{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8TB73","secondaryAccessions":["A8K0Q0","Q6UWE5","Q9H5P7"],"uniProtkbId":"NDNF_HUMAN","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-09-19","entryVersion":164,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein NDNF"}},"alternativeNames":[{"fullName":{"value":"Neuron-derived neurotrophic factor"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"NDNF"},"synonyms":[{"value":"C4orf31"}],"orfNames":[{"value":"UNQ2748/PRO6487"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706764"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C119"}],"value":"Binds heparin and chondroitin sulfate"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706764"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Expressed in neurons along the gonadotropin-releasing hormone (GnRH) expressing neurons migratory route"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"}],"value":"Up-regulated by hypoxia (at protein level)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C119"}],"value":"O-glycosylated; contains heparan sulfate and chondroitin sulfate"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8C119"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Hypogonadotropic hypogonadism 25 with anosmia","diseaseAccession":"DI-05798","acronym":"HH25","description":"A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone, and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). HH25 is an autosomal dominant form with anosmia, characterized by intrafamilial variable expressivity and incomplete penetrance.","diseaseCrossReference":{"database":"MIM","id":"618841"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB15573.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAB15573.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Protein NDNF","featureId":"PRO_0000301965"},{"type":"Domain","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Fibronectin type-III 1"},{"type":"Domain","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"Fibronectin type-III 2"},{"type":"Glycosylation","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"in HH25; loss of protein expression","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"featureId":"VAR_084037","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in HH25; no effect on protein abundance; no effect on function in cellular response to fibroblast growth factor stimulus; dbSNP:rs200466645","featureCrossReferences":[{"database":"dbSNP","id":"rs200466645"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"featureId":"VAR_084038","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"in HH25; no effect on protein abundance; decreased secretion; loss of function in cellular response to fibroblast growth factor stimulus","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"featureId":"VAR_084039","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in Ref. 2; BAF82304","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1016","category":"Disease","name":"Hypogonadotropic hypogonadism"},{"id":"KW-0956","category":"Disease","name":"Kallmann syndrome"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Amygdala","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"20969804","citationType":"journal article","authors":["Kuang X.L.","Zhao X.M.","Xu H.F.","Shi Y.Y.","Deng J.B.","Sun G.T."],"citationCrossReferences":[{"database":"PubMed","id":"20969804"},{"database":"DOI","id":"10.1186/1471-2202-11-137"}],"title":"Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development.","publicationDate":"2010","journal":"BMC Neurosci.","firstPage":"137","lastPage":"137","volume":"11"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":6,"citation":{"id":"24706764","citationType":"journal article","authors":["Ohashi K.","Enomoto T.","Joki Y.","Shibata R.","Ogura Y.","Kataoka Y.","Shimizu Y.","Kambara T.","Uemura Y.","Yuasa D.","Matsuo K.","Hayakawa S.","Hiramatsu-Ito M.","Murohara T.","Ouchi N."],"citationCrossReferences":[{"database":"PubMed","id":"24706764"},{"database":"DOI","id":"10.1074/jbc.m114.555789"}],"title":"Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"14132","lastPage":"14144","volume":"289"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"31883645","citationType":"journal article","authors":["Messina A.","Pulli K.","Santini S.","Acierno J.","Kaensaekoski J.","Cassatella D.","Xu C.","Casoni F.","Malone S.A.","Ternier G.","Conte D.","Sidis Y.","Tommiska J.","Vaaralahti K.","Dwyer A.","Gothilf Y.","Merlo G.R.","Santoni F.","Niederlaender N.J.","Giacobini P.","Raivio T.","Pitteloud N."],"citationCrossReferences":[{"database":"PubMed","id":"31883645"},{"database":"DOI","id":"10.1016/j.ajhg.2019.12.003"}],"title":"Neuron-derived neurotrophic factor is mutated in congenital hypogonadotropic hypogonadism.","publicationDate":"2020","journal":"Am. J. Hum. Genet.","firstPage":"58","lastPage":"70","volume":"106"},"referencePositions":["INVOLVEMENT IN HH25","VARIANTS HH25 62-LYS--CYS-568 DEL; SER-201 AND 469-TRP--CYS-568 DEL","CHARACTERIZATION OF VARIANTS HH25 62-LYS--CYS-568 DEL; SER-201 AND 469-TRP--CYS-568 DEL","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY358821","properties":[{"key":"ProteinId","value":"AAQ89180.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK026844","properties":[{"key":"ProteinId","value":"BAB15573.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK289615","properties":[{"key":"ProteinId","value":"BAF82304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471056","properties":[{"key":"ProteinId","value":"EAX05266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC019351","properties":[{"key":"ProteinId","value":"AAH19351.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3717.2","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_078850.3","properties":[{"key":"NucleotideSequenceId","value":"NM_024574.4"}]},{"database":"RefSeq","id":"XP_024309980.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024454212.2"}]},{"database":"RefSeq","id":"XP_024309981.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024454213.2"}]},{"database":"RefSeq","id":"XP_054206794.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054350819.1"}]},{"database":"RefSeq","id":"XP_054206795.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054350820.1"}]},{"database":"AlphaFoldDB","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122755","properties":[{"key":"Interactions","value":"16"}]},{"database":"FunCoup","id":"Q8TB73","properties":[{"key":"Number of interactors","value":"272"}]},{"database":"IntAct","id":"Q8TB73","properties":[{"key":"Interactions","value":"13"}]},{"database":"STRING","id":"9606.ENSP00000369014","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q8TB73","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q8TB73","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NDNF","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"121949126","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000369014","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"73973","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"52933","properties":[{"key":"antibodies","value":"89 antibodies from 17 providers"}]},{"database":"DNASU","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000379692.9","properties":[{"key":"ProteinId","value":"ENSP00000369014.4"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871774.1","properties":[{"key":"ProteinId","value":"ENSP00000541833.