{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P43034","secondaryAccessions":["B2R7Q7","Q8WZ88","Q8WZ89"],"uniProtkbId":"LIS1_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":237,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000305"}],"value":"Platelet-activating factor acetylhydrolase IB subunit beta"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lissencephaly-1 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF acetylhydrolase 45 kDa subunit"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH 45 kDa subunit"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAFAH alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:8574"}],"value":"PAFAH1B1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS1"},{"value":"MDCR"},{"value":"MDS"},{"value":"PAFAHA"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P43033"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15173193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22956769"}],"value":"Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P43033"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11001923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11163258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11889140"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12556484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14962739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14970193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22159412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23097494"}],"value":"Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with IQGAP1, KATNB1 and NUDC. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling (By similarity). Can self-associate. Interacts with DCX, dynein, dynactin, NDE1, NDEL1 and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with INTS13. Interacts with DCDC1 (PubMed:22159412)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5","geneName":"DISC1","intActId":"EBI-529989"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"P07900","geneName":"HSP90AA1","intActId":"EBI-296047"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q9GZM8","geneName":"NDEL1","intActId":"EBI-928842"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q8WVJ2","geneName":"NUDCD2","intActId":"EBI-1052153"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q8IVD9","geneName":"NUDCD3","intActId":"EBI-744342"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"P68402","geneName":"PAFAH1B2","intActId":"EBI-713724"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q15102","geneName":"PAFAH1B3","intActId":"EBI-711522"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P43034","intActId":"EBI-720620"},"interactantTwo":{"uniProtKBAccession":"Q9CZA6","geneName":"Nde1","intActId":"EBI-309934"},"numberOfExperiments":6,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane"}]},"subcellularLocations":[{"location":{"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14654843"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P43034-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P43034-2"],"sequenceIds":["VSP_019376","VSP_019377","VSP_019378","VSP_019379"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Fairly ubiquitous expression in both the frontal and occipital areas of the brain"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Dimerization mediated by the LisH domain may be required to activate dynein"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Lissencephaly 1","diseaseAccession":"DI-00670","acronym":"LIS1","description":"A classical lissencephaly. It is characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles and often hypoplasia of the corpus callosum.","diseaseCrossReference":{"database":"MIM","id":"607432"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11163258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11502906"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15007136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15173193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9063735"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Subcortical band heterotopia","diseaseAccession":"DI-01094","acronym":"SBH","description":"SBH is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.","diseaseCrossReference":{"database":"MIM","id":"607432"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10441340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14581661"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Miller-Dieker lissencephaly syndrome","diseaseAccession":"DI-00769","acronym":"MDLS","description":"A contiguous gene deletion syndrome of chromosome 17p13.3, characterized by classical lissencephaly and distinct facial features. Additional congenital malformations can be part of the condition.","diseaseCrossReference":{"database":"MIM","id":"247200"}},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P68402"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15102"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q29460"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity) (Ref.4). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Belongs to the WD repeat LIS1/nudF family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAA02882.1","note":"Chimeric cDNA.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Platelet-activating factor acetylhydrolase IB subunit beta","featureId":"PRO_0000051061"},{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"LisH","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Repeat","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"WD 1"},{"type":"Repeat","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD 2"},{"type":"Repeat","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"WD 3"},{"type":"Repeat","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"WD 4"},{"type":"Repeat","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"WD 5"},{"type":"Repeat","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"WD 6"},{"type":"Repeat","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"WD 7"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Interaction with NDE1","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Interaction with dynein and dynactin"},{"type":"Region","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Interaction with DCX","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11001923"}]},{"type":"Region","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Coiled coil","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Modified residue","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_019376","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_019377","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_019378","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Alternative sequence","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_019379","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"in LIS1; dbSNP:rs121434486","featureCrossReferences":[{"database":"dbSNP","id":"rs121434486"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11502906"}],"featureId":"VAR_015398","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in LIS1; abrogates interaction with NDE1 and reduces neuronal migration in vitro; dbSNP:rs121434482","featureCrossReferences":[{"database":"dbSNP","id":"rs121434482"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11163258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15173193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9063735"}],"featureId":"VAR_007724","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in LIS1; dbSNP:rs121434487","featureCrossReferences":[{"database":"dbSNP","id":"rs121434487"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11502906"}],"featureId":"VAR_015399","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in SBH; abrogates interaction with NDE1 and reduces neuronal migration in vitro; dbSNP:rs121434484","featureCrossReferences":[{"database":"dbSNP","id":"rs121434484"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10441340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11163258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15173193"}],"featureId":"VAR_010203","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in SBH; somatic mosaicism in 18% of lymphocytes and 21% of hair root cells; dbSNP:rs121434488","featureCrossReferences":[{"database":"dbSNP","id":"rs121434488"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14581661"}],"featureId":"VAR_037300","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in LIS1; dbSNP:rs121434490","featureCrossReferences":[{"database":"dbSNP","id":"rs121434490"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15007136"}],"featureId":"VAR_037301","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"in LIS1; reduces neuronal migration in