{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P11717","secondaryAccessions":["Q7Z7G9","Q96PT5"],"uniProtkbId":"MPRI_HUMAN","entryAudit":{"firstPublicDate":"1989-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":252,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cation-independent mannose-6-phosphate receptor"},"shortNames":[{"value":"CI Man-6-P receptor"},{"value":"CI-MPR"},{"value":"M6PR"}]},"alternativeNames":[{"fullName":{"value":"300 kDa mannose 6-phosphate receptor"},"shortNames":[{"value":"MPR 300"}]},{"fullName":{"value":"Insulin-like growth factor 2 receptor"}},{"fullName":{"value":"Insulin-like growth factor II receptor"},"shortNames":[{"value":"IGF-II receptor"}]},{"fullName":{"value":"M6P/IGF2 receptor"},"shortNames":[{"value":"M6P/IGF2R"}]}],"cdAntigenNames":[{"value":"CD222"}],"flag":"Precursor"},"genes":[{"geneName":{"value":"IGF2R"},"synonyms":[{"value":"MPRI"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10900005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2963003"}],"value":"Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10900005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11387475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37158588"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18817523"}],"value":"Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Interacts with the heterotrimeric retromer cargo-selective complex (CSC), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (Probable). Interacts with SNX32; the interaction is involved in intracellular trafficking of the receptor (PubMed:37158588)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"Q9UJY5","geneName":"GGA1","intActId":"EBI-447141"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"Q9NZ52","geneName":"GGA3","intActId":"EBI-447404"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"P01344","geneName":"IGF2","intActId":"EBI-7178764"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"P01344-1","geneName":"IGF2","intActId":"EBI-15658078"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"P11717","geneName":"IGF2R","intActId":"EBI-1048580"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P11717","intActId":"EBI-1048580"},"interactantTwo":{"uniProtKBAccession":"Q6VY07","geneName":"PACS1","intActId":"EBI-2555014"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10900005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"}],"value":"Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"}],"value":"Endosome membrane","id":"SL-0100"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"value":"Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"}],"value":"Palmitoylated (PubMed:18817523). Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus (PubMed:18817523)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MRL1/IGF2R family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/380/IGF2R","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"}]},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":2491,"modifier":"EXACT"}},"description":"Cation-independent mannose-6-phosphate receptor","featureId":"PRO_0000019229"},{"type":"Topological domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":2304,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"}]},{"type":"Transmembrane","location":{"start":{"value":2305,"modifier":"EXACT"},"end":{"value":2327,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":2328,"modifier":"EXACT"},"end":{"value":2491,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"}]},{"type":"Domain","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"MRH 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"MRH 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"MRH 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"MRH 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":762,"modifier":"EXACT"}},"description":"MRH 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":765,"modifier":"EXACT"},"end":{"value":924,"modifier":"EXACT"}},"description":"MRH 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1079,"modifier":"EXACT"}},"description":"MRH 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1082,"modifier":"EXACT"},"end":{"value":1219,"modifier":"EXACT"}},"description":"MRH 8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1225,"modifier":"EXACT"},"end":{"value":1363,"modifier":"EXACT"}},"description":"MRH 9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1367,"modifier":"EXACT"},"end":{"value":1508,"modifier":"EXACT"}},"description":"MRH 10","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1514,"modifier":"EXACT"},"end":{"value":1648,"modifier":"EXACT"}},"description":"MRH 11","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1650,"modifier":"EXACT"},"end":{"value":1797,"modifier":"EXACT"}},"description":"MRH 12","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":1802,"modifier":"EXACT"},"end":{"value":1989,"modifier":"EXACT"}},"description":"Fibronectin type-II","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00479"}]},{"type":"Domain","location":{"start":{"value":1992,"modifier":"EXACT"},"end":{"value":2127,"modifier":"EXACT"}},"description":"MRH 14","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Domain","location":{"start":{"value":2135,"modifier":"EXACT"},"end":{"value":2280,"modifier":"EXACT"}},"description":"MRH 15","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Region","location":{"start":{"value":2424,"modifier":"EXACT"},"end":{"value":2491,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2444,"modifier":"EXACT"},"end":{"value":2459,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2464,"modifier":"EXACT"},"end":{"value":2477,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2479,"modifier":"EXACT"},"end":{"value":2491,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2352,"modifier":"EXACT"},"end":{"value":2352,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":2409,"modifier":"EXACT"},"end":{"value":2409,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":2425,"modifier":"EXACT"},"end":{"value":2425,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q07113"}]},{"type":"Modified residue","location":{"start":{"value":2479,"modifier":"EXACT"},"end":{"value":2479,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":2484,"modifier":"EXACT"},"end":{"value":2484,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17487921"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18220336"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19369195"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Glycosylation","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754519"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754519"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":626,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":871,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":951,"modifier":"EXACT"},"end":{"value":951,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":957,"modifier":"EXACT"},"end":{"value":957,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1164,"modifier":"EXACT"},"end":{"value":1164,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1246,"modifier":"EXACT"},"end":{"value":1246,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12754519"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1312,"modifier":"EXACT"},"end":{"value":1312,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1656,"modifier":"EXACT"},"end":{"value":1656,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1757,"modifier":"EXACT"},"end":{"value":1757,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1816,"modifier":"EXACT"},"end":{"value":1816,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2085,"modifier":"EXACT"},"end":{"value":2085,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2136,"modifier":"EXACT"},"end":{"value":2136,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":627,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":731,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":814,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":823,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":875,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":970,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1042,"modifier":"EXACT"},"end":{"value":1077,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1084,"modifier":"EXACT"},"end":{"value":1125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1134,"modifier":"EXACT"},"end":{"value":1142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1177,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1190,"modifier":"EXACT"},"end":{"value":1217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1227,"modifier":"EXACT"},"end":{"value":1262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1270,"modifier":"EXACT"},"end":{"value":1282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1319,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1333,"modifier":"EXACT"},"end":{"value":1361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1369,"modifier":"EXACT"},"end":{"value":1408,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1420,"modifier":"EXACT"},"end":{"value":1427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1461,"modifier":"EXACT"},"end":{"value":1494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1476,"modifier":"EXACT"},"end":{"value":1506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":1516,"modifier":"EXACT"},"end":{"value":1553,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1559,"modifier":"EXACT"},"end":{"value":1566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1598,"modifier":"EXACT"},"end":{"value":1634,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1614,"modifier":"EXACT"},"end":{"value":1646,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1652,"modifier":"EXACT"},"end":{"value":1695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1706,"modifier":"EXACT"},"end":{"value":1713,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1750,"modifier":"EXACT"},"end":{"value":1783,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1766,"modifier":"EXACT"},"end":{"value":1795,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1804,"modifier":"EXACT"},"end":{"value":1839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1850,"modifier":"EXACT"},"end":{"value":1856,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1975,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1903,"modifier":"EXACT"},"end":{"value":1927,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00479"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1917,"modifier":"EXACT"},"end":{"value":1942,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00479"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1957,"modifier":"EXACT"},"end":{"value":1987,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":1994,"modifier":"EXACT"},"end":{"value":2029,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":2039,"modifier":"EXACT"},"end":{"value":2046,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":2082,"modifier":"EXACT"},"end":{"value":2113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":2096,"modifier":"EXACT"},"end":{"value":2125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18046459"}]},{"type":"Disulfide