{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q02297","secondaryAccessions":["A5YAK4","A5YAK5","A8K1L2","B7Z4Z3","E9PHH4","O14667","P98202","Q02298","Q02299","Q07110","Q07111","Q12779","Q12780","Q12781","Q12782","Q12783","Q12784","Q15491","Q7RTV9","Q7RTW0","Q7RTW1","Q7RTW2","Q8NFN1","Q8NFN2","Q8NFN3","Q9UPE3"],"uniProtkbId":"NRG1_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":257,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Pro-neuregulin-1, membrane-bound isoform"},"shortNames":[{"value":"Pro-NRG1"}]},"contains":[{"recommendedName":{"fullName":{"value":"Neuregulin-1"}},"alternativeNames":[{"fullName":{"value":"Acetylcholine receptor-inducing activity"},"shortNames":[{"value":"ARIA"}]},{"fullName":{"value":"Breast cancer cell differentiation factor p45"}},{"fullName":{"value":"Glial growth factor"}},{"fullName":{"value":"Heregulin"},"shortNames":[{"value":"HRG"}]},{"fullName":{"value":"Neu differentiation factor"}},{"fullName":{"value":"Sensory and motor neuron-derived factor"}}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"NRG1"},"synonyms":[{"value":"GGF"},{"value":"HGL"},{"value":"HRGA"},{"value":"NDF"},{"value":"SMDF"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P43322"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10867024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1348215"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20682778"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902537"}],"value":"Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P43322"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6DR98"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20682778"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778). Interacts with NRDC and BACE1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q02297-6","intActId":"EBI-15651799"},"interactantTwo":{"uniProtKBAccession":"P21860","geneName":"ERBB3","intActId":"EBI-720706"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-6","intActId":"EBI-15651799"},"interactantTwo":{"uniProtKBAccession":"Q15303","geneName":"ERBB4","intActId":"EBI-80371"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-7","intActId":"EBI-2460927"},"interactantTwo":{"uniProtKBAccession":"P04626","geneName":"ERBB2","intActId":"EBI-641062"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-7","intActId":"EBI-2460927"},"interactantTwo":{"uniProtKBAccession":"P21860","geneName":"ERBB3","intActId":"EBI-720706"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"P07307-3","geneName":"ASGR2","intActId":"EBI-12808270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"P21854","geneName":"CD72","intActId":"EBI-307924"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"Q8N5M9","geneName":"JAGN1","intActId":"EBI-10266796"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"Q86VI4","geneName":"LAPTM4B","intActId":"EBI-3267258"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"Q96JQ5","geneName":"MS4A4A","intActId":"EBI-12820341"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"P60201-2","geneName":"PLP1","intActId":"EBI-12188331"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02297-10","intActId":"EBI-12842334"},"interactantTwo":{"uniProtKBAccession":"Q969K7","geneName":"TMEM54","intActId":"EBI-3922833"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Pro-neuregulin-1, membrane-bound isoform","note":{"texts":[{"value":"Does not seem to be active"}]},"subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Neuregulin-1","subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 8","note":{"texts":[{"value":"May be nuclear"}]},"subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 9","note":{"texts":[{"value":"Has a signal peptide"}]},"subcellularLocations":[{"location":{"value":"Secreted","id":"SL-0243"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 10","note":{"texts":[{"value":"May possess an internal uncleaved signal sequence"}]},"subcellularLocations":[{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Alpha"}],"isoformIds":["Q02297-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Alpha1A"}],"isoformIds":["Q02297-2"],"sequenceIds":["VSP_003431"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"Alpha2B"}],"isoformIds":["Q02297-3"],"sequenceIds":["VSP_003434","VSP_003435"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"Alpha3"}],"isoformIds":["Q02297-4"],"sequenceIds":["VSP_003432","VSP_003433"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"Beta1"},{"value":"Beta1A"}],"isoformIds":["Q02297-6"],"sequenceIds":["VSP_003428"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"synonyms":[{"value":"Beta2"}],"isoformIds":["Q02297-7"],"sequenceIds":["VSP_003427"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"synonyms":[{"value":"Beta3"},{"value":"GGFHFB1"}],"isoformIds":["Q02297-8"],"sequenceIds":["VSP_003429","VSP_003430"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"synonyms":[{"value":"GGF2"},{"value":"GGFHPP2"}],"isoformIds":["Q02297-9"],"sequenceIds":["VSP_003425","VSP_003426","VSP_003429","VSP_003430"],"isoformSequenceStatus":"Described"},{"name":{"value":"10"},"synonyms":[{"value":"SMDF"}],"isoformIds":["Q02297-10"],"sequenceIds":["VSP_037562","VSP_037565","VSP_003429","VSP_003430"],"isoformSequenceStatus":"Described"},{"name":{"value":"11"},"synonyms":[{"value":"Type IV-beta1a"}],"isoformIds":["Q02297-11"],"sequenceIds":["VSP_037563","VSP_037564","VSP_003426","VSP_003428"],"isoformSequenceStatus":"Described"},{"name":{"value":"12"},"isoformIds":["Q02297-12"],"sequenceIds":["VSP_003427","VSP_046417"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9), type III NRGs (isoforms with a Cys-rich domain, isoform 10) and type IV NRGs (isoforms with additional 5' exons, isoform 11). All these isoforms perform distinct tissue-specific functions."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17565985"}],"value":"Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17565985"}],"value":"Detectable at early embryonic ages. Isoform 10 is highly expressed in developing spinal motor neurons and in developing cranial nerve nuclei. Expression is maintained only in both adult motor neurons and dorsal root ganglion neurons. Type IV isoforms are expressed in fetal brain"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"value":"ERBB receptor binding is elicited entirely by the EGF-like domain"}],"commentType":"DOMAIN"},{"texts":[{"value":"Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity)"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with TENM4. The translocation fuses the 5'-end of TENM4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breast carcinoma samples, including ductal, lobular, medullary, and mucinous histological types, neither in other breast cancer cell lines"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Potential internal signal sequence at positions 76-100"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 10"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAA19955.1","note":"Contaminating sequence. Sequence of unknown origin in the N-terminal part.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAC51756.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/129","ftp":false,"note":"Tipping the mind - Issue 129 of June 2011"}],"features":[{"type":"Propeptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7689552"}],"featureId":"PRO_0000019462"},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Pro-neuregulin-1, membrane-bound isoform","featureId":"PRO_0000019463"},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Neuregulin-1","featureId":"PRO_0000019464"},{"type":"Topological domain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Helical; Note=Internal signal sequence","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like C2-type"},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form gamma-heregulin"},{"type":"Glycosylation","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8639490"}]},{"type":"Disulfide bond","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8639490"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8639490"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7782315"}],"featureId":"VSP_037562","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}],"featureId":"VSP_003425","alternativeSequence":{"originalSequence":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSP","alternativeSequences":["MRWRRAPRRSGRPGPRAQRPGSAARSSPPLPLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSVGSVQELAQRAAVVIEGKVHPQRRQQGALDRKAAAAAGEAGAWGGDREPPAAGPRALGPPAEEPLLAANGTVPSWPTAPVPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRC"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"in isoform 11","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17565985"}],"featureId":"VSP_037563","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in isoform 11","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17565985"}],"featureId":"VSP_037564","alternativeSequence":{"originalSequence":"KKPESAAGSQSP","alternativeSequences":["MGKGRAGRVGTT"]}},{"type":"Alternative sequence","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in isoform 9 and isoform 11","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17565985"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}],"featureId":"VSP_003426","alternativeSequence":{"originalSequence":"EIITGMPASTEGAYVSSESPIRISVSTEGANTSSS","alternativeSequences":["A"]}},{"type":"Alternative sequence","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7782315"}],"featureId":"VSP_037565","alternativeSequence":{"originalSequence":"S","alternativeSequences":["MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKL"]}},{"type":"Alternative sequence","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"in isoform 8, isoform 9 and isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7782315"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}],"featureId":"VSP_003429","alternativeSequence":{"originalSequence":"QPGFTGARCTENVPMKVQNQEKAEELYQK","alternativeSequences":["PNEFTGDRCQNYVMASFYSTSTPFLSLPE"]}},{"type":"Alternative sequence","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in isoform 6 and isoform 11","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17565985"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003428","alternativeSequence":{"originalSequence":"QPGFTGARCTENVPMKVQNQEK","alternativeSequences":["PNEFTGDRCQNYVMASFYKHLGIEFME"]}},{"type":"Alternative sequence","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"in isoform 7 and isoform 12","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003427","alternativeSequence":{"originalSequence":"QPGFTGARCTENVPMKVQNQE","alternativeSequences":["PNEFTGDRCQNYVMASFY"]}},{"type":"Alternative sequence","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003432","alternativeSequence":{"originalSequence":"KAEELYQKRVLTIT","alternativeSequences":["SAQMSLLVIAAKTT"]}},{"type":"Alternative sequence","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003431","alternativeSequence":{"originalSequence":"K","alternativeSequences":["KHLGIEFIE"]}},{"type":"Alternative