{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y2J8","secondaryAccessions":["Q96DA7","Q9UPN2"],"uniProtkbId":"PADI2_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-05-30","entryVersion":187,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein-arginine deiminase type-2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044909"}],"value":"3.5.3.15"}]},"alternativeNames":[{"fullName":{"value":"PAD-H19"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12392711"}],"value":"Peptidylarginine deiminase II"}},{"fullName":{"value":"Protein-arginine deiminase type II"}}]},"genes":[{"geneName":{"value":"PADI2"},"synonyms":[{"value":"KIAA0994"},{"value":"PAD2"},{"value":"PDI2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044909"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30044909"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"value":"Binding of Ca(2+) triggers a conformation change that is essential for catalytic activity."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9Y2J8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9Y2J8-2"],"sequenceIds":["VSP_056385"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12392711"}],"value":"Detected in keratinocytes in epidermis (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA76838.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Protein-arginine deiminase type-2","featureId":"PRO_0000220026"},{"type":"Active site","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}]},{"type":"Binding site","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2K"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2K"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2K"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2D"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2F"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2K"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2M"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1"}},{"type":"Binding site","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"4"}},{"type":"Binding site","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2"}},{"type":"Binding site","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N26"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2G"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2L"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"3"}},{"type":"Binding site","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Binding site","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N28"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2C"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2I"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"5"}},{"type":"Alternative sequence","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_056385","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Mildly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Mildly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Mildly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Loss of enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Strongly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Loss of enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Strongly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Strongly reduced enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"Loss of enzyme activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25621824"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"in Ref. 1; BAA82557","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["L"]}},{"type":"Beta strand","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":6,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOL"}]},{"type":"Beta strand","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2B"}]},{"type":"Beta strand","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N20"}]},{"type":"Beta strand","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B97"}]},{"type":"Beta strand","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Turn","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B98"}]},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B96"}]},{"type":"Helix","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B96"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2M"}]},{"type":"Beta strand","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B97"}]},{"type":"Beta strand","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Turn","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B96"}]},{"type":"Beta strand","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2C"}]},{"type":"Helix","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2N"}]},{"type":"Beta strand","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2N"}]},{"type":"Helix","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2M"}]},{"type":"Beta strand","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOL"}]},{"type":"Beta strand","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2B"}]},{"type":"Helix","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":416,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Turn","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2B"}]},{"type":"Helix","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Turn","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9B97"}]},{"type":"Beta strand","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":592,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9DOL"}]},{"type":"Helix","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":628,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Beta strand","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]},{"type":"Helix","location":{"start":{"value":660,"modifier":"EXACT"},"end":{"value":662,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4N2K"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12392711","citationType":"journal article","authors":["Ishigami A.","Ohsawa T.","Asaga H.","Akiyama K.","Kuramoto M.","Maruyama N."],"citationCrossReferences":[{"database":"PubMed","id":"12392711"},{"database":"DOI","id":"10.1016/s0003-9861(02)00516-7"}],"title":"Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin.","publicationDate":"2002","journal":"Arch. Biochem. Biophys.","firstPage":"25","lastPage":"31","volume":"407"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","CATALYTIC ACTIVITY","SUBCELLULAR LOCATION","COFACTOR","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15087120","citationType":"journal article","authors":["Chavanas S.","Mechin M.