bond","location":{"start":{"value":2188,"modifier":"EXACT"},"end":{"value":2194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":2232,"modifier":"EXACT"},"end":{"value":2266,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":2248,"modifier":"EXACT"},"end":{"value":2278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Natural variant","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"in dbSNP:rs8191704","featureCrossReferences":[{"database":"dbSNP","id":"rs8191704"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021304","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in dbSNP:rs8191746","featureCrossReferences":[{"database":"dbSNP","id":"rs8191746"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020470","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in dbSNP:rs8191753","featureCrossReferences":[{"database":"dbSNP","id":"rs8191753"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021305","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in dbSNP:rs8191754","featureCrossReferences":[{"database":"dbSNP","id":"rs8191754"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020471","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in dbSNP:rs8191758","featureCrossReferences":[{"database":"dbSNP","id":"rs8191758"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021306","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"in dbSNP:rs8191776","featureCrossReferences":[{"database":"dbSNP","id":"rs8191776"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021307","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"in dbSNP:rs6413489","featureCrossReferences":[{"database":"dbSNP","id":"rs6413489"}],"featureId":"VAR_020472","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":604,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"in dbSNP:rs8191797","featureCrossReferences":[{"database":"dbSNP","id":"rs8191797"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020473","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":724,"modifier":"EXACT"}},"description":"in dbSNP:rs6413491","featureCrossReferences":[{"database":"dbSNP","id":"rs6413491"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020474","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":817,"modifier":"EXACT"}},"description":"in dbSNP:rs8191808","featureCrossReferences":[{"database":"dbSNP","id":"rs8191808"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021308","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":856,"modifier":"EXACT"},"end":{"value":856,"modifier":"EXACT"}},"description":"in dbSNP:rs8191819","featureCrossReferences":[{"database":"dbSNP","id":"rs8191819"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020475","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1107,"modifier":"EXACT"},"end":{"value":1107,"modifier":"EXACT"}},"description":"in dbSNP:rs8191842","featureCrossReferences":[{"database":"dbSNP","id":"rs8191842"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020476","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":1124,"modifier":"EXACT"},"end":{"value":1124,"modifier":"EXACT"}},"description":"in dbSNP:rs8191843","featureCrossReferences":[{"database":"dbSNP","id":"rs8191843"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021309","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"in dbSNP:rs8191844","featureCrossReferences":[{"database":"dbSNP","id":"rs8191844"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_020477","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1254,"modifier":"EXACT"},"end":{"value":1254,"modifier":"EXACT"}},"description":"in dbSNP:rs2230043","featureCrossReferences":[{"database":"dbSNP","id":"rs2230043"}],"featureId":"VAR_050428","alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1315,"modifier":"EXACT"},"end":{"value":1315,"modifier":"EXACT"}},"description":"in dbSNP:rs8191859","featureCrossReferences":[{"database":"dbSNP","id":"rs8191859"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021310","alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":1335,"modifier":"EXACT"},"end":{"value":1335,"modifier":"EXACT"}},"description":"in dbSNP:rs8191860","featureCrossReferences":[{"database":"dbSNP","id":"rs8191860"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021311","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1395,"modifier":"EXACT"},"end":{"value":1395,"modifier":"EXACT"}},"description":"in dbSNP:rs2230048","featureCrossReferences":[{"database":"dbSNP","id":"rs2230048"}],"featureId":"VAR_050429","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1619,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"in dbSNP:rs629849","featureCrossReferences":[{"database":"dbSNP","id":"rs629849"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2957598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2963003"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.3"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021312","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":1696,"modifier":"EXACT"},"end":{"value":1696,"modifier":"EXACT"}},"description":"in dbSNP:rs11552587","featureCrossReferences":[{"database":"dbSNP","id":"rs11552587"}],"featureId":"VAR_050430","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1832,"modifier":"EXACT"},"end":{"value":1832,"modifier":"EXACT"}},"description":"in dbSNP:rs8191904","featureCrossReferences":[{"database":"dbSNP","id":"rs8191904"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021313","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1860,"modifier":"EXACT"},"end":{"value":1860,"modifier":"EXACT"}},"description":"in dbSNP:rs8191905","featureCrossReferences":[{"database":"dbSNP","id":"rs8191905"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021314","alternativeSequence":{"originalSequence":"G","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1908,"modifier":"EXACT"},"end":{"value":1908,"modifier":"EXACT"}},"description":"in dbSNP:rs8191908","featureCrossReferences":[{"database":"dbSNP","id":"rs8191908"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021315","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":2020,"modifier":"EXACT"},"end":{"value":2020,"modifier":"EXACT"}},"description":"in dbSNP:rs1805075","featureCrossReferences":[{"database":"dbSNP","id":"rs1805075"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_014722","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":2459,"modifier":"EXACT"},"end":{"value":2459,"modifier":"EXACT"}},"description":"in dbSNP:rs8191955","featureCrossReferences":[{"database":"dbSNP","id":"rs8191955"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_021316","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"in Ref. 1; CAA68395 and 3; AAF16870","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":845,"modifier":"EXACT"},"end":{"value":845,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1489,"modifier":"EXACT"},"end":{"value":1489,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":1703,"modifier":"EXACT"},"end":{"value":1703,"modifier":"EXACT"}},"description":"in Ref. 1; CAA68395 and 3; AAF16870","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":2026,"modifier":"EXACT"},"end":{"value":2026,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":2075,"modifier":"EXACT"},"end":{"value":2075,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":2156,"modifier":"EXACT"},"end":{"value":2156,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":2160,"modifier":"EXACT"},"end":{"value":2160,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":2176,"modifier":"EXACT"},"end":{"value":2176,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":2330,"modifier":"EXACT"},"end":{"value":2330,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":2335,"modifier":"EXACT"},"end":{"value":2335,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":2341,"modifier":"EXACT"},"end":{"value":2341,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":2410,"modifier":"EXACT"},"end":{"value":2410,"modifier":"EXACT"}},"description":"in Ref. 2; AAA59866","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["T"]}},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":380,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Turn","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Helix","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Turn","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":566,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":586,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Helix","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P8I"}]},{"type":"Beta strand","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":632,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":641,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":655,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":670,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":676,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":688,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":701,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":725,"modifier":"EXACT"},"end":{"value":731,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Turn","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":743,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Helix","location":{"start":{"value":757,"modifier":"EXACT"},"end":{"value":759,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V02"}]},{"type":"Beta