{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P42857","secondaryAccessions":["B4DXC5","Q49AQ1"],"uniProtkbId":"NSG1_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":183,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Neuronal vesicle trafficking-associated protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20878061"}],"value":"Neuron-enriched endosomal protein of 21 kDa"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:18790"}],"value":"Neuron-specific protein family member 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:18790"}],"value":"NSG1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20599942"}],"value":"D4S234"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20878061"}],"value":"NEEP21"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62092"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20878061"}],"value":"Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62092"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30312582"}],"value":"Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (PubMed:30312582)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O75787","geneName":"ATP6AP2","intActId":"EBI-2512037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"J3KQ12","geneName":"BSCL2","intActId":"EBI-11532900"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q96G97-4","geneName":"BSCL2","intActId":"EBI-10178113"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q7KYR7-4","geneName":"BTN2A1","intActId":"EBI-17841208"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q13936","geneName":"CACNA1C","intActId":"EBI-1038838"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8N5K1","geneName":"CISD2","intActId":"EBI-1045797"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q96BA8","geneName":"CREB3L1","intActId":"EBI-6942903"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"P00387","geneName":"CYB5R3","intActId":"EBI-1046040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q9Y282","geneName":"ERGIC3","intActId":"EBI-781551"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"P34910-2","geneName":"EVI2B","intActId":"EBI-17640610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"P12318-2","geneName":"FCGR2A","intActId":"EBI-17187481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O15552","geneName":"FFAR2","intActId":"EBI-2833872"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q96LL3","geneName":"FIMP","intActId":"EBI-12887376"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8TBE3","geneName":"FNDC9","intActId":"EBI-12142257"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q99795","geneName":"GPA33","intActId":"EBI-4289554"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O15529","geneName":"GPR42","intActId":"EBI-18076404"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8N6L0","geneName":"KASH5","intActId":"EBI-749265"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"P43628","geneName":"KIR2DL3","intActId":"EBI-8632435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O14880","geneName":"MGST3","intActId":"EBI-724754"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"P35372-10","geneName":"OPRM1","intActId":"EBI-12807478"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q13113","geneName":"PDZK1IP1","intActId":"EBI-716063"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O43688","geneName":"PLPP2","intActId":"EBI-722017"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8NC24","geneName":"RELL2","intActId":"EBI-10269209"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"O14863","geneName":"SLC30A4","intActId":"EBI-13918058"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8TBB6","geneName":"SLC7A14","intActId":"EBI-5235586"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q9HBV2","geneName":"SPACA1","intActId":"EBI-17498703"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q96CE8","geneName":"TM4SF18","intActId":"EBI-13351685"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q8IV31","geneName":"TMEM139","intActId":"EBI-7238458"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q6UWW9","geneName":"TMEM207","intActId":"EBI-13301303"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q96B21","geneName":"TMEM45B","intActId":"EBI-3923061"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q4KMG9","geneName":"TMEM52B","intActId":"EBI-18178701"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P42857","intActId":"EBI-6380741"},"interactantTwo":{"uniProtKBAccession":"Q9Y320","geneName":"TMX2","intActId":"EBI-6447886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62092"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599942"}],"value":"Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Golgi apparatus, trans-Golgi network membrane","id":"SL-0267"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Endosome membrane","id":"SL-0100"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Early endosome membrane","id":"SL-0093"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Late endosome membrane","id":"SL-0151"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Lysosome lumen","id":"SL-0156"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Recycling endosome membrane","id":"SL-0231"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Cytoplasmic vesicle membrane","id":"SL-0089"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Golgi apparatus, Golgi stack membrane","id":"SL-0136"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}],"value":"Endosome, multivesicular body membrane","id":"SL-0175"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599942"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P42857-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P42857-2"],"sequenceIds":["VSP_054333"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20878061"}],"value":"Up-regulated by TP53 after DNA damage (PubMed:20599942). Up-regulated by genotoxic stress (PubMed:20878061)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NSG family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Neuronal vesicle trafficking-associated protein 1","featureId":"PRO_0000164363"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}]},{"type":"Region","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Required for GRIP1 interaction","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P02683"}]},{"type":"Alternative