vitro; dbSNP:rs121434485","featureCrossReferences":[{"database":"dbSNP","id":"rs121434485"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11502906"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15173193"}],"featureId":"VAR_015400","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"in Ref. 3; AAL34972/AAL34973","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"in Ref. 3; AAL34973","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"in Ref. 3; AAL34973","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Turn","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E0Z"}]},{"type":"Beta strand","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FDT"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Helix","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Helix","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E0Z"}]},{"type":"Beta strand","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E11"}]},{"type":"Beta strand","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DZY"}]},{"type":"Beta strand","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Turn","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DZY"}]},{"type":"Beta strand","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Helix","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]},{"type":"Beta strand","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MT1"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0451","category":"Disease","name":"Lissencephaly"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"8355785","citationType":"journal article","authors":["Reiner O.","Carrozzo R.","Shen Y.","Wehnert M.","Faustinella F.","Dobyns W.B.","Caskey C.T.","Ledbetter D.H."],"citationCrossReferences":[{"database":"PubMed","id":"8355785"},{"database":"DOI","id":"10.1038/364717a0"}],"title":"Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.","publicationDate":"1993","journal":"Nature","firstPage":"717","lastPage":"721","volume":"364"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9063735","citationType":"journal article","authors":["Lo Nigro C.","Chong S.S.","Smith A.C.M.","Dobyns W.B.","Carrozzo R.","Ledbetter D.H."],"citationCrossReferences":[{"database":"PubMed","id":"9063735"},{"database":"DOI","id":"10.1093/hmg/6.2.157"}],"title":"Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome.","publicationDate":"1997","journal":"Hum. Mol. Genet.","firstPage":"157","lastPage":"164","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT LIS1 ARG-149"]},{"referenceNumber":3,"citation":{"id":"CI-C90C3GQD77U79","citationType":"submission","authors":["Zhao M.J.","Xia S.L.","Li T.P."],"title":"High expression of the lissencephaly gene in hepatocarcinoma patients.","publicationDate":"NOV-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-FRME3P6JM2P7I","citationType":"submission","authors":["Feng Z.","Zhang B.","Peng X.","Yuan J.","Qiang B."],"publicationDate":"JUL-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"11001923","citationType":"journal article","authors":["Caspi M.","Atlas R.","Kantor A.","Sapir T.","Reiner O."],"citationCrossReferences":[{"database":"PubMed","id":"11001923"},{"database":"DOI","id":"10.1093/oxfordjournals.hmg.a018911"}],"title":"Interaction between LIS1 and doublecortin, two lissencephaly gene products.","publicationDate":"2000","journal":"Hum. Mol. Genet.","firstPage":"2205","lastPage":"2213","volume":"9"},"referencePositions":["INTERACTION WITH DCX"]},{"referenceNumber":10,"citation":{"id":"11163258","citationType":"journal article","authors":["Feng Y.","Olson E.C.","Stukenberg P.T.","Flanagan L.A.","Kirschner M.W.","Walsh C.A."],"citationCrossReferences":[{"database":"PubMed","id":"11163258"},{"database":"DOI","id":"10.1016/s0896-6273(00)00145-8"}],"title":"LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.","publicationDate":"2000","journal":"Neuron","firstPage":"665","lastPage":"679","volume":"28"},"referencePositions":["INTERACTION WITH NDE1","CHARACTERIZATION OF VARIANTS LIS1 ARG-149 AND SBH PRO-169"]},{"referenceNumber":11,"citation":{"id":"11889140","citationType":"journal article","authors":["Tai C.-Y.","Dujardin D.L.","Faulkner N.E.","Vallee R.B."],"citationCrossReferences":[{"database":"PubMed","id":"11889140"},{"database":"DOI","id":"10.1083/jcb.200109046"}],"title":"Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.","publicationDate":"2002","journal":"J. Cell Biol.","firstPage":"959","lastPage":"968","volume":"156"},"referencePositions":["SELF-ASSOCIATION","INTERACTION WITH RSN; DYNEIN AND DYNACTIN","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"11940666","citationType":"journal article","authors":["Coquelle F.M.","Caspi M.","Cordelieres F.P.","Dompierre J.P.","Dujardin D.L.","Koifman C.","Martin P.","Hoogenraad C.C.","Akhmanova A.","Galjart N.","De Mey J.R.","Reiner O."],"citationCrossReferences":[{"database":"PubMed","id":"11940666"},{"database":"DOI","id":"10.1128/mcb.22.9.3089-3102.2002"}],"title":"LIS1, CLIP-170's key to the dynein/dynactin pathway.","publicationDate":"2002","journal":"Mol. Cell. Biol.","firstPage":"3089","lastPage":"3102","volume":"22"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"12556484","citationType":"journal article","authors":["Yan X.","Li F.","Liang Y.","Shen Y.","Zhao X.","Huang Q.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"12556484"},{"database":"DOI","id":"10.1128/mcb.23.4.1239-1250.2003"}],"title":"Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"1239","lastPage":"1250","volume":"23"},"referencePositions":["INTERACTION WITH NDEL1"]},{"referenceNumber":14,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"14970193","citationType":"journal article","authors":["Liang Y.","Yu W.","Li Y.","Yang Z.","Yan X.","Huang Q.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"14970193"},{"database":"DOI","id":"10.1083/jcb.200308058"}],"title":"Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.","publicationDate":"2004","journal":"J. Cell Biol.","firstPage":"557","lastPage":"566","volume":"164"},"referencePositions":["INTERACTION WITH NDEL1"]},{"referenceNumber":16,"citation":{"id":"15173193","citationType":"journal article","authors":["Tanaka T.","Serneo F.F.","Higgins C.","Gambello M.J.","Wynshaw-Boris A.","Gleeson J.G."],"citationCrossReferences":[{"database":"PubMed","id":"15173193"},{"database":"DOI","id":"10.1083/jcb.200309025"}],"title":"Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.","publicationDate":"2004","journal":"J. Cell Biol.","firstPage":"709","lastPage":"721","volume":"165"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","CHARACTERIZATION OF VARIANTS LIS1 ARG-149; SBH PRO-169 AND LIS1 HIS-317"]},{"referenceNumber":17,"citation":{"id":"14962739","citationType":"journal article","authors":["Brandon N.J.","Handford E.J.","Schurov I.","Rain J.-C.","Pelling M.","Duran-Jimeniz B.","Camargo L.M.","Oliver K.R.","Beher D.","Shearman M.S.","Whiting P.J."],"citationCrossReferences":[{"database":"PubMed","id":"14962739"},{"database":"DOI","id":"10.1016/j.mcn.2003.09.009"}],"title":"Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.","publicationDate":"2004","journal":"Mol. Cell. Neurosci.","firstPage":"42","lastPage":"55","volume":"25"},"referencePositions":["INTERACTION WITH DISC1"]},{"referenceNumber":18,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"22159412","citationType":"journal article","authors":["Kaplan A.","Reiner O."],"citationCrossReferences":[{"database":"PubMed","id":"22159412"},{"database":"DOI","id":"10.1242/jcs.085407"}],"title":"Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.","publicationDate":"2011","journal":"J. Cell Sci.","firstPage":"3989","lastPage":"4000","volume":"124"},"referencePositions":["INTERACTION WITH DCDC1"]},{"referenceNumber":21,"citation":{"id":"22956769","citationType":"journal article","authors":["Splinter D.","Razafsky D.S.","Schlager M.A.","Serra-Marques A.","Grigoriev I.","Demmers J.","Keijzer N.","Jiang K.","Poser I.","Hyman A.A.","Hoogenraad C.C.","King S.J.","Akhmanova A."],"citationCrossReferences":[{"database":"PubMed","id":"22956769"},{"database":"DOI","id":"10.1091/mbc.e12-03-0210"}],"title":"BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.","publicationDate":"2012","journal":"Mol. Biol. Cell","firstPage":"4226","lastPage":"4241","volume":"23"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"23097494","citationType":"journal article","authors":["Jodoin J.N.","Shboul M.","Sitaram P.","Zein-Sabatto H.","Reversade B.","Lee E.","Lee L.A."],"citationCrossReferences":[{"database":"PubMed","id":"23097494"},{"database":"DOI","id":"10.1091/mbc.e12-07-0558"}],"title":"Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry.","publicationDate":"2012","journal":"Mol. Biol. Cell","firstPage":"4713","lastPage":"4724","volume":"23"},"referencePositions":["INTERACTION WITH INTS13"]},{"referenceNumber":23,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"10441340","citationType":"journal