strand","location":{"start":{"value":935,"modifier":"EXACT"},"end":{"value":937,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Turn","location":{"start":{"value":939,"modifier":"EXACT"},"end":{"value":941,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":944,"modifier":"EXACT"},"end":{"value":946,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Helix","location":{"start":{"value":948,"modifier":"EXACT"},"end":{"value":950,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":956,"modifier":"EXACT"},"end":{"value":959,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":969,"modifier":"EXACT"},"end":{"value":971,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":982,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1002,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1007,"modifier":"EXACT"},"end":{"value":1013,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1032,"modifier":"EXACT"},"end":{"value":1042,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1047,"modifier":"EXACT"},"end":{"value":1059,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Helix","location":{"start":{"value":1060,"modifier":"EXACT"},"end":{"value":1062,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1064,"modifier":"EXACT"},"end":{"value":1074,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1087,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1093,"modifier":"EXACT"},"end":{"value":1095,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Helix","location":{"start":{"value":1097,"modifier":"EXACT"},"end":{"value":1099,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1102,"modifier":"EXACT"},"end":{"value":1104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1106,"modifier":"EXACT"},"end":{"value":1111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1113,"modifier":"EXACT"},"end":{"value":1115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1116,"modifier":"EXACT"},"end":{"value":1122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1124,"modifier":"EXACT"},"end":{"value":1126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Helix","location":{"start":{"value":1127,"modifier":"EXACT"},"end":{"value":1129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Turn","location":{"start":{"value":1136,"modifier":"EXACT"},"end":{"value":1138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1139,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1148,"modifier":"EXACT"},"end":{"value":1151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1175,"modifier":"EXACT"},"end":{"value":1177,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1183,"modifier":"EXACT"},"end":{"value":1190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1198,"modifier":"EXACT"},"end":{"value":1203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1206,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Helix","location":{"start":{"value":1214,"modifier":"EXACT"},"end":{"value":1216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z31"}]},{"type":"Beta strand","location":{"start":{"value":1221,"modifier":"EXACT"},"end":{"value":1224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1228,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Turn","location":{"start":{"value":1232,"modifier":"EXACT"},"end":{"value":1234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1237,"modifier":"EXACT"},"end":{"value":1239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1241,"modifier":"EXACT"},"end":{"value":1244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1255,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1279,"modifier":"EXACT"},"end":{"value":1285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1287,"modifier":"EXACT"},"end":{"value":1289,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1291,"modifier":"EXACT"},"end":{"value":1297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1303,"modifier":"EXACT"},"end":{"value":1305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1308,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1317,"modifier":"EXACT"},"end":{"value":1319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Turn","location":{"start":{"value":1320,"modifier":"EXACT"},"end":{"value":1322,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1326,"modifier":"EXACT"},"end":{"value":1332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1335,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1338,"modifier":"EXACT"},"end":{"value":1340,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1341,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1350,"modifier":"EXACT"},"end":{"value":1357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1358,"modifier":"EXACT"},"end":{"value":1360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1361,"modifier":"EXACT"},"end":{"value":1363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1370,"modifier":"EXACT"},"end":{"value":1372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1380,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1382,"modifier":"EXACT"},"end":{"value":1384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1387,"modifier":"EXACT"},"end":{"value":1389,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1402,"modifier":"EXACT"},"end":{"value":1405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1407,"modifier":"EXACT"},"end":{"value":1409,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1410,"modifier":"EXACT"},"end":{"value":1413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1415,"modifier":"EXACT"},"end":{"value":1418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1421,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1425,"modifier":"EXACT"},"end":{"value":1433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1445,"modifier":"EXACT"},"end":{"value":1447,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1450,"modifier":"EXACT"},"end":{"value":1456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1464,"modifier":"EXACT"},"end":{"value":1467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1469,"modifier":"EXACT"},"end":{"value":1476,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1486,"modifier":"EXACT"},"end":{"value":1491,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Turn","location":{"start":{"value":1492,"modifier":"EXACT"},"end":{"value":1494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1502,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Helix","location":{"start":{"value":1503,"modifier":"EXACT"},"end":{"value":1505,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z30"}]},{"type":"Beta strand","location":{"start":{"value":1512,"modifier":"EXACT"},"end":{"value":1514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5IEI"}]},{"type":"Beta strand","location":{"start":{"value":1517,"modifier":"EXACT"},"end":{"value":1519,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Turn","location":{"start":{"value":1521,"modifier":"EXACT"},"end":{"value":1523,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1526,"modifier":"EXACT"},"end":{"value":1528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Helix","location":{"start":{"value":1530,"modifier":"EXACT"},"end":{"value":1532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1533,"modifier":"EXACT"},"end":{"value":1536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1538,"modifier":"EXACT"},"end":{"value":1542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Turn","location":{"start":{"value":1543,"modifier":"EXACT"},"end":{"value":1545,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1546,"modifier":"EXACT"},"end":{"value":1550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1552,"modifier":"EXACT"},"end":{"value":1554,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1557,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6Z32"}]},{"type":"Beta strand","location":{"start":{"value":1563,"modifier":"EXACT"},"end":{"value":1567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Turn","location":{"start":{"value":1568,"modifier":"EXACT"},"end":{"value":1570,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1573,"modifier":"EXACT"},"end":{"value":1576,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5IEI"}]},{"type":"Beta strand","location":{"start":{"value":1582,"modifier":"EXACT"},"end":{"value":1584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1587,"modifier":"EXACT"},"end":{"value":1592,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1596,"modifier":"EXACT"},"end":{"value":1598,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2L2A"}]},{"type":"Beta strand","location":{"start":{"value":1599,"modifier":"EXACT"},"end":{"value":1601,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1607,"modifier":"EXACT"},"end":{"value":1614,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1616,"modifier":"EXACT"},"end":{"value":1618,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2L2A"}]},{"type":"Beta strand","location":{"start":{"value":1625,"modifier":"EXACT"},"end":{"value":1630,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Turn","location":{"start":{"value":1631,"modifier":"EXACT"},"end":{"value":1634,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Beta strand","location":{"start":{"value":1635,"modifier":"EXACT"},"end":{"value":1642,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Helix","location":{"start":{"value":1643,"modifier":"EXACT"},"end":{"value":1645,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1GP0"}]},{"type":"Turn","location":{"start":{"value":1649,"modifier":"EXACT"},"end":{"value":1651,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2CNJ"}]},{"type":"Beta