sequence","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"in isoform 8, isoform 9 and isoform 10","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7782315"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}],"featureId":"VSP_003430","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003433","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"in isoform 12","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_046417","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003434","alternativeSequence":{"originalSequence":"YVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVS","alternativeSequences":["HNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL"]}},{"type":"Alternative sequence","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":640,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7509448"}],"featureId":"VSP_003435","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in dbSNP:rs3924999","featureCrossReferences":[{"database":"dbSNP","id":"rs3924999"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17565985"}],"featureId":"VAR_009307","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"in dbSNP:rs10503929","featureCrossReferences":[{"database":"dbSNP","id":"rs10503929"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17565985"}],"featureId":"VAR_053531","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"","featureId":"VAR_009308","alternativeSequence":{"originalSequence":"M","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-185 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-185 and E-187.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20682778"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-187. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-187.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20682778"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Defective in integrin-binding and in inducing ERBB3 phosphorylation; when associated with or without E-181 or E-185. No effect on ERBB3-binding, defective in integrin-binding and in ternary complex formation with ERBB3 and integrins, and defective in inducing NRG1-ERBB signaling; when associated with E-181 and E-185.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20682778"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in Ref. 2; AAA19953","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in Ref. 10; ABQ53539","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"in Ref. 10; ABQ53540","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"in Ref. 2; AAA19953","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"in Ref. 2; AAA19951","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Turn","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Helix","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7SJL"}]},{"type":"Beta strand","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Turn","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Helix","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Beta strand","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HRE"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Beta strand","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HRE"}]},{"type":"Beta strand","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Beta strand","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7MN5"}]},{"type":"Beta strand","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1HAF"}]},{"type":"Natural variant","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"},"sequence":"Q02297-10"},"description":"in dbSNP:rs3735774","featureCrossReferences":[{"database":"dbSNP","id":"rs3735774"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VAR_082866","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"},"sequence":"Q02297-10"},"description":"in dbSNP:rs34822181","featureCrossReferences":[{"database":"dbSNP","id":"rs34822181"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VAR_082867","alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1350381","citationType":"journal article","authors":["Holmes W.E.","Sliwkowski M.X.","Akita R.W.","Henzel W.J.","Lee J.","Park J.W.","Yansura D.","Abadi N.","Raab H.","Lewis G.D.","Shepard H.M.","Kuang W.-J.","Wood W.I.","Goeddel D.V.","Vandlen R.L."],"citationCrossReferences":[{"database":"PubMed","id":"1350381"},{"database":"DOI","id":"10.1126/science.256.5060.1205"}],"title":"Identification of heregulin, a specific activator of p185erbB2.","publicationDate":"1992","journal":"Science","firstPage":"1205","lastPage":"1210","volume":"256"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6; 7 AND 8)","PARTIAL PROTEIN SEQUENCE"]},{"referenceNumber":2,"citation":{"id":"7509448","citationType":"journal article","authors":["Wen D.","Suggs S.V.","Karunagaran D.","Liu N.","Cupples R.L.","Luo Y.","Janssen A.M.","Ben-Baruch N.","Trollinger D.B.","Jacobsen V.L.","Meng S.-Y.","Lu H.S.","Hu S.","Chang D.","Yang W.","Yanigahara D.","Koski R.A.","Yarden Y."],"citationCrossReferences":[{"database":"PubMed","id":"7509448"},{"database":"DOI","id":"10.1128/mcb.14.3.1909-1919.1994"}],"title":"Structural and functional aspects of the multiplicity of Neu differentiation factors.","publicationDate":"1994","journal":"Mol. Cell. Biol.","firstPage":"1909","lastPage":"1919","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 6; 7 AND 8)"],"referenceComments":[{"value":"Kidney adenocarcinoma","type":"TISSUE"},{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"8096067","citationType":"journal article","authors":["Marchionni M.A.","Goodearl A.D.J.","Chen M.S.","Bermingham-McDonogh O.","Kirk C.","Hendricks M.","Danehy F.","Misumi D.","Sudhalter J.","Kobayashi K.","Wroblewski D.","Lynch C.","Baldasarre M.","Hiles I.","Davis J.B.","Hsuan J.J.","Totty N.F.","Otsu M.","McBurney R.N.","Waterfield M.D.","Stroobant P.","Gwynne D."],"citationCrossReferences":[{"database":"PubMed","id":"8096067"},{"database":"DOI","id":"10.1038/362312a0"}],"title":"Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.","publicationDate":"1993","journal":"Nature","firstPage":"312","lastPage":"318","volume":"362"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"7782315","citationType":"journal article","authors":["Ho W.-H.","Armanini M.P.","Nuijens A.","Phillips H.S.","Osheroff P.L."],"citationCrossReferences":[{"database":"PubMed","id":"7782315"},{"database":"DOI","id":"10.1074/jbc.270.24.14523"}],"title":"Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"14523","lastPage":"14532","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10)"],"referenceComments":[{"value":"Brain stem","type":"TISSUE"},{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 10 AND 12)","VARIANT THR-289"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. III","Engels R.","Gloeckner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.J.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"9333014","citationType":"journal article","authors":["Schaefer G.","Fitzpatrick V.D.","Sliwkowski M.X."],"citationCrossReferences":[{"database":"PubMed","id":"9333014"},{"database":"DOI","id":"10.1038/sj.onc.1201317"}],"title":"Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175.","publicationDate":"1997","journal":"Oncogene","firstPage":"1385","lastPage":"1394","volume":"15"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF GAMMA-HEREGULIN FUSION PROTEIN"],"referenceComments":[{"value":"Mammary cancer","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"12145742","citationType":"journal article","authors":["Stefansson H.","Sigurdsson E.","Steinthorsdottir V.","Bjornsdottir S.","Sigmundsson T.","Ghosh S.","Brynjolfsson J.","Gunnarsdottir S.","Ivarsson O.","Chou T.T.","Hjaltason O.","Birgisdottir B.","Jonsson H.","Gudnadottir V.G.","Gudmundsdottir E.","Bjornsson A.","Ingvarsson B.","Ingason A.","Sigfusson S.","Hardardottir H.","Harvey R.P.","Brunner D.","Mutel V.","Gonzalo A.","Lemke G.","Sainz J.","Johannesson G.","Andresson T.","Gudbjartsson D.","Manolescu A.","Frigge M.L.","Gurney M.E.","Kong A.","Gulcher J.R.","Petursson H.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"12145742"},{"database":"DOI","id":"10.1086/342734"}],"title":"Neuregulin 1 and susceptibility to Schizophrenia.","publicationDate":"2002","journal":"Am. J. Hum. Genet.","firstPage":"877","lastPage":"892","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 8 AND 9)","SUSCEPTIBILITY TO SCHIZOPHRENIA"]},{"referenceNumber":10,"citation":{"id":"17565985","citationType":"journal article","authors":["Tan W.","Wang Y.","Gold B.","Chen J.","Dean M.","Harrison P.J.","Weinberger D.R.","Law A.J."],"citationCrossReferences":[{"database":"PubMed","id":"17565985"},{"database":"DOI","id":"10.1074/jbc.m702953200"}],"title":"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"24343","lastPage":"24351","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11)","ALTERNATIVE SPLICING","VARIANTS GLN-38 AND THR-289","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"},{"value":"Prefrontal cortex","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 10)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Duodenum","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"CI-98UFFNDJ91HHK","citationType":"submission","authors":["Schoumacher F.","Herzer S.","Flury N.","Kueng W.","Mueller H.","Eppenberger U."],"publicationDate":"SEP-1997","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-211 (ISOFORM 1)"]},{"referenceNumber":13,"citation":{"id":"7689552","citationType":"journal article","authors":["Culouscou J.-M.","Plowman G.D.","Carlton G.W.","Green J.M.","Shoyab M."],"citationCrossReferences":[{"database":"PubMed","id":"7689552"},{"database":"DOI","id":"10.1016/s0021-9258(17)46636-1"}],"title":"Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.","publicationDate":"1993","journal":"J. Biol. Chem.","firstPage":"18407","lastPage":"18410","volume":"268"},"referencePositions":["PROTEIN SEQUENCE OF 20-28"]},{"referenceNumber":14,"citation":{"id":"1348215","citationType":"journal article","authors":["Peles E.","Bacus S.S.","Koski R.A.","Lu H.S.","Wen D.","Ogden S.G.","Levy R.B.","Yarden Y."],"citationCrossReferences":[{"database":"PubMed","id":"1348215"},{"database":"DOI","id":"10.1016/0092-8674(92)90131-u"}],"title":"Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells.","publicationDate":"1992","journal":"Cell","firstPage":"205","lastPage":"216","volume":"69"},"referencePositions":["PARTIAL PROTEIN SEQUENCE (ISOFORM 1)","FUNCTION","GLYCOSYLATION"]},{"referenceNumber":15,"citation":{"id":"7902537","citationType":"journal article","authors":["Plowman G.D.","Green J.M.","Culouscou J.M.","Carlton G.W.","Rothwell V.M.","Buckley S."],"citationCrossReferences":[{"database":"PubMed","id":"7902537"},{"database":"DOI","id":"10.1038/366473a0"}],"title":"Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.","publicationDate":"1993","journal":"Nature","firstPage":"473","lastPage":"475","volume":"366"},"referencePositions":["BINDING TO ERBB4","FUNCTION"]},{"referenceNumber":16,"citation":{"id":"10523851","citationType":"journal article","authors":["Wang X.