article","authors":["Pilz D.T.","Kuc J.","Matsumoto N.","Bodurtha J.","Bernadi B.","Tassinari C.A.","Dobyns W.B.","Ledbetter D.H."],"citationCrossReferences":[{"database":"PubMed","id":"10441340"},{"database":"DOI","id":"10.1093/hmg/8.9.1757"}],"title":"Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1.","publicationDate":"1999","journal":"Hum. Mol. Genet.","firstPage":"1757","lastPage":"1760","volume":"8"},"referencePositions":["VARIANT SBH PRO-169"]},{"referenceNumber":25,"citation":{"id":"11502906","citationType":"journal article","authors":["Leventer R.J.","Cardoso C.","Ledbetter D.H.","Dobyns W.B."],"citationCrossReferences":[{"database":"PubMed","id":"11502906"},{"database":"DOI","id":"10.1212/wnl.57.3.416"}],"title":"LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ.","publicationDate":"2001","journal":"Neurology","firstPage":"416","lastPage":"422","volume":"57"},"referencePositions":["VARIANTS LIS1 SER-31; SER-162 AND HIS-317"]},{"referenceNumber":26,"citation":{"id":"14581661","citationType":"journal article","authors":["Sicca F.","Kelemen A.","Genton P.","Das S.","Mei D.","Moro F.","Dobyns W.B.","Guerrini R."],"citationCrossReferences":[{"database":"PubMed","id":"14581661"},{"database":"DOI","id":"10.1212/wnl.61.8.1042"}],"title":"Mosaic mutations of the LIS1 gene cause subcortical band heterotopia.","publicationDate":"2003","journal":"Neurology","firstPage":"1042","lastPage":"1046","volume":"61"},"referencePositions":["VARIANT SBH PRO-241"]},{"referenceNumber":27,"citation":{"id":"15007136","citationType":"journal article","authors":["Torres F.R.","Montenegro M.A.","Marques-de-Faria A.P.","Guerreiro M.M.","Cendes F.","Lopes-Cendes I."],"citationCrossReferences":[{"database":"PubMed","id":"15007136"},{"database":"DOI","id":"10.1212/01.wnl.0000113725.46254.fd"}],"title":"Mutation screening in a cohort of patients with lissencephaly and subcortical band heterotopia.","publicationDate":"2004","journal":"Neurology","firstPage":"799","lastPage":"802","volume":"62"},"referencePositions":["VARIANT LIS1 PRO-277"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L13385","properties":[{"key":"ProteinId","value":"AAA02880.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L13386","properties":[{"key":"ProteinId","value":"AAA02881.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L13387","properties":[{"key":"ProteinId","value":"AAA02882.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U72342","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72334","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72335","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72336","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72337","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72338","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72339","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72340","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U72341","properties":[{"key":"ProteinId","value":"AAC51111.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF208837","properties":[{"key":"ProteinId","value":"AAL34972.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF208838","properties":[{"key":"ProteinId","value":"AAL34973.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF400434","properties":[{"key":"ProteinId","value":"AAK92483.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313078","properties":[{"key":"ProteinId","value":"BAG35904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX538346","properties":[{"key":"ProteinId","value":"CAD98141.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471108","properties":[{"key":"ProteinId","value":"EAW90536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC064638","properties":[{"key":"ProteinId","value":"AAH64638.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32528.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P43034-1"},{"database":"PIR","id":"S36113","properties":[{"key":"EntryName","value":"S36113"}]},{"database":"RefSeq","id":"NP_000421.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000430.4"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_016880190.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017024701.2"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_047292118.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436162.1"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_047292119.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436163.1"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_054172276.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316301.1"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_054172277.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316302.1"}],"isoformId":"P43034-1"},{"database":"RefSeq","id":"XP_054172278.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316303.1"}],"isoformId":"P43034-1"},{"database":"PDB","id":"7MT1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=86-410"}]},{"database":"PDB","id":"8DYU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"B/C=2-410"}]},{"database":"PDB","id":"8DYV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.97 A"},{"key":"Chains","value":"B=2-410"}]},{"database":"PDB","id":"8FDT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"B/C=2-410"}]},{"database":"PDB","id":"8FDU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"B/C=2-410"}]},{"database":"PDB","id":"8PQW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"B/C/D/E=1-410"}]},{"database":"PDB","id":"8PQY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.80 A"},{"key":"Chains","value":"B/C=1-410"}]},{"database":"PDB","id":"8PQZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.50 A"},{"key":"Chains","value":"B/C/D/E/K/L=1-410"}]},{"database":"PDB","id":"8PTK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"10.00 A"},{"key":"Chains","value":"1/2/3/4=1-410"}]},{"database":"PDB","id":"9DZY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"C/E=2-410"}]},{"database":"PDB","id":"9E0T","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"B/C=2-410"}]},{"database":"PDB","id":"9E0W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"C=2-410"}]},{"database":"PDB","id":"9E0Z","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.86 A"},{"key":"Chains","value":"C/D=1-410"}]},{"database":"PDB","id":"9E11","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.86 A"},{"key":"Chains","value":"C/D=1-410"}]},{"database":"PDB","id":"9E13","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"O/P=1-410"}]},{"database":"PDB","id":"9E14","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.00 A"},{"key":"Chains","value":"O/P=1-410"}]},{"database":"PDB","id":"9E22","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E=2-410"}]},{"database":"PDB","id":"9YNC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.93 A"},{"key":"Chains","value":"C/D/E/F=1-410"}]},{"database":"PDB","id":"9YND","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.26 A"},{"key":"Chains","value":"B/C/D/E=1-410"}]},{"database":"PDB","id":"9YNE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.46 A"},{"key":"Chains","value":"B/C=1-410"}]},{"database":"PDB","id":"9YNH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.50 A"},{"key":"Chains","value":"O/P=1-410"}]},{"database":"PDBsum","id":"7MT1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DYU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8DYV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FDT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FDU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PQW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PQY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PQZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8PTK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DZY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E0T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E0W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E0Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E11","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E13","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E14","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E22","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YNC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YND","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YNE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9YNH","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17826","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17828","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17829","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-17873","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27782","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27783","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29012","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29014","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47342","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47370","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47372","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47378","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47380","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47382","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47383","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47429","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73173","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73174","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73175","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73179","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111085","properties":[{"key":"Interactions","value":"269"}]},{"database":"ComplexPortal","id":"CPX-10326","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase IB complex, alpha1-alpha1 variant"}]},{"database":"ComplexPortal","id":"CPX-10328","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase IB complex, alpha2-alpha2 variant"}]},{"database":"ComplexPortal","id":"CPX-10329","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase IB complex, alpha1-alpha2 variant"}]},{"database":"DIP","id":"DIP-35691N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P43034","properties":[{"key":"Number of interactors","value":"2269"}]},{"database":"IntAct","id":"P43034","properties":[{"key":"Interactions","value":"71"}]},{"database":"MINT","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-PAFAH1B1","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000380378","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P43034","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PAFAH1B1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1170794","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-103","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-104","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000380378","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55575","properties":[{"key":"Description","value":"-"}],"isoformId":"P43034-1"},{"database":"ProteomicsDB","id":"55576","properties":[{"key":"Description","value":"-"}],"isoformId":"P43034-2"},{"database":"Pumba","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P43034","properties":[{"key":"antibodies","value":"5 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3850","properties":[{"key":"antibodies","value":"313 antibodies from 42 providers"}]},{"database":"DNASU","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000397195.10","properties":[{"key":"ProteinId","value":"ENSP00000380378.4"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000576586.6","properties":[{"key":"ProteinId","value":"ENSP00000461087.2"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000675202.1","properties":[{"key":"ProteinId","value":"ENSP00000502843.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000675331.1","properties":[{"key":"ProteinId","value":"ENSP00000502031.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000675390.1","properties":[{"key":"ProteinId","value":"ENSP00000501969.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000676098.1","properties":[{"key":"ProteinId","value":"ENSP00000502735.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000676188.1","properties":[{"key":"ProteinId","value":"ENSP00000502577.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000713986.1","properties":[{"key":"ProteinId","value":"ENSP00000519277.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000713987.1","properties":[{"key":"ProteinId","value":"ENSP00000519278.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863847.1","properties":[{"key":"ProteinId","value":"ENSP00000533906.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863848.1","properties":[{"key":"ProteinId","value":"ENSP00000533907.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863849.1","properties":[{"key":"ProteinId","value":"ENSP00000533908.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863850.1","properties":[{"key":"ProteinId","value":"ENSP00000533909.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863851.1","properties":[{"key":"ProteinId","value":"ENSP00000533910.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863853.1","properties":[{"key":"ProteinId","value":"ENSP00000533912.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000863854.1","properties":[{"key":"ProteinId","value":"ENSP00000533913.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000934916.1","properties":[{"key":"ProteinId","value":"ENSP00000604975.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000934917.1","properties":[{"key":"ProteinId","value":"ENSP00000604976.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000934918.1","properties":[{"key":"ProteinId","value":"ENSP00000604977.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000934919.1","properties":[{"key":"ProteinId","value":"ENSP00000604978.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"Ensembl","id":"ENST00000971580.1","properties":[{"key":"ProteinId","value":"ENSP00000641639.1"},{"key":"GeneId","value":"ENSG00000007168.16"}],"isoformId":"P43034-1"},{"database":"GeneID","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5048","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000397195.10","properties":[{"key":"ProteinId","value":"ENSP00000380378.4"},{"key":"RefSeqNucleotideId","value":"NM_000430.4"},{"key":"RefSeqProteinId","value":"NP_000421.1"}]},{"database":"UCSC","id":"uc002fuw.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P43034-1"},{"database":"AGR","id":"HGNC:8574","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA32905","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PAFAH1B1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"PAFAH1B1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"HPA","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"PAFAH1B1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"247200","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"601545","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"607432","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"217385","properties":[{"key":"Disease","value":"17p13.3 microduplication syndrome"}]},{"database":"Orphanet","id":"95232","properties":[{"key":"Disease","value":"Lissencephaly due to LIS1 mutation"}]},{"database":"Orphanet","id":"531","properties":[{"key":"Disease","value":"Miller-Dieker syndrome"}]},{"database":"Orphanet","id":"99796","properties":[{"key":"Disease","value":"Subcortical band heterotopia"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0295","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WHVATKE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P43034","properties":[{"key":"Number of GO annotations","value":"15 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-141444","properties":[{"key":"PathwayName","value":"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"}]},{"database":"Reactome","id":"R-HSA-2467813","properties":[{"key":"PathwayName","value":"Separation of Sister Chromatids"}]},{"database":"Reactome","id":"R-HSA-2500257","properties":[{"key":"PathwayName","value":"Resolution of Sister Chromatid Cohesion"}]},{"database":"Reactome","id":"R-HSA-2565942","properties":[{"key":"PathwayName","value":"Regulation of PLK1 Activity at G2/M Transition"}]},{"database":"Reactome","id":"R-HSA-380259","properties":[{"key":"PathwayName","value":"Loss of Nlp from mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-380270","properties":[{"key":"PathwayName","value":"Recruitment of mitotic centrosome proteins and complexes"}]},{"database":"Reactome","id":"R-HSA-380284","properties":[{"key":"PathwayName","value":"Loss of proteins required for interphase microtubule organization from the centrosome"}]},{"database":"Reactome","id":"R-HSA-380320","properties":[{"key":"PathwayName","value":"Recruitment of NuMA to mitotic centrosomes"}]},{"database":"Reactome","id":"R-HSA-5620912","properties":[{"key":"PathwayName","value":"Anchoring of the basal body to the plasma membrane"}]},{"database":"Reactome","id":"R-HSA-5663220","properties":[{"key":"PathwayName","value":"RHO GTPases Activate Formins"}]},{"database":"Reactome","id":"R-HSA-6811436","properties":[{"key":"PathwayName","value":"COPI-independent Golgi-to-ER retrograde traffic"}]},{"database":"Reactome","id":"R-HSA-68877","properties":[{"key":"PathwayName","value":"Mitotic Prometaphase"}]},{"database":"Reactome","id":"R-HSA-8854518","properties":[{"key":"PathwayName","value":"AURKA Activation by TPX2"}]},{"database":"Reactome","id":"R-HSA-9648025","properties":[{"key":"PathwayName","value":"EML4 and NUDC in mitotic spindle