{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q29983","secondaryAccessions":["A8KQR0","A9LRW5","A9QVE0","B1VJF1","O60917","O60918","O60919","O60920","O60933","O77956","O78150","O78151","O78152","O78153","O97987","O97988","O97989","O97990","O97991","O97992","O97993","O97994","O97995","O98234","O98235","O98236","O98237","O98238","P79506","P79507","P79508","P79509","P79510","P79511","P79512","P79513","P79514","P79515","P79516","P79517","P79518","P79519","P79520","P79521","Q5C9P8","Q5XM81","Q70I48","Q70I49","Q7JFH9","Q7JFI0","Q7JFI1","Q7JFI2","Q7YQ98","Q861I1","Q95464","Q95HA2","Q95HD6","Q95HN4","Q95HN5","Q95HN6","Q95IB2","Q95IY7","Q99692","Q9BCR3","Q9BCR4","Q9BCR5","Q9BCR6","Q9BCR7","Q9BCR8","Q9BCR9","Q9BCS0","Q9BCS1","Q9BCS2","Q9BCS3","Q9BCS4","Q9BD20","Q9GIZ1","Q9GIZ2","Q9GIZ3","Q9GIZ4","Q9GIZ5","Q9GIZ6","Q9GJ01","Q9GJ02","Q9GJ03","Q9GJ04","Q9GJ05","Q9GJ06","Q9GJ07","Q9GJ08","Q9GJ09","Q9MY21","Q9TQ86","Q9TQ87","Q9TQ88","Q9TQ89","Q9TQ92","Q9TQ93","Q9TQ94","Q9TQ95","Q9TQ96","Q9TQ97","Q9TQ98","Q9TQ99","Q9TQA0","Q9TQA1","Q9TQA2","Q9TQA3","Q9TQA4","Q9TQI9","Q9TQJ0","Q9TQJ1","Q9TQJ9","Q9TQK0","Q9TQK1","Q9TQK2","Q9TQK8","Q9TQK9","Q9TQL0","Q9TQL1","Q9TQL2","Q9TQL3","Q9TQL4","Q9UE04","Q9UE05","Q9UE06","Q9UE11"],"uniProtkbId":"MICA_HUMAN","entryAudit":{"firstPublicDate":"2008-05-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":197,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"MHC class I polypeptide-related sequence A"},"shortNames":[{"value":"MIC-A"}]},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CAI41907.1"}],"value":"MICA"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8613147"}],"value":"PERB11.1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10426993"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11224526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11491531"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11777960"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9497295"}],"value":"Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10426993"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10426994"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11323699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11491531"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17495932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9396860"}],"value":"Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19793804"}],"value":"(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL142"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q29983","intActId":"EBI-1031130"},"interactantTwo":{"uniProtKBAccession":"P26718","geneName":"KLRK1","intActId":"EBI-458344"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q29983","intActId":"EBI-1031130"},"interactantTwo":{"uniProtKBAccession":"P17931","geneName":"LGALS3","intActId":"EBI-1170392"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10363723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"}],"value":"Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10363723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21928280"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10363723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10363723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12466900"}],"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12466900"}],"value":"MICA1"}],"isoformIds":["Q29983-1"],"isoformSequenceStatus":"Displayed"},{"name":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12466900"}],"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12466900"}],"value":"MICA2"}],"isoformIds":["Q29983-2"],"sequenceIds":["VSP_055366"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10359807"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10363723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10691930"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12902493"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17565371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9396860"}],"value":"Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11224526"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11485740"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11830641"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15995699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16750166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18287244"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9497295"}],"value":"By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8901601"}],"value":"N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370336"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12384702"}],"value":"Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21928280"}],"value":"Palmitoylated on cysteine residues in the cytoplasmic tail leading to its association with membrane microdomains enriched in cholesterol"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24872415"}],"value":"N-glycosylation is necessary for cell surface expression"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18230726"}],"value":"(Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The following alleles of MICA are known: MICA*001, MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009, MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016, MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024, MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031, MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038, MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045, MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052, MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that of MICA*001"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","note":{"texts":[{"value":"Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Psoriasis 1","diseaseAccession":"DI-02231","acronym":"PSORS1","description":"A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.","diseaseCrossReference":{"database":"MIM","id":"177900"}},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Psoriatic arthritis","diseaseAccession":"DI-02697","acronym":"PSORAS","description":"An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).","diseaseCrossReference":{"database":"MIM","id":"607507"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10323458"}]},"note":{"texts":[{"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11053635"}],"value":"Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Found in about 10% of examined clones"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Belongs to the MHC class I family. MIC subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"MHC class I polypeptide-related sequence A","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000337146"},{"type":"Topological domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Lipidation","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21928280"}]},{"type":"Lipidation","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21928280"}]},{"type":"Glycosylation","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24872415"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367903"}]},{"type":"Disulfide bond","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367903"}]},{"type":"Disulfide bond","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10367903"}]},{"type":"Alternative sequence","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_055366","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding; dbSNP:rs9380254","featureCrossReferences":[{"database":"dbSNP","id":"rs9380254"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10752636"}],"featureId":"VAR_043625","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055; dbSNP:rs1063630","featureCrossReferences":[{"database":"dbSNP","id":"rs1063630"}],"featureId":"VAR_043626","alternativeSequence":{"originalSequence":"W","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056; dbSNP:rs1051785","featureCrossReferences":[{"database":"dbSNP","id":"rs1051785"}],"featureId":"VAR_043627","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in allele MICA*041; dbSNP:rs17200158","featureCrossReferences":[{"database":"dbSNP","id":"rs17200158"}],"featureId":"VAR_043628","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*016, allele MICA*019, allele MICA*024, allele MICA*025, allele MICA*027, allele MICA*028, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*042, allele MICA*044, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*054 and allele MICA*056; dbSNP:rs1051786","featureCrossReferences":[{"database":"dbSNP","id":"rs1051786"}],"featureId":"VAR_043629","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in allele MICA*017; dbSNP:rs41558312","featureCrossReferences":[{"database":"dbSNP","id":"rs41558312"}],"featureId":"VAR_043630","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in allele MICA*036; dbSNP:rs41557113","featureCrossReferences":[{"database":"dbSNP","id":"rs41557113"}],"featureId":"VAR_043631","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in allele MICA*014 and allele MICA*015; dbSNP:rs41556715","featureCrossReferences":[{"database":"dbSNP","id":"rs41556715"}],"featureId":"VAR_043632","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"in allele MICA*004, allele MICA*006, allele MICA*009, allele MICA*044 and allele MICA*049; dbSNP:rs1051790","featureCrossReferences":[{"database":"dbSNP","id":"rs1051790"}],"featureId":"VAR_043633","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"in allele MICA*033; dbSNP:rs41539919","featureCrossReferences":[{"database":"dbSNP","id":"rs41539919"}],"featureId":"VAR_043634","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*012, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*018, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056; dbSNP:rs1051791","featureCrossReferences":[{"database":"dbSNP","id":"rs1051791"}],"featureId":"VAR_043635","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Natural 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