{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P14923","secondaryAccessions":["Q15093","Q15151","Q7L3S5","Q86W21","Q9BWC4","Q9HCX9"],"uniProtkbId":"PLAK_HUMAN","entryAudit":{"firstPublicDate":"1990-04-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-02","entryVersion":238,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Junction plakoglobin"}},"alternativeNames":[{"fullName":{"value":"Catenin gamma"}},{"fullName":{"value":"Desmoplakin III"}},{"fullName":{"value":"Desmoplakin-3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6207"}],"value":"JUP"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6207"}],"value":"CTNNG"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6207"}],"value":"DP3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q02257"}],"value":"Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q02257"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11790773"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12370829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16917092"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19136012"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19759396"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20859650"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21062920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21495994"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22781308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7982500"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8631907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9139698"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9152027"}],"value":"Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Identified in a complex containing at least DSP, JUP, VIM and CDH2; the complex is more abundant following crush injury in regenerating motor neurons and may promote axon outgrowth and motor fiber repair (By similarity). Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSG1 (via cytoplasmic region) (PubMed:19136012, PubMed:19759396, PubMed:8631907). Interacts with DSC1 and DSC2. Interacts with PKP2 (PubMed:11790773, PubMed:22781308). Interacts with PKP3 (via N-terminus); the interaction is required for PKP3 localization to desmosome cell-cell junctions (PubMed:20859650). Interacts with DSG4 (PubMed:21495994). Interacts with DSP (PubMed:16917092)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P25054","geneName":"APC","intActId":"EBI-727707"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z4M1","geneName":"AXIN1","intActId":"EBI-16429430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"O15169","geneName":"AXIN1","intActId":"EBI-710484"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q9HAW0","geneName":"BRF2","intActId":"EBI-1055224"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P19022","geneName":"CDH2","intActId":"EBI-2256711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P35221","geneName":"CTNNA1","intActId":"EBI-701918"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q9UI47-2","geneName":"CTNNA3","intActId":"EBI-11962928"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q9NSA3","geneName":"CTNNBIP1","intActId":"EBI-747082"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P26196","geneName":"DDX6","intActId":"EBI-351257"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q02413","geneName":"DSG1","intActId":"EBI-1045757"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q14192","geneName":"FHL2","intActId":"EBI-701903"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"P23327","geneName":"HRC","intActId":"EBI-9639760"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P14923","intActId":"EBI-702484"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,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