formation"}]},{"database":"SignaLink","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P43034","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000007168","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5048","properties":[{"key":"hits","value":"790 hits in 1166 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"ChiTaRS","id":"PAFAH1B1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"PAFAH1B1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P43034","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P43034","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P43034","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P43034","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0008247","properties":[{"key":"GoTerm","value":"C:1-alkyl-2-acetylglycerophosphocholine esterase complex"},{"key":"GoEvidenceType","value":"EXP:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15572112"}]},{"database":"GO","id":"GO:0000235","properties":[{"key":"GoTerm","value":"C:astral microtubule"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11940666"}]},{"database":"GO","id":"GO:1904115","properties":[{"key":"GoTerm","value":"C:axon cytoplasm"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0005938","properties":[{"key":"GoTerm","value":"C:cell cortex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11940666"}]},{"database":"GO","id":"GO:0031252","properties":[{"key":"GoTerm","value":"C:cell leading edge"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090724","properties":[{"key":"GoTerm","value":"C:central region of growth cone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21399614"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"8028668"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005871","properties":[{"key":"GoTerm","value":"C:kinesin complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000776","properties":[{"key":"GoTerm","value":"C:kinetochore"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11056532"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11889140"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11940666"}]},{"database":"GO","id":"GO:0005875","properties":[{"key":"GoTerm","value":"C:microtubule associated complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11889140"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031514","properties":[{"key":"GoTerm","value":"C:motile cilium"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11940666"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0098685","properties":[{"key":"GoTerm","value":"C:Schaffer collateral - CA1 synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032420","properties":[{"key":"GoTerm","value":"C:stereocilium"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0034452","properties":[{"key":"GoTerm","value":"F:dynactin binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"11056532"}]},{"database":"GO","id":"GO:0070840","properties":[{"key":"GoTerm","value":"F:dynein complex binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11889140"}]},{"database":"GO","id":"GO:0045505","properties":[{"key":"GoTerm","value":"F:dynein intermediate chain binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"8028668"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0043274","properties":[{"key":"GoTerm","value":"F:phospholipase binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"8028668"}]},{"database":"GO","id":"GO:0051219","properties":[{"key":"GoTerm","value":"F:phosphoprotein binding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001675","properties":[{"key":"GoTerm","value":"P:acrosome assembly"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0030036","properties":[{"key":"GoTerm","value":"P:actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0008344","properties":[{"key":"GoTerm","value":"P:adult locomotory behavior"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9063735"}]},{"database":"GO","id":"GO:0060117","properties":[{"key":"GoTerm","value":"P:auditory receptor cell development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048854","properties":[{"key":"GoTerm","value":"P:brain morphogenesis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9063735"}]},{"database":"GO","id":"GO:0021987","properties":[{"key":"GoTerm","value":"P:cerebral cortex development"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9063735"}]},{"database":"GO","id":"GO:0021895","properties":[{"key":"GoTerm","value":"P:cerebral cortex neuron differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0090102","properties":[{"key":"GoTerm","value":"P:cochlea development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021540","properties":[{"key":"GoTerm","value":"P:corpus callosum morphogenesis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9063735"}]},{"database":"GO","id":"GO:0043622","properties":[{"key":"GoTerm","value":"P:cortical microtubule organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051660","properties":[{"key":"GoTerm","value":"P:establishment of centrosome localization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000132","properties":[{"key":"GoTerm","value":"P:establishment of mitotic spindle orientation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11056532"}]},{"database":"GO","id":"GO:0042249","properties":[{"key":"GoTerm","value":"P:establishment of planar polarity of embryonic epithelium"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0021766","properties":[{"key":"GoTerm","value":"P:hippocampus development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0021819","properties":[{"key":"GoTerm","value":"P:layer formation in cerebral cortex"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0007611","properties":[{"key":"GoTerm","value":"P:learning or memory"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0000226","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0090176","properties":[{"key":"GoTerm","value":"P:microtubule cytoskeleton organization involved in establishment of planar polarity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031023","properties":[{"key":"GoTerm","value":"P:microtubule organizing center organization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11163258"}]},{"database":"GO","id":"GO:0051012","properties":[{"key":"GoTerm","value":"P:microtubule sliding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007017","properties":[{"key":"GoTerm","value":"P:microtubule-based process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11940666"}]},{"database":"GO","id":"GO:0050804","properties":[{"key":"GoTerm","value":"P:modulation of chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010977","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron projection development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007405","properties":[{"key":"GoTerm","value":"P:neuroblast proliferation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0050885","properties":[{"key":"GoTerm","value":"P:neuromuscular process controlling balance"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"9063735"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11163258"}]},{"database":"GO","id":"GO:0007097","properties":[{"key":"GoTerm","value":"P:nuclear migration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0062234","properties":[{"key":"GoTerm","value":"P:platelet activating factor catabolic process"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15572112"}]},{"database":"GO","id":"GO:0046469","properties":[{"key":"GoTerm","value":"P:platelet activating factor metabolic process"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"8028668"}]},{"database":"GO","id":"GO:0045773","properties":[{"key":"GoTerm","value":"P:positive regulation of axon extension"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0061003","properties":[{"key":"GoTerm","value":"P:positive regulation of dendritic spine morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0040019","properties":[{"key":"GoTerm","value":"P:positive regulation of embryonic development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045931","properties":[{"key":"GoTerm","value":"P:positive regulation of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0038026","properties":[{"key":"GoTerm","value":"P:reelin-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070507","properties":[{"key":"GoTerm","value":"P:regulation of microtubule cytoskeleton organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008090","properties":[{"key":"GoTerm","value":"P:retrograde axonal transport"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0017145","properties":[{"key":"GoTerm","value":"P:stem cell division"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019226","properties":[{"key":"GoTerm","value":"P:transmission of nerve impulse"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"GO","id":"GO:0047496","properties":[{"key":"GoTerm","value":"P:vesicle transport along