-C.","Takahara H.","Kawada A.","Nachat R.","Serre G.","Simon M."],"citationCrossReferences":[{"database":"PubMed","id":"15087120"},{"database":"DOI","id":"10.1016/j.gene.2003.12.038"}],"title":"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.","publicationDate":"2004","journal":"Gene","firstPage":"19","lastPage":"27","volume":"330"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"10231032","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Suyama M.","Kikuno R.","Hirosawa M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10231032"},{"database":"DOI","id":"10.1093/dnares/6.1.63"}],"title":"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1999","journal":"DNA Res.","firstPage":"63","lastPage":"70","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Pancreas","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"30044909","citationType":"journal article","authors":["Nemmara V.V.","Tilvawala R.","Salinger A.J.","Miller L.","Nguyen S.H.","Weerapana E.","Thompson P.R."],"citationCrossReferences":[{"database":"PubMed","id":"30044909"},{"database":"DOI","id":"10.1021/acschembio.8b00578"}],"title":"Citrullination Inactivates Nicotinamide- N-methyltransferase.","publicationDate":"2018","journal":"ACS Chem. Biol.","firstPage":"2663","lastPage":"2672","volume":"13"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":7,"citation":{"id":"25621824","citationType":"journal article","authors":["Slade D.J.","Fang P.","Dreyton C.J.","Zhang Y.","Fuhrmann J.","Rempel D.","Bax B.D.","Coonrod S.A.","Lewis H.D.","Guo M.","Gross M.L.","Thompson P.R."],"citationCrossReferences":[{"database":"PubMed","id":"25621824"},{"database":"DOI","id":"10.1021/cb500933j"}],"title":"Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.","publicationDate":"2015","journal":"ACS Chem. Biol.","firstPage":"1043","lastPage":"1053","volume":"10"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) IN COMPLEX WITH CALCIUM","FUNCTION","CATALYTIC ACTIVITY","SUBUNIT","COFACTOR","ACTIVE SITE","MUTAGENESIS OF ASP-123; ASP-125; ASP-166; ASP-169; ASP-177; TRP-348; GLN-350; GLU-354; ASP-370; ARG-373; ASP-374; ASP-389; GLU-412 AND CYS-647"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N20"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N22"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N24"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N25"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4N2N"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB030176","properties":[{"key":"ProteinId","value":"BAA82557.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ549502","properties":[{"key":"ProteinId","value":"CAE47740.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB023211","properties":[{"key":"ProteinId","value":"BAA76838.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC009701","properties":[{"key":"ProteinId","value":"AAH09701.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS177.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2J8-1"},{"database":"RefSeq","id":"NP_031391.2","properties":[{"key":"NucleotideSequenceId","value":"NM_007365.3"}],"isoformId":"Q9Y2J8-1"},{"database":"PDB","id":"4N20","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.66 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N22","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N24","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.97 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N25","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.93 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N26","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.94 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N28","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.69 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.02 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"4N2N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"9B96","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"9B97","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"9B98","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"9DOL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.77 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDB","id":"9OVQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.17 A"},{"key":"Chains","value":"A=1-665"}]},{"database":"PDBsum","id":"4N20","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N22","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N24","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N25","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N28","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4N2N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B96","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9B98","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DOL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9OVQ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116404","properties":[{"key":"Interactions","value":"7"}]},{"database":"FunCoup","id":"Q9Y2J8","properties":[{"key":"Number of interactors","value":"82"}]},{"database":"IntAct","id":"Q9Y2J8","properties":[{"key":"Interactions","value":"5"}]},{"database":"STRING","id":"9606.ENSP00000364635","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1909487","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB00155","properties":[{"key":"GenericName","value":"Citrulline"}]},{"database":"iPTMnet","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PADI2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"7531171","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000364635","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76266","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"85817","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2J8-1"},{"database":"Antibodypedia","id":"29317","properties":[{"key":"antibodies","value":"279 antibodies from 30 providers"}]},{"database":"DNASU","id":"11240","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000375481.1","properties":[{"key":"ProteinId","value":"ENSP00000364630.1"},{"key":"GeneId","value":"ENSG00000117115.14"}],"isoformId":"Q9Y2J8-2"},{"database":"Ensembl","id":"ENST00000375486.9","properties":[{"key":"ProteinId","value":"ENSP00000364635.4"},{"key":"GeneId","value":"ENSG00000117115.14"}],"isoformId":"Q9Y2J8-1"},{"database":"Ensembl","id":"ENST00000707396.1","properties":[{"key":"ProteinId","value":"ENSP00000516860.1"},{"key":"GeneId","value":"ENSG00000291387.1"}],"isoformId":"Q9Y2J8-1"},{"database":"Ensembl","id":"ENST00000707399.1","properties":[{"key":"ProteinId","value":"ENSP00000516861.1"},{"key":"GeneId","value":"ENSG00000291387.1"}],"isoformId":"Q9Y2J8-2"},{"database":"GeneID","id":"11240","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:11240","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000375486.9","properties":[{"key":"ProteinId","value":"ENSP00000364635.4"},{"key":"RefSeqNucleotideId","value":"NM_007365.3"},{"key":"RefSeqProteinId","value":"NP_031391.2"}]},{"database":"UCSC","id":"uc001baf.