{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P30559","secondaryAccessions":["Q15071"],"uniProtkbId":"OXYR_HUMAN","entryAudit":{"firstPublicDate":"1993-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-03","entryVersion":205,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1313946"}],"value":"Oxytocin receptor"},"shortNames":[{"value":"OT-R"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20647384"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:8529"}],"value":"OXTR"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P97926"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19934046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20647384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21896752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22069312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22123970"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24367110"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"6278592"}],"value":"G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:11923477, PubMed:22069312, PubMed:32832646, PubMed:35104164, PubMed:35241813, PubMed:35851571). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (PubMed:22069312, PubMed:35241813, PubMed:35851571). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:19934046, PubMed:20647384, PubMed:21896752, PubMed:22123970, PubMed:24367110). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (PubMed:6278592). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70536"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"}],"value":"Directly inhibited by progesterone, which prevents oxytocin-binding (By similarity). Cholesterol and magnesium act as allosteric activators (PubMed:32832646, PubMed:35241813)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16179383"}],"value":"Interacts (when phosphorylated following prolonged stimulation by oxytocin) with ARRB1 and/or ARRB2, leading to receptor desensitization"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16179383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22069312"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11279203"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14976224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16179383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19423652"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"}],"value":"Phosphorylation at Ser-261 by PRKD1 promotes association with G(q) G protein and downstream signaling, enhancing long-term social memory (PubMed:35104164). Phosphorylated by GRK2, GRK3 and/or GRK6 following prolonged stimulation by oxytocin, promoting association with beta-arrestin (ARRB1 or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling (PubMed:11279203, PubMed:14976224, PubMed:16179383, PubMed:19423652)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19934046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20647384"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21896752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22123970"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24367110"}],"value":"Variations in OXTR are associated with social perception and behavior (PubMed:19934046, PubMed:20647384, PubMed:21896752, PubMed:22123970, PubMed:24367110). A common polymorphism (rs53576) within intron 3 of the OXTR gene has been shown to affect social behavior: compared to carriers of the G allele (GG), carriers of the A allele (AA or AG) often exhibit reduced trust, lower self-esteem and increased susceptibility to depression and behavioral problems under stress (PubMed:19934046, PubMed:20647384, PubMed:21896752, PubMed:22123970). Another polymorphism within intron 3 (rs237887) is associated with social memory: individuals with the A allele (considered as the ancestral allele) are associated with impaired face recognition memory, reduced emotional empathy and lower prosociality (PubMed:24367110)"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Oxytocin receptor","featureId":"PRO_0000069998"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Transmembrane","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Topological domain","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Region","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16113"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"}],"ligand":{"name":"cholesterol","id":"ChEBI:CHEBI:16113"}},{"type":"Modified residue","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Phosphoserine; by PKD/PRKD1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"}]},{"type":"Modified residue","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70536"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70536"}]},{"type":"Glycosylation","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]},{"type":"Natural variant","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"in dbSNP:rs237906","featureCrossReferences":[{"database":"dbSNP","id":"rs237906"}],"featureId":"VAR_031570","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in dbSNP:rs4686302","featureCrossReferences":[{"database":"dbSNP","id":"rs4686302"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1313946"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"}],"featureId":"VAR_031571","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"prevents phosphorylation by PRKD1, leading to decreased G(q)-dependent signaling; dbSNP:rs200362197","featureCrossReferences":[{"database":"dbSNP","id":"rs200362197"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"}],"featureId":"VAR_091521","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Decreased activation by magnesium.