{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q13526","secondaryAccessions":["A8K4V9","Q53X75"],"uniProtkbId":"PIN1_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":232,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21497122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23623683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29686383"}],"value":"5.2.1.8"}]},"alternativeNames":[{"fullName":{"value":"Peptidyl-prolyl cis-trans isomerase Pin1"},"shortNames":[{"value":"PPIase Pin1"}]},{"fullName":{"value":"Rotamase Pin1"}}]},"genes":[{"geneName":{"value":"PIN1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QUR7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15664191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16644721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17828269"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21497122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22033920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22608923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23623683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26942675"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27561354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29686383"}],"value":"Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). Acts as a negative regulator of adipocyte browning by binding to phosphorylated PRDM16, targeting PRDM16 for degradation (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16237"},{"database":"Rhea","id":"RHEA-COMP:10747"},{"database":"Rhea","id":"RHEA-COMP:10748"},{"database":"ChEBI","id":"CHEBI:83833"},{"database":"ChEBI","id":"CHEBI:83834"}],"ecNumber":"5.2.1.8","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21497122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23623683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29686383"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QUR7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11470801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15664191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16644721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17828269"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18628984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19367327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21497122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22033920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22608923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23623683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26942675"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29686383"}],"value":"Interacts with STIL (By similarity). Interacts with KIF20B (PubMed:11470801). Interacts with NEK6 (PubMed:16476580). Interacts (via WW domain) with PRKX (PubMed:19367327). Interacts with BTK (PubMed:16644721). Interacts (via PpiC domain) with DAPK1 (PubMed:21497122). Interacts with the phosphorylated form of RAF1 (PubMed:15664191). Interacts (via WW domain) with ATCAY; upon NGF stimulation (PubMed:18628984). Interacts with PML (isoform PML-4) (PubMed:22033920). Interacts with BCL6 (PubMed:17828269). Interacts with FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation (PubMed:22608923). Directly interacts with RBBP8/CtIP; this interaction depends upon RBBP8 phosphorylation (PubMed:23623683). Interacts (via WW domain) with IRAK3/IRAK-M (when phosphorylated at 'Ser-110') in response to IL33-mediated (but not TLR4 ligand LPS) dendritic cell stimulation (PubMed:29686383). Interacts with PGK1 (when phosphorylated at 'Ser-203'); the interaction is direct, occurs under hypoxic conditions, and targets PGK1 to the mitochondrion by promoting interactions with the TOM complex (PubMed:26942675). Interacts with PRDM16 (when phosphorylated); the interaction promotes PRDM16 degradation (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q9NYB9","geneName":"ABI2","intActId":"EBI-743598"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q9NYB9-2","geneName":"ABI2","intActId":"EBI-11096309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q13085","geneName":"ACACA","intActId":"EBI-717681"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P78563","geneName":"ADARB1","intActId":"EBI-2967304"},"numberOfExperiments":12,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q96IF1","geneName":"AJUBA","intActId":"EBI-949782"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"A2BDD9","geneName":"AMOT","intActId":"EBI-17286414"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q4VCS5-2","geneName":"AMOT","intActId":"EBI-3891843"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q6AI12","geneName":"ANKRD40","intActId":"EBI-2838246"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P05067-4","geneName":"APP","intActId":"EBI-302641"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P85298-4","geneName":"ARHGAP8","intActId":"EBI-9523517"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"O94989","geneName":"ARHGEF15","intActId":"EBI-740691"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q03989","geneName":"ARID5A","intActId":"EBI-948603"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q86V38","geneName":"ATN1","intActId":"EBI-11954292"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q99728-1","geneName":"BARD1","intActId":"EBI-21498323"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q9H165-2","geneName":"BCL11A","intActId":"EBI-10183342"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P38398-1","geneName":"BRCA1","intActId":"EBI-21498346"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q9H0E9-2","geneName":"BRD8","intActId":"EBI-10304361"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q3SXR2","geneName":"C3orf36","intActId":"EBI-18036948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"P35520","geneName":"CBS","intActId":"EBI-740135"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q8NA61","geneName":"CBY2","intActId":"EBI-741724"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13526","intActId":"EBI-714158"},"interactantTwo":{"uniProtKBAccession":"Q8NA61-2","geneName":"CBY2","intActId":"EBI-115248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