{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q13007","secondaryAccessions":["Q2YHE5","Q53XZ7","Q5YLN8","Q96DB0","Q96KG4"],"uniProtkbId":"IL24_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":220,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Interleukin-24"},"shortNames":[{"value":"IL-24"}]},"alternativeNames":[{"fullName":{"value":"Melanoma differentiation-associated gene 7 protein"},"shortNames":[{"value":"MDA-7"}]},{"fullName":{"value":"Suppression of tumorigenicity 16 protein"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"IL24"},"synonyms":[{"value":"MDA7"},{"value":"ST16"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q925S4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11706020"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25168428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27687232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30111632"}],"value":"Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q13007","intActId":"EBI-3915542"},"interactantTwo":{"uniProtKBAccession":"Q13315","geneName":"ATM","intActId":"EBI-495465"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13007","intActId":"EBI-3915542"},"interactantTwo":{"uniProtKBAccession":"O96017","geneName":"CHEK2","intActId":"EBI-1180783"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13007","intActId":"EBI-3915542"},"interactantTwo":{"uniProtKBAccession":"P09874","geneName":"PARP1","intActId":"EBI-355676"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q13007","intActId":"EBI-3915542"},"interactantTwo":{"uniProtKBAccession":"Q06609","geneName":"RAD51","intActId":"EBI-297202"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11706020"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q13007-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q13007-2"],"sequenceIds":["VSP_042673"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q13007-3"],"sequenceIds":["VSP_042673","VSP_042674"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"mda-7s"}],"isoformIds":["Q13007-4"],"sequenceIds":["VSP_043915"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Up-regulated in melanoma cells induced to terminally differentiate"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27687232"}],"value":"Upon influenza virus infection"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11706020"}],"value":"Glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23078624"}],"value":"Ubiquitination at Lys-122 promotes proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the IL-10 family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Interleukin_24","ftp":false,"note":"Interleukin-24 entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340161"}]},{"type":"Chain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Interleukin-24","featureId":"PRO_0000015386"},{"type":"Glycosylation","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30111632"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6DF3"}]},{"type":"Cross-link","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23078624"}]},{"type":"Alternative sequence","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16313301"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.7"}],"featureId":"VSP_042673","alternativeSequence":{"originalSequence":"A","alternativeSequences":["AS"]}},{"type":"Alternative sequence","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15304100"}],"featureId":"VSP_043915","alternativeSequence":{"originalSequence":"RPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL","alternativeSequences":["SKLRITSRVPGCCSRRFCRTSRKKMRCFPSETVHTGGFCYSGEHSNSWT"]}},{"type":"Alternative sequence","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16313301"}],"featureId":"VSP_042674","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"in dbSNP:rs1150258","featureCrossReferences":[{"database":"dbSNP","id":"rs1150258"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11704829"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_011974","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"in dbSNP:rs3093431","featureCrossReferences":[{"database":"dbSNP","id":"rs3093431"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_013097","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in dbSNP:rs3093446","featureCrossReferences":[{"database":"dbSNP","id":"rs3093446"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_013098","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Beta strand","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Beta strand","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DF3"}]},{"type":"Helix","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]},{"type":"Helix","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GG1"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8545104","citationType":"journal article","authors":["Jiang H.","Lin J.J.","Su Z.-Z.","Goldstein N.I.","Fisher P.B."],"citationCrossReferences":[{"database":"PubMed","id":"8545104"}],"title":"Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.","publicationDate":"1995","journal":"Oncogene","firstPage":"2477","lastPage":"2486","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Melanoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-37P0BUE745M04","citationType":"submission","authors":["Peat J.","Kube D.","Eskdale J.","Jueliger S.","Gallagher G."],"title":"The human MDA-7 gene.","publicationDate":"JUN-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"11704829","citationType":"journal article","authors":["Huang E.Y.","Madireddi M.T.","Gopalkrishnan R.V.","Leszczyniecka M.","Su Z.