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Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19555689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22480440"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24824780"}],"value":"Interacts with SCRIB (via phosphorylated PDZ-binding motif), EZR, SNX27, NHERF1 and NHERF2. Interacts with CTNNB1; the interaction is enhanced upon Wnt stimulation. Interacts with MYH10. 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