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9Y2J8-1"},{"database":"AGR","id":"HGNC:18341","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA32900","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11240","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"11240","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PADI2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"HPA","id":"ENSG00000117115","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, skeletal muscle, tongue)"}]},{"database":"MIM","id":"607935","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVJA","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_021911_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NHYFQRC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5102063at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9Y2J8","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS04094-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.5.3.15","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"BRENDA","id":"3.5.3.6","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-3247509","properties":[{"key":"PathwayName","value":"Chromatin modifying enzymes"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"SignaLink","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000117115","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"11240","properties":[{"key":"hits","value":"11 hits in 1155 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"PADI2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"PADI2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"11240","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9Y2J8","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q9Y2J8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9Y2J8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000117115","properties":[{"key":"ExpressionPatterns","value":"Expressed in medial globus pallidus and 181 other cell types or tissues"}]},{"database":"GO","id":"GO:0035578","properties":[{"key":"GoTerm","value":"C:azurophil granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12392711"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0000791","properties":[{"key":"GoTerm","value":"C:euchromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22853951"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0140794","properties":[{"key":"GoTerm","value":"F:histone arginine deiminase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0140798","properties":[{"key":"GoTerm","value":"F:histone H3R26 arginine deiminase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22853951"}]},{"database":"GO","id":"GO:0030331","properties":[{"key":"GoTerm","value":"F:nuclear estrogen receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22853951"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25621824"}]},{"database":"GO","id":"GO:0004668","properties":[{"key":"GoTerm","value":"F:protein-arginine deiminase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12392711"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15629448"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18645041"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25621824"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030520","properties":[{"key":"GoTerm","value":"P:estrogen receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22853951"}]},{"database":"GO","id":"GO:0070100","properties":[{"key":"GoTerm","value":"P:negative regulation of chemokine-mediated signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18645041"}]},{"database":"GO","id":"GO:1901624","properties":[{"key":"GoTerm","value":"P:negative regulation of lymphocyte chemotaxis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18645041"}]},{"database":"GO","id":"GO:0021762","properties":[{"key":"GoTerm","value":"P:substantia nigra development"},{"key":"GoEvidenceType","value":"HEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007007","source":"PubMed","id":"22926577"}]},{"database":"GO","id":"GO:0045815","properties":[{"key":"GoTerm","value":"P:transcription initiation-coupled chromatin remodeling"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22853951"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1700:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1700","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, central domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001247","properties":[{"key":"EntryName","value":"Protein-arginine_deiminase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":665,"molWeight":75564,"crc64":"8D417A87A02D6839","md5":"23FCF218C7C7B39B8EE42F21FBDF41D1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Active site":1,"Binding site":22,"Alternative sequence":1,"Mutagenesis":14,"Sequence conflict":1,"Beta strand":48,"Helix":29,"Turn":4},"uniParcId":"UPI00001314AF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R660","uniProtkbId":"A0ACI8R660_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Protein-arginine deiminase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"3.5.3.15"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001913"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":684,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R660"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R660"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578775.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000908716.1","properties":[{"key":"ProteinId","value":"ENSP00000578775.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1700:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1700","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, central domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001247","properties":[{"key":"EntryName","value":"Protein-arginine_deiminase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVETLQGIKKFLLELHRVLPPCLYQYPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":687,"molWeight":78205,"crc64":"78225391AB51F9E8","md5":"65DD98D6FBC30DBEE7D4D6E248CEA537"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI000511EDD0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UGG9","uniProtkbId":"A0ACI8UGG9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Protein-arginine deiminase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"3.5.3.15"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001913"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001247"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UGG9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UGG9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000615900.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000945841.1","properties":[{"key":"ProteinId","value":"ENSP00000615900.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1700:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1700","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, central domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001247","properties":[{"key":"EntryName","value":"Protein-arginine_deiminase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQVRAPGLHHRGLTPGARDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":681,"molWeight":77241,"crc64":"D9EF79A233A7140F","md5":"B309CDC205FF7BA4AC1927C7D90BF574"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI004031F5E1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R639","uniProtkbId":"A0ACI8R639_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"}],"value":"Peptidyl arginine deiminase 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R639"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R639"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578778.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000908719.1","properties":[{"key":"ProteinId","value":"ENSP00000578778.