strand","location":{"start":{"value":1653,"modifier":"EXACT"},"end":{"value":1656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1659,"modifier":"EXACT"},"end":{"value":1662,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1664,"modifier":"EXACT"},"end":{"value":1666,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1669,"modifier":"EXACT"},"end":{"value":1671,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1673,"modifier":"EXACT"},"end":{"value":1675,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1690,"modifier":"EXACT"},"end":{"value":1692,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1694,"modifier":"EXACT"},"end":{"value":1696,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1697,"modifier":"EXACT"},"end":{"value":1700,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1711,"modifier":"EXACT"},"end":{"value":1714,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1717,"modifier":"EXACT"},"end":{"value":1719,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1722,"modifier":"EXACT"},"end":{"value":1727,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1732,"modifier":"EXACT"},"end":{"value":1734,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5N"}]},{"type":"Beta strand","location":{"start":{"value":1735,"modifier":"EXACT"},"end":{"value":1737,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1743,"modifier":"EXACT"},"end":{"value":1745,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1759,"modifier":"EXACT"},"end":{"value":1766,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1775,"modifier":"EXACT"},"end":{"value":1777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1781,"modifier":"EXACT"},"end":{"value":1783,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1784,"modifier":"EXACT"},"end":{"value":1791,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1792,"modifier":"EXACT"},"end":{"value":1794,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1801,"modifier":"EXACT"},"end":{"value":1804,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1805,"modifier":"EXACT"},"end":{"value":1807,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1809,"modifier":"EXACT"},"end":{"value":1811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1814,"modifier":"EXACT"},"end":{"value":1816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1818,"modifier":"EXACT"},"end":{"value":1821,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1825,"modifier":"EXACT"},"end":{"value":1829,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1832,"modifier":"EXACT"},"end":{"value":1836,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1838,"modifier":"EXACT"},"end":{"value":1840,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1845,"modifier":"EXACT"},"end":{"value":1847,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1850,"modifier":"EXACT"},"end":{"value":1858,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1863,"modifier":"EXACT"},"end":{"value":1877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1878,"modifier":"EXACT"},"end":{"value":1881,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1882,"modifier":"EXACT"},"end":{"value":1888,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1895,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1905,"modifier":"EXACT"},"end":{"value":1909,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1912,"modifier":"EXACT"},"end":{"value":1916,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1920,"modifier":"EXACT"},"end":{"value":1924,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1926,"modifier":"EXACT"},"end":{"value":1932,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":1933,"modifier":"EXACT"},"end":{"value":1936,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1939,"modifier":"EXACT"},"end":{"value":1943,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1950,"modifier":"EXACT"},"end":{"value":1957,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":1972,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":1973,"modifier":"EXACT"},"end":{"value":1975,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1976,"modifier":"EXACT"},"end":{"value":1984,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":1995,"modifier":"EXACT"},"end":{"value":2000,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2002,"modifier":"EXACT"},"end":{"value":2004,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":2005,"modifier":"EXACT"},"end":{"value":2007,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2011,"modifier":"EXACT"},"end":{"value":2013,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2015,"modifier":"EXACT"},"end":{"value":2019,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2022,"modifier":"EXACT"},"end":{"value":2026,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2043,"modifier":"EXACT"},"end":{"value":2048,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2054,"modifier":"EXACT"},"end":{"value":2059,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":2060,"modifier":"EXACT"},"end":{"value":2062,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2064,"modifier":"EXACT"},"end":{"value":2068,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2071,"modifier":"EXACT"},"end":{"value":2076,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2089,"modifier":"EXACT"},"end":{"value":2096,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2098,"modifier":"EXACT"},"end":{"value":2109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Turn","location":{"start":{"value":2110,"modifier":"EXACT"},"end":{"value":2113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2114,"modifier":"EXACT"},"end":{"value":2121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Helix","location":{"start":{"value":2122,"modifier":"EXACT"},"end":{"value":2124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2V5O"}]},{"type":"Beta strand","location":{"start":{"value":2350,"modifier":"EXACT"},"end":{"value":2355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N5X"}]},{"type":"Beta strand","location":{"start":{"value":2368,"modifier":"EXACT"},"end":{"value":2373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N5X"}]},{"type":"Helix","location":{"start":{"value":2486,"modifier":"EXACT"},"end":{"value":2490,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1JWG"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"2957598","citationType":"journal article","authors":["Morgan D.O.","Edman J.C.","Standring D.N.","Fried V.A.","Smith M.C.","Roth R.A.","Rutter W.J."],"citationCrossReferences":[{"database":"PubMed","id":"2957598"},{"database":"DOI","id":"10.1038/329301a0"}],"title":"Insulin-like growth factor II receptor as a multifunctional binding protein.","publicationDate":"1987","journal":"Nature","firstPage":"301","lastPage":"307","volume":"329"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PARTIAL PROTEIN SEQUENCE","VARIANT GLY-1619","CLEAVAGE OF SIGNAL PEPTIDE AFTER CYS-23","TOPOLOGY"]},{"referenceNumber":2,"citation":{"id":"2963003","citationType":"journal article","authors":["Oshima A.","Nolan C.M.","Kyle J.W.","Grubb J.H.","Sly W.S."],"citationCrossReferences":[{"database":"PubMed","id":"2963003"},{"database":"DOI","id":"10.1016/s0021-9258(18)69243-9"}],"title":"The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.","publicationDate":"1988","journal":"J. Biol. Chem.","firstPage":"2553","lastPage":"2562","volume":"263"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","VARIANT GLY-1619","FUNCTION"]},{"referenceNumber":3,"citation":{"id":"CI-CAAA6047VG2LV","citationType":"submission","authors":["Gemma A.","Seike Y.","Uematsu K.","Seike M.","Bennett W.P.","Harris C.C.","Kudoh S."],"title":"The genomic structure of the gene encoding the human mannose 6 phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R).","publicationDate":"NOV-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT GLY-1619"]},{"referenceNumber":4,"citation":{"id":"9892739","citationType":"journal article","authors":["Killian J.K.","Jirtle R.L."],"citationCrossReferences":[{"database":"PubMed","id":"9892739"},{"database":"DOI","id":"10.1007/s003359900947"}],"title":"Genomic structure of the human M6P/IGF2 receptor.","publicationDate":"1999","journal":"Mamm. Genome","firstPage":"74","lastPage":"77","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-9GALQ4R1NUH3Q","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS HIS-91; LEU-203; ASP-231; VAL-252; GLY-273; GLN-512; SER-604; THR-724; VAL-817; SER-856; MET-1107; ILE-1124; SER-1184; GLU-1315; HIS-1335; GLY-1619; HIS-1832; ASP-1860; MET-1908; SER-2020 AND VAL-2459"]},{"referenceNumber":6,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"10900005","citationType":"journal article","authors":["Ikushima H.","Munakata Y.","Ishii T.","Iwata S.","Terashima M.","Tanaka H.","Schlossman S.F.","Morimoto C."],"citationCrossReferences":[{"database":"PubMed","id":"10900005"},{"database":"DOI","id":"10.1073/pnas.97.15.8439"}],"title":"Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation.","publicationDate":"2000","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"8439","lastPage":"8444","volume":"97"},"referencePositions":["FUNCTION","INTERACTION WITH DPP4","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"11387475","citationType":"journal article","authors":["Puertollano R.","Aguilar R.C.","Gorshkova I.","Crouch R.J.","Bonifacino J.S."],"citationCrossReferences":[{"database":"PubMed","id":"11387475"},{"database":"DOI","id":"10.1126/science.1060750"}],"title":"Sorting of mannose 6-phosphate receptors mediated by the GGAs.","publicationDate":"2001","journal":"Science","firstPage":"1712","lastPage":"1716","volume":"292"},"referencePositions":["INTERACTION WITH GGA1; GGA2 AND GGA3"]},{"referenceNumber":9,"citation":{"id":"12754519","citationType":"journal article","authors":["Zhang H.","Li X.