{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O14745","secondaryAccessions":["B3KY21","O43552","Q86WQ5"],"uniProtkbId":"NHRF1_HUMAN","entryAudit":{"firstPublicDate":"2004-02-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":239,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Na(+)/H(+) exchange regulatory cofactor NHE-RF1"},"shortNames":[{"value":"NHERF-1"}]},"alternativeNames":[{"fullName":{"value":"Ezrin-radixin-moesin-binding phosphoprotein 50"},"shortNames":[{"value":"EBP50"}]},{"fullName":{"value":"Regulatory cofactor of Na(+)/H(+) exchanger"}},{"fullName":{"value":"Sodium-hydrogen exchanger regulatory factor 1"}},{"fullName":{"value":"Solute carrier family 9 isoform A3 regulatory factor 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11075"}],"value":"NHERF1"},"synonyms":[{"value":"NHERF"},{"value":"SLC9A3R1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10499588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18784102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9096337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9430655"}],"value":"Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P70441"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10499588"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11285285"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11304524"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11684085"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11882663"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11956211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12004055"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12080081"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12154080"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12193606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12403779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12444018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12444019"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12471024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12830000"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15020681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16615918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19555689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22506049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34189428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9096337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9314537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9430655"}],"value":"Homodimer, and heterodimer with NHERF2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 and CFTR. Binds ARHGAP17, EPI64, RACK1, OPRK1, GNAQ, CTNNB1 and PLCB3. Binds PDZK1 (By similarity). Interacts with CLCN3. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-NHERF1-MSN complex which is disrupted upon TCR activation. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1. Interacts with TRPC4 (via the PDZ-binding domain). Directly interacts with HTR4 (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting (By similarity). Interacts with SLC26A3 (By similarity). Interacts with MCC. Interacts with SLC34A1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5. Interacts (via PDZ domains) with ACE2 (via PDZ-binding motif); the interaction may enhance ACE2 membrane residence 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Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. 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