{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8WTW4","secondaryAccessions":["A8K831","Q6FGS2","Q9Y249","Q9Y497"],"uniProtkbId":"NPRL2_HUMAN","entryAudit":{"firstPublicDate":"2004-05-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-05-10","entryVersion":173,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"GATOR1 complex protein NPRL2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"value":"Gene 21 protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"value":"G21 protein"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11085536"}],"value":"Nitrogen permease regulator 2-like protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11085536"}],"value":"NPR2-like protein"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18616680"}],"value":"Tumor suppressor candidate 4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18616680"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:24969"}],"value":"NPRL2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18616680"}],"value":"TUSC4"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23723238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27173016"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38006878"}],"value":"Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway (PubMed:23723238, PubMed:29590090, PubMed:35338845, PubMed:38006878). In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (PubMed:23723238, PubMed:29590090, PubMed:35338845). In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2 (PubMed:23723238, PubMed:36528027). Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GTPase activator activity and under methionine-sufficient conditions, the GTPase activator activity is inhibited by PRMT1 through methylation and consequently inducing timely mTORC1 activation (PubMed:27173016, PubMed:30651352, PubMed:35338845)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18616680"}],"value":"Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling (PubMed:18616680). Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues (PubMed:18616680). May act as a tumor suppressor (PubMed:18616680). Suppresses cell growth and enhances sensitivity to various anticancer drugs (PubMed:18616680)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18616680"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19521502"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23723238"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36007018"}],"value":"Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3 (PubMed:19521502, PubMed:23723238, PubMed:29590090, PubMed:35338845). GATOR1 mediates the strong interaction of the GATOR complex with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) heterodimers (PubMed:23723238, PubMed:29590090). GATOR1 interacts with GPR155/LYCHOS; interaction takes place in presence of cholesterol and prevents interaction between GATOR1 and KICSTOR (PubMed:36007018). Interacts with PDPK1 (PubMed:18616680)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8WTW4","intActId":"EBI-1043552"},"interactantTwo":{"uniProtKBAccession":"Q12980","geneName":"NPRL3","intActId":"EBI-2650314"},"numberOfExperiments":10,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28199306"}],"value":"Localization to lysosomes is mediated by the KICSTOR complex and is amino acid-independent"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28199306"}],"value":"Lysosome membrane","id":"SL-0157"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8WTW4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8WTW4-2"],"sequenceIds":["VSP_010329","VSP_010330","VSP_010331"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26505888"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27173016"}],"value":"Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:26505888, PubMed:27173016). Expressed in most lung cancer cell lines tested"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"value":"The arginine finger is critical for the GTPase-activating mechanism"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}],"value":"In the presence of abundant amino acids, ubiquitinated at Lys-158 and Lys-357 via 'Lys-6'-linked ubiquitination by the WDR24 component of the GATOR2 complex, thereby inhibiting the GATOR1 complex and promoting mTORC1 activation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38006878"}],"value":"Asymmetric dimethylation at Arg-78 by PRMT1 inhibits the GTPase activator activity of the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23723238"}],"value":"Inactivating mutations and truncating deletions in the genes encoding GATOR1 proteins, including NPRL2, are detected in glioblastoma and ovarian tumors and are associated with loss of heterozygosity events. Inactivation of GATOR1 proteins promotes constitutive localization of mTORC1 to the lysosomal membrane and blocks mTORC1 inactivation following amino acid withdrawal (PubMed:23723238)"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epilepsy, familial focal, with variable foci 2","diseaseAccession":"DI-04832","acronym":"FFEVF2","description":"An autosomal dominant form of epilepsy characterized by focal seizures arising from different cortical regions, including the