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Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity (PubMed:31152061)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31152061"}],"value":"Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Aortic aneurysm, familial thoracic 10","diseaseAccession":"DI-04842","acronym":"AAT10","description":"A form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. 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