sequence","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_054333","alternativeSequence":{}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9013775","citationType":"journal article","authors":["Carlock L.","Vo T.","Lorincz M.","Walker P.D.","Bessert D.","Wisniewski D.","Dunbar J.C."],"citationCrossReferences":[{"database":"PubMed","id":"9013775"},{"database":"DOI","id":"10.1016/s0169-328x(96)00115-5"}],"title":"Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons.","publicationDate":"1996","journal":"Brain Res. Mol. Brain Res.","firstPage":"202","lastPage":"212","volume":"42"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"20599942","citationType":"journal article","authors":["Kudoh T.","Kimura J.","Lu Z.G.","Miki Y.","Yoshida K."],"citationCrossReferences":[{"database":"PubMed","id":"20599942"},{"database":"DOI","id":"10.1016/j.yexcr.2010.06.025"}],"title":"D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage.","publicationDate":"2010","journal":"Exp. Cell Res.","firstPage":"2849","lastPage":"2858","volume":"316"},"referencePositions":["INDUCTION","SUBCELLULAR LOCATION","FUNCTION"]},{"referenceNumber":6,"citation":{"id":"20878061","citationType":"journal article","authors":["Ohnishi S.","Futamura M.","Kamino H.","Nakamura Y.","Kitamura N.","Miyamoto Y.","Miyamoto T.","Shinogi D.","Goda O.","Arakawa H."],"citationCrossReferences":[{"database":"PubMed","id":"20878061"},{"database":"DOI","id":"10.3892/ijo_00000765"}],"title":"Identification of NEEP21, encoding neuron-enriched endosomal protein of 21 kDa, as a transcriptional target of tumor suppressor p53.","publicationDate":"2010","journal":"Int. J. Oncol.","firstPage":"1133","lastPage":"1141","volume":"37"},"referencePositions":["INDUCTION","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"30312582","citationType":"journal article","authors":["Rasila T.","Saavalainen O.","Attalla H.","Lankila P.","Haglund C.","Hoelttae E.","Andersson L.C."],"citationCrossReferences":[{"database":"PubMed","id":"30312582"},{"database":"DOI","id":"10.1016/j.ajpath.2018.09.006"}],"title":"Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.","publicationDate":"2019","journal":"Am. J. Pathol.","firstPage":"177","lastPage":"189","volume":"189"},"referencePositions":["INTERACTION WITH FAM171A1"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M98529","properties":[{"key":"ProteinId","value":"AAA60152.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M98528","properties":[{"key":"ProteinId","value":"AAA60355.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK301911","properties":[{"key":"ProteinId","value":"BAG63337.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC105415","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC110814","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001745","properties":[{"key":"ProteinId","value":"AAH01745.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC034227","properties":[{"key":"ProteinId","value":"AAH34227.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3376.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P42857-1"},{"database":"CCDS","id":"CCDS93472.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P42857-2"},{"database":"RefSeq","id":"NP_001035190.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001040101.2"}],"isoformId":"P42857-1"},{"database":"RefSeq","id":"NP_001274692.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001287763.2"}],"isoformId":"P42857-1"},{"database":"RefSeq","id":"NP_001369157.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001382228.1"}],"isoformId":"P42857-2"},{"database":"RefSeq","id":"NP_055207.1","properties":[{"key":"NucleotideSequenceId","value":"NM_014392.5"}],"isoformId":"P42857-1"},{"database":"RefSeq","id":"XP_054205652.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054349677.1"}],"isoformId":"P42857-1"},{"database":"RefSeq","id":"XP_054205653.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054349678.1"}],"isoformId":"P42857-1"},{"database":"RefSeq","id":"XP_054205654.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054349679.1"}],"isoformId":"P42857-1"},{"database":"AlphaFoldDB","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"117976","properties":[{"key":"Interactions","value":"39"}]},{"database":"FunCoup","id":"P42857","properties":[{"key":"Number of interactors","value":"307"}]},{"database":"IntAct","id":"P42857","properties":[{"key":"Interactions","value":"40"}]},{"database":"MINT","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NSG1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000388823","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P42857","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NSG1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1168680","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000388823","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"5425","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55560","properties":[{"key":"Description","value":"-"}],"isoformId":"P42857-1"},{"database":"Antibodypedia","id":"22570","properties":[{"key":"antibodies","value":"223 antibodies from 29 providers"}]},{"database":"DNASU","id":"27065","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000397958.5","properties":[{"key":"ProteinId","value":"ENSP00000381049.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000421177.6","properties":[{"key":"ProteinId","value":"ENSP00000388823.2"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000433139.6","properties":[{"key":"ProteinId","value":"ENSP00000408833.2"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000504171.1","properties":[{"key":"ProteinId","value":"ENSP00000425803.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-2"},{"database":"Ensembl","id":"ENST00000505246.5","properties":[{"key":"ProteinId","value":"ENSP00000421841.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000506380.5","properties":[{"key":"ProteinId","value":"ENSP00000425423.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000513555.5","properties":[{"key":"ProteinId","value":"ENSP00000426358.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000513829.5","properties":[{"key":"ProteinId","value":"ENSP00000425345.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000621129.5","properties":[{"key":"ProteinId","value":"ENSP00000480081.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000889808.1","properties":[{"key":"ProteinId","value":"ENSP00000559867.