-J.","Martin D.B.","Aebersold R."],"citationCrossReferences":[{"database":"PubMed","id":"12754519"},{"database":"DOI","id":"10.1038/nbt827"}],"title":"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.","publicationDate":"2003","journal":"Nat. Biotechnol.","firstPage":"660","lastPage":"666","volume":"21"},"referencePositions":["GLYCOSYLATION AT ASN-112; ASN-581; ASN-747 AND ASN-1246"]},{"referenceNumber":10,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409; SER-2479 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"17487921","citationType":"journal article","authors":["Giorgianni F.","Zhao Y.","Desiderio D.M.","Beranova-Giorgianni S."],"citationCrossReferences":[{"database":"PubMed","id":"17487921"},{"database":"DOI","id":"10.1002/elps.200600782"}],"title":"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.","publicationDate":"2007","journal":"Electrophoresis","firstPage":"2027","lastPage":"2034","volume":"28"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Prostate cancer","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"19367720","citationType":"journal article","authors":["Carrascal M.","Ovelleiro D.","Casas V.","Gay M.","Abian J."],"citationCrossReferences":[{"database":"PubMed","id":"19367720"},{"database":"DOI","id":"10.1021/pr800500r"}],"title":"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"5167","lastPage":"5176","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"T-cell","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"18817523","citationType":"journal article","authors":["McCormick P.J.","Dumaresq-Doiron K.","Pluviose A.S.","Pichette V.","Tosato G.","Lefrancois S."],"citationCrossReferences":[{"database":"PubMed","id":"18817523"},{"database":"DOI","id":"10.1111/j.1600-0854.2008.00814.x"}],"title":"Palmitoylation controls recycling in lysosomal sorting and trafficking.","publicationDate":"2008","journal":"Traffic","firstPage":"1984","lastPage":"1997","volume":"9"},"referencePositions":["FUNCTION","INTERACTION WITH THE RETROMER COMPLEX","SUBCELLULAR LOCATION","PALMITOYLATION"]},{"referenceNumber":18,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-626 AND ASN-747"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":20,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":21,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409; SER-2479 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2352","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":23,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409; SER-2479 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":26,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409; SER-2479 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2409; SER-2479 AND SER-2484","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":28,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":29,"citation":{"id":"37158588","citationType":"journal article","authors":["Sugatha J.","Priya A.","Raj P.","Jaimon E.","Swaminathan U.","Jose A.","Pucadyil T.J.","Datta S."],"citationCrossReferences":[{"database":"PubMed","id":"37158588"},{"database":"DOI","id":"10.7554/elife.84396"}],"title":"Insights into cargo sorting by SNX32 and its role in neurite outgrowth.","publicationDate":"2023","journal":"Elife","firstPage":"0","lastPage":"0","volume":"12"},"referencePositions":["INTERACTION WITH SNX32"]},{"referenceNumber":30,"citation":{"id":"18046459","citationType":"journal article","authors":["Brown J.","Delaine C.","Zaccheo O.J.","Siebold C.","Gilbert R.J.","van Boxel G.","Denley A.","Wallace J.C.","Hassan A.B.","Forbes B.E.","Jones E.Y."],"citationCrossReferences":[{"database":"PubMed","id":"18046459"},{"database":"DOI","id":"10.1038/sj.emboj.7601938"}],"title":"Structure and functional analysis of the IGF-II/IGF2R interaction.","publicationDate":"2008","journal":"EMBO J.","firstPage":"265","lastPage":"276","volume":"27"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 1508-2128 ALONE AND IN COMPLEX WITH IGF2","DISULFIDE BONDS","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Y00285","properties":[{"key":"ProteinId","value":"CAA68395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J03528","properties":[{"key":"ProteinId","value":"AAA59866.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF109291","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109244","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109245","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109246","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109247","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109248","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109249","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109250","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109251","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109252","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109253","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109254","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109255","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109256","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109257","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109258","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109259","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109260","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109261","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109262","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109263","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109264","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109265","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109266","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109267","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109268","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109269","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109270","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109271","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109272","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109273","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109274","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109275","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109276","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109277","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109278","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109279","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109280","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109281","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109282","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109283","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109284","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109285","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109286","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109287","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109288","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109289","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF109290","properties":[{"key":"ProteinId","value":"AAF16870.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF069333","properties":[{"key":"ProteinId","value":"AAL04402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY293855","properties":[{"key":"ProteinId","value":"AAP37954.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353625","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL035691","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS5273.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A28372","properties":[{"key":"EntryName","value":"A28372"}]},{"database":"RefSeq","id":"NP_000867.3","properties":[{"key":"NucleotideSequenceId","value":"NM_000876.4"}]},{"database":"PDB","id":"1E6F","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.75 A"},{"key":"Chains","value":"A/B=1508-1650"}]},{"database":"PDB","id":"1GP0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1508-1650"}]},{"database":"PDB","id":"1GP3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"A=1508-1650"}]},{"database":"PDB","id":"1GQB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1508-1650"}]},{"database":"PDB","id":"1JPL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"E/F/G/H=2480-2491"}]},{"database":"PDB","id":"1JWG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"C/D=2479-2491"}]},{"database":"PDB","id":"1LF8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"E/F/G/H=2480-2491"}]},{"database":"PDB","id":"2CNJ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"D=1508-1651"}]},{"database":"PDB","id":"2L29","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1508-1647"}]},{"database":"PDB","id":"2L2A","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1508-1647"}]},{"database":"PDB","id":"2M68","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1508-1649"}]},{"database":"PDB","id":"2M6T","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=1508-1649"}]},{"database":"PDB","id":"2V5N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1508-1800"}]},{"database":"PDB","id":"2V5O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.91 A"},{"key":"Chains","value":"A=1508-2128"}]},{"database":"PDB","id":"2V5P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"4.10 A"},{"key":"Chains","value":"A/B=1508-1993"}]},{"database":"PDB","id":"5IEI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=1508-1649"}]},{"database":"PDB","id":"6N5X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"A=2347-2377"}]},{"database":"PDB","id":"6N5Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.26 A"},{"key":"Chains","value":"A=2347-2377"}]},{"database":"PDB","id":"6P8I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"A=36-763"}]},{"database":"PDB","id":"6V02","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.46 A"},{"key":"Chains","value":"A=43-763"}]},{"database":"PDB","id":"6Z30","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A=1222-1510"}]},{"database":"PDB","id":"6Z31","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/B=1082-1220"}]},{"database":"PDB","id":"6Z32","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.47 A"},{"key":"Chains","value":"A/B=927-1649"}]},{"database":"PDB","id":"8AFZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"10.00 