{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q99705","secondaryAccessions":["B2RBX6","Q5R3J1","Q96S47","Q9BV08"],"uniProtkbId":"MCHR1_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-01-24","entryVersion":201,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10421367"}],"value":"Melanin-concentrating hormone receptor 1"},"shortNames":[{"value":"MCH receptor 1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15340116"}],"value":"MCH-R1"},{"value":"MCHR-1"}]},"alternativeNames":[{"fullName":{"value":"G protein-coupled receptor 24"}},{"fullName":{"value":"MCH-1R"},"shortNames":[{"value":"MCH1R"},{"value":"MCHR"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10421367"}],"value":"SLC-1"}},{"fullName":{"value":"Somatostatin receptor-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4479"}],"value":"MCHR1"},"synonyms":[{"value":"GPR24"},{"value":"SLC1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10421367"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15166293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340116"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"value":"G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (PubMed:10421367, PubMed:15340116, PubMed:38710677, PubMed:39616153). Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep (PubMed:10421367, PubMed:15166293, PubMed:15941924)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16945926"}],"value":"Interacts with NCDN; this interaction inhibits G protein-coupled signal transduction"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q99705","intActId":"EBI-36483704"},"interactantTwo":{"uniProtKBAccession":"O60894","geneName":"RAMP1","intActId":"EBI-962893"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99705","intActId":"EBI-36483704"},"interactantTwo":{"uniProtKBAccession":"O60895","geneName":"RAMP2","intActId":"EBI-9009040"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99705","intActId":"EBI-36483704"},"interactantTwo":{"uniProtKBAccession":"O60896","geneName":"RAMP3","intActId":"EBI-720447"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10421367"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"15340116"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8977118"}],"value":"Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAC14587.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH01736.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH21146.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAO14670.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAP35371.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAS72373.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB60890.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAG37373.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAG30383.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"EAW60388.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Melanin-concentrating hormone receptor 1","featureId":"PRO_0000069734"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WSS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWH"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWI"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWJ"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWN"}]},{"type":"Natural variant","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"in dbSNP:rs11914085","featureCrossReferences":[{"database":"dbSNP","id":"rs11914085"}],"featureId":"VAR_049417","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"in dbSNP:rs750210146","featureCrossReferences":[{"database":"dbSNP","id":"rs750210146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"}],"featureId":"VAR_026655","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15166293"}],"featureId":"VAR_026656","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"in dbSNP:rs550313335","featureCrossReferences":[{"database":"dbSNP","id":"rs550313335"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"}],"featureId":"VAR_026657","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in dbSNP:rs45439291","featureCrossReferences":[{"database":"dbSNP","id":"rs45439291"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15166293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"}],"featureId":"VAR_026658","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"in dbSNP:rs539260735","featureCrossReferences":[{"database":"dbSNP","id":"rs539260735"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"}],"featureId":"VAR_026659","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"in dbSNP:rs149604804","featureCrossReferences":[{"database":"dbSNP","id":"rs149604804"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15941924"}],"featureId":"VAR_026660","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Mutagenesis","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi and Gq activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi and Gq activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Decreased MCH-induced Gi and Gq activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"Decreased MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi activity. Increased basal activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Increased MCH-induced Gq activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Decreased MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Loss of MCH-induced Gi activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39616153"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWM"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWN"}]},{"type":"Helix","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Beta strand","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Turn","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]},{"type":"Helix","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WWK"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10441476","citationType":"journal article","authors":["Shimomura Y.","Mori M.","Sugo T.","Ishibashi Y.","Abe M.","Kurokawa T.","Onda H.","Nishimura O.","Sumino Y.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"10441476"},{"database":"DOI","id":"10.1006/bbrc.1999.1104"}],"title":"Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.","publicationDate":"1999","journal":"Biochem. Biophys. Res. Commun.","firstPage":"622","lastPage":"626","volume":"261"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"15941924","citationType":"journal article","authors":["Wermter A.-K.","Reichwald K.","Buech T.","Geller F.","Platzer C.","Huse K.","Hess C.","Remschmidt H.","Gudermann T.","Preibisch G.","Siegfried W.","Goldschmidt H.-P.","Li W.-D.","Price R.A.","Biebermann H.","Krude H.","Vollmert C.","Wichmann H.-E.","Illig T.","Soerensen T.I.A.","Astrup A.","Larsen L.H.","Pedersen O.","Eberle D.","Clement K.","Blundell J.","Wabitsch M.","Schaefer H.","Platzer M.","Hinney A.","Hebebrand J."],"citationCrossReferences":[{"database":"PubMed","id":"15941924"},{"database":"DOI","id":"10.1530/eje.1.01917"}],"title":"Mutation analysis of the MCHR1 gene in human obesity.","publicationDate":"2005","journal":"Eur. J. Endocrinol.","firstPage":"851","lastPage":"862","volume":"152"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANTS HIS-141; MET-236; GLN-248; SER-308 AND MET-342","FUNCTION"]},{"referenceNumber":3,"citation":{"id":"15461802","citationType":"journal article","authors":["Collins J.E.","Wright C.L.","Edwards C.A.","Davis M.P.","Grinham J.A.","Cole C.G.","Goward M.E.","Aguado B.","Mallya M.","Mokrab Y.","Huckle E.J.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15461802"},{"database":"DOI","id":"10.1186/gb-2004-5-10-r84"}],"title":"A genome annotation-driven approach to cloning the human ORFeome.","publicationDate":"2004","journal":"Genome Biol.","firstPage":"R84.1","lastPage":"R84.11","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"CI-FVDHJ9M17HT1Q","citationType":"submission","authors":["King M.M.","Aronstam R.S.","Sharma S.V."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"MAR-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"10591208","citationType":"journal article","authors":["Dunham I.","Hunt A.R.","Collins J.E.","Bruskiewich R.","Beare D.M.","Clamp M.","Smink L.J.","Ainscough R.","Almeida J.P.","Babbage A.K.","Bagguley C.","Bailey J.","Barlow K.F.","Bates K.N.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Buck D.","Burgess J.","Burrill W.D.","Burton J.","Carder C.","Carter N.P.","Chen Y.","Clark G.","Clegg S.M.","Cobley V.E.","Cole C.G.","Collier R.E.","Connor R.","Conroy D.","Corby N.R.","Coville G.J.","Cox A.V.","Davis J.","Dawson E.","Dhami P.D.","Dockree C.","Dodsworth S.J.","Durbin R.M.","Ellington A.G.","Evans K.L.","Fey J.M.","Fleming K.","French L.","Garner A.A.","Gilbert J.G.R.","Goward M.E.","Grafham D.V.","Griffiths M.N.D.","Hall C.","Hall R.E.","Hall-Tamlyn G.","Heathcott R.W.","Ho S.","Holmes S.","Hunt S.E.","Jones M.C.","Kershaw J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.F.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Martyn I.D.","Mashreghi-Mohammadi M.","Matthews L.H.","Mccann O.T.","Mcclay J.","Mclaren S.","McMurray A.A.","Milne S.A.","Mortimore B.J.","Odell C.N.","Pavitt R.","Pearce A.V.","Pearson D.","Phillimore B.J.C.T.","Phillips S.H.","Plumb R.W.","Ramsay H.","Ramsey Y.","Rogers L.","Ross M.T.","Scott C.E.","Sehra H.K.","Skuce C.D.","Smalley S.","Smith M.L.","Soderlund C.","Spragon L.","Steward C.A.","Sulston J.E.","Swann R.M.","Vaudin M.","Wall M.","Wallis J.M.","Whiteley M.N.","Willey D.L.","Williams L.","Williams S.A.","Williamson H.","Wilmer T.E.","Wilming L.","Wright C.L.","Hubbard T.","Bentley D.R.","Beck S.","Rogers J.","Shimizu N.","Minoshima S.","Kawasaki K.","Sasaki T.","Asakawa S.","Kudoh J.","Shintani A.","Shibuya K.","Yoshizaki Y.","Aoki N.","Mitsuyama S.","Roe B.A.","Chen F.","Chu L.","Crabtree J.","Deschamps S.","Do A.","Do T.","Dorman A.","Fang F.","Fu Y.","Hu P.","Hua A.","Kenton S.","Lai H.","Lao H.I.","Lewis J.","Lewis S.","Lin S.