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000889809.1","properties":[{"key":"ProteinId","value":"ENSP00000559868.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000930399.1","properties":[{"key":"ProteinId","value":"ENSP00000600458.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"Ensembl","id":"ENST00000930400.1","properties":[{"key":"ProteinId","value":"ENSP00000600459.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-2"},{"database":"Ensembl","id":"ENST00000930401.1","properties":[{"key":"ProteinId","value":"ENSP00000600460.1"},{"key":"GeneId","value":"ENSG00000168824.16"}],"isoformId":"P42857-1"},{"database":"GeneID","id":"27065","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:27065","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000621129.5","properties":[{"key":"ProteinId","value":"ENSP00000480081.1"},{"key":"RefSeqNucleotideId","value":"NM_014392.5"},{"key":"RefSeqProteinId","value":"NP_055207.1"}]},{"database":"UCSC","id":"uc003ghz.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P42857-1"},{"database":"AGR","id":"HGNC:18790","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"27065","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"27065","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NSG1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:18790","properties":[{"key":"GeneName","value":"NSG1"}]},{"database":"HPA","id":"ENSG00000168824","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, pituitary gland, skin)"}]},{"database":"MIM","id":"607645","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000168824","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000168824","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSAI","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000483","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_112085_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MQGRCMP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8924576at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P42857","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P42857","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000168824","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"27065","properties":[{"key":"hits","value":"14 hits in 1105 CRISPR screens"}]},{"database":"ChiTaRS","id":"NSG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"27065","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P42857","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P42857","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P42857","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000168824","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 181 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P42857","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9013775"}]},{"database":"GO","id":"GO:0030659","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20599942"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20599942"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032580","properties":[{"key":"GoTerm","value":"C:Golgi cisterna membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005770","properties":[{"key":"GoTerm","value":"C:late endosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031902","properties":[{"key":"GoTerm","value":"C:late endosome membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016328","properties":[{"key":"GoTerm","value":"C:lateral plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043202","properties":[{"key":"GoTerm","value":"C:lysosomal lumen"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032585","properties":[{"key":"GoTerm","value":"C:multivesicular body membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9013775"}]},{"database":"GO","id":"GO:0098845","properties":[{"key":"GoTerm","value":"C:postsynaptic endosome"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036477","properties":[{"key":"GoTerm","value":"C:somatodendritic compartment"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032588","properties":[{"key":"GoTerm","value":"C:trans-Golgi network membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032051","properties":[{"key":"GoTerm","value":"F:clathrin light chain binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035255","properties":[{"key":"GoTerm","value":"F:ionotropic glutamate receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042982","properties":[{"key":"GoTerm","value":"P:amyloid precursor protein metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20599942"}]},{"database":"GO","id":"GO:0048268","properties":[{"key":"GoTerm","value":"P:clathrin coat assembly"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016197","properties":[{"key":"GoTerm","value":"P:endosomal transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0099627","properties":[{"key":"GoTerm","value":"P:neurotransmitter receptor cycle"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098887","properties":[{"key":"GoTerm","value":"P:neurotransmitter receptor transport, endosome to postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001921","properties":[{"key":"GoTerm","value":"P:positive regulation of receptor recycling"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0099630","properties":[{"key":"GoTerm","value":"P:postsynaptic neurotransmitter receptor cycle"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001881","properties":[{"key":"GoTerm","value":"P:receptor recycling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1900271","properties":[{"key":"GoTerm","value":"P:regulation of long-term synaptic potentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098814","properties":[{"key":"GoTerm","value":"P:spontaneous synaptic transmission"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR009431","properties":[{"key":"EntryName","value":"NSG"}]},{"database":"PANTHER","id":"PTHR28546:SF3","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28546","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06387","properties":[{"key":"EntryName","value":"Calcyon"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF002383","properties":[{"key":"EntryName","value":"Calcyon"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA","length":185,"molWeight":20913,"crc64":"4B7086C18BC11605","md5":"AC782CF131B69D0D5839773D0C262C71"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":32,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":2,"Transmembrane":1,"Region":1,"Alternative