{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P08138","secondaryAccessions":["B2R961","B4E096"],"uniProtkbId":"TNR16_HUMAN","entryAudit":{"firstPublicDate":"1988-08-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1988-08-01","entryVersion":242,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tumor necrosis factor receptor superfamily member 16"}},"alternativeNames":[{"fullName":{"value":"Gp80-LNGFR"}},{"fullName":{"value":"Low affinity neurotrophin receptor p75NTR"}},{"fullName":{"value":"Low-affinity nerve growth factor receptor"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3022937"}],"value":"NGF receptor"}]},{"fullName":{"value":"Low-affinity nerve growth factor receptor p75NGFR"}},{"fullName":{"value":"Low-affinity nerve growth factor receptor p75NGR"}},{"fullName":{"value":"p75 ICD"}}],"cdAntigenNames":[{"value":"CD271"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"NGFR"},"synonyms":[{"value":"TNFRSF16"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0W1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14966521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23785138"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24908487"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3022937"}],"value":"Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07174"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0W1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10514511"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10544233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11244088"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12963025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14966521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19052207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22155786"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22566094"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24908487"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9915784"}],"value":"Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487). The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). Interacts with RTN4R (PubMed:19052207). Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 (PubMed:10514511, PubMed:10544233, PubMed:12963025, PubMed:9915784). Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (PubMed:11244088). Interacts with BEX1 (By similarity). Interacts with BEX3 (By similarity). Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity). Interacts (via death domain) with RAB31 (By similarity). Interacts with LINGO1 (PubMed:14966521). Interacts with NRADD (By similarity). Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity). Interacts (via death domain) with ARHGDIA and RIPK2 (PubMed:26646181). Interacts with BFAR (PubMed:22566094)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","chainId":"PRO_0000000093","intActId":"EBI-2431589"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P33681","geneName":"CD80","intActId":"EBI-1031024"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"Q96FE5","geneName":"LINGO1","intActId":"EBI-719955"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P01138","geneName":"NGF","intActId":"EBI-1028250"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P01138","geneName":"NGF","chainId":"PRO_0000019600","intActId":"EBI-9249861"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"Q9Y467","geneName":"SALL2","intActId":"EBI-746180"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"Q9UNE7","geneName":"STUB1","intActId":"EBI-357085"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"O75509","geneName":"TNFRSF21","intActId":"EBI-2313231"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"P25233","geneName":"Ndn","intActId":"EBI-1801080"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P08138","intActId":"EBI-1387782"},"interactantTwo":{"uniProtKBAccession":"Q9CPR8","geneName":"Nsmce3","intActId":"EBI-5529102"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3022937"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22566094"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0W1"}],"value":"Perikaryon","id":"SL-0197"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0W1"}],"value":"Cell projection, growth cone","id":"SL-0288"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0W1"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P08138-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P08138-2"],"sequenceIds":["VSP_056850"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P07174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"}],"value":"The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The extracellular domain is responsible for interaction with NTRK1"}],"commentType":"DOMAIN"},{"texts":[{"value":"N- and O-glycosylated"}],"commentType":"PTM"},{"texts":[{"value":"O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc"}],"commentType":"PTM"},{"texts":[{"value":"Phosphorylated on serine residues"}],"commentType":"PTM"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Tumor necrosis factor receptor superfamily member 16","featureId":"PRO_0000034591"},{"type":"Topological domain","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"TNFR-Cys 1"},{"type":"Repeat","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"TNFR-Cys 2"},{"type":"Repeat","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"TNFR-Cys 