-P.","Loh P.","Malaj E.","Nguyen T.","Pan H.","Phan S.","Qi S.","Qian Y.","Ray L.","Ren Q.","Shaull S.","Sloan D.","Song L.","Wang Q.","Wang Y.","Wang Z.","White J.","Willingham D.","Wu H.","Yao Z.","Zhan M.","Zhang G.","Chissoe S.","Murray J.","Miller N.","Minx P.","Fulton R.","Johnson D.","Bemis G.","Bentley D.","Bradshaw H.","Bourne S.","Cordes M.","Du Z.","Fulton L.","Goela D.","Graves T.","Hawkins J.","Hinds K.","Kemp K.","Latreille P.","Layman D.","Ozersky P.","Rohlfing T.","Scheet P.","Walker C.","Wamsley A.","Wohldmann P.","Pepin K.","Nelson J.","Korf I.","Bedell J.A.","Hillier L.W.","Mardis E.","Waterston R.","Wilson R.","Emanuel B.S.","Shaikh T.","Kurahashi H.","Saitta S.","Budarf M.L.","McDermid H.E.","Johnson A.","Wong A.C.C.","Morrow B.E.","Edelmann L.","Kim U.J.","Shizuya H.","Simon M.I.","Dumanski J.P.","Peyrard M.","Kedra D.","Seroussi E.","Fransson I.","Tapia I.","Bruder C.E.","O'Brien K.P.","Wilkinson P.","Bodenteich A.","Hartman K.","Hu X.","Khan A.S.","Lane L.","Tilahun Y.","Wright H."],"citationCrossReferences":[{"database":"PubMed","id":"10591208"},{"database":"DOI","id":"10.1038/990031"}],"title":"The DNA sequence of human chromosome 22.","publicationDate":"1999","journal":"Nature","firstPage":"489","lastPage":"495","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"8977118","citationType":"journal article","authors":["Kolakowski L.F. Jr.","Jung B.P.","Nguyen T.","Johnson M.P.","Lynch K.R.","Cheng R.","Heng H.H.Q.","George S.R.","O'Dowd B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8977118"},{"database":"DOI","id":"10.1016/s0014-5793(96)01160-x"}],"title":"Characterization of a human gene related to genes encoding somatostatin receptors.","publicationDate":"1996","journal":"FEBS Lett.","firstPage":"253","lastPage":"258","volume":"398"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-353","TISSUE SPECIFICITY"]},{"referenceNumber":11,"citation":{"id":"10421367","citationType":"journal article","authors":["Chambers J.","Ames R.S.","Bergsma D.","Muir A.","Fitzgerald L.R.","Hervieu G.","Dytko G.M.","Foley J.J.","Martin J.","Liu W.S.","Park J.","Ellis C.","Ganguly S.","Konchar S.","Cluderay J.","Leslie R.","Wilson S.","Sarau H.M."],"citationCrossReferences":[{"database":"PubMed","id":"10421367"},{"database":"DOI","id":"10.1038/22313"}],"title":"Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.","publicationDate":"1999","journal":"Nature","firstPage":"261","lastPage":"265","volume":"400"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"15340116","citationType":"journal article","authors":["Hawes B.E.","Green B.","O'Neill K.","Fried S.","Arreaza M.G.","Qiu P.","Simon J.S."],"citationCrossReferences":[{"database":"PubMed","id":"15340116"},{"database":"DOI","id":"10.1038/oby.2004.167"}],"title":"Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.","publicationDate":"2004","journal":"Obes. Res.","firstPage":"1327","lastPage":"1334","volume":"12"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"16945926","citationType":"journal article","authors":["Francke F.","Ward R.J.","Jenkins L.","Kellett E.","Richter D.","Milligan G.","Baechner D."],"citationCrossReferences":[{"database":"PubMed","id":"16945926"},{"database":"DOI","id":"10.1074/jbc.m602889200"}],"title":"Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"32496","lastPage":"32507","volume":"281"},"referencePositions":["INTERACTION WITH NCDN"]},{"referenceNumber":14,"citation":{"id":"38710677","citationType":"journal article","authors":["He Q.","Yuan Q.","Shan H.","Wu C.","Gu Y.","Wu K.","Hu W.","Zhang Y.","He X.","Xu H.E.","Zhao L.H."],"citationCrossReferences":[{"database":"PubMed","id":"38710677"},{"database":"DOI","id":"10.1038/s41421-024-00679-8"}],"title":"Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.","publicationDate":"2024","journal":"Cell Discov.","firstPage":"48","lastPage":"48","volume":"10"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.01 ANGSTROMS) OF 1-336 IN COMPLEX WITH GNAI1; GBB1; GBG2 AND MCH","DISULFIDE BONDS","FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF GLN-127; THR-152 AND TYR-301"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WSS"}]},{"referenceNumber":15,"citation":{"id":"39616153","citationType":"journal article","authors":["Ye X.","Liu G.","Li X.","He B.","Tao Y.","Guan J.","Mu Y.","Liu H.","Gong W."],"citationCrossReferences":[{"database":"PubMed","id":"39616153"},{"database":"DOI","id":"10.1038/s41421-024-00754-0"}],"title":"Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1.","publicationDate":"2024","journal":"Cell Discov.","firstPage":"124","lastPage":"124","volume":"10"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.61 ANGSTROMS) OF 1-327 IN COMPLEX WITH GNAI1; GBB1; GBG2 AND MCH","DISULFIDE BONDS","FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF LYS-70; LEU-71; GLN-127; ILE-185; PHE-187; TYR-293; ILE-297 AND TYR-301"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWL"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWM"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8WWN"}]},{"referenceNumber":16,"citation":{"id":"15166293","citationType":"journal article","authors":["Gibson W.T.","Pissios P.","Trombly D.J.","Luan J.","Keogh J.","Wareham N.J.","Maratos-Flier E.","O'Rahilly S.","Farooqi I.S."],"citationCrossReferences":[{"database":"PubMed","id":"15166293"},{"database":"DOI","id":"10.1038/oby.2004.89"}],"title":"Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.","publicationDate":"2004","journal":"Obes. Res.","firstPage":"743","lastPage":"749","volume":"12"},"referencePositions":["VARIANTS HIS-181 AND GLN-248","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB063174","properties":[{"key":"ProteinId","value":"BAB60890.