A"},{"key":"Chains","value":"C=2347-2377"}]},{"database":"PDBsum","id":"1E6F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GP0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GP3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1GQB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JPL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1JWG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1LF8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2CNJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L29","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2L2A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2M68","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2M6T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2V5N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2V5O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2V5P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5IEI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N5X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N5Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P8I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V02","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z30","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z31","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6Z32","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8AFZ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-15413","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109703","properties":[{"key":"Interactions","value":"441"}]},{"database":"CORUM","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-6027N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P11717","properties":[{"key":"Number of interactors","value":"1582"}]},{"database":"IntAct","id":"P11717","properties":[{"key":"Interactions","value":"179"}]},{"database":"MINT","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-IGF2R","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000349437","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3240","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB01272","properties":[{"key":"GenericName","value":"Alglucosidase alfa"}]},{"database":"DrugBank","id":"DB02900","properties":[{"key":"GenericName","value":"alpha-D-mannose 6-phosphate"}]},{"database":"DrugBank","id":"DB16099","properties":[{"key":"GenericName","value":"Avalglucosidase alfa"}]},{"database":"DrugBank","id":"DB13173","properties":[{"key":"GenericName","value":"Cerliponase alfa"}]},{"database":"DrugBank","id":"DB16708","properties":[{"key":"GenericName","value":"Cipaglucosidase alfa"}]},{"database":"DrugBank","id":"DB11848","properties":[{"key":"GenericName","value":"Mannose 6-phosphate"}]},{"database":"DrugBank","id":"DB01277","properties":[{"key":"GenericName","value":"Mecasermin"}]},{"database":"DrugBank","id":"DB14751","properties":[{"key":"GenericName","value":"Mecasermin rinfabate"}]},{"database":"DrugCentral","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.B.247.1.2","properties":[{"key":"FamilyName","value":"the mannose 6-phosphate receptor (m6pr) family"}]},{"database":"UniLectin","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P11717","properties":[{"key":"glycosylation","value":"38 N-Linked glycans (16 sites)"}]},{"database":"GlyCosmos","id":"P11717","properties":[{"key":"glycosylation","value":"23 sites, 41 glycans"}]},{"database":"GlyGen","id":"P11717","properties":[{"key":"glycosylation","value":"35 sites, 110 N-linked glycans (21 sites), 2 O-linked glycans (10 sites)"}]},{"database":"iPTMnet","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"IGF2R","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"317373416","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-2601","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-2642","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000349437","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52802","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1396","properties":[{"key":"antibodies","value":"756 antibodies from 44 providers"}]},{"database":"DNASU","id":"3482","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000356956.6","properties":[{"key":"ProteinId","value":"ENSP00000349437.1"},{"key":"GeneId","value":"ENSG00000197081.16"}]},{"database":"GeneID","id":"3482","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3482","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000356956.6","properties":[{"key":"ProteinId","value":"ENSP00000349437.1"},{"key":"RefSeqNucleotideId","value":"NM_000876.4"},{"key":"RefSeqProteinId","value":"NP_000867.3"}]},{"database":"UCSC","id":"uc003qta.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5467","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29701","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3482","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3482","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"IGF2R","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5467","properties":[{"key":"GeneName","value":"IGF2R"}]},{"database":"HPA","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"IGF2R","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"147280","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4504","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000013943","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001182_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FITYQSS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P11717","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-432722","properties":[{"key":"PathwayName","value":"Golgi Associated Vesicle Biogenesis"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-6811440","properties":[{"key":"PathwayName","value":"Retrograde transport at the Trans-Golgi-Network"}]},{"database":"Reactome","id":"R-HSA-8856825","properties":[{"key":"PathwayName","value":"Cargo recognition for clathrin-mediated endocytosis"}]},{"database":"Reactome","id":"R-HSA-8856828","properties":[{"key":"PathwayName","value":"Clathrin-mediated endocytosis"}]},{"database":"SignaLink","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000197081","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3482","properties":[{"key":"hits","value":"22 hits in 1171 CRISPR screens"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P11717","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Insulin-like_growth_factor_2_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3482","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P11717","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P11717","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"P11717","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P11717","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10900005"}]},{"database":"GO","id":"GO:0030118","properties":[{"key":"GoTerm","value":"C:clathrin coat"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030669","properties":[{"key":"GoTerm","value":"C:clathrin-coated endocytic vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0005769","properties":[{"key":"GoTerm","value":"C:early endosome"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17959629"}]},{"database":"GO","id":"GO:0030139","properties":[{"key":"GoTerm","value":"C:endocytic vesicle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10900005"}]},{"database":"GO","id":"GO:0005768","properties":[{"key":"GoTerm","value":"C:endosome"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15078902"}]},{"database":"GO","id":"GO:0010008","properties":[{"key":"GoTerm","value":"C:endosome membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18817523"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21423176"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18817523"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18817523"}]},{"database":"GO","id":"GO:0005770","properties":[{"key":"GoTerm","value":"C:late endosome"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22456507"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005641","properties":[{"key":"GoTerm","value":"C:nuclear envelope lumen"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030667","properties":[{"key":"GoTerm","value":"C:secretory granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005802","properties":[{"key":"GoTerm","value":"C:trans-Golgi network"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17959629"}]},{"database":"GO","id":"GO:0032588","properties":[{"key":"GoTerm","value":"C:trans-Golgi network membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030140","properties":[{"key":"GoTerm","value":"C:trans-Golgi network transport vesicle"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15078902"}]},{"database":"GO","id":"GO:0030133","properties":[{"key":"GoTerm","value":"C:transport vesicle"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0038024","properties":[{"key":"GoTerm","value":"F:cargo receptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10799489"}]},{"database":"GO","id":"GO:0005537","properties":[{"key":"GoTerm","value":"F:D-mannose binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0019899","properties":[{"key":"GoTerm","value":"F:enzyme binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001965","properties":[{"key":"GoTerm","value":"F:G-protein alpha-subunit binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22681933"}]},{"database":"GO","id":"GO:0005520","properties":[{"key":"GoTerm","value":"F:insulin-like growth factor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031995","properties":[{"key":"GoTerm","value":"F:insulin-like growth factor II binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051219","properties":[{"key":"GoTerm","value":"F:phosphoprotein binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10900005"}]},{"database":"GO","id":"GO:0001972","properties":[{"key":"GoTerm","value":"F:retinoic acid binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1905394","properties":[{"key":"GoTerm","value":"F:retromer complex binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18817523"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7753549"}]},{"database":"GO","id":"GO:0031100","properties":[{"key":"GoTerm","value":"P:animal organ regeneration"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090160","properties":[{"key":"GoTerm","value":"P:Golgi to lysosome transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10799489"}]},{"database":"GO","id":"GO:0044794","properties":[{"key":"GoTerm","value":"P:host-mediated activation of viral process"},{"key":"GoEvidenceType","value":"IMP:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20889566"}]},{"database":"GO","id":"GO:0001889","properties":[{"key":"GoTerm","value":"P:liver development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009791","properties":[{"key":"GoTerm","value":"P:post-embryonic development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006622","properties":[{"key":"GoTerm","value":"P:protein targeting to lysosome"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032526","properties":[{"key":"GoTerm","value":"P:response