-Z.","Lebedeva I.V.","Kang D.","Jiang H.","Lin J.J.","Alexandre D.","Chen Y.","Vozhilla N.","Mei M.X.","Christiansen K.A.","Sivo F.","Goldstein N.I.","Mhashilkar A.B.","Chada S.","Huberman E.","Pestka S.","Fisher P.B."],"citationCrossReferences":[{"database":"PubMed","id":"11704829"},{"database":"DOI","id":"10.1038/sj.onc.1204897"}],"title":"Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties.","publicationDate":"2001","journal":"Oncogene","firstPage":"7051","lastPage":"7063","volume":"20"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT HIS-124"],"referenceComments":[{"value":"Fibroblast","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15304100","citationType":"journal article","authors":["Allen M.","Pratscher B.","Roka F.","Krepler C.","Wacheck V.","Schofer C.","Pehamberger H.","Muller M.","Lucas T."],"citationCrossReferences":[{"database":"PubMed","id":"15304100"},{"database":"DOI","id":"10.1111/j.0022-202x.2004.23321.x"}],"title":"Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma.","publicationDate":"2004","journal":"J. Invest. Dermatol.","firstPage":"583","lastPage":"588","volume":"123"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)"]},{"referenceNumber":5,"citation":{"id":"CI-6O51O0FGU22BO","citationType":"submission","authoringGroup":["SeattleSNPs variation discovery resource"],"publicationDate":"NOV-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS HIS-124; ARG-125 AND LEU-131"]},{"referenceNumber":6,"citation":{"id":"16313301","citationType":"journal article","authors":["Allen M.","Pratscher B.","Krepler C.","Frei K.","Schofer C.","Pehamberger H.","Muller M.","Lucas T."],"citationCrossReferences":[{"database":"PubMed","id":"16313301"},{"database":"DOI","id":"10.1111/j.1744-313x.2005.00540.x"}],"title":"Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5.","publicationDate":"2005","journal":"Int. J. Immunogenet.","firstPage":"375","lastPage":"378","volume":"32"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)","ALTERNATIVE SPLICING"]},{"referenceNumber":7,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":8,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"15340161","citationType":"journal article","authors":["Zhang Z.","Henzel W.J."],"citationCrossReferences":[{"database":"PubMed","id":"15340161"},{"database":"DOI","id":"10.1110/ps.04682504"}],"title":"Signal peptide prediction based on analysis of experimentally verified cleavage sites.","publicationDate":"2004","journal":"Protein Sci.","firstPage":"2819","lastPage":"2824","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 52-66"]},{"referenceNumber":11,"citation":{"id":"9826712","citationType":"journal article","authors":["Su Z.-Z.","Madireddi M.T.","Lin J.J.","Young C.S.H.","Kitada S.","Reed J.C.","Goldstein N.I.","Fisher P.B."],"citationCrossReferences":[{"database":"PubMed","id":"9826712"},{"database":"DOI","id":"10.1073/pnas.95.24.14400"}],"title":"The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.","publicationDate":"1998","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"14400","lastPage":"14405","volume":"95"},"referencePositions":["CHARACTERIZATION"]},{"referenceNumber":12,"citation":{"id":"11706020","citationType":"journal article","authors":["Wang M.","Tan Z.","Zhang R.","Kotenko S.V.","Liang P."],"citationCrossReferences":[{"database":"PubMed","id":"11706020"},{"database":"DOI","id":"10.1074/jbc.m106043200"}],"title":"Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"7341","lastPage":"7347","volume":"277"},"referencePositions":["FUNCTION","GLYCOSYLATION","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"23078624","citationType":"journal article","authors":["Tian H.","Li L.","Zhang B.","Di J.","Chen F.","Li H.","Liu J.","Pei D.","Zheng J."],"citationCrossReferences":[{"database":"PubMed","id":"23078624"},{"database":"DOI","id":"10.1089/jir.2012.0055"}],"title":"Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24.","publicationDate":"2012","journal":"J. Interferon Cytokine Res.","firstPage":"575","lastPage":"582","volume":"32"},"referencePositions":["UBIQUITINATION AT LYS-122"]},{"referenceNumber":14,"citation":{"id":"25168428","citationType":"journal article","authors":["Jin S.H.","Choi D.","Chun Y.J.","Noh M."],"citationCrossReferences":[{"database":"PubMed","id":"25168428"},{"database":"DOI","id":"10.1016/j.taap.2014.08.019"}],"title":"Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors.","publicationDate":"2014","journal":"Toxicol. Appl. Pharmacol.","firstPage":"199","lastPage":"206","volume":"280"},"referencePositions":["FUNCTION"]},{"referenceNumber":15,"citation":{"id":"27687232","citationType":"journal article","authors":["Seong R.K.","Choi Y.K.","Shin O.S."],"citationCrossReferences":[{"database":"PubMed","id":"27687232"},{"database":"DOI","id":"10.1007/s12275-016-6383-2"}],"title":"MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication.","publicationDate":"2016","journal":"J. Microbiol.","firstPage":"695","lastPage":"700","volume":"54"},"referencePositions":["FUNCTION","INDUCTION BY INFLUENZA VIRUS"]},{"referenceNumber":16,"citation":{"id":"30111632","citationType":"journal article","authors":["Lubkowski J.","Sonmez C.","Smirnov S.V.","Anishkin A.","Kotenko S.V.","Wlodawer A."],"citationCrossReferences":[{"database":"PubMed","id":"30111632"},{"database":"DOI","id":"10.4049/jimmunol.1800726"}],"title":"Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2.","publicationDate":"2018","journal":"J. Immunol.","firstPage":"2082","lastPage":"2093","volume":"201"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 52-206","FUNCTION","DISULFIDE BOND"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6DF3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U16261","properties":[{"key":"ProteinId","value":"AAA91780.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF276916","properties":[{"key":"ProteinId","value":"AAG41401.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF235005","properties":[{"key":"ProteinId","value":"AAK52589.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY237723","properties":[{"key":"ProteinId","value":"AAO67513.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY062931","properties":[{"key":"ProteinId","value":"AAL34146.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY641441","properties":[{"key":"ProteinId","value":"AAV52801.