microtubule"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"10729324"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP03953","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.130.10.10:FF:000038","properties":[{"key":"EntryName","value":"Lissencephaly-1 homolog B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03141","properties":[{"key":"EntryName","value":"lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"7"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR","length":410,"molWeight":46638,"crc64":"3AB68D2641BA31C9","md5":"5C0EA3FCA7C3AB6ACDE8A7559448AEBC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":8,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"DISEASE":3,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Repeat":7,"Region":6,"Coiled coil":1,"Modified residue":2,"Alternative sequence":4,"Natural variant":7,"Sequence conflict":3,"Turn":7,"Beta strand":31,"Helix":4},"uniParcId":"UPI0000163BF4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PFU3","uniProtkbId":"A0A6Q8PFU3_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":27,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Platelet-activating factor acetylhydrolase IB subunit alpha"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lissencephaly-1 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF acetylhydrolase 45 kDa subunit"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH 45 kDa subunit"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAFAH alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"}],"value":"PAFAH1B1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Dimerization mediated by the LisH domain may be required to activate dynein"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Belongs to the WD repeat LIS1/nudF family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Interaction with NDE1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Interaction with dynein and dynactin","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022782"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022963"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A6Q8PFU3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A6Q8PFU3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501976.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_011522203.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011523901.3"}]},{"database":"RefSeq","id":"XP_011522204.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011523902.4"}]},{"database":"RefSeq","id":"XP_011522205.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011523903.3"}]},{"database":"RefSeq","id":"XP_054172273.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316298.1"}]},{"database":"RefSeq","id":"XP_054172274.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316299.1"}]},{"database":"RefSeq","id":"XP_054172275.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316300.1"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PFU3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6Q8PFU3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A6Q8PFU3","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000674608.1","properties":[{"key":"ProteinId","value":"ENSP00000501976.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"Ensembl","id":"ENST00000863852.1","properties":[{"key":"ProteinId","value":"ENSP00000533911.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"GeneID","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"OpenTargets","id":"ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A6Q8PFU3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005875","properties":[{"key":"GoTerm","value":"C:microtubule associated complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005819","properties":[{"key":"GoTerm","value":"C:spindle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070840","properties":[{"key":"GoTerm","value":"F:dynein complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000132","properties":[{"key":"GoTerm","value":"P:establishment of mitotic spindle orientation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030900","properties":[{"key":"GoTerm","value":"P:forebrain development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051012","properties":[{"key":"GoTerm","value":"P:microtubule sliding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000038","properties":[{"key":"EntryName","value":"Lissencephaly-1 homolog B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03141","properties":[{"key":"EntryName","value":"lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"7"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"6"}]}],"sequence":{"value":"MVLSQRQRDELDWFQRGEDSILNKADEARNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR","length":428,"molWeight":48770,"crc64":"C8A6B58279FD70C3","md5":"1B55F12E0E5C5AD0505B677D6067639D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Repeat":7,"Region":5},"uniParcId":"UPI0005D018C0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I3L3N5","uniProtkbId":"I3L3N5_HUMAN","entryAudit":{"firstPublicDate":"2012-07-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":74,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Platelet-activating factor acetylhydrolase IB subunit alpha"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lissencephaly-1 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF acetylhydrolase 45 kDa subunit"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH 45 kDa subunit"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAFAH alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"}],"value":"PAFAH1B1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Dimerization mediated by the LisH domain may be required to activate dynein"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Belongs to the WD repeat LIS1/nudF family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Interaction with NDE1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"Interaction with dynein and dynactin","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"I3L3N5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"I3L3N5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000460591.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I3L3N5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"I3L3N5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"I3L3N5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"47277","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3850","properties":[{"key":"antibodies","value":"313 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000574468.2","properties":[{"key":"ProteinId","value":"ENSP00000460591.2"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"UCSC","id":"uc059znz.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000288_57_15_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PAFAH1B1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"I3L3N5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005875","properties":[{"key":"GoTerm","value":"C:microtubule associated complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005819","properties":[{"key":"GoTerm","value":"C:spindle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070840","properties":[{"key":"GoTerm","value":"F:dynein complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000132","properties":[{"key":"GoTerm","value":"P:establishment of mitotic spindle orientation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051012","properties":[{"key":"GoTerm","value":"P:microtubule sliding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03141","properties":[{"key":"EntryName","value":"lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR22847:SF637","properties":[{"key":"EntryName","value":"WD REPEAT DOMAIN 5B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22847","properties":[{"key":"EntryName","value":"WD40 REPEAT PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"6"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSEVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR","length":376,"molWeight":42941,"crc64":"91FFC75E8C9C0F31","md5":"E9A9AC9053F67D109E9448189FAE9E40"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Domain":1,"Repeat":6,"Region":5},"uniParcId":"UPI0032C8E77A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BH67","uniProtkbId":"A0AAQ5BH67_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Platelet-activating factor acetylhydrolase IB subunit alpha"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lissencephaly-1 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF acetylhydrolase 45 kDa subunit"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH 45 kDa subunit"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAFAH alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"}],"value":"PAFAH1B1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Dimerization mediated by the LisH domain may be required to activate dynein"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Belongs to the WD repeat LIS1/nudF family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Interaction with NDE1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Interaction with dynein and dynactin","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BH67"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BH67"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519274.