{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P11245","secondaryAccessions":["O43637","O60654","O60655","Q13146","Q16697","Q2MLE4","Q2MLF5","Q2MLG8","Q2MLJ6","Q2MLK4","Q2MLK6","Q2MLN7","Q6LET4","Q86XS0","Q86XS1","Q96KY8","Q96T64","Q96T65","Q9H220"],"uniProtkbId":"ARY2_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-02-23","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7915226"}],"value":"Arylamine N-acetyltransferase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}],"value":"2.3.1.5"}]},"alternativeNames":[{"fullName":{"value":"Arylamide acetylase 2"}},{"fullName":{"value":"N-acetyltransferase type 2"},"shortNames":[{"value":"NAT-2"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7915226"}],"value":"N-hydroxyarylamine O-acetyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}],"value":"2.3.1.118"}]},{"fullName":{"value":"Polymorphic arylamine N-acetyltransferase"},"shortNames":[{"value":"PNAT"}]}]},"genes":[{"geneName":{"value":"NAT2"},"synonyms":[{"value":"AAC2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}],"value":"Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). Participates in the detoxification of a plethora of hydrazine and arylamine drugs, and is able to bioactivate several known carcinogens"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an arylamine + acetyl-CoA = an N-acetylarylamine + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16613"},{"database":"ChEBI","id":"CHEBI:13790"},{"database":"ChEBI","id":"CHEBI:50471"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"}],"ecNumber":"2.3.1.5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"an N-hydroxyarylamine + acetyl-CoA = an N-acetoxyarylamine + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20277"},{"database":"ChEBI","id":"CHEBI:13792"},{"database":"ChEBI","id":"CHEBI:21494"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"}],"ecNumber":"2.3.1.118","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":1545.0,"unit":"nmol/min/mg","enzyme":"enzyme for N-acetyltransferase activity toward sulfamethazine (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"}]}],"michaelisConstants":[{"constant":8.21,"unit":"uM","substrate":"2-aminofluorene (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]},{"constant":15.9,"unit":"uM","substrate":"4-aminobiphenyl (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]},{"constant":28.6,"unit":"uM","substrate":"3,2-dimethyl-4-aminobiphenyl (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]},{"constant":355.0,"unit":"uM","substrate":"acetyl-CoA (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"}]},{"constant":483.0,"unit":"uM","substrate":"sulfamethazine (measured with the enzyme encoded by allele NAT2*4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"}]}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P11245","intActId":"EBI-9057228"},"interactantTwo":{"uniProtKBAccession":"Q13315","geneName":"ATM","intActId":"EBI-495465"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11245","intActId":"EBI-9057228"},"interactantTwo":{"uniProtKBAccession":"O95243-2","geneName":"MBD4","intActId":"EBI-6448717"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11245","intActId":"EBI-9057228"},"interactantTwo":{"uniProtKBAccession":"Q06609","geneName":"RAD51","intActId":"EBI-297202"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10970160"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11337936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1381364"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16416399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17264801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18304320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2734109"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.7"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"value":"Genetic variations in NAT2 determine the rate of acetylation of various arylamine and heterocyclic amine substrates that include therapeutic and carcinogenic agents. They influence drug therapy response and susceptibility to chemical toxicity [MIM:243400]. Different alleles are known, whose combination defines the rapid, intermediate and slow acetylator phenotypes. Allele NAT2*4 sequence is historically considered as the reference in most publications. The sequence shown in this entry corresponds to the translation of allele NAT2*12A, which is the one represented in the human reference genome (GRCh38/hg38 assembly) and has an arginine at position 268 (Ref.7). The enzyme encoded by allele NAT2*4 differs by the variant p.Arg268Lys (PubMed:2734109). The two alloenzymes have comparable arylamine N-acetyltransferase activity (PubMed:11337936)"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the arylamine N-acetyltransferase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAK51711.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/41498/NAT2","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"NAT","resourceUrl":"https://nat.mbg.duth.gr/","ftp":false,"note":"NAT alleles"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Arylamine N-acetyltransferase 2","featureId":"PRO_0000107905"},{"type":"Active 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dbSNP:rs1801279","featureCrossReferences":[{"database":"dbSNP","id":"rs1801279"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11337936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16416399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18304320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_004608","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in allele NAT2*19; decreased arylamine N-acetyltransferase activity when associated in cis with K-268; decreased N-hydroxyarylamine O-acetyltransferase when associated in cis with K-268; dbSNP:rs1805158","featureCrossReferences":[{"database":"dbSNP","id":"rs1805158"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10970160"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12222688"}],"featureId":"VAR_009075","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*5G, allele NAT2*5I, allele NAT2*5K, allele NAT2*5L, allele NAT2*5M, allele NAT2*14C and allele NAT2*14F; 7 to 12-fold lower Vmax; decreased arylamine N-acetyltransferase activity when associated in cis with K-268; loss of arylamine N-acetyltransferase activity when associated in cis with F-137; dbSNP:rs1801280","featureCrossReferences":[{"database":"dbSNP","id":"rs1801280"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11337936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16416399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17264801"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18304320"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7915226"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.11"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.12"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.9"}],"featureId":"VAR_004609","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural 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dbSNP:rs1799930","featureCrossReferences":[{"database":"dbSNP","id":"rs1799930"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11337936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1381364"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16416399"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18304320"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.14"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"}],"featureId":"VAR_004610","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in allele NAT2*12G; 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N-acetyltransferase activity when associated in cis with E-286; 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