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT007156","properties":[{"key":"ProteinId","value":"AAP35820.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC098935","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC009681","properties":[{"key":"ProteinId","value":"AAH09681.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1471.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-1"},{"database":"CCDS","id":"CCDS53465.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-2"},{"database":"CCDS","id":"CCDS53466.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-3"},{"database":"CCDS","id":"CCDS73021.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-4"},{"database":"RefSeq","id":"NP_001172085.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001185156.1"}],"isoformId":"Q13007-2"},{"database":"RefSeq","id":"NP_001172086.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001185157.1"}],"isoformId":"Q13007-3"},{"database":"RefSeq","id":"NP_001172087.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001185158.1"}],"isoformId":"Q13007-4"},{"database":"RefSeq","id":"NP_006841.1","properties":[{"key":"NucleotideSequenceId","value":"NM_006850.3"}],"isoformId":"Q13007-1"},{"database":"RefSeq","id":"XP_047297719.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441763.1"}],"isoformId":"Q13007-2"},{"database":"RefSeq","id":"XP_047297730.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047441774.1"}],"isoformId":"Q13007-1"},{"database":"RefSeq","id":"XP_054189934.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054333959.1"}],"isoformId":"Q13007-2"},{"database":"PDB","id":"6DF3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"C=52-206"}]},{"database":"PDB","id":"6GG1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A=54-206"}]},{"database":"PDBsum","id":"6DF3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GG1","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116199","properties":[{"key":"Interactions","value":"33"}]},{"database":"ComplexPortal","id":"CPX-10310","properties":[{"key":"EntryName","value":"Interleukin-24 receptor-ligand complex, type 1"}]},{"database":"ComplexPortal","id":"CPX-10311","properties":[{"key":"EntryName","value":"Interleukin-24 receptor-ligand complex, type 2"}]},{"database":"FunCoup","id":"Q13007","properties":[{"key":"Number of interactors","value":"509"}]},{"database":"IntAct","id":"Q13007","properties":[{"key":"Interactions","value":"25"}]},{"database":"MINT","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-IL24","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000375795","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q13007","properties":[{"key":"glycosylation","value":"3 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q13007","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"iPTMnet","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"IL24","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"2497340","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000375795","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"59095","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-1"},{"database":"ProteomicsDB","id":"59096","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-2"},{"database":"ProteomicsDB","id":"59097","properties":[{"key":"Description","value":"-"}],"isoformId":"Q13007-3"},{"database":"ABCD","id":"Q13007","properties":[{"key":"antibodies","value":"31 sequenced antibodies"}]},{"database":"Antibodypedia","id":"1466","properties":[{"key":"antibodies","value":"495 antibodies from 32 providers"}]},{"database":"DNASU","id":"11009","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000294984.7","properties":[{"key":"ProteinId","value":"ENSP00000294984.2"},{"key":"GeneId","value":"ENSG00000162892.16"}],"isoformId":"Q13007-1"},{"database":"Ensembl","id":"ENST00000367093.3","properties":[{"key":"ProteinId","value":"ENSP00000356060.3"},{"key":"GeneId","value":"ENSG00000162892.16"}],"isoformId":"Q13007-3"},{"database":"Ensembl","id":"ENST00000391929.7","properties":[{"key":"ProteinId","value":"ENSP00000375795.3"},{"key":"GeneId","value":"ENSG00000162892.16"}],"isoformId":"Q13007-2"},{"database":"Ensembl","id":"ENST00000611909.4","properties":[{"key":"ProteinId","value":"ENSP00000484900.1"},{"key":"GeneId","value":"ENSG00000162892.16"}],"isoformId":"Q13007-4"},{"database":"GeneID","id":"11009","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:11009","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000294984.7","properties":[{"key":"ProteinId","value":"ENSP00000294984.2"},{"key":"RefSeqNucleotideId","value":"NM_006850.3"},{"key":"RefSeqProteinId","value":"NP_006841.1"}]},{"database":"UCSC","id":"uc001hes.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q13007-1"},{"database":"AGR","id":"HGNC:11346","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29825","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11009","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"11009","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"IL24","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11346","properties":[{"key":"GeneName","value":"IL24"}]},{"database":"HPA","id":"ENSG00000162892","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid tissue, urinary bladder)"}]},{"database":"MIM","id":"604136","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SUXZ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183124","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_098690_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WMGKFYR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9938154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q13007","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8854691","properties":[{"key":"PathwayName","value":"Interleukin-20 family signaling"}]},{"database":"SignaLink","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000162892","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"11009","properties":[{"key":"hits","value":"14 