-Z.","Jolicoeur E.M.","Conte N.","Chaffanet M.","Zhang Y.","Mozziconacci M.-J.","Feiner H.","Birnbaum D.","Pebusque M.-J.","Ron D."],"citationCrossReferences":[{"database":"PubMed","id":"10523851"},{"database":"DOI","id":"10.1038/sj.onc.1202950"}],"title":"Gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line.","publicationDate":"1999","journal":"Oncogene","firstPage":"5718","lastPage":"5721","volume":"18"},"referencePositions":["CHROMOSOMAL TRANSLOCATION"]},{"referenceNumber":17,"citation":{"id":"10597312","citationType":"journal article","authors":["Liu X.","Baker E.","Eyre H.J.","Sutherland G.R.","Zhou M."],"citationCrossReferences":[{"database":"PubMed","id":"10597312"},{"database":"DOI","id":"10.1038/sj.onc.1203136"}],"title":"Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation.","publicationDate":"1999","journal":"Oncogene","firstPage":"7110","lastPage":"7114","volume":"18"},"referencePositions":["CHROMOSOMAL TRANSLOCATION"]},{"referenceNumber":18,"citation":{"id":"10867024","citationType":"journal article","authors":["Sweeney C.","Lai C.","Riese D.J. II","Diamonti A.J.","Cantley L.C.","Carraway K.L. III"],"citationCrossReferences":[{"database":"PubMed","id":"10867024"},{"database":"DOI","id":"10.1074/jbc.c901015199"}],"title":"Ligand discrimination in signaling through an ErbB4 receptor homodimer.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"19803","lastPage":"19807","volume":"275"},"referencePositions":["BINDING TO ERBB4"]},{"referenceNumber":19,"citation":{"id":"20682778","citationType":"journal article","authors":["Ieguchi K.","Fujita M.","Ma Z.","Davari P.","Taniguchi Y.","Sekiguchi K.","Wang B.","Takada Y.K.","Takada Y."],"citationCrossReferences":[{"database":"PubMed","id":"20682778"},{"database":"DOI","id":"10.1074/jbc.m110.113878"}],"title":"Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"31388","lastPage":"31398","volume":"285"},"referencePositions":["FUNCTION","BINDING TO ERBB3 AND INTEGRINS","IDENTIFICATION IN A TERNARY COMPLEX WITH ERBB3 AND INTEGRINS","MUTAGENESIS OF LYS-181; LYS-185 AND LYS-187"]},{"referenceNumber":20,"citation":{"id":"8062828","citationType":"journal article","authors":["Nagata K.","Kohda D.","Hatanaka H.","Ichikawa S.","Matsuda S.","Yamamoto T.","Suzuki A.","Inagaki F."],"citationCrossReferences":[{"database":"PubMed","id":"8062828"},{"database":"DOI","id":"10.1002/j.1460-2075.1994.tb06658.x"}],"title":"Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.","publicationDate":"1994","journal":"EMBO J.","firstPage":"3517","lastPage":"3523","volume":"13"},"referencePositions":["STRUCTURE BY NMR OF 175-241 (ISOFORM 1)"]},{"referenceNumber":21,"citation":{"id":"8639490","citationType":"journal article","authors":["Jacobsen N.E.","Abadi N.","Sliwkowski M.X.","Reilly D.","Skelton N.J.","Fairbrother W.J."],"citationCrossReferences":[{"database":"PubMed","id":"8639490"},{"database":"DOI","id":"10.1021/bi952626l"}],"title":"High-resolution solution structure of the EGF-like domain of heregulin-alpha.","publicationDate":"1996","journal":"Biochemistry","firstPage":"3402","lastPage":"3417","volume":"35"},"referencePositions":["STRUCTURE BY NMR OF 177-239 (ISOFORM 1)","DISULFIDE BONDS"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M94165","properties":[{"key":"ProteinId","value":"AAA58638.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M94166","properties":[{"key":"ProteinId","value":"AAA58639.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M94167","properties":[{"key":"ProteinId","value":"AAA58640.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M94168","properties":[{"key":"ProteinId","value":"AAA58641.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02325","properties":[{"key":"ProteinId","value":"AAA19950.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02326","properties":[{"key":"ProteinId","value":"AAA19951.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02327","properties":[{"key":"ProteinId","value":"AAA19952.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02328","properties":[{"key":"ProteinId","value":"AAA19953.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02329","properties":[{"key":"ProteinId","value":"AAA19954.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U02330","properties":[{"key":"ProteinId","value":"AAA19955.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L12260","properties":[{"key":"ProteinId","value":"AAB59622.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L12261","properties":[{"key":"ProteinId","value":"AAB59358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L41827","properties":[{"key":"ProteinId","value":"AAC41764.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK289927","properties":[{"key":"ProteinId","value":"BAF82616.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK298132","properties":[{"key":"ProteinId","value":"BAH12729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068359","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC083977","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC103675","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113209","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF009227","properties":[{"key":"ProteinId","value":"AAC51756.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF491780","properties":[{"key":"ProteinId","value":"AAM71137.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF491780","properties":[{"key":"ProteinId","value":"AAM71139.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF491780","properties":[{"key":"ProteinId","value":"AAM71140.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EF372273","properties":[{"key":"ProteinId","value":"ABQ53539.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF372274","properties":[{"key":"ProteinId","value":"ABQ53540.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63411.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC064587","properties":[{"key":"ProteinId","value":"AAH64587.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC073871","properties":[{"key":"ProteinId","value":"AAH73871.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF026146","properties":[{"key":"ProteinId","value":"AAD01795.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00044.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00045.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00046.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS47836.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-9"},{"database":"CCDS","id":"CCDS55218.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-11"},{"database":"CCDS","id":"CCDS55219.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-12"},{"database":"CCDS","id":"CCDS6083.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-6"},{"database":"CCDS","id":"CCDS6084.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-7"},{"database":"CCDS","id":"CCDS6085.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-1"},{"database":"CCDS","id":"CCDS6086.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-3"},{"database":"CCDS","id":"CCDS6087.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-10"},{"database":"CCDS","id":"CCDS94274.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-8"},{"database":"PIR","id":"A43273","properties":[{"key":"EntryName","value":"A43273"}]},{"database":"PIR","id":"A56943","properties":[{"key":"EntryName","value":"A56943"}]},{"database":"PIR","id":"B43273","properties":[{"key":"EntryName","value":"B43273"}]},{"database":"PIR","id":"C43273","properties":[{"key":"EntryName","value":"C43273"}]},{"database":"PIR","id":"D43273","properties":[{"key":"EntryName","value":"D43273"}]},{"database":"PIR","id":"I38403","properties":[{"key":"EntryName","value":"I38403"}]},{"database":"PIR","id":"I38404","properties":[{"key":"EntryName","value":"I38404"}]},{"database":"PIR","id":"I38408","properties":[{"key":"EntryName","value":"I38408"}]},{"database":"PIR","id":"S32357","properties":[{"key":"EntryName","value":"S32357"}]},{"database":"RefSeq","id":"NP_001153467.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159995.3"}]},{"database":"RefSeq","id":"NP_001153471.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159999.3"}]},{"database":"RefSeq","id":"NP_001153473.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160001.3"}],"isoformId":"Q02297-11"},{"database":"RefSeq","id":"NP_001153477.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160005.2"}]},{"database":"RefSeq","id":"NP_001153480.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160008.2"}],"isoformId":"Q02297-12"},{"database":"RefSeq","id":"NP_001309134.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322205.2"}]},{"database":"RefSeq","id":"NP_001309135.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322206.2"}]},{"database":"RefSeq","id":"NP_001309136.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322207.2"}]},{"database":"RefSeq","id":"NP_039250.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013956.5"}],"isoformId":"Q02297-6"},{"database":"RefSeq","id":"NP_039251.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013957.5"}],"isoformId":"Q02297-7"},{"database":"RefSeq","id":"NP_039252.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013958.4"}],"isoformId":"Q02297-8"},{"database":"RefSeq","id":"NP_039253.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013959.4"}],"isoformId":"Q02297-10"},{"database":"RefSeq","id":"NP_039254.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013960.5"}],"isoformId":"Q02297-3"},{"database":"RefSeq","id":"NP_039256.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013962.3"}],"isoformId":"Q02297-9"},{"database":"RefSeq","id":"NP_039258.