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF490537","properties":[{"key":"ProteinId","value":"AAO14670.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR456497","properties":[{"key":"ProteinId","value":"CAG30383.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT006725","properties":[{"key":"ProteinId","value":"AAP35371.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY562945","properties":[{"key":"ProteinId","value":"AAS72373.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK314857","properties":[{"key":"ProteinId","value":"BAG37373.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Z86090","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471095","properties":[{"key":"ProteinId","value":"EAW60388.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001736","properties":[{"key":"ProteinId","value":"AAH01736.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC021146","properties":[{"key":"ProteinId","value":"AAH21146.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U71092","properties":[{"key":"ProteinId","value":"AAC14587.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS14004.2","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"JC7080","properties":[{"key":"EntryName","value":"JC7080"}]},{"database":"RefSeq","id":"NP_005288.4","properties":[{"key":"NucleotideSequenceId","value":"NM_005297.4"}]},{"database":"PDB","id":"8WSS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"R=1-336"}]},{"database":"PDB","id":"8WWH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.43 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.81 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8WWN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"R=1-327"}]},{"database":"PDB","id":"8YNS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.33 A"},{"key":"Chains","value":"R=247-327"}]},{"database":"PDB","id":"8YNT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.43 A"},{"key":"Chains","value":"R=247-327"}]},{"database":"PDBsum","id":"8WSS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WWN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8YNS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8YNT","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37823","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37888","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37889","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37890","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37891","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37892","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37893","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37894","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39429","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39430","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109106","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q99705","properties":[{"key":"Number of interactors","value":"612"}]},{"database":"IntAct","id":"Q99705","properties":[{"key":"Interactions","value":"4"}]},{"database":"NDEx","id":"IQUERY-CP-MCHR1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000249016","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL344","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB14787","properties":[{"key":"GenericName","value":"BMS-830216"}]},{"database":"DrugBank","id":"DB00502","properties":[{"key":"GenericName","value":"Haloperidol"}]},{"database":"DrugBank","id":"DB06027","properties":[{"key":"GenericName","value":"NGD-4715"}]},{"database":"GuidetoPHARMACOLOGY","id":"280","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.A.14.13.6","properties":[{"key":"FamilyName","value":"the g-protein-coupled receptor (gpcr) family"}]},{"database":"GlyCosmos","id":"Q99705","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q99705","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"PhosphoSitePlus","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MCHR1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"33860175","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000249016","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"300","properties":[{"key":"antibodies","value":"321 antibodies from 33 providers"}]},{"database":"DNASU","id":"2847","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000249016.5","properties":[{"key":"ProteinId","value":"ENSP00000249016.5"},{"key":"GeneId","value":"ENSG00000128285.5"}]},{"database":"GeneID","id":"2847","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2847","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000249016.5","properties":[{"key":"ProteinId","value":"ENSP00000249016.5"},{"key":"RefSeqNucleotideId","value":"NM_005297.4"},{"key":"RefSeqProteinId","value":"NP_005288.4"}]},{"database":"UCSC","id":"uc003ayz.