3"},{"type":"Repeat","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"TNFR-Cys 4"},{"type":"Domain","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Death","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00064"}]},{"type":"Region","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Mediates interaction with KIDINS220","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Glycosylation","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"CAR_000231"},{"type":"Disulfide bond","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Disulfide bond","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00206"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_056850","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in dbSNP:rs2072446","featureCrossReferences":[{"database":"dbSNP","id":"rs2072446"}],"featureId":"VAR_020010","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Decreased interaction with ARHGDIA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Decreased interaction with ARHGDIA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Decreased interaction with ARHGDIA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26646181"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Turn","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ZGG"}]},{"type":"Helix","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5ZGG"}]},{"type":"Beta strand","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X8T"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X8T"}]},{"type":"Turn","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X8T"}]},{"type":"Turn","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X8T"}]},{"type":"Beta strand","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8X8T"}]},{"type":"Helix","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Beta strand","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7CSQ"}]},{"type":"Helix","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Helix","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Beta strand","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Helix","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Helix","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3EWV"}]},{"type":"Helix","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Turn","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]},{"type":"Beta strand","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2N80"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"3022937","citationType":"journal article","authors":["Johnson D.","Lanahan A.","Buck C.R.","Sehgal A.","Morgan C.","Mercer E.","Bothwell M.","Chao M."],"citationCrossReferences":[{"database":"PubMed","id":"3022937"},{"database":"DOI","id":"10.1016/0092-8674(86)90619-7"}],"title":"Expression and structure of the human NGF receptor.","publicationDate":"1986","journal":"Cell","firstPage":"545","lastPage":"554","volume":"47"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"},{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"2850481","citationType":"journal article","authors":["Sehgal A.","Patil N.","Chao M."],"citationCrossReferences":[{"database":"PubMed","id":"2850481"},{"database":"DOI","id":"10.1128/mcb.8.8.3160-3167.1988"}],"title":"A constitutive promoter directs expression of the nerve growth factor receptor gene.","publicationDate":"1988","journal":"Mol. Cell. Biol.","firstPage":"3160","lastPage":"3167","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22"]},{"referenceNumber":7,"citation":{"id":"10514511","citationType":"journal article","authors":["Ye X.","Mehlen P.","Rabizadeh S.","VanArsdale T.","Zhang H.","Shin H.","Wang J.J.L.","Leo E.","Zapata J.M.","Hauser C.A.","Reed J.C.","Bredesen D.E."],"citationCrossReferences":[{"database":"PubMed","id":"10514511"},{"database":"DOI","id":"10.1074/jbc.274.42.30202"}],"title":"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"30202","lastPage":"30208","volume":"274"},"referencePositions":["INTERACTION WITH TRAF2; TRAF4 AND TRAF6"]},{"referenceNumber":8,"citation":{"id":"9915784","citationType":"journal article","authors":["Khursigara G.","Orlinick J.R.","Chao M.V."],"citationCrossReferences":[{"database":"PubMed","id":"9915784"},{"database":"DOI","id":"10.1074/jbc.274.5.2597"}],"title":"Association of the p75 neurotrophin receptor with TRAF6.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"2597","lastPage":"2600","volume":"274"},"referencePositions":["INTERACTION WITH TRAF6"]},{"referenceNumber":9,"citation":{"id":"10544233","citationType":"journal article","authors":["Irie S.","Hachiya T.","Rabizadeh S.","Maruyama W.","Mukai J.","Li Y.","Reed J.C.","Bredesen D.E.","Sato T.A."],"citationCrossReferences":[{"database":"PubMed","id":"10544233"},{"database":"DOI","id":"10.1016/s0014-5793(99)01324-1"}],"title":"Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.","publicationDate":"1999","journal":"FEBS Lett.","firstPage":"191","lastPage":"198","volume":"460"},"referencePositions":["INTERACTION WITH PTPN13"]},{"referenceNumber":10,"citation":{"id":"11244088","citationType":"journal article","authors":["Wooten M.W.","Seibenhener M.L.","Mamidipudi V.","Diaz-Meco M.T.","Barker P.A.","Moscat J."],"citationCrossReferences":[{"database":"PubMed","id":"11244088"},{"database":"DOI","id":"10.1074/jbc.c000869200"}],"title":"The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"7709","lastPage":"7712","volume":"276"},"referencePositions":["INTERACTION WITH TRAF6 AND SQSTM1"]},{"referenceNumber":11,"citation":{"id":"12963025","citationType":"journal article","authors":["Bai D.","Chen H.","Huang B.