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871775.1","properties":[{"key":"ProteinId","value":"ENSP00000541834.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871776.1","properties":[{"key":"ProteinId","value":"ENSP00000541835.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871778.1","properties":[{"key":"ProteinId","value":"ENSP00000541837.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871779.1","properties":[{"key":"ProteinId","value":"ENSP00000541838.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000871780.1","properties":[{"key":"ProteinId","value":"ENSP00000541839.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000959904.1","properties":[{"key":"ProteinId","value":"ENSP00000629963.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"Ensembl","id":"ENST00000959905.1","properties":[{"key":"ProteinId","value":"ENSP00000629964.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"GeneID","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:79625","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000379692.9","properties":[{"key":"ProteinId","value":"ENSP00000369014.4"},{"key":"RefSeqNucleotideId","value":"NM_024574.4"},{"key":"RefSeqProteinId","value":"NP_078850.3"}]},{"database":"UCSC","id":"uc003idq.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:26256","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA147358639","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NDNF","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26256","properties":[{"key":"GeneName","value":"NDNF"}]},{"database":"HPA","id":"ENSG00000173376","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lung, placenta, retina)"}]},{"database":"MalaCards","id":"NDNF","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"616506","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618841","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000173376","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"478","properties":[{"key":"Disease","value":"Kallmann syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000173376","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4806","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007586","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_041753_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YLFRDTS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9872501at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8TB73","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000173376","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"79625","properties":[{"key":"hits","value":"15 hits in 1145 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"NDNF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8TB73","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8TB73","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"Q8TB73","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000173376","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal glomerulus and 164 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8TB73","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20969804"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31883645"}]},{"database":"GO","id":"GO:0140144","properties":[{"key":"GoTerm","value":"C:non-collagenous component of basement membrane"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"36399478"}]},{"database":"GO","id":"GO:0005539","properties":[{"key":"GoTerm","value":"F:glycosaminoglycan binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24706764"}]},{"database":"GO","id":"GO:0044344","properties":[{"key":"GoTerm","value":"P:cellular response to fibroblast growth factor stimulus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31883645"}]},{"database":"GO","id":"GO:0030198","properties":[{"key":"GoTerm","value":"P:extracellular matrix organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0021828","properties":[{"key":"GoTerm","value":"P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20969804"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20969804"}]},{"database":"GO","id":"GO:0010811","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-substrate adhesion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010976","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron projection development"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20969804"}]},{"database":"GO","id":"GO:0002931","properties":[{"key":"GoTerm","value":"P:response to ischemia"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24706764"}]},{"database":"GO","id":"GO:0061042","properties":[{"key":"GoTerm","value":"P:vascular wound healing"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR019326","properties":[{"key":"EntryName","value":"NDNF"}]},{"database":"InterPro","id":"IPR045805","properties":[{"key":"EntryName","value":"NDNF_C"}]},{"database":"InterPro","id":"IPR055271","properties":[{"key":"EntryName","value":"NDNF_Fn(III)_1"}]},{"database":"InterPro","id":"IPR056225","properties":[{"key":"EntryName","value":"NDNF_N"}]},{"database":"PANTHER","id":"PTHR14619","properties":[{"key":"EntryName","value":"NEURON-DERIVED NEUROTROPHIC FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14619:SF1","properties":[{"key":"EntryName","value":"PROTEIN NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10179","properties":[{"key":"EntryName","value":"NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19433","properties":[{"key":"EntryName","value":"NDNF_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24354","properties":[{"key":"EntryName","value":"NDNF_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRKFC","length":568,"molWeight":64673,"crc64":"140498575659675F","md5":"70E1D8C9B75CBCF2B4DE606DF0B494B3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"DISEASE":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Glycosylation":1,"Natural variant":3,"Sequence conflict":1},"uniParcId":"UPI00001D6985"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6RF18","uniProtkbId":"D6RF18_HUMAN","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-07-13","entryVersion":76,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"}],"value":"Neuron derived neurotrophic factor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"}],"value":"NDNF"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003087568"},{"type":"Domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Neuron-derived neurotrophic factor N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24354"}]},{"type":"Region","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"D6RF18"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"D6RF18"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000426723.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC105254","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6RF18","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"D6RF18","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"14430","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"52933","properties":[{"key":"antibodies","value":"89 antibodies from 17 providers"}]},{"database":"Ensembl","id":"ENST00000511408.1","properties":[{"key":"ProteinId","value":"ENSP00000426723.