{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q86TG7","secondaryAccessions":["B4DSP0","Q96A68","Q9UPV1"],"uniProtkbId":"PEG10_HUMAN","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":182,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Retrotransposon-derived protein PEG10"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"}],"value":"Embryonal carcinoma differentiation-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"}],"value":"Mammalian retrotransposon-derived protein 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"value":"Myelin expression factor 3-like protein 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"value":"MEF3-like protein 1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11318613"}],"value":"Paternally expressed gene 10 protein"}},{"fullName":{"value":"Retrotransposon gag domain-containing protein 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15611116"}],"value":"Retrotransposon-derived gag-like polyprotein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"}],"value":"Ty3/Gypsy-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11318613"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:14005"}],"value":"PEG10"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"}],"value":"EDR"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10231032"}],"value":"KIAA1051e"},{"value":"MAR2"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"}],"value":"MART2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"value":"MEF3L1"},{"value":"RGAG3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15611116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16423995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26235627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30094509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidence is however required to confirm this result (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7TN75"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15611116"}],"value":"Homooligomer; homooligomerizes into virion-like capsids (By similarity). Interacts with ACVRL1 (PubMed:15611116). Interacts with SIAH1 and SIAH2 (PubMed:12810624)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"Q13137","geneName":"CALCOCO2","intActId":"EBI-739580"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"O95751","geneName":"LDOC1","intActId":"EBI-740738"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"Q17RB0","geneName":"RTL8B","intActId":"EBI-10238588"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"A6ZKI3","geneName":"RTL8C","intActId":"EBI-10174072"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"Q8IUQ4","geneName":"SIAH1","intActId":"EBI-747107"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7","intActId":"EBI-2858265"},"interactantTwo":{"uniProtKBAccession":"Q9H0E2","geneName":"TOLLIP","intActId":"EBI-74615"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"Q9NQT4","geneName":"EXOSC5","intActId":"EBI-371876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"O95751","geneName":"LDOC1","intActId":"EBI-740738"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"Q96QF0-7","geneName":"RAB3IP","intActId":"EBI-11984839"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"Q9BWD3","geneName":"RTL8A","intActId":"EBI-741643"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"Q17RB0","geneName":"RTL8B","intActId":"EBI-10238588"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TG7-2","intActId":"EBI-6259410"},"interactantTwo":{"uniProtKBAccession":"A6ZKI3","geneName":"RTL8C","intActId":"EBI-10174072"},"numberOfExperiments":10,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"Forms virion-like extracellular vesicles that are released from cells (PubMed:34413232). Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line (PubMed:12810624)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"Extracellular vesicle membrane","id":"SL-0500"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15611116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16423995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17621626"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative initiation","Ribosomal frameshifting"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17942406"}],"value":"RF1/RF2"}],"isoformIds":["Q86TG7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17942406"}],"value":"RF1"}],"isoformIds":["Q86TG7-2"],"sequenceIds":["VSP_032007","VSP_032008"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q86TG7-3"],"sequenceIds":["VSP_061361","VSP_032007","VSP_032008"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q86TG7-4"],"sequenceIds":["VSP_061362"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q86TG7-5"],"sequenceIds":["VSP_061362","VSP_032007","VSP_032008"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11318613"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12810624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15611116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16423995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17621626"}],"value":"Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12620933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17942406"}],"value":"Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16423995"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17050006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18625225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20362226"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26235627"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28992046"}],"value":"Expression is directly regulated by E2F1 and E2F4, which bind to its promoter and direct its expression (PubMed:17050006, PubMed:18625225, PubMed:28193232, PubMed:28992046). Up-regulated by MYC (PubMed:16423995). Strongly overepressed in a number of tumors, such has hepatocellular carcinoma (HCC), pancreatic or neuroendocrine prostate cancers (PubMed:20362226, PubMed:26235627, PubMed:28193232)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34357660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"The protein is evolutionarily related to retrotransposon Gag proteins: it contains the capsid (CA) and nucleocapsid (NC) subdomains of gag"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"In addition to the capsid (CA) and nucleocapsid (NC) subdomains of gag proteins, this isoform contains subdomains of pol, namely a protease (PRO) domain and a predicted reverse transcriptase (RT)-like domain"}],"commentType":"DOMAIN","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17942406"}],"value":"Undergoes proteolytic cleavage"}],"commentType":"PTM","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34413232"}],"value":"Can be reprogrammed to form virion-like capsids that deliver engineered cargo mRNAs bearing RNA signals from PEG10 5'- and 3'-UTR into target cells"}],"commentType":"BIOTECHNOLOGY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11318613"}],"value":"The PEG10 locus is imprinted, giving rise to paternally expressed proteins"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17942406"}],"value":"Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-319 and Lys-320 (PubMed:17942406). The ribosomal frameshifting efficiency yield up to 66% of isoform 1 compared to isoform 2 (PubMed:17942406)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17942406"}],"value":"Produced by conventional translation"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084274"}],"value":"Produced by alternative initiation (PubMed:20084274). Translation initiates from a non-AUG codon (CUG codon) (PubMed:20084274)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084274"}],"value":"Produced by alternative initiation and ribosomal frameshifting (PubMed:20084274). Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-395 and Lys-396 (PubMed:20084274). Translation initiates from a non-AUG codon (CUG codon) (PubMed:20084274)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Produced by alternative initiation (Probable). Translation initiates from a non-AUG codon (CUG codon) (Probable)"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17369855"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21677654"}],"value":"Was reported to be activated by androgen receptor agonist dihydrotestosterone (DHT) in hepatic cancer cells (HCC), resulting in HCC growth and apoptotic resistance. However, this study was later retracted"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous translation","sequence":"BAA83003.2","note":"Wrong choice of frame.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44104/PEG10","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/245/","ftp":false,"note":"I'll borrow that, thank you - Issue 245 of March 2022"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Retrotransposon-derived protein PEG10","featureId":"PRO_0000323026"},{"type":"Zinc 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