{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P13647","secondaryAccessions":["Q6PI71","Q6UBJ0","Q8TA91"],"uniProtkbId":"K2C5_HUMAN","entryAudit":{"firstPublicDate":"1990-01-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-03","entryVersion":258,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Keratin, type II cytoskeletal 5"}},"alternativeNames":[{"fullName":{"value":"58 kDa cytokeratin"}},{"fullName":{"value":"Cytokeratin-5"},"shortNames":[{"value":"CK-5"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24940650"}],"value":"Keratin-5"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2476664"}],"value":"K5"}]},{"fullName":{"value":"Type-II keratin Kb5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6442"}],"value":"KRT5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1372711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694855"}],"value":"Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (PubMed:1372711, PubMed:1694855). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10852826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15731013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1694855"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22705788"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24940650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28899683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31995743"}],"value":"Heterodimers composed of type I and type II keratin; forms parallel coiled-coil heterodimers (PubMed:1694855, PubMed:22705788, PubMed:24940650, PubMed:31995743). Two heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order intermediate filaments (PubMed:1694855). Forms a heterodimer (via 2B domains) with KRT14 (via 2B domains) (PubMed:22705788, PubMed:24940650, PubMed:31995743). Interacts with PLEC isoform 1C, when in a heterodimer with KRT14 (PubMed:24940650). May interact with KRT25 (PubMed:28899683). Interacts with TCHP (PubMed:15731013). Interacts with EPPK1 (By similarity). Interacts with AMELX (By similarity). Interacts with PKP1 (via N-terminus) and PKP2 (PubMed:10852826)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"P18054","geneName":"ALOX12","intActId":"EBI-1633210"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q0VD86","geneName":"INCA1","intActId":"EBI-6509505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q9BVG8","geneName":"KIFC3","intActId":"EBI-2125614"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q9BVG8-5","geneName":"KIFC3","intActId":"EBI-14069005"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"P02533","geneName":"KRT14","intActId":"EBI-702178"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"P19012","geneName":"KRT15","intActId":"EBI-739566"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"P08779","geneName":"KRT16","intActId":"EBI-356410"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"P08727","geneName":"KRT19","intActId":"EBI-742756"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q2M2I5","geneName":"KRT24","intActId":"EBI-2952736"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q7Z3Z0","geneName":"KRT25","intActId":"EBI-11980019"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q7Z3Y8","geneName":"KRT27","intActId":"EBI-3044087"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q7Z3Y7","geneName":"KRT28","intActId":"EBI-11980489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q15323","geneName":"KRT31","intActId":"EBI-948001"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q92764","geneName":"KRT35","intActId":"EBI-1058674"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"O76015","geneName":"KRT38","intActId":"EBI-1047263"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q6A162","geneName":"KRT40","intActId":"EBI-10171697"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q13835-2","geneName":"PKP1","intActId":"EBI-9087684"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P13647","intActId":"EBI-702187"},"interactantTwo":{"uniProtKBAccession":"Q14134","geneName":"TRIM29","intActId":"EBI-702370"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20128788"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20128788"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26758872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31302245"}],"value":"Expressed in corneal epithelium (at protein level) (PubMed:26758872). Expressed in keratinocytes (at protein level) (PubMed:20128788, PubMed:31302245)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"}],"value":"Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (By similarity). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (By similarity). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"}],"value":"O-glycosylated"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2A, generalized severe","diseaseAccession":"DI-06251","acronym":"EBS2A","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2A is an autosomal dominant, severe form characterized by extensive intraepidermal blistering from the time of birth with herpetiform marginal spreading and central healing. Oral mucosal involvement, nail dystrophy, onychogryposis, formation of milia, and palmoplantar hyperkeratosis are common features.","diseaseCrossReference":{"database":"MIM","id":"619555"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10730767"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12655565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1372711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16786515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16882168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19691749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20128788"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21375516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21623745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26432462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8757772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9036937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9406827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9989794"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.23"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2B, generalized intermediate","diseaseAccession":"DI-06252","acronym":"EBS2B","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2B is an autosomal dominant form characterized by generalized blistering manifesting at birth. The tendency to blistering diminishes in adolescence, when it may become localized to hands and feet.","diseaseCrossReference":{"database":"MIM","id":"619588"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11407988"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16882168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17855059"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21375516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21623745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23450297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26432462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7534039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7686424"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9740251"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9989794"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2C, localized","diseaseAccession":"DI-06253","acronym":"EBS2C","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2C is an autosomal dominant form with intraepidermal blistering mainly restricted to hands and feet beginning in infancy. Nails may be thick and dystrophic.","diseaseCrossReference":{"database":"MIM","id":"619594"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10782015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11973334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12655565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12707098"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14723728"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15140024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15347343"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16786515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16882168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19220453"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21375516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21623745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26432462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30240119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7506097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7520042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7688477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8595431"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8807337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9804357"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive","diseaseAccession":"DI-06254","acronym":"EBS2D","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2D is an autosomal recessive form characterized by widespread intraepidermal skin blistering and erosions from birth. Death may occur in the neonatal period.","diseaseCrossReference":{"database":"MIM","id":"619599"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11973334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22832485"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31302245"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2E, with migratory circinate erythema","diseaseAccession":"DI-00466","acronym":"EBS2E","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2E is an autosomal dominant form in which multiple vesicles are present from birth onward and acquire over time a typical migratory circinate pattern on an erythematous background. Postinflammatory hyperpigmentation develops gradually and may have a mottled pattern.","diseaseCrossReference":{"database":"MIM","id":"609352"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12925204"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Epidermolysis bullosa simplex 2F, with mottled pigmentation","diseaseAccession":"DI-00467","acronym":"EBS2F","description":"A form of epidermolysis bullosa simplex, a group of skin fragility disorders characterized by skin blistering due to cleavage within the basal layer of keratinocytes, and erosions caused by minor mechanical trauma. There is a broad spectrum of clinical severity ranging from minor blistering on the feet, to subtypes with extracutaneous involvement and a lethal outcome. EBS2F is an autosomal dominant form characterized by generalized skin blistering of intermediate severity beginning at birth, with mottled or reticulate pigmentation developing gradually. Focal keratoses of palms and soles and dystrophic, thickened nails develop over time.","diseaseCrossReference":{"database":"MIM","id":"131960"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10494094"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16882168"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21375516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21623745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26432462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8799157"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Dowling-Degos disease 1","diseaseAccession":"DI-01503","acronym":"DDD1","description":"An autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.","diseaseCrossReference":{"database":"MIM","id":"179850"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16465624"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21569119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22437315"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01188"}],"value":"Belongs to the intermediate filament family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Keratin, type II cytoskeletal 5","featureId":"PRO_0000063727"},{"type":"Domain","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"IF rod","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01188"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"Head"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Coil 1A"},{"type":"Region","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Linker 1"},{"type":"Region","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Coil 1B"},{"type":"Region","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Linker 12"},{"type":"Region","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"Coil 2"},{"type":"Region","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Tail"},{"type":"Region","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Stutter"},{"type":"Modified residue","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P6Q2"}]},{"type":"Modified residue","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P6Q2"}]},{"type":"Modified residue","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"}]},{"type":"Modified residue","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q922U2"}]},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Phosphothreonine; 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