temporal, frontal, parietal, and occipital lobes. Seizure types commonly include temporal lobe epilepsy, frontal lobe epilepsy, and nocturnal frontal lobe epilepsy. Some patients may have intellectual disability or autism spectrum disorders. Seizure onset usually occurs in the first or second decades, although later onset has been reported, and there is phenotypic variability within families. A subset of patients have structural brain abnormalities. Penetrance of the disorder is incomplete.","diseaseCrossReference":{"database":"MIM","id":"617116"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26505888"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27173016"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"GATOR1 complex protein NPRL2","featureId":"PRO_0000213319"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Interaction with PDPK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18616680"}]},{"type":"Binding site","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58189"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338845"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T3C"}],"ligand":{"name":"GDP","id":"ChEBI:CHEBI:58189"}},{"type":"Site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Arginine finger","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}]},{"type":"Modified residue","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38006878"}]},{"type":"Cross-link","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}]},{"type":"Cross-link","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_010329","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_010330","alternativeSequence":{"originalSequence":"KLIQFGLMKNLI","alternativeSequences":["SEENLLGHLGVT"]}},{"type":"Alternative sequence","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_010331","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in FFEVF2; dbSNP:rs886037965","featureCrossReferences":[{"database":"dbSNP","id":"rs886037965"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26505888"}],"featureId":"VAR_077122","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"in FFEVF2; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26505888"}],"featureId":"VAR_077123","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"in FFEVF2; uncertain significance; dbSNP:rs745518585","featureCrossReferences":[{"database":"dbSNP","id":"rs745518585"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27173016"}],"featureId":"VAR_077124","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in FFEVF2; uncertain significance; dbSNP:rs149128231","featureCrossReferences":[{"database":"dbSNP","id":"rs149128231"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26505888"}],"featureId":"VAR_077125","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"In RL1 mutant; abolished ability of the GATOR1 complex to inhibit mTORC1 signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"PTLGP","alternativeSequences":["GSGSG"]}},{"type":"Mutagenesis","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Abolished GTPase activating protein activity toward RagA/RRAGA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Abolished GTPase activating protein activity toward RagA/RRAGA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35338845"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"In RL2 mutant; does not affect ability of the GATOR1 complex to inhibit mTORC1 signaling.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"SFVSM","alternativeSequences":["GSGSG"]}},{"type":"Mutagenesis","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Decreased ubiquitination by the GATOR2 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Does not affect ubiquitination by the GATOR2 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Decreased ubiquitination by the GATOR2 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36528027"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Does not affect the GTPase activating protein activity of the GATOR1 complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30651352"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"in Ref. 6; AAH21984","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Beta strand","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Turn","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Turn","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FW5"}]},{"type":"Helix","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FW5"}]},{"type":"Turn","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Turn","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Turn","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FW5"}]},{"type":"Beta strand","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9O5A"}]},{"type":"Beta strand","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9O5A"}]},{"type":"Helix","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Helix","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Turn","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9V0J"}]},{"type":"Beta strand","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FW5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0887","category":"Disease","name":"Epilepsy"},{"id":"KW-0343","category":"Molecular function","name":"GTPase activation"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0043","category":"Disease","name":"Tumor suppressor"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-3CM8FML5R37O3","citationType":"submission","authors":["Kondo M.","Sekido Y.","Latif F.","Cundiff S.","Duh F.