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4479","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28867","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2847","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2847","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MCHR1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4479","properties":[{"key":"GeneName","value":"MCHR1"}]},{"database":"HPA","id":"ENSG00000128285","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, endometrium, ovary)"}]},{"database":"MalaCards","id":"MCHR1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"601751","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000128285","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000128285","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154272","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_8_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6076970at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q99705","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-HSA-416476","properties":[{"key":"PathwayName","value":"G alpha (q) signalling events"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"Reactome","id":"R-HSA-5620922","properties":[{"key":"PathwayName","value":"BBSome-mediated cargo-targeting to cilium"}]},{"database":"SignaLink","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000128285","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2847","properties":[{"key":"hits","value":"11 hits in 1140 CRISPR screens"}]},{"database":"ChiTaRS","id":"MCHR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Melanin-concentrating_hormone_receptor_1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2847","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q99705","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q99705","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"RNAct","id":"Q99705","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000128285","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 114 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q99705","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0097731","properties":[{"key":"GoTerm","value":"C:9+0 non-motile cilium"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0060170","properties":[{"key":"GoTerm","value":"C:ciliary membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005929","properties":[{"key":"GoTerm","value":"C:cilium"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28154160"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0097730","properties":[{"key":"GoTerm","value":"C:non-motile cilium"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39616153"}]},{"database":"GO","id":"GO:0004930","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042562","properties":[{"key":"GoTerm","value":"F:hormone binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030273","properties":[{"key":"GoTerm","value":"F:melanin-concentrating hormone receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39616153"}]},{"database":"GO","id":"GO:0042923","properties":[{"key":"GoTerm","value":"F:neuropeptide binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008188","properties":[{"key":"GoTerm","value":"F:neuropeptide receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10860944"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007193","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38710677"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39616153"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097009","properties":[{"key":"GoTerm","value":"P:energy homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007631","properties":[{"key":"GoTerm","value":"P:feeding behavior"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10421367"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10421368"}]},{"database":"GO","id":"GO:0006091","properties":[{"key":"GoTerm","value":"P:generation of precursor metabolites and energy"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10421367"}]},{"database":"GO","id":"GO:0007218","properties":[{"key":"GoTerm","value":"P:neuropeptide signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007200","properties":[{"key":"GoTerm","value":"P:phospholipase C-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38710677"}]},{"database":"GO","id":"GO:0051928","properties":[{"key":"GoTerm","value":"P:positive regulation of calcium ion transport"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10421367"}]},{"database":"GO","id":"GO:0060259","properties":[{"key":"GoTerm","value":"P:regulation of feeding behavior"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006950","properties":[{"key":"GoTerm","value":"P:response to stress"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030431","properties":[{"key":"GoTerm","value":"P:sleep"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd15338","properties":[{"key":"EntryName","value":"7tmA_MCHR1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000115","properties":[{"key":"EntryName","value":"Melanin-concentrating