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Decreased activation by magnesium.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Activated both in presence of absence of magnesium.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35241813"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A","N"]}},{"type":"Mutagenesis","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Decreased aallosteric activation by cholesterol.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Decreased activation by cholesterol.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Abolished phosphorylation by PRKD1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Mimics phosphorylation; increased G(q)-dependent signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35104164"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Does not impair G(q)-dependent signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923477"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Abolished G(q)-dependent signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11923477"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Decreased activation by oxytocin.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35851571"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"in Ref. 4; CAA56562","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Helix","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Beta strand","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPK"}]},{"type":"Helix","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Turn","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Beta strand","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Beta strand","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Turn","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Turn","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Beta strand","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7RYC"}]},{"type":"Helix","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6TPK"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1313946","citationType":"journal article","authors":["Kimura T.","Tanizawa O.","Mori K.","Brownstein M.J.","Okayama H."],"citationCrossReferences":[{"database":"PubMed","id":"1313946"},{"database":"DOI","id":"10.1038/356526a0"}],"title":"Structure and expression of a human oxytocin receptor.","publicationDate":"1992","journal":"Nature","firstPage":"526","lastPage":"529","volume":"356"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANT THR-218"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-5E6E8E5QGCD53","citationType":"journal article","authors":["Kimura T.","Tanizawa O.","Mori K.","Brownstein M.J.","Okayama H."],"publicationDate":"1992","journal":"Nature","firstPage":"176","lastPage":"176","volume":"357"},"referencePositions":["ERRATUM OF PUBMED:1313946","SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"CI-13OQKFGN0COQA","citationType":"submission","authors":["Kopatz S.A.","Aronstam R.S.","Sharma S.V."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"SEP-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT THR-218"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"7798245","citationType":"journal article","authors":["Inoue T.","Kimura T.","Azuma C.","Inazawa J.","Takemura M.","Kikuchi T.","Kubota Y.","Ogita K.","Saji F."],"citationCrossReferences":[{"database":"PubMed","id":"7798245"},{"database":"DOI","id":"10.1016/s0021-9258(18)31656-9"}],"title":"Structural organization of the human oxytocin receptor gene.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"32451","lastPage":"32456","volume":"269"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308"]},{"referenceNumber":5,"citation":{"id":"6278592","citationType":"journal article","authors":["Fuchs A.R.","Fuchs F.","Husslein P.","Soloff M.S.","Fernstroem M.J."],"citationCrossReferences":[{"database":"PubMed","id":"6278592"},{"database":"DOI","id":"10.1126/science.6278592"}],"title":"Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor.","publicationDate":"1982","journal":"Science","firstPage":"1396","lastPage":"1398","volume":"215"},"referencePositions":["FUNCTION"]},{"referenceNumber":6,"citation":{"id":"11279203","citationType":"journal article","authors":["Oakley R.H.","Laporte S.A.","Holt J.A.","Barak L.S.","Caron M.G."],"citationCrossReferences":[{"database":"PubMed","id":"11279203"},{"database":"DOI","id":"10.1074/jbc.m101450200"}],"title":"Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"19452","lastPage":"19460","volume":"276"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":7,"citation":{"id":"11923477","citationType":"journal article","authors":["Yang M.","Wang W.","Zhong M.","Philippi A.","Lichtarge O.","Sanborn B.M."],"citationCrossReferences":[{"database":"PubMed","id":"11923477"},{"database":"DOI","id":"10.1210/mend.16.4.0807"}],"title":"Lysine 270 in the third intracellular domain of the oxytocin receptor is an important