-M.","Wei M.-H.","Lerman M.I.","Minna J.D."],"title":"Gene 21, a new candidate human tumor suppressor gene located in the 3p21.3 small cell lung cancer homozygous deletion region homologous to the yeast nitrogen permease regulator NPR2.","publicationDate":"OCT-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":4,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"11085536","citationType":"journal article","authoringGroup":["The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium"],"authors":["Lerman M.I.","Minna J.D."],"citationCrossReferences":[{"database":"PubMed","id":"11085536"}],"title":"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.","publicationDate":"2000","journal":"Cancer Res.","firstPage":"6116","lastPage":"6133","volume":"60"},"referencePositions":["DISCUSSION OF SEQUENCE"]},{"referenceNumber":8,"citation":{"id":"11980673","citationType":"journal article","authors":["Ji L.","Nishizaki M.","Gao B.","Burbee D.","Kondo M.","Kamibayashi C.","Xu K.","Yen N.","Atkinson E.N.","Fang B.","Lerman M.I.","Roth J.A.","Minna J.D."],"citationCrossReferences":[{"database":"PubMed","id":"11980673"}],"title":"Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.","publicationDate":"2002","journal":"Cancer Res.","firstPage":"2715","lastPage":"2720","volume":"62"},"referencePositions":["DISCUSSION OF SEQUENCE"]},{"referenceNumber":9,"citation":{"id":"18616680","citationType":"journal article","authors":["Kurata A.","Katayama R.","Watanabe T.","Tsuruo T.","Fujita N."],"citationCrossReferences":[{"database":"PubMed","id":"18616680"},{"database":"DOI","id":"10.1111/j.1349-7006.2008.00874.x"}],"title":"TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.","publicationDate":"2008","journal":"Cancer Sci.","firstPage":"1827","lastPage":"1834","volume":"99"},"referencePositions":["FUNCTION","INTERACTION WITH PDPK1"]},{"referenceNumber":10,"citation":{"id":"19521502","citationType":"journal article","authors":["Neklesa T.K.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"19521502"},{"database":"DOI","id":"10.1371/journal.pgen.1000515"}],"title":"A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.","publicationDate":"2009","journal":"PLoS Genet.","firstPage":"E1000515","lastPage":"E1000515","volume":"5"},"referencePositions":["INTERACTION WITH NPRL3"]},{"referenceNumber":11,"citation":{"id":"23723238","citationType":"journal article","authors":["Bar-Peled L.","Chantranupong L.","Cherniack A.D.","Chen W.W.","Ottina K.A.","Grabiner B.C.","Spear E.D.","Carter S.L.","Meyerson M.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"23723238"},{"database":"DOI","id":"10.1126/science.1232044"}],"title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.","publicationDate":"2013","journal":"Science","firstPage":"1100","lastPage":"1106","volume":"340"},"referencePositions":["FUNCTION","IDENTIFICATION IN GATOR COMPLEX","INTERACTION WITH RRAG PROTEINS"]},{"referenceNumber":12,"citation":{"id":"28199306","citationType":"journal article","authors":["Wolfson R.L.","Chantranupong L.","Wyant G.A.","Gu X.","Orozco J.M.","Shen K.","Condon K.J.","Petri S.","Kedir J.","Scaria S.M.","Abu-Remaileh M.","Frankel W.N.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"28199306"},{"database":"DOI","id":"10.1038/nature21423"}],"title":"KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.","publicationDate":"2017","journal":"Nature","firstPage":"438","lastPage":"442","volume":"543"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"30651352","citationType":"journal article","authors":["Shen K.","Valenstein M.L.","Gu X.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"30651352"},{"database":"DOI","id":"10.1074/jbc.ac119.007382"}],"title":"Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.","publicationDate":"2019","journal":"J. Biol. Chem.","firstPage":"2970","lastPage":"2975","volume":"294"},"referencePositions":["FUNCTION","ARGININE FINGER","DOMAIN","MUTAGENESIS OF 17-PRO--PRO-21; GLY-20; ARG-78; 117-SER--MET-121; ARG-279; ARG-295; ARG-300; ARG-311; ARG-324; ARG-343 AND ARG-368"]},{"referenceNumber":14,"citation":{"id":"36007018","citationType":"journal article","authors":["Shin H.R.","Citron Y.R.","Wang L.","Tribouillard L.","Goul C.S.","Stipp R.","Sugasawa Y.","Jain A.","Samson N.","Lim C.Y.","Davis O.B.","Castaneda-Carpio D.","Qian M.","Nomura D.K.","Perera R.M.","Park E.","Covey D.F.","Laplante M.","Evers A.S.","Zoncu R."],"citationCrossReferences":[{"database":"PubMed","id":"36007018"},{"database":"DOI","id":"10.1126/science.abg6621"}],"title":"Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.","publicationDate":"2022","journal":"Science","firstPage":"1290","lastPage":"1298","volume":"377"},"referencePositions":["INTERACTION WITH GPR155"]},{"referenceNumber":15,"citation":{"id":"36528027","citationType":"journal article","authors":["Jiang C.","Dai X.","He S.","Zhou H.","Fang L.","Guo