to retinoic acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1904772","properties":[{"key":"GoTerm","value":"P:response to tetrachloromethane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7753549"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd00062","properties":[{"key":"EntryName","value":"FN2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.10.10:FF:000006","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000004","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000005","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000006","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000007","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000009","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000010","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000011","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000012","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000013","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000015","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000016","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000017","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000019","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000020","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000022","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.10.10","properties":[{"key":"EntryName","value":"Fibronectin, type II, collagen-binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.130.10","properties":[{"key":"EntryName","value":"Mannose-6-phosphate receptor binding domain"},{"key":"MatchStatus","value":"15"}]},{"database":"InterPro","id":"IPR000479","properties":[{"key":"EntryName","value":"CIMR_rpt"}]},{"database":"InterPro","id":"IPR000562","properties":[{"key":"EntryName","value":"FN_type2_dom"}]},{"database":"InterPro","id":"IPR036943","properties":[{"key":"EntryName","value":"FN_type2_sf"}]},{"database":"InterPro","id":"IPR013806","properties":[{"key":"EntryName","value":"Kringle-like"}]},{"database":"InterPro","id":"IPR009011","properties":[{"key":"EntryName","value":"Man6P_isomerase_rcpt-bd_dom_sf"}]},{"database":"InterPro","id":"IPR044865","properties":[{"key":"EntryName","value":"MRH_dom"}]},{"database":"PANTHER","id":"PTHR15071:SF17","properties":[{"key":"EntryName","value":"CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15071","properties":[{"key":"EntryName","value":"MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00878","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"15"}]},{"database":"Pfam","id":"PF00040","properties":[{"key":"EntryName","value":"fn2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00013","properties":[{"key":"EntryName","value":"FNTYPEII"}]},{"database":"SMART","id":"SM01404","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00059","properties":[{"key":"EntryName","value":"FN2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57440","properties":[{"key":"EntryName","value":"Kringle-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50911","properties":[{"key":"EntryName","value":"Mannose 6-phosphate receptor domain"},{"key":"MatchStatus","value":"15"}]},{"database":"PROSITE","id":"PS00023","properties":[{"key":"EntryName","value":"FN2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51092","properties":[{"key":"EntryName","value":"FN2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51914","properties":[{"key":"EntryName","value":"MRH"},{"key":"MatchStatus","value":"15"}]}],"sequence":{"value":"MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI","length":2491,"molWeight":274375,"crc64":"3841ADE559B48057","md5":"861B2DE5C5451DB56AE335A742F0A7BE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":6,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"PTM":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":15,"Region":1,"Compositional bias":3,"Modified residue":5,"Glycosylation":18,"Disulfide bond":59,"Natural variant":25,"Sequence conflict":15,"Helix":41,"Beta strand":172,"Turn":28},"uniParcId":"UPI0000072478"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2YQS7","uniProtkbId":"A0A7I2YQS7_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"}],"value":"Insulin like growth factor 2 receptor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"}],"value":"IGF2R"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5029635348"},{"type":"Domain","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Disulfide bond","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2YQS7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2YQS7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504419.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035691","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353625","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2YQS7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2YQS7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000676781.1","properties":[{"key":"ProteinId","value":"ENSP00000504419.1"},{"key":"GeneId","value":"ENSG00000197081.16"}]},{"database":"HGNC","id":"HGNC:5467","properties":[{"key":"GeneName","value":"IGF2R"}]},{"database":"OpenTargets","id":"ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000013943","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2YQS7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005537","properties":[{"key":"GoTerm","value":"F:D-mannose binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007041","properties":[{"key":"GoTerm","value":"P:lysosomal transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.70.130.10:FF:000011","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000016","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000019","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000022","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.130.10","properties":[{"key":"EntryName","value":"Mannose-6-phosphate receptor binding domain"},{"key":"MatchStatus","value":"5"}]},{"database":"InterPro","id":"IPR000479","properties":[{"key":"EntryName","value":"CIMR_rpt"}]},{"database":"InterPro","id":"IPR009011","properties":[{"key":"EntryName","value":"Man6P_isomerase_rcpt-bd_dom_sf"}]},{"database":"InterPro","id":"IPR044865","properties":[{"key":"EntryName","value":"MRH_dom"}]},{"database":"PANTHER","id":"PTHR15071:SF17","properties":[{"key":"EntryName","value":"CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15071","properties":[{"key":"EntryName","value":"MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00878","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM01404","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF50911","properties":[{"key":"EntryName","value":"Mannose 6-phosphate receptor domain"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS51914","properties":[{"key":"EntryName","value":"MRH"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSA","length":685,"molWeight":75192,"crc64":"0C2EA8FF849095E6","md5":"F8EED1799714381141DD38B9C751674D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":5,"Disulfide bond":6},"uniParcId":"UPI0018BA005F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V381","uniProtkbId":"A0A7I2V381_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"}],"value":"Insulin like growth factor 2 receptor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"}],"value":"IGF2R"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":1432,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5029679651"},{"type":"Domain","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":619,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":762,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":765,"modifier":"EXACT"},"end":{"value":924,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":1079,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":1082,"modifier":"EXACT"},"end":{"value":1219,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Domain","location":{"start":{"value":1225,"modifier":"EXACT"},"end":{"value":1363,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Disulfide bond","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":617,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":672,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]},{"type":"Disulfide bond","location":{"start":{"value":823,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V381"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V381"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503314.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035691","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353625","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"A0A7I2V381","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677704.1","properties":[{"key":"ProteinId","value":"ENSP00000503314.1"},{"key":"GeneId","value":"ENSG00000197081.16"}]},{"database":"HGNC","id":"HGNC:5467","properties":[{"key":"GeneName","value":"IGF2R"}]},{"database":"OpenTargets","id":"ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000013943","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V381","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005537","properties":[{"key":"GoTerm","value":"F:D-mannose binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007041","properties":[{"key":"GoTerm","value":"P:lysosomal transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"2.70.130.10:FF:000005","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000009","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000011","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000012","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000015","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000016","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000019","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000020","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.130.10:FF:000022","properties":[{"key":"EntryName","value":"Insulin-like growth factor 2 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.130.10","properties":[{"key":"EntryName","value":"Mannose-6-phosphate receptor binding