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013964.5"}],"isoformId":"Q02297-1"},{"database":"PDB","id":"1HAE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=177-239"}]},{"database":"PDB","id":"1HAF","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=177-239"}]},{"database":"PDB","id":"1HRE","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=175-241"}]},{"database":"PDB","id":"1HRF","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=175-241"}]},{"database":"PDB","id":"3U7U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"G/H/I/J/K/L=175-225"}]},{"database":"PDB","id":"7MN5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"H=176-237"}]},{"database":"PDB","id":"7MN6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.09 A"},{"key":"Chains","value":"H=176-237"}]},{"database":"PDB","id":"7MN8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.45 A"},{"key":"Chains","value":"H=176-237"}]},{"database":"PDB","id":"7SJL","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=34-133"}]},{"database":"PDB","id":"8U4I","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"C/D=177-225"}]},{"database":"PDB","id":"8U4L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"C=177-225"}]},{"database":"PDBsum","id":"1HAE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HAF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HRE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1HRF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3U7U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MN5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MN6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SJL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8U4I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8U4L","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41883","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41886","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109332","properties":[{"key":"Interactions","value":"112"}]},{"database":"CORUM","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-355N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q02297","properties":[{"key":"Number of interactors","value":"633"}]},{"database":"IntAct","id":"Q02297","properties":[{"key":"Interactions","value":"84"}]},{"database":"MINT","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NRG1","properties":[{"key":"Evidences","value":"14 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000287842","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q02297","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q02297","properties":[{"key":"glycosylation","value":"6 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NRG1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"9297018","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000287842","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"20533","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58070","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-1"},{"database":"ProteomicsDB","id":"58071","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-10"},{"database":"ProteomicsDB","id":"58072","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-11"},{"database":"ProteomicsDB","id":"58073","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-2"},{"database":"ProteomicsDB","id":"58074","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-3"},{"database":"ProteomicsDB","id":"58075","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-4"},{"database":"ProteomicsDB","id":"58076","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-6"},{"database":"ProteomicsDB","id":"58077","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-7"},{"database":"ProteomicsDB","id":"58078","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-8"},{"database":"ProteomicsDB","id":"58079","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-9"},{"database":"ABCD","id":"Q02297","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000287842.7","properties":[{"key":"ProteinId","value":"ENSP00000287842.4"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-6"},{"database":"Ensembl","id":"ENST00000356819.7","properties":[{"key":"ProteinId","value":"ENSP00000349275.6"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-7"},{"database":"Ensembl","id":"ENST00000405005.8","properties":[{"key":"ProteinId","value":"ENSP00000384620.2"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-1"},{"database":"Ensembl","id":"ENST00000519301.6","properties":[{"key":"ProteinId","value":"ENSP00000429582.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-11"},{"database":"Ensembl","id":"ENST00000520407.5","properties":[{"key":"ProteinId","value":"ENSP00000434640.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-9"},{"database":"Ensembl","id":"ENST00000520502.7","properties":[{"key":"ProteinId","value":"ENSP00000433289.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-10"},{"database":"Ensembl","id":"ENST00000521670.5","properties":[{"key":"ProteinId","value":"ENSP00000428828.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-3"},{"database":"Ensembl","id":"ENST00000523079.5","properties":[{"key":"ProteinId","value":"ENSP00000430120.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-12"},{"database":"Ensembl","id":"ENST00000650919.1","properties":[{"key":"ProteinId","value":"ENSP00000498811.1"},{"key":"GeneId","value":"ENSG00000157168.23"}],"isoformId":"Q02297-8"},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3084","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000405005.8","properties":[{"key":"ProteinId","value":"ENSP00000384620.2"},{"key":"RefSeqNucleotideId","value":"NM_013964.5"},{"key":"RefSeqProteinId","value":"NP_039258.1"}]},{"database":"UCSC","id":"uc003xip.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q02297-1"},{"database":"AGR","id":"HGNC:7997","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"3084","properties":[{"key":"Number of evidences","value":"1 clinical assertion and 9 evidence items across 4 molecular profiles"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NRG1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"HPA","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (liver)"}]},{"database":"MalaCards","id":"NRG1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"142445","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QRUM","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_023628_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"XKSELRI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q02297","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1227986","properties":[{"key":"PathwayName","value":"Signaling by ERBB2"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1236394","properties":[{"key":"PathwayName","value":"Signaling by ERBB4"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1250196","properties":[{"key":"PathwayName","value":"SHC1 events in ERBB2 signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1250342","properties":[{"key":"PathwayName","value":"PI3K events in ERBB4 signaling"}]},{"database":"Reactome","id":"R-HSA-1250347","properties":[{"key":"PathwayName","value":"SHC1 events in ERBB4 signaling"}]},{"database":"Reactome","id":"R-HSA-1251985","properties":[{"key":"PathwayName","value":"Nuclear signaling by ERBB4"}]},{"database":"Reactome","id":"R-HSA-1257604","properties":[{"key":"PathwayName","value":"PIP3 activates AKT signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1306955","properties":[{"key":"PathwayName","value":"GRB7 events in ERBB2 signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1358803","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2:ERBB3 signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-1963640","properties":[{"key":"PathwayName","value":"GRB2 events in ERBB2 signaling"}]},{"database":"Reactome","id":"R-HSA-1963642","properties":[{"key":"PathwayName","value":"PI3K events in ERBB2 signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-2219530","properties":[{"key":"PathwayName","value":"Constitutive Signaling by Aberrant PI3K in Cancer"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-5673001","properties":[{"key":"PathwayName","value":"RAF/MAP kinase cascade"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-6785631","properties":[{"key":"PathwayName","value":"ERBB2 Regulates Cell Motility"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-6811558","properties":[{"key":"PathwayName","value":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-8847993","properties":[{"key":"PathwayName","value":"ERBB2 Activates PTK6 Signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-8863795","properties":[{"key":"PathwayName","value":"Downregulation of ERBB2 signaling"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-9620244","properties":[{"key":"PathwayName","value":"Long-term potentiation"}]},{"database":"Reactome","id":"R-HSA-9664565","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 KD Mutants"}],"isoformId":"Q02297-10"},{"database":"Reactome","id":"R-HSA-9665686","properties":[{"key":"PathwayName","value":"Signaling by ERBB2 TMD/JMD mutants"}],"isoformId":"Q02297-10"},{"database":"SignaLink","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000157168","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Neuregulin_1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q02297","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q02297","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q02297","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q02297","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016324","properties":[{"key":"GoTerm","value":"C:apical plasma membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28822966"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16221846"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045499","properties":[{"key":"GoTerm","value":"F:chemorepellent activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10372964"}]},{"database":"GO","id":"GO:0043125","properties":[{"key":"GoTerm","value":"F:ErbB-3 class receptor binding"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20682778"}]},{"database":"GO","id":"GO:0008083","properties":[{"key":"GoTerm","value":"F:growth factor activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8096067"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20682778"}]},{"database":"GO","id":"GO:0016151","properties":[{"key":"GoTerm","value":"F:nickel cation binding"},{"key":"GoEvidenceType","value":"IPI:DisProt"}]},{"database":"GO","id":"GO:0030296","properties":[{"key":"GoTerm","value":"F:protein tyrosine kinase activator activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632177"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28822966"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0030971","properties":[{"key":"GoTerm","value":"F:receptor tyrosine kinase binding"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1348215"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}]},{"database":"GO","id":"GO:0003712","properties":[{"key":"GoTerm","value":"F:transcription coregulator activity"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15073182"}]},{"database":"GO","id":"GO:0030297","properties":[{"key":"GoTerm","value":"F:transmembrane receptor protein tyrosine kinase activator activity"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1348215"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1350381"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IPI:DisProt"}]},{"database":"GO","id":"GO:0032148","properties":[{"key":"GoTerm","value":"P:activation of protein kinase B activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20682778"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0055007","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0060379","properties":[{"key":"GoTerm","value":"P:cardiac muscle cell myoblast differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17336907"}]},{"database":"GO","id":"GO:0007154","properties":[{"key":"GoTerm","value":"P:cell communication"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17432114"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008283","properties":[{"key":"GoTerm","value":"P:cell population proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0007169","properties":[{"key":"GoTerm","value":"P:cell surface receptor protein tyrosine kinase signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0060956","properties":[{"key":"GoTerm","value":"P:endocardial cell differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17336907"}]},{"database":"GO","id":"GO:0038127","properties":[{"key":"GoTerm","value":"P:ERBB signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11389077"}]},{"database":"GO","id":"GO:0038128","properties":[{"key":"GoTerm","value":"P:ERBB2 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0038133","properties":[{"key":"GoTerm","value":"P:ERBB2-ERBB3 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0038135","properties":[{"key":"GoTerm","value":"P:ERBB2-ERBB4 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19632177"}]},{"database":"GO","id":"GO:0038129","properties":[{"key":"GoTerm","value":"P:ERBB3 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27353365"}]},{"database":"GO","id":"GO:0038130","properties":[{"key":"GoTerm","value":"P:ERBB4 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28822966"}]},{"database":"GO","id":"GO:0038138","properties":[{"key":"GoTerm","value":"P:ERBB4-ERBB4 signaling pathway"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28822966"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8702723"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030879","properties":[{"key":"GoTerm","value":"P:mammary gland development"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17432114"}]},{"database":"GO","id":"GO:0010667","properties":[{"key":"GoTerm","value":"P:negative regulation of cardiac muscle cell apoptotic process"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15073182"}]},{"database":"GO","id":"GO:2001240","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0051048","properties":[{"key":"GoTerm","value":"P:negative regulation of secretion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10559227"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17432114"}]},{"database":"GO","id":"GO:0014032","properties":[{"key":"GoTerm","value":"P:neural crest cell development"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17432114"}]},{"database":"GO","id":"GO:0007422","properties":[{"key":"GoTerm","value":"P:peripheral nervous system development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060045","properties":[{"key":"GoTerm","value":"P:positive regulation of cardiac muscle cell proliferation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0030307","properties":[{"key":"GoTerm","value":"P:positive regulation of cell growth"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20682778"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20682778"}]},{"database":"GO","id":"GO:1900086","properties":[{"key":"GoTerm","value":"P:positive regulation of peptidyl-tyrosine autophosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0031334","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10559227"}]},{"database":"GO","id":"GO:0051155","properties":[{"key":"GoTerm","value":"P:positive regulation of striated muscle cell differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0099149","properties":[{"key":"GoTerm","value":"P:regulation of postsynaptic neurotransmitter receptor internalization"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16221846"}]},{"database":"GO","id":"GO:0055012","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle cell differentiation"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}]},{"database":"GO","id":"GO:0003222","properties":[{"key":"GoTerm","value":"P:ventricular trabecula myocardium morphogenesis"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17336907"}]},{"database":"GO","id":"GO:0042060","properties":[{"key":"GoTerm","value":"P:wound healing"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16412517"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP01520","properties":[{"key":"Description","value":"-"}],"isoformId":"Q02297-10"},{"database":"DisProt","id":"DP03306","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":640,"molWeight":70392,"crc64":"C30D3F614AADFF62","md5":"F5BD6E05385EFF0AC5E1D40809B1E004"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":11,"SUBCELLULAR LOCATION":5,"ALTERNATIVE PRODUCTS":11,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":2,"PTM":2,"DISEASE":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":2,"WEB RESOURCE":1},"countByFeatureType":{"Propeptide":1,"Chain":2,"Topological domain":2,"Transmembrane":1,"Domain":2,"Region":5,"Compositional bias":5,"Site":1,"Glycosylation":3,"Disulfide bond":4,"Alternative sequence":16,"Natural variant":5,"Mutagenesis":3,"Sequence conflict":5,"Helix":3,"Beta strand":14,"Turn":2},"uniParcId":"UPI000013DED6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C114","uniProtkbId":"A0A494C114_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C114"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C114"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498833.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001153477.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160005.2"}]},{"database":"AlphaFoldDB","id":"A0A494C114","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C114","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C114","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000650967.1","properties":[{"key":"ProteinId","value":"ENSP00000498833.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C114","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE","length":207,"molWeight":22715,"crc64":"9E78DF98A10A2B5D","md5":"8994DBEAAEF7B98CD5BDABD5D987DB47"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Disulfide bond":1},"uniParcId":"UPI0000154AF1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6MW54","uniProtkbId":"A6MW54_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":94,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13842.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13842.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13842.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17565985","citationType":"journal article","authors":["Tan W.","Wang Y.","Gold B.","Chen J.","Dean M.","Harrison P.J.","Weinberger D.R.","Law A.J."],"citationCrossReferences":[{"database":"PubMed","id":"17565985"},{"database":"DOI","id":"10.1074/jbc.M702953200"}],"title":"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"24343","lastPage":"24351","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13842.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13842.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF517295","properties":[{"key":"ProteinId","value":"ABR13842.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001309134.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322205.2"}]},{"database":"AlphaFoldDB","id":"A6MW54","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6MW54","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIGKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKAFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRPREKKFDHHPQQFSSFHHN","length":454,"molWeight":50514,"crc64":"129727D7A36393FF","md5":"D0CFF31276458E1AE4D4B291927D9C34"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":4,"Compositional bias":4,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001579CEB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0FYA9","uniProtkbId":"B0FYA9_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-26","entryVersion":103,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY66350.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY66350.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY66350.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-E5UB594HL1GCO","citationType":"submission","authors":["Tan W.","Dean M.","Weinberger D.R.","Law A.J."],"publicationDate":"DEC-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY66350.1"}],"value":"Brain hippocampus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY66350.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU363510","properties":[{"key":"ProteinId","value":"ABY66350.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153476.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160004.3"}]},{"database":"AlphaFoldDB","id":"B0FYA9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B0FYA9","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL","length":458,"molWeight":50555,"crc64":"F092E3E0F16F9BBB","md5":"2E4EF17B5BD8614DDC142386D688B080"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":3,"Compositional bias":3,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI000163AC17"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C043","uniProtkbId":"A0A494C043_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":38,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C043"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C043"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498367.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A494C043","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C043","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"Ensembl","id":"ENST00000652588.1","properties":[{"key":"ProteinId","value":"ENSP00000498367.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C043","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPVTAVFWAIYWKNRVPIPYMLAASTGVCFPAGPHSPNSLTLPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER","length":461,"molWeight":50593,"crc64":"C69897A493245050","md5":"5F02521697981F47B8422FCDF00C0287"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":3,"Compositional bias":4,"Disulfide bond":1},"uniParcId":"UPI00108B8746"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C1F8","uniProtkbId":"A0A494C1F8_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":555,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C1F8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C1F8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499008.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001153467.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159995.3"}]},{"database":"AlphaFoldDB","id":"A0A494C1F8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C1F8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C1F8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000652698.1","properties":[{"key":"ProteinId","value":"ENSP00000499008.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C1F8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":607,"molWeight":67155,"crc64":"26201498D4F08462","md5":"E6B91E9F66A1643A7681260FA558196B"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":4,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI0001A47185"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B9EK51","uniProtkbId":"B9EK51_HUMAN","entryAudit":{"firstPublicDate":"2009-03-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-03-24","entryVersion":78,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI50610.