determinant for G alpha(q) coupling specificity.","publicationDate":"2002","journal":"Mol. Endocrinol.","firstPage":"814","lastPage":"823","volume":"16"},"referencePositions":["FUNCTION","MUTAGENESIS OF LYS-268 AND LYS-270"]},{"referenceNumber":8,"citation":{"id":"14976224","citationType":"journal article","authors":["Hasbi A.","Devost D.","Laporte S.A.","Zingg H.H."],"citationCrossReferences":[{"database":"PubMed","id":"14976224"},{"database":"DOI","id":"10.1210/me.2003-0440"}],"title":"Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.","publicationDate":"2004","journal":"Mol. Endocrinol.","firstPage":"1277","lastPage":"1286","volume":"18"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":9,"citation":{"id":"16179383","citationType":"journal article","authors":["Smith M.P.","Ayad V.J.","Mundell S.J.","McArdle C.A.","Kelly E.","Lopez Bernal A."],"citationCrossReferences":[{"database":"PubMed","id":"16179383"},{"database":"DOI","id":"10.1210/me.2005-0031"}],"title":"Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells.","publicationDate":"2006","journal":"Mol. Endocrinol.","firstPage":"379","lastPage":"388","volume":"20"},"referencePositions":["PHOSPHORYLATION","SUBCELLULAR LOCATION","INTERACTION WITH ARRB2"]},{"referenceNumber":10,"citation":{"id":"19423652","citationType":"journal article","authors":["Willets J.M.","Brighton P.J.","Mistry R.","Morris G.E.","Konje J.C.","Challiss R.A."],"citationCrossReferences":[{"database":"PubMed","id":"19423652"},{"database":"DOI","id":"10.1210/me.2009-0047"}],"title":"Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle.","publicationDate":"2009","journal":"Mol. Endocrinol.","firstPage":"1272","lastPage":"1280","volume":"23"},"referencePositions":["PHOSPHORYLATION"]},{"referenceNumber":11,"citation":{"id":"19934046","citationType":"journal article","authors":["Rodrigues S.M.","Saslow L.R.","Garcia N.","John O.P.","Keltner D."],"citationCrossReferences":[{"database":"PubMed","id":"19934046"},{"database":"DOI","id":"10.1073/pnas.0909579106"}],"title":"Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"21437","lastPage":"21441","volume":"106"},"referencePositions":["FUNCTION","POLYMORPHISM"]},{"referenceNumber":12,"citation":{"id":"20647384","citationType":"journal article","authors":["Tost H.","Kolachana B.","Hakimi S.","Lemaitre H.","Verchinski B.A.","Mattay V.S.","Weinberger D.R.","Meyer-Lindenberg A."],"citationCrossReferences":[{"database":"PubMed","id":"20647384"},{"database":"DOI","id":"10.1073/pnas.1003296107"}],"title":"A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13936","lastPage":"13941","volume":"107"},"referencePositions":["FUNCTION","POLYMORPHISM"]},{"referenceNumber":13,"citation":{"id":"21896752","citationType":"journal article","authors":["Saphire-Bernstein S.","Way B.M.","Kim H.S.","Sherman D.K.","Taylor S.E."],"citationCrossReferences":[{"database":"PubMed","id":"21896752"},{"database":"DOI","id":"10.1073/pnas.1113137108"}],"title":"Oxytocin receptor gene (OXTR) is related to psychological resources.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15118","lastPage":"15122","volume":"108"},"referencePositions":["FUNCTION","POLYMORPHISM"]},{"referenceNumber":14,"citation":{"id":"22123970","citationType":"journal article","authors":["Chen F.S.","Kumsta R.","von Dawans B.","Monakhov M.","Ebstein R.P.","Heinrichs M."],"citationCrossReferences":[{"database":"PubMed","id":"22123970"},{"database":"DOI","id":"10.1073/pnas.1113079108"}],"title":"Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"19937","lastPage":"19942","volume":"108"},"referencePositions":["FUNCTION","POLYMORPHISM"]},{"referenceNumber":15,"citation":{"id":"22069312","citationType":"journal article","authors":["Busnelli M.","Sauliere A.","Manning M.","Bouvier M.","Gales C.","Chini B."],"citationCrossReferences":[{"database":"PubMed","id":"22069312"},{"database":"DOI","id":"10.1074/jbc.m111.277178"}],"title":"Functional selective oxytocin-derived agonists discriminate between individual G protein family subtypes.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"3617","lastPage":"3629","volume":"287"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"24367110","citationType":"journal article","authors":["Skuse D.H.","Lori A.","Cubells J.F.","Lee I.","Conneely K.N.","Puura K.","Lehtimaeki T.","Binder E.B.","Young L.J."],"citationCrossReferences":[{"database":"PubMed","id":"24367110"},{"database":"DOI","id":"10.1073/pnas.1302985111"}],"title":"Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.","publicationDate":"2014","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1987","lastPage":"1992","volume":"111"},"referencePositions":["FUNCTION","POLYMORPHISM"]},{"referenceNumber":17,"citation":{"id":"35104164","citationType":"journal article","authors":["Wang F.","Yin X.S.","Lu J.","Cen C.","Wang Y."],"citationCrossReferences":[{"database":"PubMed","id":"35104164"},{"database":"DOI","id":"10.1126/scisignal.abd0033"}],"title":"Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.","publicationDate":"2022","journal":"Sci. Signal.","firstPage":"eabd0033","lastPage":"eabd0033","volume":"15"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-261","MUTAGENESIS OF SER-261","CHARACTERIZATION OF VARIANT HIS-259"]},{"referenceNumber":18,"citation":{"id":"32832646","citationType":"journal