J.","Liu S.","Zhang T.","Pan W.","Yu H.","Fu T.","Li D.","Inuzuka H.","Wang P.","Xiao J.","Wei W."],"citationCrossReferences":[{"database":"PubMed","id":"36528027"},{"database":"DOI","id":"10.1016/j.molcel.2022.11.021"}],"title":"Ring domains are essential for GATOR2-dependent mTORC1 activation.","publicationDate":"2023","journal":"Mol. Cell","firstPage":"74","lastPage":"89","volume":"83"},"referencePositions":["FUNCTION","UBIQUITINATION AT LYS-158 AND LYS-357","MUTAGENESIS OF LYS-158; LYS-328 AND LYS-357"]},{"referenceNumber":16,"citation":{"id":"38006878","citationType":"journal article","authors":["Jiang C.","Liu J.","He S.","Xu W.","Huang R.","Pan W.","Li X.","Dai X.","Guo J.","Zhang T.","Inuzuka H.","Wang P.","Asara J.M.","Xiao J.","Wei W."],"citationCrossReferences":[{"database":"PubMed","id":"38006878"},{"database":"DOI","id":"10.1016/j.cmet.2023.11.001"}],"title":"PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.","publicationDate":"2023","journal":"Cell Metab.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","METHYLATION AT ARG-78"]},{"referenceNumber":17,"citation":{"id":"29590090","citationType":"journal article","authors":["Shen K.","Huang R.K.","Brignole E.J.","Condon K.J.","Valenstein M.L.","Chantranupong L.","Bomaliyamu A.","Choe A.","Hong C.","Yu Z.","Sabatini D.M."],"citationCrossReferences":[{"database":"PubMed","id":"29590090"},{"database":"DOI","id":"10.1038/nature26158"}],"title":"Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.","publicationDate":"2018","journal":"Nature","firstPage":"64","lastPage":"69","volume":"556"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY IN COMPLEX WITH RRAGA; RRAGC; DEPDC5 AND NPRL3","FUNCTION","IDENTIFICATION IN GATOR1 COMPLEX"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CES"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CET"}]},{"referenceNumber":18,"citation":{"id":"35338845","citationType":"journal article","authors":["Egri S.B.","Ouch C.","Chou H.T.","Yu Z.","Song K.","Xu C.","Shen K."],"citationCrossReferences":[{"database":"PubMed","id":"35338845"},{"database":"DOI","id":"10.1016/j.molcel.2022.03.002"}],"title":"Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"1836","lastPage":"1849","volume":"82"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY IN COMPLEX WITH RRAGA; RRAGC; DEPDC5; NPRL3; LAMTOR1; LAMTOR2; LAMTOR3; LAMTOR4 AND LAMTOR5","FUNCTION","IDENTIFICATION IN GATOR1 COMPLEX","MUTAGENESIS OF ARG-78"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T3A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T3B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7T3C"}]},{"referenceNumber":19,"citation":{"id":"26505888","citationType":"journal article","authoringGroup":["Epilepsy Electroclinical Study Group"],"authors":["Ricos M.G.","Hodgson B.L.","Pippucci T.","Saidin A.","Ong Y.S.","Heron S.E.","Licchetta L.","Bisulli F.","Bayly M.A.","Hughes J.","Baldassari S.","Palombo F.","Santucci M.","Meletti S.","Berkovic S.F.","Rubboli G.","Thomas P.Q.","Scheffer I.E.","Tinuper P.","Geoghegan J.","Schreiber A.W.","Dibbens L.M."],"citationCrossReferences":[{"database":"PubMed","id":"26505888"},{"database":"DOI","id":"10.1002/ana.24547"}],"title":"Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.","publicationDate":"2016","journal":"Ann. Neurol.","firstPage":"120","lastPage":"131","volume":"79"},"referencePositions":["INVOLVEMENT IN FFEVF2","VARIANTS FFEVF2 PRO-105; SER-110 AND HIS-214","TISSUE SPECIFICITY"]},{"referenceNumber":20,"citation":{"id":"27173016","citationType":"journal article","authors":["Weckhuysen S.","Marsan E.","Lambrecq V.","Marchal C.","Morin-Brureau M.","An-Gourfinkel I.","Baulac M.","Fohlen M.","Kallay Zetchi C.","Seeck M.","de la Grange P.","Dermaut B.","Meurs A.","Thomas P.","Chassoux F.","Leguern E.","Picard F.","Baulac S."],"citationCrossReferences":[{"database":"PubMed","id":"27173016"},{"database":"DOI","id":"10.1111/epi.13391"}],"title":"Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.","publicationDate":"2016","journal":"Epilepsia","firstPage":"994","lastPage":"1003","volume":"57"},"referencePositions":["INVOLVEMENT IN FFEVF2","VARIANT FFEVF2 HIS-198","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF040707","properties":[{"key":"ProteinId","value":"AAC62535.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF040708","properties":[{"key":"ProteinId","value":"AAC62536.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292196","properties":[{"key":"ProteinId","value":"BAF84885.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR542035","properties":[{"key":"ProteinId","value":"CAG46832.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"AAB67310.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW65106.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471055","properties":[{"key":"ProteinId","value":"EAW65107.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC021984","properties":[{"key":"ProteinId","value":"AAH21984.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC056861","properties":[{"key":"ProteinId","value":"AAH56861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2826.