sequence":1},"uniParcId":"UPI0000130549"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VEV7","uniProtkbId":"A0ACI8VEV7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040239"}],"value":"Neuronal vesicle trafficking-associated protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041410"}],"value":"Neuron-enriched endosomal protein of 21 kDa"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042477"}],"value":"Neuron-specific protein family member 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"}],"value":"NSG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045207"}],"value":"Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004156"}],"value":"Cytoplasmic vesicle membrane","id":"SL-0089"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004146"}],"value":"Early endosome membrane","id":"SL-0093"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004333"}],"value":"Endosome, multivesicular body membrane","id":"SL-0175"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037859"}],"value":"Golgi apparatus, Golgi stack membrane","id":"SL-0136"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004198"}],"value":"Golgi apparatus, trans-Golgi network membrane","id":"SL-0267"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004414"}],"value":"Late endosome membrane","id":"SL-0151"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004227"}],"value":"Lysosome lumen","id":"SL-0156"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004565"}],"value":"Recycling endosome membrane","id":"SL-0231"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007767"}],"value":"Belongs to the NSG family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VEV7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VEV7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"}],"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000633849.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC105415","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC110814","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000930402.1","properties":[{"key":"ProteinId","value":"ENSP00000600461.1"},{"key":"GeneId","value":"ENSG00000168824.16"}]},{"database":"Ensembl","id":"ENST00000963790.1","properties":[{"key":"ProteinId","value":"ENSP00000633849.1"},{"key":"GeneId","value":"ENSG00000168824.16"}]},{"database":"HGNC","id":"HGNC:18790","properties":[{"key":"GeneName","value":"NSG1"}]},{"database":"OpenTargets","id":"ENSG00000168824","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000000483","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"InterPro","id":"IPR009431","properties":[{"key":"EntryName","value":"NSG"}]},{"database":"PANTHER","id":"PTHR28546:SF3","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28546","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06387","properties":[{"key":"EntryName","value":"Calcyon"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKNTQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA","length":148,"molWeight":16731,"crc64":"089B423F576CB06F","md5":"886AFE3747893D7B907822A4CB38264B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"uniParcId":"UPI00006E0EC3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RL36","uniProtkbId":"A0ACI8RL36_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040239"}],"value":"Neuronal vesicle trafficking-associated protein 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041410"}],"value":"Neuron-enriched endosomal protein of 21 kDa"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042477"}],"value":"Neuron-specific protein family member 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"}],"value":"NSG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045207"}],"value":"Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004279"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004156"}],"value":"Cytoplasmic vesicle membrane","id":"SL-0089"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004146"}],"value":"Early endosome membrane","id":"SL-0093"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004333"}],"value":"Endosome, multivesicular body membrane","id":"SL-0175"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037859"}],"value":"Golgi apparatus, Golgi stack membrane","id":"SL-0136"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004198"}],"value":"Golgi apparatus, trans-Golgi network membrane","id":"SL-0267"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004414"}],"value":"Late endosome membrane","id":"SL-0151"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004227"}],"value":"Lysosome lumen","id":"SL-0156"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004606"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004565"}],"value":"Recycling endosome membrane","id":"SL-0231"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007767"}],"value":"Belongs to the NSG family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023228"}],"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RL36"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RL36"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022968"}],"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000559869.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC105415","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC110814","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000889810.1","properties":[{"key":"ProteinId","value":"ENSP00000559869.1"},{"key":"GeneId","value":"ENSG00000168824.16"}]},{"database":"HGNC","id":"HGNC:18790","properties":[{"key":"GeneName","value":"NSG1"}]},{"database":"OpenTargets","id":"ENSG00000168824","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000000483","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"InterPro","id":"IPR009431","properties":[{"key":"EntryName","value":"NSG"}]},{"database":"PANTHER","id":"PTHR28546:SF3","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28546","properties":[{"key":"EntryName","value":"NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06387","properties":[{"key":"EntryName","value":"Calcyon"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF002383","properties":[{"key":"EntryName","value":"Calcyon"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA","length":182,"molWeight":20570,"crc64":"BFC8873547A9333B","md5":"61D6C90E4A2C6D0A93143BA5F30E1B15"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI004031AD45"}}]}