article","authors":["Waltenspuehl Y.","Schoeppe J.","Ehrenmann J.","Kummer L.","Plueckthun A."],"citationCrossReferences":[{"database":"PubMed","id":"32832646"},{"database":"DOI","id":"10.1126/sciadv.abb5419"}],"title":"Crystal structure of the human oxytocin receptor.","publicationDate":"2020","journal":"Sci. Adv.","firstPage":"eabb5419","lastPage":"eabb5419","volume":"6"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 35-356 IN COMPLEX WITH CHOLESTEROL","FUNCTION","ACTIVITY REGULATION","MUTAGENESIS OF GLU-42; ASP-100; LYS-116; GLN-119; GLN-171; TYR-200; TRP-203 AND PHE-291"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6TPK"}]},{"referenceNumber":19,"citation":{"id":"35851571","citationType":"journal article","authors":["Waltenspuehl Y.","Ehrenmann J.","Vacca S.","Thom C.","Medalia O.","Plueckthun A."],"citationCrossReferences":[{"database":"PubMed","id":"35851571"},{"database":"DOI","id":"10.1038/s41467-022-31325-0"}],"title":"Structural basis for the activation and ligand recognition of the human oxytocin receptor.","publicationDate":"2022","journal":"Nat. Commun.","firstPage":"4153","lastPage":"4153","volume":"13"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.25 ANGSTROMS) OF 1-359 IN COMPLEX WITH OXYTOCIN; GNAO1; GNB1 AND GNG2","FUNCTION","MUTAGENESIS OF GLN-171; ILE-201; ILE-204 AND PHE-291"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7QVM"}]},{"referenceNumber":20,"citation":{"id":"35241813","citationType":"journal article","authors":["Meyerowitz J.G.","Robertson M.J.","Barros-Alvarez X.","Panova O.","Nwokonko R.M.","Gao Y.","Skiniotis G."],"citationCrossReferences":[{"database":"PubMed","id":"35241813"},{"database":"DOI","id":"10.1038/s41594-022-00728-4"}],"title":"The oxytocin signaling complex reveals a molecular switch for cation dependence.","publicationDate":"2022","journal":"Nat. Struct. Mol. Biol.","firstPage":"274","lastPage":"281","volume":"29"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH OXYTOCIN; GNB1; GNG2 AND MAGNESIUM","FUNCTION","ACTIVITY REGULATION","MUTAGENESIS OF ARG-34; ASP-100 AND PHE-103"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7RYC"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X64878","properties":[{"key":"ProteinId","value":"CAA46097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY389507","properties":[{"key":"ProteinId","value":"AAQ91333.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X80282","properties":[{"key":"ProteinId","value":"CAA56562.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS2570.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A55493","properties":[{"key":"EntryName","value":"A55493"}]},{"database":"RefSeq","id":"NP_000907.2","properties":[{"key":"NucleotideSequenceId","value":"NM_000916.4"}]},{"database":"RefSeq","id":"NP_001341582.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354653.2"}]},{"database":"RefSeq","id":"NP_001341583.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354654.2"}]},{"database":"RefSeq","id":"NP_001341584.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354655.2"}]},{"database":"RefSeq","id":"NP_001341585.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354656.3"}]},{"database":"PDB","id":"6TPK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=35-356"}]},{"database":"PDB","id":"7QVM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"R=1-359"}]},{"database":"PDB","id":"7RYC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"O=1-389"}]},{"database":"PDBsum","id":"6TPK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7QVM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7RYC","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14180","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-24733","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"111061","properties":[{"key":"Interactions","value":"15"}]},{"database":"CORUM","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P30559","properties":[{"key":"Number of interactors","value":"1306"}]},{"database":"IntAct","id":"P30559","properties":[{"key":"Interactions","value":"18"}]},{"database":"MINT","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-OXTR","properties":[{"key":"Evidences","value":"8 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000324270","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2049","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09059","properties":[{"key":"GenericName","value":"Atosiban"}]},{"database":"DrugBank","id":"DB12292","properties":[{"key":"GenericName","value":"Barusiban"}]},{"database":"DrugBank","id":"DB01282","properties":[{"key":"GenericName","value":"Carbetocin"}]},{"database":"DrugBank","id":"DB20573","properties":[{"key":"GenericName","value":"Cligosiban"}]},{"database":"DrugBank","id":"DB00035","properties":[{"key":"GenericName","value":"Desmopressin"}]},{"database":"DrugBank","id":"DB11934","properties":[{"key":"GenericName","value":"Epelsiban"}]},{"database":"DrugBank","id":"DB12643","properties":[{"key":"GenericName","value":"Nelivaptan"}]},{"database":"DrugBank","id":"DB00107","properties":[{"key":"GenericName","value":"Oxytocin"}]},{"database":"DrugBank","id":"DB13929","properties":[{"key":"GenericName","value":"Relcovaptan"}]},{"database":"DrugBank","id":"DB11818","properties":[{"key":"GenericName","value":"Retosiban"}]},{"database":"DrugBank","id":"DB00067","properties":[{"key":"GenericName","value":"Vasopressin"}]},{"database":"DrugCentral","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"369","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.A.14.10.4","properties":[{"key":"FamilyName","value":"the