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WTW4-1"},{"database":"RefSeq","id":"NP_006536.3","properties":[{"key":"NucleotideSequenceId","value":"NM_006545.5"}],"isoformId":"Q8WTW4-1"},{"database":"PDB","id":"6CES","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"N=1-380"}]},{"database":"PDB","id":"6CET","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.40 A"},{"key":"Chains","value":"N=1-380"}]},{"database":"PDB","id":"7T3A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"B=1-380"}]},{"database":"PDB","id":"7T3B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"B=1-380"}]},{"database":"PDB","id":"7T3C","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"B=1-380"}]},{"database":"PDB","id":"8FW5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.08 A"},{"key":"Chains","value":"B=1-380"}]},{"database":"PDB","id":"9O5A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"H=1-380"}]},{"database":"PDB","id":"9O5D","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.34 A"},{"key":"Chains","value":"D=1-380"}]},{"database":"PDB","id":"9O5E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"5.00 A"},{"key":"Chains","value":"D/G=1-380"}]},{"database":"PDB","id":"9V0J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"A=1-380"}]},{"database":"AlphaFoldDB","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25652","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25653","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25654","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29497","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64665","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70135","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70140","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-70141","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7464","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7465","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115885","properties":[{"key":"Interactions","value":"138"}]},{"database":"ComplexPortal","id":"CPX-6226","properties":[{"key":"EntryName","value":"GATOR1 complex"}]},{"database":"CORUM","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-50746N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8WTW4","properties":[{"key":"Number of interactors","value":"552"}]},{"database":"IntAct","id":"Q8WTW4","properties":[{"key":"Interactions","value":"57"}]},{"database":"NDEx","id":"IQUERY-CP-NPRL2","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000232501","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NPRL2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"47117604","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000232501","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"74610","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WTW4-1"},{"database":"ProteomicsDB","id":"74611","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8WTW4-2"},{"database":"Pumba","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"30939","properties":[{"key":"antibodies","value":"324 antibodies from 36 providers"}]},{"database":"DNASU","id":"10641","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000232501.8","properties":[{"key":"ProteinId","value":"ENSP00000232501.3"},{"key":"GeneId","value":"ENSG00000114388.15"}],"isoformId":"Q8WTW4-1"},{"database":"GeneID","id":"10641","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10641","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000232501.8","properties":[{"key":"ProteinId","value":"ENSP00000232501.3"},{"key":"RefSeqNucleotideId","value":"NM_006545.5"},{"key":"RefSeqProteinId","value":"NP_006536.3"}]},{"database":"UCSC","id":"uc003daj.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8WTW4-1"},{"database":"AGR","id":"HGNC:24969","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA165697981","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10641","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10641","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NPRL2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"NPRL2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"HPA","id":"ENSG00000114388","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"NPRL2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"607072","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"617116","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"98820","properties":[{"key":"Disease","value":"Familial focal epilepsy with variable foci"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3789","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_014995_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAKDHRM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"338854at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8WTW4","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9639288","properties":[{"key":"PathwayName","value":"Amino acids regulate mTORC1"}]},{"database":"SignaLink","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000114388","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10641","properties":[{"key":"hits","value":"48 