{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UKS7","secondaryAccessions":["Q53YJ5","Q6PQC5","Q6PQC6","Q6PQC7","Q6PQC8","Q6PQD0","Q6PQD1","Q8N6S1"],"uniProtkbId":"IKZF2_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":214,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Zinc finger protein Helios"}},"alternativeNames":[{"fullName":{"value":"Ikaros family zinc finger protein 2"}}]},"genes":[{"geneName":{"value":"IKZF2"},"synonyms":[{"value":"HELIOS"},{"value":"ZNFN1A2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P81183"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316189"}],"value":"Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs) (By similarity). May possibly act via STAT5-mediated signaling (By similarity). Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter (PubMed:37316189). In Tregs, required for FOXP3 recruitment to the IL2 promoter (By similarity). Required for outer hair cells maturation and, consequently, for hearing (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10978333"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34826259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34826260"}],"value":"Can form homodimers (PubMed:34826259). Interacts with IKZF1 and IKZF3 (PubMed:34826259, PubMed:34826260). Interacts with IKZF4 (PubMed:10978333, PubMed:34826259). Interacts with IKZF5 (PubMed:10978333). 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