{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P35240","secondaryAccessions":["O95683","Q8WUJ2","Q969N0","Q969Q3","Q96T30","Q96T31","Q96T32","Q96T33","Q9BTW3","Q9UNG9","Q9UNH3","Q9UNH4"],"uniProtkbId":"MERL_HUMAN","entryAudit":{"firstPublicDate":"1994-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1994-02-01","entryVersion":260,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Merlin"}},"alternativeNames":[{"fullName":{"value":"Moesin-ezrin-radixin-like protein"}},{"fullName":{"value":"Neurofibromin-2"}},{"fullName":{"value":"Schwannomerlin"}},{"fullName":{"value":"Schwannomin"}}]},"genes":[{"geneName":{"value":"NF2"},"synonyms":[{"value":"SCH"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20159598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20178741"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21167305"}],"value":"Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10669747"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10861283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15541357"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15598747"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18332868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19144871"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20159599"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20178741"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21167305"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9430655"}],"value":"Interacts with NHERF1, HGS and AGAP2. Interacts with LAYN (By similarity). Interacts with SGSM3. Interacts (via FERM domain) with MPP1. Interacts with WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1. Interacts (via FERM domain) with NOP53; the interaction is direct (PubMed:21167305). Interacts with SCHIP1; the interaction is direct 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