-R."],"citationCrossReferences":[{"database":"PubMed","id":"12963025"},{"database":"DOI","id":"10.1016/j.bbrc.2003.08.033"}],"title":"RanBPM is a novel binding protein for p75NTR.","publicationDate":"2003","journal":"Biochem. Biophys. Res. Commun.","firstPage":"552","lastPage":"557","volume":"309"},"referencePositions":["INTERACTION WITH RANBP9"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"14966521","citationType":"journal article","authors":["Mi S.","Lee X.","Shao Z.","Thill G.","Ji B.","Relton J.","Levesque M.","Allaire N.","Perrin S.","Sands B.","Crowell T.","Cate R.L.","McCoy J.M.","Pepinsky R.B."],"citationCrossReferences":[{"database":"PubMed","id":"14966521"},{"database":"DOI","id":"10.1038/nn1188"}],"title":"LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.","publicationDate":"2004","journal":"Nat. Neurosci.","firstPage":"221","lastPage":"228","volume":"7"},"referencePositions":["FUNCTION","INTERACTION WITH LINGO1"]},{"referenceNumber":13,"citation":{"id":"8627329","citationType":"journal article","authors":["Chapman B.S.","Eckart M.R.","Kaufman S.E.","Lapointe G.R."],"citationCrossReferences":[{"database":"PubMed","id":"8627329"},{"database":"DOI","id":"10.1046/j.1471-4159.1996.66041707.x"}],"title":"O-linked oligosaccharide on the 75-kDa neurotrophin receptor.","publicationDate":"1996","journal":"J. Neurochem.","firstPage":"1707","lastPage":"1716","volume":"66"},"referencePositions":["STRUCTURE OF O-LINKED CARBOHYDRATE"]},{"referenceNumber":14,"citation":{"id":"19052207","citationType":"journal article","authors":["Budel S.","Padukkavidana T.","Liu B.P.","Feng Z.","Hu F.","Johnson S.","Lauren J.","Park J.H.","McGee A.W.","Liao J.","Stillman A.","Kim J.E.","Yang B.Z.","Sodi S.","Gelernter J.","Zhao H.","Hisama F.","Arnsten A.F.","Strittmatter S.M."],"citationCrossReferences":[{"database":"PubMed","id":"19052207"},{"database":"DOI","id":"10.1523/jneurosci.3828-08.2008"}],"title":"Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.","publicationDate":"2008","journal":"J. Neurosci.","firstPage":"13161","lastPage":"13172","volume":"28"},"referencePositions":["INTERACTION WITH RTN4R"]},{"referenceNumber":15,"citation":{"id":"22155786","citationType":"journal article","authors":["Deinhardt K.","Kim T.","Spellman D.S.","Mains R.E.","Eipper B.A.","Neubert T.A.","Chao M.V.","Hempstead B.L."],"citationCrossReferences":[{"database":"PubMed","id":"22155786"},{"database":"DOI","id":"10.1126/scisignal.2002060"}],"title":"Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RA82","lastPage":"RA82","volume":"4"},"referencePositions":["INTERACTION WITH SORCS2 AND TRIO"]},{"referenceNumber":16,"citation":{"id":"22566094","citationType":"journal article","authors":["Li H.","Shi H.","Huo K."],"citationCrossReferences":[{"database":"PubMed","id":"22566094"},{"database":"DOI","id":"10.1007/s11427-012-4306-y"}],"title":"p75NTR signal transduction suppressed by BFAR and p75NTR interactions.","publicationDate":"2012","journal":"Sci. China Life Sci.","firstPage":"367","lastPage":"374","volume":"55"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH BFAR"]},{"referenceNumber":17,"citation":{"id":"23785138","citationType":"journal article","authors":["Baeza-Raja B.","Eckel-Mahan K.","Zhang L.","Vagena E.","Tsigelny I.F.","Sassone-Corsi P.","Ptacek L.J.","Akassoglou K."],"citationCrossReferences":[{"database":"PubMed","id":"23785138"},{"database":"DOI","id":"10.1523/jneurosci.2757-12.2013"}],"title":"p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.","publicationDate":"2013","journal":"J. Neurosci.","firstPage":"10221","lastPage":"10234","volume":"33"},"referencePositions":["FUNCTION"]},{"referenceNumber":18,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"24908487","citationType":"journal article","authors":["Glerup S.","Olsen D.","Vaegter C.B.","Gustafsen C.","Sjoegaard S.S.","Hermey G.","Kjolby M.","Molgaard S.","Ulrichsen M.","Boggild S.","Skeldal S.","Fjorback A.N.","Nyengaard J.R.","Jacobsen J.","Bender D.","Bjarkam C.R.","Soerensen E.S.","Fuechtbauer E.M.","Eichele G.","Madsen P.","Willnow T.E.","Petersen C.M.","Nykjaer A."],"citationCrossReferences":[{"database":"PubMed","id":"24908487"},{"database":"DOI","id":"10.1016/j.neuron.2014.04.022"}],"title":"SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.","publicationDate":"2014","journal":"Neuron","firstPage":"1074","lastPage":"1087","volume":"82"},"referencePositions":["INTERACTION WITH SORCS2","FUNCTION"]},{"referenceNumber":20,"citation":{"id":"26646181","citationType":"journal article","authors":["Lin Z.","Tann J.Y.","Goh E.T.","Kelly C.","Lim K.B.","Gao J.F.","Ibanez C.F."],"citationCrossReferences":[{"database":"PubMed","id":"26646181"},{"database":"DOI","id":"10.7554/elife.11692"}],"title":"Structural basis of death domain signaling in the p75 neurotrophin receptor.","publicationDate":"2015","journal":"Elife","firstPage":"e11692","lastPage":"e11692","volume":"4"},"referencePositions":["STRUCTURE BY NMR OF 330-427 IN COMPLEXES WITH RIPK2 AND ARHGDIA","FUNCTION","SUBUNIT","DOMAIN","MUTAGENESIS OF LYS-343; ASP-412 AND GLU-420"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2N80"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2N83"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2N97"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M14764","properties":[{"key":"ProteinId","value":"AAB59544.