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"NPRL2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"TUSC4","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10641","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8WTW4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8WTW4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q8WTW4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000114388","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 203 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8WTW4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:1990130","properties":[{"key":"GoTerm","value":"C:GATOR1 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35338845"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28199306"}]},{"database":"GO","id":"GO:0005774","properties":[{"key":"GoTerm","value":"C:vacuolar membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005096","properties":[{"key":"GoTerm","value":"F:GTPase activator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30651352"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35338845"}]},{"database":"GO","id":"GO:0034198","properties":[{"key":"GoTerm","value":"P:cellular response to amino acid starvation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30651352"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35338845"}]},{"database":"GO","id":"GO:0033673","properties":[{"key":"GoTerm","value":"P:negative regulation of kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18616680"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29590090"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30651352"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35338845"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":380,"molWeight":43658,"crc64":"5ECA201CE073F964","md5":"51E174D6F8E822C8874A3B0D8EDE9C17"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":2,"DISEASE":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Binding site":1,"Site":1,"Modified residue":1,"Cross-link":2,"Alternative sequence":3,"Natural variant":4,"Mutagenesis":14,"Sequence conflict":1,"Beta strand":18,"Turn":6,"Helix":22},"uniParcId":"UPI0000072BFE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QID6","uniProtkbId":"A0ACI8QID6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-06-10","entryVersion":3,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564778.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000894719.2","properties":[{"key":"ProteinId","value":"ENSP00000564778.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIEVALRIWMGPPADESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":392,"molWeight":44980,"crc64":"30A5F316CC6B7339","md5":"FA686CC26D394459B560A051595152A1"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI00403194C9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TM84","uniProtkbId":"A0ACI8TM84_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-06-10","entryVersion":3,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601064.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000931005.2","properties":[{"key":"ProteinId","value":"ENSP00000601064.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLEILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":298,"molWeight":34237,"crc64":"6192EED0D90E1A1B","md5":"BE6E208F345F75F650B2F40D9AC0AEBC"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI0040324671"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TMD0","uniProtkbId":"A0ACI8TMD0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-06-10","entryVersion":3,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601065.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000931006.2","properties":[{"key":"ProteinId","value":"ENSP00000601065.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITLESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":323,"molWeight":37391,"crc64":"3DFBF03CAE25428D","md5":"5A7F35FED8B19983B10974810E9BE37C"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI004031EEBF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VD95","uniProtkbId":"A0ACI8VD95_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-06-10","entryVersion":3,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000636355.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000966296.2","properties":[{"key":"ProteinId","value":"ENSP00000636355.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGRHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":381,"molWeight":43815,"crc64":"F7C4427A4D9BB72E","md5":"BC9103DD818EE393E32312732B284B08"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI00403184A4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ17","uniProtkbId":"A0ACP2DJ17_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704126.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034309.1","properties":[{"key":"ProteinId","value":"ENSP00000704126.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ21","uniProtkbId":"A0ACP2DJ21_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704106.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034289.1","properties":[{"key":"ProteinId","value":"ENSP00000704106.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITV","length":57,"molWeight":6594,"crc64":"62C5689B3BBF1E0C","md5":"A2E50B3943ED079C31078AA247BB536C"},"extraAttributes":{"uniParcId":"UPI000198CB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ23","uniProtkbId":"A0ACP2DJ23_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704114.