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Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (PubMed:39909992)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15721269"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23393389"}],"value":"NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15721269, PubMed:23393389). Involved in redox signaling in vascular cells (PubMed:23393389). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage (PubMed:23393389)"}],"commentType":"FUNCTION","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15721269"}],"value":"Lacks superoxide-generating NADPH oxidase activity"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63180"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:18421"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10869423"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11032835"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15155719"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15572675"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15927447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16019190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16179589"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16230378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16324151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25062272"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 4","reaction":{"name":"NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:63180"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:18421"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15721269"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23393389"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + O2 + H(+) = H2O2 + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.6.3.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14966267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15356101"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15927447"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21343298"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25062272"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25062272"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHI8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14966267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15572675"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16019190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16324151"}],"value":"Inhibited by plumbagin (By similarity). 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