g-protein-coupled receptor (gpcr) family"}]},{"database":"GlyCosmos","id":"P30559","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"P30559","properties":[{"key":"glycosylation","value":"3 sites, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"OXTR","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"143811431","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000324270","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54722","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10144","properties":[{"key":"antibodies","value":"372 antibodies from 37 providers"}]},{"database":"CPTC","id":"P30559","properties":[{"key":"antibodies","value":"2 antibodies"}]},{"database":"DNASU","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000316793.8","properties":[{"key":"ProteinId","value":"ENSP00000324270.2"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"Ensembl","id":"ENST00000894689.1","properties":[{"key":"ProteinId","value":"ENSP00000564748.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"Ensembl","id":"ENST00000894690.1","properties":[{"key":"ProteinId","value":"ENSP00000564749.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"Ensembl","id":"ENST00000894691.1","properties":[{"key":"ProteinId","value":"ENSP00000564750.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"Ensembl","id":"ENST00000894692.1","properties":[{"key":"ProteinId","value":"ENSP00000564751.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"GeneID","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5021","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000316793.8","properties":[{"key":"ProteinId","value":"ENSP00000324270.2"},{"key":"RefSeqNucleotideId","value":"NM_000916.4"},{"key":"RefSeqProteinId","value":"NP_000907.2"}]},{"database":"UCSC","id":"uc003brc.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:8529","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA32858","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"OXTR","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:8529","properties":[{"key":"GeneName","value":"OXTR"}]},{"database":"HPA","id":"ENSG00000180914","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (breast)"}]},{"database":"MalaCards","id":"OXTR","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"167055","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000180914","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000180914","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244882","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_15_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RCFFCCC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P30559","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-388479","properties":[{"key":"PathwayName","value":"Vasopressin-like receptors"}]},{"database":"Reactome","id":"R-HSA-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"SignaLink","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P30559","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000180914","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"5021","properties":[{"key":"hits","value":"15 hits in 1164 CRISPR screens"}]},{"database":"GeneWiki","id":"Oxytocin_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P30559","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P30559","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"P30559","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000180914","properties":[{"key":"ExpressionPatterns","value":"Expressed in decidua and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P30559","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16179383"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22069312"}]},{"database":"GO","id":"GO:0004990","properties":[{"key":"GoTerm","value":"F:oxytocin receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11923477"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22069312"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32832646"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35104164"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35851571"}]},{"database":"GO","id":"GO:0005000","properties":[{"key":"GoTerm","value":"F:vasopressin receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007193","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35851571"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1313946"}]},{"database":"GO","id":"GO:0032870","properties":[{"key":"GoTerm","value":"P:cellular response to hormone stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060180","properties":[{"key":"GoTerm","value":"P:female mating behavior"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007565","properties":[{"key":"GoTerm","value":"P:female pregnancy"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060138","properties":[{"key":"GoTerm","value":"P:fetal process involved in