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI50610.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI50610.1"}],"value":"Testicle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI50610.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC150609","properties":[{"key":"ProteinId","value":"AAI50610.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"B9EK51","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B9EK51","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPQLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCLVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":640,"molWeight":70378,"crc64":"475E165776D46E03","md5":"49B0E8797F46B7A28B083C51392BC91A"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":5,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI000192C4A3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q7RTV8","uniProtkbId":"Q7RTV8_HUMAN","entryAudit":{"firstPublicDate":"2003-12-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-12-15","entryVersion":131,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00048.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00048.1"}],"value":"NRG1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63408.1"}],"value":"hCG_14780"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63408.1"}]},{"referenceNumber":2,"citation":{"id":"12145742","citationType":"journal article","authors":["Stefansson H.","Sigurdsson E.","Steinthorsdottir V.","Bjornsdottir S.","Sigmundsson T.","Ghosh S.","Brynjolfsson J.","Gunnarsdottir S.","Ivarsson O.","Chou T.T.","Hjaltason O.","Birgisdottir B.","Jonsson H.","Gudnadottir V.G.","Gudmundsdottir E.","Bjornsson A.","Ingvarsson B.","Ingason A.","Sigfusson S.","Hardardottir H.","Harvey R.P.","Lai D.","Zhou M.","Brunner D.","Mutel V.","Gonzalo A.","Lemke G.","Sainz J.","Johannesson G.","Andresson T.","Gudbjartsson D.","Manolescu A.","Frigge M.L.","Gurney M.E.","Kong A.","Gulcher J.R.","Petursson H.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"12145742"},{"database":"DOI","id":"10.1086/342734"}],"title":"Neuregulin 1 and susceptibility to Schizophrenia.","publicationDate":"2002","journal":"Am. J. Hum. Genet.","firstPage":"877","lastPage":"892","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00048.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63408.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00048.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63408.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q7RTV8","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7RTV8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNTMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":640,"molWeight":70362,"crc64":"11AFC54B32527ACC","md5":"94A912119596F3942BB370809946FAD7"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":6,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI0000043797"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E3SFM9","uniProtkbId":"E3SFM9_HUMAN","entryAudit":{"firstPublicDate":"2011-01-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":65,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85612.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85612.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"20218976","citationType":"journal article","authors":["Shamir A.","Buonanno A."],"citationCrossReferences":[{"database":"PubMed","id":"20218976"},{"database":"DOI","id":"10.1111/j.1471-4159.2010.06677.x"}],"title":"Molecular and cellular characterization of Neuregulin-1 type IV isoforms.","publicationDate":"2010","journal":"J. Neurochem.","firstPage":"1163","lastPage":"1176","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85612.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85612.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ983557","properties":[{"key":"ProteinId","value":"ADN85612.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153467.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159995.3"}]},{"database":"RefSeq","id":"NP_001153471.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159999.3"}]},{"database":"RefSeq","id":"NP_001153473.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160001.3"}]},{"database":"RefSeq","id":"NP_001309130.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322201.2"}]},{"database":"RefSeq","id":"NP_001309131.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322202.2"}]},{"database":"AlphaFoldDB","id":"E3SFM9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E3SFM9","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHVANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":590,"molWeight":65446,"crc64":"FBC248D48892ADBD","md5":"B4819A34E21140FFCAC84AB1D82ADF52"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":4,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI0001E7A271"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q7RTW3","uniProtkbId":"Q7RTW3_HUMAN","entryAudit":{"firstPublicDate":"2003-12-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-12-15","entryVersion":141,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF83419.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63416.1"}],"value":"NRG1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63416.1"}],"value":"hCG_14780"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63416.1"}]},{"referenceNumber":2,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63416.1"}]},{"referenceNumber":3,"citation":{"id":"CI-96UCQGGE2UV0L","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Ishii S.","Watanabe K.","Sugiyama A.","Murakawa K.","Kaida T.","Tsuchiya K.","Fukuzumi Y.","Kumagai A.","Oishi Y.","Yamamoto S.","Ono Y.","Komori Y.","Yamazaki M.","Kisu Y.","Nishikawa T.","Sugano S.","Nomura N.","Isogai T."],"title":"NEDO human cDNA sequencing project.","publicationDate":"OCT-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF83419.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK290730","properties":[{"key":"ProteinId","value":"BAF83419.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63416.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_039251.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013957.5"}]},{"database":"AlphaFoldDB","id":"Q7RTW3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q7RTW3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7RTW3","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNTMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":637,"molWeight":70169,"crc64":"0B89DF6E2ED70333","md5":"420F86FF0C204EBEA1DFD5D624253888"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":6,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI0000043795"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q7RTW4","uniProtkbId":"Q7RTW4_HUMAN","entryAudit":{"firstPublicDate":"2003-12-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-12-15","entryVersion":128,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00041.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00041.1"}],"value":"NRG1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63415.1"}],"value":"hCG_14780"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63415.1"}]},{"referenceNumber":2,"citation":{"id":"12145742","citationType":"journal article","authors":["Stefansson H.","Sigurdsson E.","Steinthorsdottir V.","Bjornsdottir S.","Sigmundsson T.","Ghosh S.","Brynjolfsson J.","Gunnarsdottir S.","Ivarsson O.","Chou T.T.","Hjaltason O.","Birgisdottir B.","Jonsson H.","Gudnadottir V.G.","Gudmundsdottir E.","Bjornsson A.","Ingvarsson B.","Ingason A.","Sigfusson S.","Hardardottir H.","Harvey R.P.","Lai D.","Zhou M.","Brunner D.","Mutel V.","Gonzalo A.","Lemke G.","Sainz J.","Johannesson G.","Andresson T.","Gudbjartsson D.","Manolescu A.","Frigge M.L.","Gurney M.E.","Kong A.","Gulcher J.R.","Petursson H.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"12145742"},{"database":"DOI","id":"10.1086/342734"}],"title":"Neuregulin 1 and susceptibility to Schizophrenia.","publicationDate":"2002","journal":"Am. J. Hum. Genet.","firstPage":"877","lastPage":"892","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00041.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63415.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00041.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63415.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q7RTW4","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7RTW4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNTMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":645,"molWeight":71127,"crc64":"04B7AFF528CDD628","md5":"B2FB55379C156E815E5705E862D374D0"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":6,"Compositional bias":5,"Disulfide bond":1},"uniParcId":"UPI0000043794"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6MW55","uniProtkbId":"A6MW55_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":106,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13843.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13843.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":498,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13843.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17565985","citationType":"journal article","authors":["Tan W.","Wang Y.","Gold B.","Chen J.","Dean M.","Harrison P.J.","Weinberger D.R.","Law A.J."],"citationCrossReferences":[{"database":"PubMed","id":"17565985"},{"database":"DOI","id":"10.1074/jbc.M702953200"}],"title":"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"24343","lastPage":"24351","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13843.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13843.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF517296","properties":[{"key":"ProteinId","value":"ABR13843.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153471.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159999.3"}]},{"database":"AlphaFoldDB","id":"A6MW55","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6MW55","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPQLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKDKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYASKNVISSEHIVEREAETPFSTSHYTSTAHHSTTVTQTPSHSWSNEHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPA","length":498,"molWeight":55035,"crc64":"90574C187B0C5E7C","md5":"2F434949899A308F8F4D18272049EDFF"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":4,"Compositional bias":3,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001579CEC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6MW56","uniProtkbId":"A6MW56_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":103,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13844.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13844.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13844.