hormone receptor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR008361","properties":[{"key":"EntryName","value":"MCH_rcpt"}]},{"database":"InterPro","id":"IPR004047","properties":[{"key":"EntryName","value":"MCHR1"}]},{"database":"PANTHER","id":"PTHR24229:SF91","properties":[{"key":"EntryName","value":"MELANIN-CONCENTRATING HORMONE RECEPTOR 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24229","properties":[{"key":"EntryName","value":"NEUROPEPTIDES RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR01507","properties":[{"key":"EntryName","value":"MCH1RECEPTOR"}]},{"database":"PRINTS","id":"PR01783","properties":[{"key":"EntryName","value":"MCHRECEPTOR"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT","length":353,"molWeight":38940,"crc64":"0C7D692C92667EDC","md5":"93203A14A2523E6C5F4D4B7DB27C3268"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1,"SEQUENCE CAUTION":10},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Region":1,"Compositional bias":1,"Glycosylation":3,"Disulfide bond":1,"Natural variant":7,"Mutagenesis":11,"Helix":13,"Beta strand":7,"Turn":1},"uniParcId":"UPI000003DBC8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6ZJ87","uniProtkbId":"A6ZJ87_HUMAN","entryAudit":{"firstPublicDate":"2007-08-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-05-25","entryVersion":107,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022022"}],"value":"Melanin-concentrating hormone receptor 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096855"}],"value":"G protein-coupled receptor 24"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032830"}],"value":"MCH-1R"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"}],"value":"MCHR1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096132"}],"value":"G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium. Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096552"}],"value":"Interacts with NCDN; this interaction inhibits G protein-coupled signal transduction"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A6ZJ87"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"18477386","citationType":"journal article","authors":["Cole C.G.","McCann O.T.","Collins J.E.","Oliver K.","Willey D.","Gribble S.M.","Yang F.","McLaren K.","Rogers J.","Ning Z.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"18477386"},{"database":"DOI","id":"10.1186/gb-2008-9-5-r78"}],"title":"Finishing the finished human chromosome 22 sequence.","publicationDate":"2008","journal":"Genome Biol.","firstPage":"R78","lastPage":"R78","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000370841.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z86090","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A6ZJ87","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A6ZJ87","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A6ZJ87","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"300","properties":[{"key":"antibodies","value":"321 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000381433.3","properties":[{"key":"ProteinId","value":"ENSP00000370841.3"},{"key":"GeneId","value":"ENSG00000128285.5"}]},{"database":"UCSC","id":"uc062eoh.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:4479","properties":[{"key":"GeneName","value":"MCHR1"}]},{"database":"OpenTargets","id":"ENSG00000128285","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000128285","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000154272","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_082138_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6076970at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"MCHR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSG00000128285","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 114 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A6ZJ87","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030273","properties":[{"key":"GoTerm","value":"F:melanin-concentrating hormone receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007218","properties":[{"key":"GoTerm","value":"P:neuropeptide signaling pathway"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000968","properties":[{"key":"EntryName","value":"Melanin-concentrating hormone receptor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR008361","properties":[{"key":"EntryName","value":"MCH_rcpt"}]},{"database":"InterPro","id":"IPR004047","properties":[{"key":"EntryName","value":"MCHR1"}]},{"database":"PANTHER","id":"PTHR24229:SF91","properties":[{"key":"EntryName","value":"MELANIN-CONCENTRATING HORMONE RECEPTOR 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24229","properties":[{"key":"EntryName","value":"NEUROPEPTIDES RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR01507","properties":[{"key":"EntryName","value":"MCH1RECEPTOR"}]},{"database":"PRINTS","id":"PR01783","properties":[{"key":"EntryName","value":"MCHRECEPTOR"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT","length":227,"molWeight":24837,"crc64":"C66C4237BDA82C62","md5":"2CDF02FF8EA669C0E67B02270920C0BF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI001E24885C"}}]}