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001247","properties":[{"key":"EntryName","value":"Protein-arginine_deiminase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":628,"molWeight":71392,"crc64":"2D5FB11E1FAB5C1D","md5":"00960D10308D3214DA55C15670535B59"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI004032537F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T516","uniProtkbId":"A0ACI8T516_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"}],"value":"Peptidyl arginine deiminase 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T516"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T516"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000592968.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000922909.1","properties":[{"key":"ProteinId","value":"ENSP00000592968.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIDPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":563,"molWeight":63988,"crc64":"CBAED64A3708904A","md5":"B25E1442E1A2BAED545167E996816533"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI004031F4E9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RR56","uniProtkbId":"A0ACI8RR56_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"}],"value":"Peptidyl arginine deiminase 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RR56"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RR56"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578776.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000908717.1","properties":[{"key":"ProteinId","value":"ENSP00000578776.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKTRSSANAISTSWAGGSSTMWSSTRVAPRSCCSSWKASVSPTRASQAWSPSMSACWSTWPSMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":549,"molWeight":61892,"crc64":"6DB2D92632A13EB0","md5":"22A323060DD74C3D12CC4B0B0256FBB2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00017A725B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SH11","uniProtkbId":"A0ACI8SH11_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"}],"value":"Peptidyl arginine deiminase 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"}],"value":"PADI2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SH11"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SH11"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578777.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000908718.1","properties":[{"key":"ProteinId","value":"ENSP00000578777.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1700","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, central domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYRDLPGCGRRPGWCGGEEQPKEDPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":498,"molWeight":57033,"crc64":"ACC111D25889CD31","md5":"D1F598E4243EAAAA6D5D944D21F6B186"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI004032514B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RV47","uniProtkbId":"A0ACI8RV47_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"}],"value":"Peptidyl arginine deiminase 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"}],"value":"PADI2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057234"}],"value":"Catalyzes the deimination of arginine residues of proteins"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18089"},{"database":"Rhea","id":"RHEA-COMP:10532"},{"database":"Rhea","id":"RHEA-COMP:10588"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29965"},{"database":"ChEBI","id":"CHEBI:83397"}],"ecNumber":"3.5.3.15","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048487"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008166"}],"value":"Belongs to the protein arginine deiminase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08526"}]},{"type":"Domain","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Protein-arginine deiminase (PAD) central","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08527"}]},{"type":"Domain","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"Protein-arginine deiminase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03068"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RV47"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RV47"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000578774.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL049569","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000908715.1","properties":[{"key":"ProteinId","value":"ENSP00000578774.1"},{"key":"GeneId","value":"ENSG00000117115.14"}]},{"database":"HGNC","id":"HGNC:18341","properties":[{"key":"GeneName","value":"PADI2"}]},{"database":"OpenTargets","id":"ENSG00000117115","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000153217","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd04214","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1860:FF:000001","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.75.10.10:FF:000003","properties":[{"key":"EntryName","value":"Protein-arginine deiminase type-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.75.10.10","properties":[{"key":"EntryName","value":"L-arginine/glycine Amidinotransferase, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1700","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, central domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.40.1860","properties":[{"key":"EntryName","value":"Protein-arginine deiminase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR004303","properties":[{"key":"EntryName","value":"PAD"}]},{"database":"InterPro","id":"IPR013530","properties":[{"key":"EntryName","value":"PAD_C"}]},{"database":"InterPro","id":"IPR036556","properties":[{"key":"EntryName","value":"PAD_central_sf"}]},{"database":"InterPro","id":"IPR013732","properties":[{"key":"EntryName","value":"PAD_N"}]},{"database":"InterPro","id":"IPR038685","properties":[{"key":"EntryName","value":"PAD_N_sf"}]},{"database":"InterPro","id":"IPR013733","properties":[{"key":"EntryName","value":"Prot_Arg_deaminase_cen_dom"}]},{"database":"PANTHER","id":"PTHR10837","properties":[{"key":"EntryName","value":"PEPTIDYLARGININE DEIMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10837:SF12","properties":[{"key":"EntryName","value":"PROTEIN-ARGININE DEIMINASE TYPE-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03068","properties":[{"key":"EntryName","value":"PAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08527","properties":[{"key":"EntryName","value":"PAD_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08526","properties":[{"key":"EntryName","value":"PAD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001247","properties":[{"key":"EntryName","value":"Protein-arginine_deiminase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55909","properties":[{"key":"EntryName","value":"Pentein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110083","properties":[{"key":"EntryName","value":"Peptidylarginine deiminase Pad4, middle domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEEVATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISLDVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDPFFGQRYIHILGRRKLYHVVKYTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVNGKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVPIPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQENLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP","length":623,"molWeight":70801,"crc64":"0C31A5B0D8D46550","md5":"FE75EE38EA9597193E902806E16B98DE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3},"uniParcId":"UPI00403250DD"}}]}