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17565985","citationType":"journal article","authors":["Tan W.","Wang Y.","Gold B.","Chen J.","Dean M.","Harrison P.J.","Weinberger D.R.","Law A.J."],"citationCrossReferences":[{"database":"PubMed","id":"17565985"},{"database":"DOI","id":"10.1074/jbc.M702953200"}],"title":"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.","publicationDate":"2007","journal":"J. Biol. Chem.","firstPage":"24343","lastPage":"24351","volume":"282"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13844.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR13844.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF517297","properties":[{"key":"ProteinId","value":"ABR13844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153467.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159995.3"}]},{"database":"AlphaFoldDB","id":"A6MW56","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6MW56","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSAASTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSPRSERNNTMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFPTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSYLRHARETPDSYRDSPHSERYVSVMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPA","length":481,"molWeight":53253,"crc64":"0E5B8B7386B8A340","md5":"47A56351107B8225E7FA914B99141B4D"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":5,"Compositional bias":5,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001579CED"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YBA3","uniProtkbId":"H0YBA3_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":88,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":597,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YBA3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YBA3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000429067.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0YBA3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YBA3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YBA3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"36654","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"Ensembl","id":"ENST00000523534.5","properties":[{"key":"ProteinId","value":"ENSP00000429067.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"UCSC","id":"uc064lum.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_023628_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"H0YBA3","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YBA3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"InterPro","id":"IPR057909","properties":[{"key":"EntryName","value":"NRG2_N"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25518","properties":[{"key":"EntryName","value":"NRG2_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VPSAGEPGEEAPYLVKVHQVWAVKAGGLKKDSLLTVRLGTWGHPAFPSCGRLKEDSRYIFFMEPDANSTSRAPAAFRASFPPLETGRNLKKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":713,"molWeight":78813,"crc64":"3CCC19092D751166","md5":"26FE8DC598CFD8341439BB6638FD8AA8"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":4,"Compositional bias":5,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001E8F0FD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C0K4","uniProtkbId":"A0A494C0K4_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C0K4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C0K4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498583.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001153476.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160004.3"}]},{"database":"AlphaFoldDB","id":"A0A494C0K4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C0K4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C0K4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000650980.1","properties":[{"key":"ProteinId","value":"ENSP00000498583.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C0K4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL","length":459,"molWeight":50686,"crc64":"0BB05971ECB36CC0","md5":"39873EF3DEC8EA1B4CAAD006ADC4673C"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":3,"Compositional bias":3,"Disulfide bond":1},"uniParcId":"UPI0001A47183"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C1F5","uniProtkbId":"A0A494C1F5_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C1F5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C1F5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000499045.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001153471.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159999.3"}]},{"database":"AlphaFoldDB","id":"A0A494C1F5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C1F5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C1F5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000650866.1","properties":[{"key":"ProteinId","value":"ENSP00000499045.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C1F5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00053","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":624,"molWeight":68888,"crc64":"0AA7C095D1B3BC39","md5":"86E6F77843917008E347B1D06619D441"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":2,"Region":5,"Compositional bias":5,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001A47188"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6PK61","uniProtkbId":"Q6PK61_HUMAN","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":122,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH06492.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH06492.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6PK61","intActId":"EBI-25938844"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH06492.1"}],"value":"Ovary","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH06492.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC006492","properties":[{"key":"ProteinId","value":"AAH06492.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153480.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160008.2"}]},{"database":"RefSeq","id":"NP_039250.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013956.5"}]},{"database":"RefSeq","id":"NP_039251.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013957.5"}]},{"database":"RefSeq","id":"NP_039254.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013960.5"}]},{"database":"RefSeq","id":"NP_039258.1","properties":[{"key":"NucleotideSequenceId","value":"NM_013964.5"}]},{"database":"AlphaFoldDB","id":"Q6PK61","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6PK61","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q6PK61","properties":[{"key":"Interactions","value":"1"}]},{"database":"PeptideAtlas","id":"Q6PK61","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3084","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31776","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPQLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE","length":241,"molWeight":26114,"crc64":"FE8B9FDF71B816B1","md5":"75CD79D0E7CF6D38EEFD0F5A0EA00572"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Disulfide bond":1},"uniParcId":"UPI0000146086"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C0Q4","uniProtkbId":"A0A494C0Q4_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"}],"value":"NRG1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":584,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C0Q4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C0Q4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498646.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001309134.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322205.2"}]},{"database":"AlphaFoldDB","id":"A0A494C0Q4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C0Q4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C0Q4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000652592.1","properties":[{"key":"ProteinId","value":"ENSP00000498646.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C0Q4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV","length":700,"molWeight":76700,"crc64":"BBC65054BC493626","md5":"A491E15565A282EAB4A2CE8A3D3625B1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":2,"Domain":1,"Region":6,"Compositional bias":7,"Disulfide bond":1},"uniParcId":"UPI000387CD08"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C1B5","uniProtkbId":"A0A494C1B5_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":39,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"}],"value":"NRG1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":447,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C1B5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C1B5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498946.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001309136.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001322207.2"}]},{"database":"AlphaFoldDB","id":"A0A494C1B5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C1B5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A494C1B5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000650819.1","properties":[{"key":"ProteinId","value":"ENSP00000498946.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A494C1B5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRTPGLVGLAVPCCACLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVDKIFEYDSPTHLDPGGLGQDPIISLDATAASAVWVSSEAYTSPVSRAQSESEVQVTVQGDKAVVSFEPSAAPTPKNRIFAFSFLPSTAPSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSER","length":483,"molWeight":52726,"crc64":"D768F4D2616C1A05","md5":"B500D3007C3D4A1670582CA0878C751E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":2,"Domain":1,"Region":4,"Compositional bias":6,"Disulfide bond":1},"uniParcId":"UPI0007A0A97E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E5RHQ1","uniProtkbId":"E5RHQ1_HUMAN","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-02-08","entryVersion":88,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"}],"value":"Neuregulin 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"}],"value":"NRG1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Disulfide bond","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E5RHQ1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E5RHQ1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000428546.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E5RHQ1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E5RHQ1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E5RHQ1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"16051","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"Ensembl","id":"ENST00000518084.5","properties":[{"key":"ProteinId","value":"ENSP00000428546.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"UCSC","id":"uc064lux.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E5RHQ1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGIC","length":101,"molWeight":11412,"crc64":"AAED5B1C2919F332","md5":"A3C09CFD4AA91D024ADD72F8417152F8"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI00000437AB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YCP0","uniProtkbId":"H0YCP0_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":78,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"}],"value":"Neuregulin 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"}],"value":"NRG1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YCP0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YCP0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432052.