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK303278","properties":[{"key":"ProteinId","value":"BAG64358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313654","properties":[{"key":"ProteinId","value":"BAG36408.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC006487","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC015656","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471109","properties":[{"key":"ProteinId","value":"EAW94677.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC050309","properties":[{"key":"ProteinId","value":"AAH50309.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M21621","properties":[{"key":"ProteinId","value":"AAA36363.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS11549.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P08138-1"},{"database":"PIR","id":"A25218","properties":[{"key":"EntryName","value":"GQHUN"}]},{"database":"RefSeq","id":"NP_002498.1","properties":[{"key":"NucleotideSequenceId","value":"NM_002507.4"}],"isoformId":"P08138-1"},{"database":"PDB","id":"2N80","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=334-427"}]},{"database":"PDB","id":"2N83","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=330-427"}]},{"database":"PDB","id":"2N97","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=330-427"}]},{"database":"PDB","id":"3EWV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"E=396-412"}]},{"database":"PDB","id":"5ZGG","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A/B=244-277"}]},{"database":"PDB","id":"7CSQ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=330-427"}]},{"database":"PDB","id":"8X8T","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B=273-332"}]},{"database":"PDBsum","id":"2N80","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2N83","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2N97","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3EWV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5ZGG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7CSQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8X8T","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"110870","properties":[{"key":"Interactions","value":"61"}]},{"database":"CORUM","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-406N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P08138","properties":[{"key":"Number of interactors","value":"1219"}]},{"database":"IntAct","id":"P08138","properties":[{"key":"Interactions","value":"29"}]},{"database":"MINT","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NGFR","properties":[{"key":"Evidences","value":"20 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000172229","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4762","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB13926","properties":[{"key":"GenericName","value":"Cenegermin"}]},{"database":"DrugCentral","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1888","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.87.4.1","properties":[{"key":"FamilyName","value":"the selenoprotein p receptor (selp-receptor) family"}]},{"database":"GlyConnect","id":"P08138","properties":[{"key":"glycosylation","value":"3 N-Linked glycans (1 site), 2 O-Linked glycans"}]},{"database":"GlyCosmos","id":"P08138","properties":[{"key":"glycosylation","value":"1 site, 10 glycans"}]},{"database":"GlyGen","id":"P08138","properties":[{"key":"glycosylation","value":"2 sites, 4 O-linked glycans (1 site)"}]},{"database":"iPTMnet","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NGFR","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"128156","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000172229","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52073","properties":[{"key":"Description","value":"-"}],"isoformId":"P08138-1"},{"database":"ProteomicsDB","id":"5660","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1461","properties":[{"key":"antibodies","value":"1704 antibodies from 52 providers"}]},{"database":"DNASU","id":"4804","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000172229.8","properties":[{"key":"ProteinId","value":"ENSP00000172229.3"},{"key":"GeneId","value":"ENSG00000064300.9"}],"isoformId":"P08138-1"},{"database":"Ensembl","id":"ENST00000504201.1","properties":[{"key":"ProteinId","value":"ENSP00000421731.1"},{"key":"GeneId","value":"ENSG00000064300.9"}],"isoformId":"P08138-2"},{"database":"GeneID","id":"4804","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:4804","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000172229.8","properties":[{"key":"ProteinId","value":"ENSP00000172229.3"},{"key":"RefSeqNucleotideId","value":"NM_002507.4"},{"key":"RefSeqProteinId","value":"NP_002498.1"}]},{"database":"UCSC","id":"uc002ioz.