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BH67","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BH67","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000713983.1","properties":[{"key":"ProteinId","value":"ENSP00000519274.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005875","properties":[{"key":"GoTerm","value":"C:microtubule associated complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005819","properties":[{"key":"GoTerm","value":"C:spindle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070840","properties":[{"key":"GoTerm","value":"F:dynein complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000132","properties":[{"key":"GoTerm","value":"P:establishment of mitotic spindle orientation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051012","properties":[{"key":"GoTerm","value":"P:microtubule sliding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_03141","properties":[{"key":"EntryName","value":"lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR19848:SF8","properties":[{"key":"EntryName","value":"F-BOX AND WD REPEAT DOMAIN CONTAINING 7"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19848","properties":[{"key":"EntryName","value":"WD40 REPEAT PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWTKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR","length":346,"molWeight":39548,"crc64":"4A94AA7575B89453","md5":"56347C7CE6E1D3000941E37D7F3ECDC5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Domain":1,"Repeat":6,"Region":5},"uniParcId":"UPI0032CADFE3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BGM1","uniProtkbId":"A0AAQ5BGM1_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Platelet-activating factor acetylhydrolase IB subunit alpha"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Lissencephaly-1 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF acetylhydrolase 45 kDa subunit"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH 45 kDa subunit"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAF-AH alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"PAFAH alpha"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"},{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"}],"value":"PAFAH1B1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"LIS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Nucleus membrane","id":"SL-0182"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Dimerization mediated by the LisH domain may be required to activate dynein"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"value":"Belongs to the WD repeat LIS1/nudF family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Interaction with NDE1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Required for self-association and interaction with PAFAH1B2 and PAFAH1B3","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Interaction with dynein and dynactin","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]},{"type":"Region","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Interaction with NDEL1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022782"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022963"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0442","category":"Biological process","name":"Lipid degradation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BGM1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BGM1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03141"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518970.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BGM1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BGM1","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000713668.1","properties":[{"key":"ProteinId","value":"ENSP00000518970.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005875","properties":[{"key":"GoTerm","value":"C:microtubule associated complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005819","properties":[{"key":"GoTerm","value":"C:spindle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0070840","properties":[{"key":"GoTerm","value":"F:dynein complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000132","properties":[{"key":"GoTerm","value":"P:establishment of mitotic spindle orientation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030900","properties":[{"key":"GoTerm","value":"P:forebrain development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051012","properties":[{"key":"GoTerm","value":"P:microtubule sliding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000038","properties":[{"key":"EntryName","value":"Lissencephaly-1 homolog B"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03141","properties":[{"key":"EntryName","value":"lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLGMYASRGL","length":394,"molWeight":44726,"crc64":"12F7EA823068B38E","md5":"5F928B74B62D05A5ECEA4730F43E993C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Domain":1,"Repeat":6,"Region":5},"uniParcId":"UPI0032CBF20C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PFT2","secondaryAccessions":["I3L384"],"uniProtkbId":"A0A6Q8PFT2_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"}],"value":"PAFAH1B1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Repeat","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A6Q8PFT2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A6Q8PFT2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000501931.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_047292120.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436164.1"}]},{"database":"RefSeq","id":"XP_054172279.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316304.1"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PFT2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6Q8PFT2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"47154","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000570400.2","properties":[{"key":"ProteinId","value":"ENSP00000460258.2"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"Ensembl","id":"ENST00000674717.1","properties":[{"key":"ProteinId","value":"ENSP00000501931.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"Ensembl","id":"ENST00000676353.1","properties":[{"key":"ProteinId","value":"ENSP00000502737.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"Ensembl","id":"ENST00000713690.1","properties":[{"key":"ProteinId","value":"ENSP00000518994.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"Ensembl","id":"ENST00000713984.1","properties":[{"key":"ProteinId","value":"ENSP00000519275.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"GeneID","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc059znt.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5048","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"OpenTargets","id":"ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3435029_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WHVATKE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PAFAH1B1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000038","properties":[{"key":"EntryName","value":"Lissencephaly-1 homolog B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"7"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"6"}]}],"sequence":{"value":"MELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR","length":345,"molWeight":38948,"crc64":"1475D801C6D1DEC7","md5":"BBD5D510FF5F19CB83E14FAA4B368CD4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Repeat":7,"Region":1,"Compositional bias":2},"uniParcId":"UPI00002005FE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PH33","uniProtkbId":"A0A6Q8PH33_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":25,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"}],"value":"PAFAH1B1"}}],"features":[{"type":"Repeat","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A6Q8PH33"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A6Q8PH33"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502507.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PH33","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6Q8PH33","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A6Q8PH33","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000676077.1","properties":[{"key":"ProteinId","value":"ENSP00000502507.