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"UCSC","id":"uc062zhw.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:26256","properties":[{"key":"GeneName","value":"NDNF"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000173376","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007586","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YLFRDTS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9872501at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NDNF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000173376","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal glomerulus and 164 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"D6RF18","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR019326","properties":[{"key":"EntryName","value":"NDNF"}]},{"database":"InterPro","id":"IPR056225","properties":[{"key":"EntryName","value":"NDNF_N"}]},{"database":"PANTHER","id":"PTHR14619","properties":[{"key":"EntryName","value":"NEURON-DERIVED NEUROTROPHIC FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14619:SF1","properties":[{"key":"EntryName","value":"PROTEIN NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24354","properties":[{"key":"EntryName","value":"NDNF_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQ","length":116,"molWeight":13500,"crc64":"E0D6DC1E6D935C93","md5":"D80B180AEFC9050876154B348ACF4B8C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0001D3B836"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PV89","uniProtkbId":"A0ACI8PV89_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024096"}],"value":"Protein NDNF"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"}],"value":"NDNF"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046135"}],"value":"Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"Protein NDNF","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051554268"},{"type":"Domain","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00060"}]},{"type":"Domain","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00060"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022902"}],"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PV89"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PV89"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000541836.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC105254","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000871777.1","properties":[{"key":"ProteinId","value":"ENSP00000541836.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"HGNC","id":"HGNC:26256","properties":[{"key":"GeneName","value":"NDNF"}]},{"database":"OpenTargets","id":"ENSG00000173376","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007586","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR019326","properties":[{"key":"EntryName","value":"NDNF"}]},{"database":"InterPro","id":"IPR045805","properties":[{"key":"EntryName","value":"NDNF_C"}]},{"database":"InterPro","id":"IPR055271","properties":[{"key":"EntryName","value":"NDNF_Fn(III)_1"}]},{"database":"InterPro","id":"IPR056225","properties":[{"key":"EntryName","value":"NDNF_N"}]},{"database":"PANTHER","id":"PTHR14619","properties":[{"key":"EntryName","value":"NEURON-DERIVED NEUROTROPHIC FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14619:SF1","properties":[{"key":"EntryName","value":"PROTEIN NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10179","properties":[{"key":"EntryName","value":"NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19433","properties":[{"key":"EntryName","value":"NDNF_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24354","properties":[{"key":"EntryName","value":"NDNF_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMAPKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGAKFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVRLKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCIYKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKSYLLDVYVIGHGGHSVKYQSKVVKTRKFC","length":519,"molWeight":59179,"crc64":"6D69B512C0DEB3F5","md5":"841FED05F6459569C8970B79CF0E49E6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2},"uniParcId":"UPI0040326ADF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6R972","uniProtkbId":"D6R972_HUMAN","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-07-13","entryVersion":79,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"}],"value":"Neuron derived neurotrophic factor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"}],"value":"NDNF"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003087540"},{"type":"Domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Neuron-derived neurotrophic factor N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24354"}]},{"type":"Region","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"D6R972"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"D6R972"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423352.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC105254","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6R972","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"D6R972","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"12920","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"52933","properties":[{"key":"antibodies","value":"89 antibodies from 17 providers"}]},{"database":"Ensembl","id":"ENST00000515757.5","properties":[{"key":"ProteinId","value":"ENSP00000423352.1"},{"key":"GeneId","value":"ENSG00000173376.15"}]},{"database":"UCSC","id":"uc062zhv.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:26256","properties":[{"key":"GeneName","value":"NDNF"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000173376","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007586","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2102460_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YLFRDTS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9872501at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"NDNF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000173376","properties":[{"key":"ExpressionPatterns","value":"Expressed in renal glomerulus and 164 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"D6R972","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR019326","properties":[{"key":"EntryName","value":"NDNF"}]},{"database":"InterPro","id":"IPR056225","properties":[{"key":"EntryName","value":"NDNF_N"}]},{"database":"PANTHER","id":"PTHR14619","properties":[{"key":"EntryName","value":"NEURON-DERIVED NEUROTROPHIC FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14619:SF1","properties":[{"key":"EntryName","value":"PROTEIN NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24354","properties":[{"key":"EntryName","value":"NDNF_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDTPKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINEEGTELFSYKGNDVEYFISSSSPSGL","length":145,"molWeight":16666,"crc64":"01B95E6A450D1946","md5":"E1A209786219B61ABF3C1812689080C0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0001D3B835"}}]}