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Promotes microtubule growth (PubMed:19255245, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:19255245, PubMed:28814570). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10188731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10644998"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14514668"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17563362"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19146815"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19255245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21646404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25217626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34996871"}],"value":"Homodimer (PubMed:19255245). Heterodimer with MAPRE1 (PubMed:19255245). Binds monomeric and polymerized GTP-bound tubulin (PubMed:10188731, PubMed:34996871). Interacts with APC2 (PubMed:10644998). Interacts with DCTN1 and SRCIN1 (PubMed:14514668, PubMed:19146815). Binds to the C-terminal domain of APC (PubMed:14514668). Interacts (via C-terminus) with CLIP1 (PubMed:17563362). Interacts with SLAIN2 and SLAIN1 (PubMed:21646404). Interacts with AKAP9 (PubMed:28814570). Interacts with PDE4DIP (PubMed:28814570). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus 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