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A6Q8PH33","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHATV","length":127,"molWeight":14361,"crc64":"016B87F535B42468","md5":"C45716A2AADD1E429874323CD7133729"},"extraAttributes":{"countByFeatureType":{"Repeat":2,"Region":1,"Compositional bias":2},"uniParcId":"UPI0016383F34"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I3L495","uniProtkbId":"I3L495_HUMAN","entryAudit":{"firstPublicDate":"2012-07-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-07-11","entryVersion":79,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"}],"value":"PAFAH1B1"}}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"I3L495"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"I3L495"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM17LGCT7E5","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUN-2024","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461087.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I3L495","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"I3L495","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"I3L495","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"I3L495","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"47443","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3850","properties":[{"key":"antibodies","value":"313 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000576586.6","properties":[{"key":"ProteinId","value":"ENSP00000461087.2"},{"key":"GeneId","value":"ENSG00000007168.15"}]},{"database":"UCSC","id":"uc059znr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"OpenTargets","id":"ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000007168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2352054_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WHVATKE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"PAFAH1B1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"I3L495","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSG","length":82,"molWeight":9632,"crc64":"DBEBE65663AC9A19","md5":"9D4381A9908B4573EECC6CD649151BAB"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI00025A2CCE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BGP0","uniProtkbId":"A0AAQ5BGP0_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"}],"value":"PAFAH1B1"}}],"features":[{"type":"Repeat","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BGP0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BGP0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518992.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BGP0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BGP0","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000713688.1","properties":[{"key":"ProteinId","value":"ENSP00000518992.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR02045","properties":[{"key":"EntryName","value":"F138DOMAIN"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHVETGFHHVGQAGLELLTS","length":142,"molWeight":15967,"crc64":"8B9429FB2260662D","md5":"E28C5673685DBCF602857E37A5DC71E4"},"extraAttributes":{"countByFeatureType":{"Repeat":2,"Region":1,"Compositional bias":2},"uniParcId":"UPI0032C5B516"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BGP7","uniProtkbId":"A0AAQ5BGP7_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"}],"value":"PAFAH1B1"}}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BGP7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BGP7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000518993.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BGP7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BGP7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000713689.1","properties":[{"key":"ProteinId","value":"ENSP00000518993.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR02045","properties":[{"key":"EntryName","value":"F138DOMAIN"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHETGFHHVGQAGLELLTS","length":206,"molWeight":23558,"crc64":"B705AE909F6BAE31","md5":"A5C7FAFF0866C93EFFCD49E46A2D90F4"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Repeat":2},"uniParcId":"UPI0032D18F16"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PG63","uniProtkbId":"A0A6Q8PG63_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":26,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"}],"value":"PAFAH1B1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"PAC1-like LisH-like dimerisation","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24951"}]},{"type":"Repeat","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022618"}],"id":"KW-0132","category":"Biological process","name":"Cell division"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022776"}],"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A6Q8PG63"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A6Q8PG63"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502117.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PG63","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6Q8PG63","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A6Q8PG63","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000675621.1","properties":[{"key":"ProteinId","value":"ENSP00000502117.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A6Q8PG63","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"CDD","id":"cd00200","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.960.30:FF:000002","properties":[{"key":"EntryName","value":"Platelet-activating factor acetylhydrolase ib"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.960.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017252","properties":[{"key":"EntryName","value":"Dynein_regulator_LIS1"}]},{"database":"InterPro","id":"IPR037190","properties":[{"key":"EntryName","value":"LIS1_N"}]},{"database":"InterPro","id":"IPR006594","properties":[{"key":"EntryName","value":"LisH"}]},{"database":"InterPro","id":"IPR056795","properties":[{"key":"EntryName","value":"PAC1-like_LisH-like_dom"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR020472","properties":[{"key":"EntryName","value":"WD40_PAC1"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050349","properties":[{"key":"EntryName","value":"WD_LIS1/nudF_dynein_reg"}]},{"database":"PANTHER","id":"PTHR44129","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN POP1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24951","properties":[{"key":"EntryName","value":"LisH_PAC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"5"}]},{"database":"PIRSF","id":"PIRSF037647","properties":[{"key":"EntryName","value":"Dynein_regulator_Lis1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00320","properties":[{"key":"EntryName","value":"GPROTEINBRPT"}]},{"database":"SMART","id":"SM00667","properties":[{"key":"EntryName","value":"LisH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF109925","properties":[{"key":"EntryName","value":"Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50896","properties":[{"key":"EntryName","value":"LISH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLDMTDICGSIFKN","length":346,"molWeight":39201,"crc64":"A43C9DDE3FED9668","md5":"1D1ABC7BA604982CC4EA681FAD51AEF1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Repeat":5},"uniParcId":"UPI001635EAB7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6Q8PGF8","uniProtkbId":"A0A6Q8PGF8_HUMAN","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-12-02","entryVersion":23,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"}],"value":"Platelet activating factor acetylhydrolase 1b regulatory subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"}],"value":"PAFAH1B1"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502242.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005696","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015799","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A6Q8PGF8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A6Q8PGF8","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000675764.1","properties":[{"key":"ProteinId","value":"ENSP00000502242.1"},{"key":"GeneId","value":"ENSG00000007168.16"}]},{"database":"HGNC","id":"HGNC:8574","properties":[{"key":"GeneName","value":"PAFAH1B1"}]},{"database":"GeneTree","id":"ENSGT00940000155039","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"674604at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSG00000007168","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 212 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A6Q8PGF8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"PANTHER","id":"PTHR12138:SF162","properties":[{"key":"EntryName","value":"CHROMOSOME UNDETERMINED SCAFFOLD_275, WHOLE GENOME SHOTGUN SEQUENCE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12138","properties":[{"key":"EntryName","value":"PRIMATE-EXPANDED PROTEIN FAMILY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLSQRQRDELLEYSGAISAYCNLHLLGSRDSPASASQVAGITEIEL","length":47,"molWeight":5094,"crc64":"71779C97C379A8E1","md5":"D720C8DD6299337FB98A368EB7A9ACAA"},"extraAttributes":{"uniParcId":"UPI0016326C90"}}]}