7G5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0Y7G5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412629.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0Y7G5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35435","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"225","properties":[{"key":"antibodies","value":"250 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000452542.5","properties":[{"key":"ProteinId","value":"ENSP00000412629.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1393047_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0Y7G5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"FunFam","id":"1.25.40.20:FF:000338","properties":[{"key":"EntryName","value":"85/88 kDa calcium-independent phospholipase A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"XLVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMI","length":197,"molWeight":21558,"crc64":"E32E92F19D1ADD98","md5":"8DC6A787C340C114F20A308115DF7D9E"},"extraAttributes":{"countByFeatureType":{"Repeat":3,"Non-terminal residue":2},"uniParcId":"UPI000173A311"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H7C3P5","uniProtkbId":"H7C3P5_HUMAN","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":67,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"}],"value":"Phospholipase A2 group VI"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"}],"value":"PLA2G6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"PNPLA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51635"}]},{"type":"Motif","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"GXGXXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Motif","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"GXSXG","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01161"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023043"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H7C3P5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H7C3P5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000413145.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"H7C3P5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H7C3P5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"H7C3P5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"45401","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000454670.1","properties":[{"key":"ProteinId","value":"ENSP00000413145.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1598273_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H7C3P5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0006629","properties":[{"key":"GoTerm","value":"P:lipid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.1090.10","properties":[{"key":"EntryName","value":"Cytosolic phospholipase A2 catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"InterPro","id":"IPR002641","properties":[{"key":"EntryName","value":"PNPLA_dom"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01734","properties":[{"key":"EntryName","value":"Patatin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51635","properties":[{"key":"EntryName","value":"PNPLA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKLDQSDTPPALPERACFAGMVRGEAHLSRTEGDADRDTV","length":168,"molWeight":18688,"crc64":"B8ED17C61C9D4B72","md5":"23B695A17E8ECE071EE89835605D3078"},"extraAttributes":{"countByCommentType":{"CAUTION":1},"countByFeatureType":{"Transmembrane":2,"Domain":1,"Motif":2,"Non-terminal residue":1},"uniParcId":"UPI000173A315"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A590UJH4","uniProtkbId":"A0A590UJH4_HUMAN","entryAudit":{"firstPublicDate":"2019-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":26,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"}],"value":"Phospholipase A2 group VI"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"}],"value":"PLA2G6"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A590UJH4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A590UJH4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499423.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A590UJH4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A590UJH4","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000665987.1","properties":[{"key":"ProteinId","value":"ENSP00000499423.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A590UJH4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRSHAQ","length":74,"molWeight":8482,"crc64":"C123131AA50C8B6D","md5":"CE43BBCE308BE4EAA89964BF7112638C"},"extraAttributes":{"uniParcId":"UPI000173A308"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7EX67","uniProtkbId":"E7EX67_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-03-08","entryVersion":89,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"}],"value":"Phospholipase A2 group VI"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"}],"value":"PLA2G6"}}],"features":[{"type":"Repeat","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Repeat","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"ANK","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}]},{"type":"Region","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00023"}],"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E7EX67"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E7EX67"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000407106.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022322","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E7EX67","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E7EX67","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E7EX67","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"18994","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000448094.5","properties":[{"key":"ProteinId","value":"ENSP00000407106.1"},{"key":"GeneId","value":"ENSG00000184381.21"}]},{"database":"UCSC","id":"uc062edm.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:9039","properties":[{"key":"GeneName","value":"PLA2G6"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184381","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000158756","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1224411_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10021675at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PLA2G6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000184381","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7EX67","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR047148","properties":[{"key":"EntryName","value":"PLPL9"}]},{"database":"PANTHER","id":"PTHR24139:SF34","properties":[{"key":"EntryName","value":"85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24139","properties":[{"key":"EntryName","value":"CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13857","properties":[{"key":"EntryName","value":"Ank_5"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLGSHPSQAGWWAWGAASDGTTGSHAHLTGPEASVHPGLHEGREADMQNLSP","length":226,"molWeight":24124,"crc64":"CC2EF1147A1C0C83","md5":"BB2A84C625D7B348EF6C6A23C1FFFE76"},"extraAttributes":{"countByFeatureType":{"Repeat":2,"Region":1},"uniParcId":"UPI000173A314"}}]}