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034297.1","properties":[{"key":"ProteinId","value":"ENSP00000704114.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITV","length":57,"molWeight":6594,"crc64":"62C5689B3BBF1E0C","md5":"A2E50B3943ED079C31078AA247BB536C"},"extraAttributes":{"uniParcId":"UPI000198CB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ29","uniProtkbId":"A0ACP2DJ29_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704117.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034300.1","properties":[{"key":"ProteinId","value":"ENSP00000704117.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ32","uniProtkbId":"A0ACP2DJ32_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704118.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034301.1","properties":[{"key":"ProteinId","value":"ENSP00000704118.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ58","uniProtkbId":"A0ACP2DJ58_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704112.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034295.1","properties":[{"key":"ProteinId","value":"ENSP00000704112.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLERAASCPWRRASRSWCPS","length":130,"molWeight":14721,"crc64":"63F846B50CD27872","md5":"D41E0EE6222929EAA508888149D415EC"},"extraAttributes":{"uniParcId":"UPI0011490101"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2FXU8","uniProtkbId":"A0ACP2FXU8_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000751203.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001081397.1","properties":[{"key":"ProteinId","value":"ENSP00000751203.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITLWKRS","length":61,"molWeight":7165,"crc64":"570880082725689B","md5":"EBF0FBA41029273C4E5B5A609A5A1229"},"extraAttributes":{"uniParcId":"UPI0049339B76"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2H7U9","uniProtkbId":"A0ACP2H7U9_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000772235.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001102429.1","properties":[{"key":"ProteinId","value":"ENSP00000772235.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3J3","uniProtkbId":"A0ACP2C3J3_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678199.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008382.1","properties":[{"key":"ProteinId","value":"ENSP00000678199.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLERAASCPWRRASRSWCPS","length":130,"molWeight":14721,"crc64":"63F846B50CD27872","md5":"D41E0EE6222929EAA508888149D415EC"},"extraAttributes":{"uniParcId":"UPI0011490101"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3J5","uniProtkbId":"A0ACP2C3J5_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678198.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008381.1","properties":[{"key":"ProteinId","value":"ENSP00000678198.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITHSYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":88,"molWeight":10097,"crc64":"0AF55993B925B363","md5":"66313ECBF6DD90D9584478FE6A8C7F0E"},"extraAttributes":{"uniParcId":"UPI0049336BB2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3L1","uniProtkbId":"A0ACP2C3L1_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678205.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008388.1","properties":[{"key":"ProteinId","value":"ENSP00000678205.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITV","length":57,"molWeight":6594,"crc64":"62C5689B3BBF1E0C","md5":"A2E50B3943ED079C31078AA247BB536C"},"extraAttributes":{"uniParcId":"UPI000198CB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3M2","uniProtkbId":"A0ACP2C3M2_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678203.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008386.1","properties":[{"key":"ProteinId","value":"ENSP00000678203.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITLWKRS","length":61,"molWeight":7165,"crc64":"570880082725689B","md5":"EBF0FBA41029273C4E5B5A609A5A1229"},"extraAttributes":{"uniParcId":"UPI0049339B76"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ11","uniProtkbId":"A0ACP2DJ11_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704115.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034298.1","properties":[{"key":"ProteinId","value":"ENSP00000704115.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ18","uniProtkbId":"A0ACP2DJ18_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704111.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034294.1","properties":[{"key":"ProteinId","value":"ENSP00000704111.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITV","length":57,"molWeight":6594,"crc64":"62C5689B3BBF1E0C","md5":"A2E50B3943ED079C31078AA247BB536C"},"extraAttributes":{"uniParcId":"UPI000198CB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ35","uniProtkbId":"A0ACP2DJ35_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704110.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034293.1","properties":[{"key":"ProteinId","value":"ENSP00000704110.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2DJ56","uniProtkbId":"A0ACP2DJ56_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000704131.