parturition"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6278592"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007595","properties":[{"key":"GoTerm","value":"P:lactation"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1313946"}]},{"database":"GO","id":"GO:0042711","properties":[{"key":"GoTerm","value":"P:maternal behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060137","properties":[{"key":"GoTerm","value":"P:maternal process involved in parturition"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060156","properties":[{"key":"GoTerm","value":"P:milk ejection reflex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006936","properties":[{"key":"GoTerm","value":"P:muscle contraction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1313946"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11923477"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35241813"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35851571"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"ISS:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24002032"}]},{"database":"GO","id":"GO:0045669","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070474","properties":[{"key":"GoTerm","value":"P:positive regulation of uterine smooth muscle contraction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6278592"}]},{"database":"GO","id":"GO:0045907","properties":[{"key":"GoTerm","value":"P:positive regulation of vasoconstriction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048167","properties":[{"key":"GoTerm","value":"P:regulation of synaptic plasticity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001992","properties":[{"key":"GoTerm","value":"P:regulation of systemic arterial blood pressure by vasopressin"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035176","properties":[{"key":"GoTerm","value":"P:social behavior"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19934046"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20647384"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21896752"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22123970"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24367110"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35104164"}]},{"database":"CDD","id":"cd15387","properties":[{"key":"EntryName","value":"7tmA_OT_R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000145","properties":[{"key":"EntryName","value":"Oxytocin receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR002062","properties":[{"key":"EntryName","value":"Oxytocn_rcpt"}]},{"database":"InterPro","id":"IPR001817","properties":[{"key":"EntryName","value":"Vasoprsn_rcpt"}]},{"database":"PANTHER","id":"PTHR24241","properties":[{"key":"EntryName","value":"NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24241:SF89","properties":[{"key":"EntryName","value":"OXYTOCIN RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00665","properties":[{"key":"EntryName","value":"OXYTOCINR"}]},{"database":"PRINTS","id":"PR00896","properties":[{"key":"EntryName","value":"VASOPRESSINR"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA","length":389,"molWeight":42772,"crc64":"97E1845DA9676439","md5":"BD56FC0890E467302FCDB237F80244A3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"PTM":1,"POLYMORPHISM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":2,"Compositional bias":1,"Binding site":3,"Modified residue":3,"Glycosylation":3,"Disulfide bond":1,"Natural variant":3,"Mutagenesis":17,"Sequence conflict":1,"Helix":14,"Beta strand":5,"Turn":3},"uniParcId":"UPI000013FEA9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2R9L7","uniProtkbId":"B2R9L7_HUMAN","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-07-01","entryVersion":137,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36564.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021826"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Oxytocin receptor"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI37444.1"}],"value":"OXTR"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63947.1"}],"value":"hCG_20370"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity. Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation. OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096387"}],"value":"Interacts (when phosphorylated following prolonged stimulation by oxytocin) with ARRB1 and/or ARRB2, leading to receptor desensitization"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Belongs to the G protein-coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Transmembrane","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Domain","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Region","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63947.1"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI37444.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI37444.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63947.1"}]},{"referenceNumber":4,"citation":{"id":"CI-6MEA4GF1I55C2","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Kaida T.","Tsuchiya K.","Iida Y.","Takayama Y.","Murakawa K.","Kanehori K.","Andoh T.","Kagawa N.","Sato R.","Kawamura Y.","Tanaka S.","Kisu Y.","Sugano S.","Goshima N.","Nomura N.","Isogai T."],"title":"NEDO functional analysis of protein and research application project.","publicationDate":"JAN-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG36564.