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P08138-1"},{"database":"AGR","id":"HGNC:7809","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA31615","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4804","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"4804","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NGFR","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:7809","properties":[{"key":"GeneName","value":"NGFR"}]},{"database":"HPA","id":"ENSG00000064300","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"162010","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000064300","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000064300","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QWPN","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00730000110974","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_052667_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YSCQDKQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10048028at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P08138","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-193634","properties":[{"key":"PathwayName","value":"Axonal growth inhibition (RHOA activation)"}]},{"database":"Reactome","id":"R-HSA-193648","properties":[{"key":"PathwayName","value":"NRAGE signals death through JNK"}]},{"database":"Reactome","id":"R-HSA-193670","properties":[{"key":"PathwayName","value":"p75NTR negatively regulates cell cycle via SC1"}]},{"database":"Reactome","id":"R-HSA-193681","properties":[{"key":"PathwayName","value":"Ceramide signalling"}]},{"database":"Reactome","id":"R-HSA-193692","properties":[{"key":"PathwayName","value":"Regulated proteolysis of p75NTR"}]},{"database":"Reactome","id":"R-HSA-205017","properties":[{"key":"PathwayName","value":"NFG and proNGF binds to p75NTR"}]},{"database":"Reactome","id":"R-HSA-205025","properties":[{"key":"PathwayName","value":"NADE modulates death signalling"}]},{"database":"Reactome","id":"R-HSA-205043","properties":[{"key":"PathwayName","value":"NRIF signals cell death from the nucleus"}]},{"database":"Reactome","id":"R-HSA-209543","properties":[{"key":"PathwayName","value":"p75NTR recruits signalling complexes"}]},{"database":"Reactome","id":"R-HSA-209560","properties":[{"key":"PathwayName","value":"NF-kB is activated and signals survival"}]},{"database":"Reactome","id":"R-HSA-209563","properties":[{"key":"PathwayName","value":"Axonal growth stimulation"}]},{"database":"SignaLink","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000064300","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"4804","properties":[{"key":"hits","value":"14 hits in 1151 CRISPR screens"}]},{"database":"ChiTaRS","id":"NGFR","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P08138","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Low-affinity_nerve_growth_factor_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"4804","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P08138","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P08138","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P08138","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000064300","properties":[{"key":"ExpressionPatterns","value":"Expressed in tibial nerve and 121 other cell types or tissues"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005911","properties":[{"key":"GoTerm","value":"C:cell-cell junction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22566094"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030426","properties":[{"key":"GoTerm","value":"C:growth cone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11927634"}]},{"database":"GO","id":"GO:0031594","properties":[{"key":"GoTerm","value":"C:neuromuscular junction"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0043204","properties":[{"key":"GoTerm","value":"C:perikaryon"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16712417"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098793","properties":[{"key":"GoTerm","value":"C:presynapse"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0001540","properties":[{"key":"GoTerm","value":"F:amyloid-beta binding"},{"key":"GoEvidenceType","value":"TAS:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"26871627"}]},{"database":"GO","id":"GO:0005516","properties":[{"key":"GoTerm","value":"F:calmodulin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24914971"}]},{"database":"GO","id":"GO:0015026","properties":[{"key":"GoTerm","value":"F:coreceptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16712417"}]},{"database":"GO","id":"GO:0005035","properties":[{"key":"GoTerm","value":"F:death receptor activity"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"11927634"}]},{"database":"GO","id":"GO:0048406","properties":[{"key":"GoTerm","value":"F:nerve growth factor binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043121","properties":[{"key":"GoTerm","value":"F:neurotrophin binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"3022937"}]},{"database":"GO","id":"GO:0031267","properties":[{"key":"GoTerm","value":"F:small GTPase binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1846035"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"11279055"}]},{"database":"GO","id":"GO:1904646","properties":[{"key":"GoTerm","value":"P:cellular response to amyloid-beta"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11927634"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035907","properties":[{"key":"GoTerm","value":"P:dorsal aorta development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097191","properties":[{"key":"GoTerm","value":"P:extrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26268439"}]},{"database":"GO","id":"GO:0042593","properties":[{"key":"GoTerm","value":"P:glucose homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001678","properties":[{"key":"GoTerm","value":"P:intracellular glucose homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006886","properties":[{"key":"GoTerm","value":"P:intracellular protein transport"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903588","properties":[{"key":"GoTerm","value":"P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"},{"key":"GoEvidenceType","value":"IGI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"26268439"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27927008"}]},{"database":"GO","id":"GO:0051402","properties":[{"key":"GoTerm","value":"P:neuron apoptotic process"},{"key":"GoEvidenceType","value":"IGI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"11927634"}]},{"database":"GO","id":"GO:2000353","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26268439"}]},{"database":"GO","id":"GO:1902895","properties":[{"key":"GoTerm","value":"P:positive regulation of miRNA transcription"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26268439"}]},{"database":"GO","id":"GO:1900182","properties":[{"key":"GoTerm","value":"P:positive regulation of protein localization to nucleus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26268439"}]},{"database":"GO","id":"GO:0099171","properties":[{"key":"GoTerm","value":"P:presynaptic modulation of chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007266","properties":[{"key":"GoTerm","value":"P:Rho protein signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16712417"}]},{"database":"CDD","id":"cd08311","properties":[{"key":"EntryName","value":"Death_p75NR"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd13416","properties":[{"key":"EntryName","value":"TNFRSF16"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.50.10:FF:000013","properties":[{"key":"EntryName","value":"Tumor necrosis factor receptor superfamily member 16"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.533.10:FF:000034","properties":[{"key":"EntryName","value":"tumor necrosis factor receptor superfamily member 16"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.50.10:FF:000012","properties":[{"key":"EntryName","value":"tumor necrosis factor receptor superfamily member 16"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.50.10:FF:000027","properties":[{"key":"EntryName","value":"tumor necrosis factor receptor superfamily member 16"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.1780","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.533.10","properties":[{"key":"EntryName","value":"Death Domain, Fas"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.50.10","properties":[{"key":"EntryName","value":"Tumor Necrosis Factor Receptor, subunit A, domain 2"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR011029","properties":[{"key":"EntryName","value":"DEATH-like_dom_sf"}]},{"database":"InterPro","id":"IPR000488","properties":[{"key":"EntryName","value":"Death_dom"}]},{"database":"InterPro","id":"IPR052302","properties":[{"key":"EntryName","value":"Neurotrophin_rcpt-DD"}]},{"database":"InterPro","id":"IPR001368","properties":[{"key":"EntryName","value":"TNFR/NGFR_Cys_rich_reg"}]},{"database":"InterPro","id":"IPR041448","properties":[{"key":"EntryName","value":"TNFR16_TM"}]},{"database":"InterPro","id":"IPR022325","properties":[{"key":"EntryName","value":"TNFR_16"}]},{"database":"InterPro","id":"IPR034046","properties":[{"key":"EntryName","value":"TNFRSF16_N"}]},{"database":"PANTHER","id":"PTHR46605","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46605:SF3","properties":[{"key":"EntryName","value":"TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00531","properties":[{"key":"EntryName","value":"Death"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18422","properties":[{"key":"EntryName","value":"TNFR_16_TM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00020","properties":[{"key":"EntryName","value":"TNFR_c6"},{"key":"MatchStatus","value":"3"}]},{"database":"PRINTS","id":"PR01966","properties":[{"key":"EntryName","value":"TNFACTORR16"}]},{"database":"SMART","id":"SM00005","properties":[{"key":"EntryName","value":"DEATH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00208","properties":[{"key":"EntryName","value":"TNFR"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF47986","properties":[{"key":"EntryName","value":"DEATH domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57586","properties":[{"key":"EntryName","value":"TNF receptor-like"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50017","properties":[{"key":"EntryName","value":"DEATH_DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00652","properties":[{"key":"EntryName","value":"TNFR_NGFR_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50050","properties":[{"key":"EntryName","value":"TNFR_NGFR_2"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV","length":427,"molWeight":45183,"crc64":"B09FA143FB3D625B","md5":"301683FE929259C5E1785D1E59FA1F43"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":12,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"DOMAIN":2,"PTM":3},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Repeat":4,"Domain":1,"Region":3,"Compositional bias":3,"Modified residue":1,"Glycosylation":1,"Disulfide bond":12,"Alternative sequence":1,"Natural variant":1,"Mutagenesis":3,"Turn":4,"Helix":8,"Beta strand":6},"uniParcId":"UPI0000049854"}}]}