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"H0YCP0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"37127","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"Ensembl","id":"ENST00000518206.5","properties":[{"key":"ProteinId","value":"ENSP00000432052.1"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"UCSC","id":"uc064luu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1997724_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YCP0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQESAQMSLLVIAAKTT","length":126,"molWeight":13248,"crc64":"CB7895CE753D0CD5","md5":"3932AE1AD59DADA534997DDFF3E0BBCA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0001F77D13"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A024QY88","uniProtkbId":"A0A024QY88_HUMAN","entryAudit":{"firstPublicDate":"2014-07-09","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-07-09","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00043.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00043.1"}],"value":"NRG1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63413.1"}],"value":"hCG_14780"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63413.1"}]},{"referenceNumber":2,"citation":{"id":"12145742","citationType":"journal article","authors":["Stefansson H.","Sigurdsson E.","Steinthorsdottir V.","Bjornsdottir S.","Sigmundsson T.","Ghosh S.","Brynjolfsson J.","Gunnarsdottir S.","Ivarsson O.","Chou T.T.","Hjaltason O.","Birgisdottir B.","Jonsson H.","Gudnadottir V.G.","Gudmundsdottir E.","Bjornsson A.","Ingvarsson B.","Ingason A.","Sigfusson S.","Hardardottir H.","Harvey R.P.","Lai D.","Zhou M.","Brunner D.","Mutel V.","Gonzalo A.","Lemke G.","Sainz J.","Johannesson G.","Andresson T.","Gudbjartsson D.","Manolescu A.","Frigge M.L.","Gurney M.E.","Kong A.","Gulcher J.R.","Petursson H.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"12145742"},{"database":"DOI","id":"10.1086/342734"}],"title":"Neuregulin 1 and susceptibility to Schizophrenia.","publicationDate":"2002","journal":"Am. J. Hum. Genet.","firstPage":"877","lastPage":"892","volume":"71"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"DAA00043.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW63413.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BK000383","properties":[{"key":"ProteinId","value":"DAA00043.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471080","properties":[{"key":"ProteinId","value":"EAW63413.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_039252.2","properties":[{"key":"NucleotideSequenceId","value":"NM_013958.4"}]},{"database":"AlphaFoldDB","id":"A0A024QY88","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A024QY88","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ExpressionAtlas","id":"A0A024QY88","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE","length":241,"molWeight":26143,"crc64":"D2450DB340E6B64D","md5":"32B66E8B62F0BD811016DA1638E63751"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Disulfide bond":1},"uniParcId":"UPI0000043799"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0FWZ3","uniProtkbId":"B0FWZ3_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-02-26","entryVersion":92,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY70644.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY70644.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY70644.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-E5UB594HL1GCO","citationType":"submission","authors":["Tan W.","Dean M.","Weinberger D.R.","Law A.J."],"publicationDate":"DEC-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY70644.1"}],"value":"Brain hippocampus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABY70644.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU359055","properties":[{"key":"ProteinId","value":"ABY70644.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001153477.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160005.2"}]},{"database":"AlphaFoldDB","id":"B0FWZ3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B0FWZ3","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3084","properties":[{"key":"hits","value":"12 hits in 1160 CRISPR screens"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE","length":206,"molWeight":22584,"crc64":"A564911EBD44BBBA","md5":"E415C416F4D017D62C2DE2F68CC0FCCE"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI000163E5FE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E3SFN0","uniProtkbId":"E3SFN0_HUMAN","entryAudit":{"firstPublicDate":"2011-01-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":57,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85613.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85613.1"}],"value":"NRG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062162"}],"value":"The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"20218976","citationType":"journal article","authors":["Shamir A.","Buonanno A."],"citationCrossReferences":[{"database":"PubMed","id":"20218976"},{"database":"DOI","id":"10.1111/j.1471-4159.2010.06677.x"}],"title":"Molecular and cellular characterization of Neuregulin-1 type IV isoforms.","publicationDate":"2010","journal":"J. Neurochem.","firstPage":"1163","lastPage":"1176","volume":"113"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85613.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADN85613.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ983558","properties":[{"key":"ProteinId","value":"ADN85613.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"E3SFN0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E3SFN0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"E3SFN0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051094","properties":[{"key":"GoTerm","value":"P:positive regulation of developmental process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010646","properties":[{"key":"GoTerm","value":"P:regulation of cell communication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05895","properties":[{"key":"EntryName","value":"Ig_Pro_neuregulin-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000263","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR013098","properties":[{"key":"EntryName","value":"Ig_I-set"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07679","properties":[{"key":"EntryName","value":"I-set"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKGRAGRVGTTALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE","length":186,"molWeight":20446,"crc64":"F2A2310D2C5FC3A4","md5":"259B34DAD012245F5EAD935C45EB324E"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":1,"Disulfide bond":1},"uniParcId":"UPI0001E7A272"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E5RHP6","uniProtkbId":"E5RHP6_HUMAN","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-09-13","entryVersion":92,"sequenceVersion":9},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034341"}],"value":"Pro-neuregulin-1, membrane-bound isoform"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"}],"value":"NRG1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008216"}],"value":"Belongs to the neuregulin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Region","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023030"}],"id":"KW-0339","category":"Molecular function","name":"Growth factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023319"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E5RHP6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E5RHP6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000430862.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC021909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022833","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC022850","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC023948","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC068931","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104000","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC104029","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458727","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF458729","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001153468.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001159996.3"}]},{"database":"AlphaFoldDB","id":"E5RHP6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E5RHP6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E5RHP6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"16047","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3706","properties":[{"key":"antibodies","value":"991 antibodies from 45 providers"}]},{"database":"Ensembl","id":"ENST00000522402.6","properties":[{"key":"ProteinId","value":"ENSP00000430862.2"},{"key":"GeneId","value":"ENSG00000157168.23"}]},{"database":"GeneID","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc064luy.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"3084","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7997","properties":[{"key":"GeneName","value":"NRG1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000157168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157326","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_161071_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"8747558at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NRG1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000157168","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 142 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E5RHP6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000073","properties":[{"key":"EntryName","value":"Pro-neuregulin-1, membrane-bound isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR040180","properties":[{"key":"EntryName","value":"Neuregulin"}]},{"database":"InterPro","id":"IPR002154","properties":[{"key":"EntryName","value":"Neuregulin_C"}]},{"database":"InterPro","id":"IPR018250","properties":[{"key":"EntryName","value":"NRG1"}]},{"database":"PANTHER","id":"PTHR11100","properties":[{"key":"EntryName","value":"HEREGULIN-NEUREGULIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11100:SF7","properties":[{"key":"EntryName","value":"PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02158","properties":[{"key":"EntryName","value":"Neuregulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01089","properties":[{"key":"EntryName","value":"NEUREGULIN"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL","length":308,"molWeight":34404,"crc64":"915B562729A4339C","md5":"939430AFDB2C7C25B943FE15BB4DDFA4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Region":2,"Compositional bias":3,"Disulfide bond":1},"uniParcId":"UPI0001A47186"}}]}