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001034314.1","properties":[{"key":"ProteinId","value":"ENSP00000704131.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVYGKEADRLSCVHRTQEVQPQCSPLQPGLRV","length":87,"molWeight":9972,"crc64":"E1B591D6FAE8376C","md5":"C6FD44E89986A40ECDAEA48A603C337F"},"extraAttributes":{"uniParcId":"UPI000198CB43"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F2Z3D4","uniProtkbId":"F2Z3D4_HUMAN","entryAudit":{"firstPublicDate":"2011-05-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-05-31","entryVersion":97,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000412779.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F2Z3D4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"F2Z3D4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"23948","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000429366.5","properties":[{"key":"ProteinId","value":"ENSP00000412779.1"},{"key":"GeneId","value":"ENSG00000114388.15"}]},{"database":"Ensembl","id":"ENST00000433999.5","properties":[{"key":"ProteinId","value":"ENSP00000415045.1"},{"key":"GeneId","value":"ENSG00000114388.15"}]},{"database":"UCSC","id":"uc062keq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2995932_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"338854at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NPRL2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"Bgee","id":"ENSG00000114388","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 203 other cell types or tissues"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITV","length":57,"molWeight":6594,"crc64":"62C5689B3BBF1E0C","md5":"A2E50B3943ED079C31078AA247BB536C"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI000198CB44"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QID5","uniProtkbId":"A0ACI8QID5_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-06-10","entryVersion":3,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"}],"value":"NPRL2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008433"}],"value":"Belongs to the NPR2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564779.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000894720.2","properties":[{"key":"ProteinId","value":"ENSP00000564779.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:1904262","properties":[{"key":"GoTerm","value":"P:negative regulation of TORC1 signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"InterPro","id":"IPR009348","properties":[{"key":"EntryName","value":"NPR2-like"}]},{"database":"PANTHER","id":"PTHR12991:SF10","properties":[{"key":"EntryName","value":"GATOR COMPLEX PROTEIN NPRL2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12991","properties":[{"key":"EntryName","value":"NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06218","properties":[{"key":"EntryName","value":"NPR2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQMSTEGPIATPLPRSLKTSSPESCLTQSKCTSSPSQSCRTSLSLSMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTPKVQDLVDDKSLQEACLSYVTKQGHKRASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKLIQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIICWK","length":391,"molWeight":44410,"crc64":"0E644F6928B1DE7E","md5":"98F3B2EF410162B9BE8DD538F3E4D0F7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0040317788"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3K1","uniProtkbId":"A0ACP2C3K1_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678201.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008384.1","properties":[{"key":"ProteinId","value":"ENSP00000678201.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVTAMEKKLIGCPVCIEHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFVSMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDFFNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQVVLQCILPNAQGPGPGR","length":257,"molWeight":28980,"crc64":"4309F885D5E1FD89","md5":"07C556068F74EB2533C791ADB11E2405"},"extraAttributes":{"uniParcId":"UPI001FB09CC2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACP2C3K4","uniProtkbId":"A0ACP2C3K4_HUMAN","entryAudit":{"firstPublicDate":"2026-11-04","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2026-11-04","entryVersion":1,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"}],"value":"NPR2 like, GATOR1 complex subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"}],"value":"NPRL2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000678207.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC002481","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00001008390.1","properties":[{"key":"ProteinId","value":"ENSP00000678207.1"},{"key":"GeneId","value":"ENSG00000114388.16"}]},{"database":"HGNC","id":"HGNC:24969","properties":[{"key":"GeneName","value":"NPRL2"}]},{"database":"OpenTargets","id":"ENSG00000114388","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000001414","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]}],"sequence":{"value":"MGSGCRIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLITVEQLRVHGGEQAEVGAHHDHLAGGAKCLRPVHSAH","length":91,"molWeight":10181,"crc64":"0EC9662D85BE2C6A","md5":"9B5158B07F8555CE77D7891D9BB10461"},"extraAttributes":{"uniParcId":"UPI004933BD58"}}]}