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC137443","properties":[{"key":"ProteinId","value":"AAI37444.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313830","properties":[{"key":"ProteinId","value":"BAG36564.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW63947.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_000907.2","properties":[{"key":"NucleotideSequenceId","value":"NM_000916.4"}]},{"database":"RefSeq","id":"NP_001341582.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354653.2"}]},{"database":"RefSeq","id":"NP_001341583.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354654.2"}]},{"database":"RefSeq","id":"NP_001341584.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354655.2"}]},{"database":"RefSeq","id":"NP_001341585.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001354656.3"}]},{"database":"AlphaFoldDB","id":"B2R9L7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B2R9L7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10144","properties":[{"key":"antibodies","value":"372 antibodies from 37 providers"}]},{"database":"DNASU","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:5021","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA32858","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"5021","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000180914","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_15_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RCFFCCC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"5021","properties":[{"key":"hits","value":"15 hits in 1164 CRISPR screens"}]},{"database":"ExpressionAtlas","id":"B2R9L7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004990","properties":[{"key":"GoTerm","value":"F:oxytocin receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005000","properties":[{"key":"GoTerm","value":"F:vasopressin receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0060180","properties":[{"key":"GoTerm","value":"P:female mating behavior"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042711","properties":[{"key":"GoTerm","value":"P:maternal behavior"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060156","properties":[{"key":"GoTerm","value":"P:milk ejection reflex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0120162","properties":[{"key":"GoTerm","value":"P:positive regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045669","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048167","properties":[{"key":"GoTerm","value":"P:regulation of synaptic plasticity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035176","properties":[{"key":"GoTerm","value":"P:social behavior"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003008","properties":[{"key":"GoTerm","value":"P:system process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd15387","properties":[{"key":"EntryName","value":"7tmA_OT_R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000145","properties":[{"key":"EntryName","value":"Oxytocin receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR002062","properties":[{"key":"EntryName","value":"Oxytocn_rcpt"}]},{"database":"InterPro","id":"IPR001817","properties":[{"key":"EntryName","value":"Vasoprsn_rcpt"}]},{"database":"PANTHER","id":"PTHR24241","properties":[{"key":"EntryName","value":"NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24241:SF89","properties":[{"key":"EntryName","value":"OXYTOCIN RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00665","properties":[{"key":"EntryName","value":"OXYTOCINR"}]},{"database":"PRINTS","id":"PR00896","properties":[{"key":"EntryName","value":"VASOPRESSINR"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA","length":389,"molWeight":42772,"crc64":"97E1845DA9676439","md5":"BD56FC0890E467302FCDB237F80244A3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":7,"Domain":1,"Region":2,"Compositional bias":1},"uniParcId":"UPI000013FEA9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JN09","uniProtkbId":"C9JN09_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":96,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021826"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Oxytocin receptor"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"}],"value":"OXTR"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity. Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation. OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096387"}],"value":"Interacts (when phosphorylated following prolonged stimulation by oxytocin) with ARRB1 and/or ARRB2, leading to receptor desensitization"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Belongs to the G protein-coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}]},{"type":"Domain","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU046427"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000389587.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC068312","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9JN09","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C9JN09","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10144","properties":[{"key":"antibodies","value":"372 antibodies from 37 providers"}]},{"database":"Ensembl","id":"ENST00000449615.1","properties":[{"key":"ProteinId","value":"ENSP00000389587.