hits in 1144 CRISPR screens"}]},{"database":"GeneWiki","id":"Interleukin_24","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"11009","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q13007","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q13007","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q13007","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000162892","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 91 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q13007","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11706020"}]},{"database":"GO","id":"GO:0043235","properties":[{"key":"GoTerm","value":"C:signaling receptor complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"30111632"}]},{"database":"GO","id":"GO:0005125","properties":[{"key":"GoTerm","value":"F:cytokine activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006915","properties":[{"key":"GoTerm","value":"P:apoptotic process"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9826712"}]},{"database":"GO","id":"GO:0071353","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-4"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35054813"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042127","properties":[{"key":"GoTerm","value":"P:regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35054813"}]},{"database":"FunFam","id":"1.20.1250.10:FF:000038","properties":[{"key":"EntryName","value":"Interleukin 24"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009079","properties":[{"key":"EntryName","value":"4_helix_cytokine-like_core"}]},{"database":"InterPro","id":"IPR020443","properties":[{"key":"EntryName","value":"IL-10/19/20/24/26"}]},{"database":"InterPro","id":"IPR020423","properties":[{"key":"EntryName","value":"IL-10_CS"}]},{"database":"InterPro","id":"IPR020444","properties":[{"key":"EntryName","value":"IL-24"}]},{"database":"PANTHER","id":"PTHR48482","properties":[{"key":"EntryName","value":"INTERLEUKIN-19-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48482:SF4","properties":[{"key":"EntryName","value":"INTERLEUKIN-24"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01937","properties":[{"key":"EntryName","value":"INTRLEUKIN24"}]},{"database":"SUPFAM","id":"SSF47266","properties":[{"key":"EntryName","value":"4-helical cytokines"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00520","properties":[{"key":"EntryName","value":"INTERLEUKIN_10"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL","length":206,"molWeight":23825,"crc64":"CB8135083EAB8DDD","md5":"3E3D71E5BB8BC8811A4A86338B204857"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Glycosylation":3,"Disulfide bond":1,"Cross-link":1,"Alternative sequence":3,"Natural variant":3,"Beta strand":2,"Helix":11},"uniParcId":"UPI0000037343"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7ETP6","uniProtkbId":"E7ETP6_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-03-08","entryVersion":65,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"}],"value":"Interleukin 24"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"}],"value":"IL24"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000418933.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC098935","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E7ETP6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1466","properties":[{"key":"antibodies","value":"495 antibodies from 32 providers"}]},{"database":"Ensembl","id":"ENST00000480741.1","properties":[{"key":"ProteinId","value":"ENSP00000418933.1"},{"key":"GeneId","value":"ENSG00000162892.16"}]},{"database":"UCSC","id":"uc057oxy.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:11346","properties":[{"key":"GeneName","value":"IL24"}]},{"database":"OpenTargets","id":"ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183124","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2947733_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9938154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000162892","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 91 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7ETP6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MNFQQRLQSLWTLASKLRITSRVPGCCSRRFCRTSRKKMRCFPSETVHTGGFCYSGEHSN","length":60,"molWeight":6973,"crc64":"26AB59540999751A","md5":"982EB98ED898BEAAC229B7D63AA66894"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0001B798D3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E7ER64","uniProtkbId":"E7ER64_HUMAN","entryAudit":{"firstPublicDate":"2011-03-08","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2011-03-08","entryVersion":61,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"}],"value":"Interleukin 24"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"}],"value":"IL24"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000356062.3"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC098935","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E7ER64","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000367095.7","properties":[{"key":"ProteinId","value":"ENSP00000356062.3"},{"key":"GeneId","value":"ENSG00000162892.16"}]},{"database":"UCSC","id":"uc057oxw.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:11346","properties":[{"key":"GeneName","value":"IL24"}]},{"database":"OpenTargets","id":"ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000162892","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183124","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3105661_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9938154at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000162892","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 91 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E7ER64","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MNFQQRLQSLWTLASKLRITSRVPGCCSRRFCRTSRMLRAVTLSTPCWSST","length":51,"molWeight":5923,"crc64":"87460564B4A81DDD","md5":"0B81938093BD322C02576C210CFBD825"},"extraAttributes":{"uniParcId":"UPI0001AE7998"}}]}