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"UCSC","id":"uc062ghn.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:8529","properties":[{"key":"GeneName","value":"OXTR"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000180914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01050000244882","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2418738_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RCFFCCC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"Bgee","id":"ENSG00000180914","properties":[{"key":"ExpressionPatterns","value":"Expressed in decidua and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9JN09","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004990","properties":[{"key":"GoTerm","value":"F:oxytocin receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005000","properties":[{"key":"GoTerm","value":"F:vasopressin receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR002062","properties":[{"key":"EntryName","value":"Oxytocn_rcpt"}]},{"database":"InterPro","id":"IPR001817","properties":[{"key":"EntryName","value":"Vasoprsn_rcpt"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00665","properties":[{"key":"EntryName","value":"OXYTOCINR"}]},{"database":"PRINTS","id":"PR00896","properties":[{"key":"EntryName","value":"VASOPRESSINR"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQ","length":92,"molWeight":9740,"crc64":"C613C64F1FF5C544","md5":"C2F3005940A8D81DCB5C9F4DE82250D0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI000155D5DA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C9JQC4","uniProtkbId":"C9JQC4_HUMAN","entryAudit":{"firstPublicDate":"2009-11-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-03","entryVersion":85,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"}],"value":"Oxytocin receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"}],"value":"OXTR"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000414828.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC068312","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C9JQC4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10144","properties":[{"key":"antibodies","value":"372 antibodies from 37 providers"}]},{"database":"Ensembl","id":"ENST00000431493.1","properties":[{"key":"ProteinId","value":"ENSP00000414828.1"},{"key":"GeneId","value":"ENSG00000180914.12"}]},{"database":"UCSC","id":"uc062gho.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:8529","properties":[{"key":"GeneName","value":"OXTR"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000180914","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01050000244882","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3244704_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RCFFCCC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"Bgee","id":"ENSG00000180914","properties":[{"key":"ExpressionPatterns","value":"Expressed in decidua and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"C9JQC4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004990","properties":[{"key":"GoTerm","value":"F:oxytocin receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR002062","properties":[{"key":"EntryName","value":"Oxytocn_rcpt"}]},{"database":"PRINTS","id":"PR00665","properties":[{"key":"EntryName","value":"OXYTOCINR"}]}],"sequence":{"value":"MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEV","length":43,"molWeight":4303,"crc64":"93626F0A883D4495","md5":"ED4F74FCA151159502B466A4EE6115A0"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":2,"Non-terminal residue":1},"uniParcId":"UPI000155D5DB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"X5DRH4","uniProtkbId":"X5DRH4_HUMAN","entryAudit":{"firstPublicDate":"2014-06-11","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2014-06-11","entryVersion":11,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}],"value":"Oxytocin receptor isoform A"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}],"value":"OXTR"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"}],"references":[{"referenceNumber":1,"citation":{"id":"24722188","citationType":"journal article","authors":["Corominas R.","Yang X.","Lin G.N.","Kang S.","Shen Y.","Ghamsari L.","Broly M.","Rodriguez M.","Tam S.","Wanamaker S.A.","Fan C.","Yi S.","Tasan M.","Lemmens I.","Kuang X.","Zhao N.","Malhotra D.","Michaelson J.J.","Vacic V.","Calderwood M.A.","Roth F.P.","Tavernier J.","Horvath S.","Salehi-Ashtiani K.","Korkin D.","Sebat J.","Hill D.E.","Hao T.","Vidal M.","Iakoucheva L.M."],"citationCrossReferences":[{"database":"PubMed","id":"24722188"}],"title":"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"3650","lastPage":"3650","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}],"value":"Adult whole brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHW56687.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ535048","properties":[{"key":"ProteinId","value":"AHW56687.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"X5DRH4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6435638at2759","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MEARSQPTGAPRQPTPAPRRRGPRATAPPDPRGATRPWRAWRWRCCVSSCSWR","length":53,"molWeight":6070,"crc64":"C6331BFD2AC41DF9","md5":"0715652C7AEFD9DF9837FF6AA2096D6F"},"extraAttributes":{"countByFeatureType":{"Region":1},"uniParcId":"UPI00044377FF"}}]}