domain"},{"key":"MatchStatus","value":"10"}]},{"database":"InterPro","id":"IPR000479","properties":[{"key":"EntryName","value":"CIMR_rpt"}]},{"database":"InterPro","id":"IPR009011","properties":[{"key":"EntryName","value":"Man6P_isomerase_rcpt-bd_dom_sf"}]},{"database":"InterPro","id":"IPR044865","properties":[{"key":"EntryName","value":"MRH_dom"}]},{"database":"PANTHER","id":"PTHR15071:SF17","properties":[{"key":"EntryName","value":"CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15071","properties":[{"key":"EntryName","value":"MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00878","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"9"}]},{"database":"SMART","id":"SM01404","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"9"}]},{"database":"SUPFAM","id":"SSF50911","properties":[{"key":"EntryName","value":"Mannose 6-phosphate receptor domain"},{"key":"MatchStatus","value":"10"}]},{"database":"PROSITE","id":"PS51914","properties":[{"key":"EntryName","value":"MRH"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTAWTWFGRETAGRRMI","length":1432,"molWeight":157884,"crc64":"64B0138E0F0FC7BB","md5":"603D67160941C4F2AC841514F77E73CA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":9,"Disulfide bond":7},"uniParcId":"UPI0018BDE7E4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0N9R6","uniProtkbId":"A0N9R6_HUMAN","entryAudit":{"firstPublicDate":"2006-12-12","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2006-12-12","entryVersion":60,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA62977.1"}],"value":"Insulin-like growth factor type 2 receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"value":"Insulin-like growth factor type II receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"value":"IGF2R"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA62977.1"}],"value":"igf2R"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5010101833"},{"type":"Non-terminal residue","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"2957598","citationType":"journal article","authors":["Morgan D.O.","Edman J.C.","Standring D.N.","Fried V.A.","Smith M.C.","Roth R.A.","Rutter W.J."],"citationCrossReferences":[{"database":"PubMed","id":"2957598"},{"database":"DOI","id":"10.1038/329301a0"}],"title":"Insulin-like growth factor II receptor as a multifunctional binding protein.","publicationDate":"1987","journal":"Nature","firstPage":"301","lastPage":"307","volume":"329"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"value":"PBL","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}]},{"referenceNumber":2,"citation":{"id":"2963003","citationType":"journal article","authors":["Oshima A.","Nolan C.M.","Kyle J.W.","Grubb J.H.","Sly W.S."],"citationCrossReferences":[{"database":"PubMed","id":"2963003"}],"title":"The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.","publicationDate":"1988","journal":"J. Biol. Chem.","firstPage":"2553","lastPage":"2562","volume":"263"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"value":"PBL","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}]},{"referenceNumber":3,"citation":{"id":"8595419","citationType":"journal article","authors":["Smrzka O.W.","Fae I.","Stoger R.","Kurzbauer R.","Fischer G.F.","Henn T.","Weith A.","Barlow D.P."],"citationCrossReferences":[{"database":"PubMed","id":"8595419"},{"database":"DOI","id":"10.1093/hmg/4.10.1945"}],"title":"Conservation of a methylation imprint and a putative imprinting box at the human IGF2R locus.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1945","lastPage":"1952","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}],"value":"PBL","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58672.1"}]},{"referenceNumber":4,"citation":{"id":"CI-EA74R4EUOC27U","citationType":"submission","authors":["Kalscheuer V.M.M."],"publicationDate":"SEP-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA62977.1"}]},{"referenceNumber":5,"citation":{"id":"8824797","citationType":"journal article","authors":["Riesewijk A.M.","Schepens M.T.","Welch T.R.","van den Berg-Loonen E.M.","Mariman E.M.","Ropers H.H.","Kalscheuer V.M."],"citationCrossReferences":[{"database":"PubMed","id":"8824797"},{"database":"DOI","id":"10.1006/geno.1996.0027"}],"title":"Maternal-specific methylation of the human IGF2R gene is not accompanied by allele-specific transcription.","publicationDate":"1996","journal":"Genomics","firstPage":"158","lastPage":"166","volume":"31"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA62977.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X83699","properties":[{"key":"ProteinId","value":"CAA58672.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X91875","properties":[{"key":"ProteinId","value":"CAA62977.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0N9R6","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0N9R6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELC","length":49,"molWeight":5015,"crc64":"C0824C7F0946FEBA","md5":"19C0C2F6A19C85251BE81437D097C12B"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI000011620C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0N9R9","uniProtkbId":"A0N9R9_HUMAN","entryAudit":{"firstPublicDate":"2006-12-12","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2006-12-12","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}],"value":"Insulin-like growth factor type II receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}],"value":"IGF2R"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"}],"references":[{"referenceNumber":1,"citation":{"id":"8595419","citationType":"journal article","authors":["Smrzka O.W.","Fae I.","Stoger R.","Kurzbauer R.","Fischer G.F.","Henn T.","Weith A.","Barlow D.P."],"citationCrossReferences":[{"database":"PubMed","id":"8595419"},{"database":"DOI","id":"10.1093/hmg/4.10.1945"}],"title":"Conservation of a methylation imprint and a putative imprinting box at the human IGF2R locus.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1945","lastPage":"1952","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}],"value":"PBL","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58675.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X83702","properties":[{"key":"ProteinId","value":"CAA58675.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S58277","properties":[{"key":"EntryName","value":"S58277"}]},{"database":"AlphaFoldDB","id":"A0N9R9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"KAQITESRAALPSCVGKP","length":18,"molWeight":1856,"crc64":"4C3B60AE44F4F90E","md5":"AB1FCF7A9241D6DB11BF1209E58711B1"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI000011620D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q13661","uniProtkbId":"Q13661_HUMAN","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"1996-11-01","entryVersion":67,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}],"value":"Mannose 6-phosphate/insulin-like growth factor-II receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}],"value":"IGF2R"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}],"value":"mannose 6-phosphate"}]}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"}],"references":[{"referenceNumber":1,"citation":{"id":"7493029","citationType":"journal article","authors":["De Souza A.T.","Hankins G.R.","Washington M.K.","Orton T.C.","Jirtle R.L."],"citationCrossReferences":[{"database":"PubMed","id":"7493029"},{"database":"DOI","id":"10.1038/ng1295-447"}],"title":"M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.","publicationDate":"1995","journal":"Nat. Genet.","firstPage":"447","lastPage":"449","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35665.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S80785","properties":[{"key":"ProteinId","value":"AAB35665.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q13661","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q13661","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"PQWRDGIIVLKYVDGDLCPDEIRK","length":24,"molWeight":2829,"crc64":"E6F2901053E17602","md5":"45C4A1A9C88CB34858139E81E00A16BD"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI000006E475"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V657","uniProtkbId":"A0A7I2V657_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2021-04-07","entryVersion":23,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"}],"value":"Insulin like growth factor 2 receptor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"}],"value":"IGF2R"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Region","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V657"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V657"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504616.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035691","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353625","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V657","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2V657","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000678224.1","properties":[{"key":"ProteinId","value":"ENSP00000504616.1"},{"key":"GeneId","value":"ENSG00000197081.16"}]},{"database":"HGNC","id":"HGNC:5467","properties":[{"key":"GeneName","value":"IGF2R"}]},{"database":"OpenTargets","id":"ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000013943","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FITYQSS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V657","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]}],"sequence":{"value":"MHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI","length":197,"molWeight":21825,"crc64":"A4974845BDA8946E","md5":"B23FEEBAB0A9423953A32916DE9C7CD7"},"extraAttributes":{"countByFeatureType":{"Transmembrane":1,"Region":1,"Compositional bias":3},"uniParcId":"UPI000D5011F5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0N9R7","uniProtkbId":"A0N9R7_HUMAN","entryAudit":{"firstPublicDate":"2006-12-12","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2006-12-12","entryVersion":65,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}],"value":"Insulin-like growth factor type II receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}],"value":"IGF2R"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}]},{"type":"Non-terminal residue","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"}],"references":[{"referenceNumber":1,"citation":{"id":"8595419","citationType":"journal article","authors":["Smrzka O.W.","Fae I.","Stoger R.","Kurzbauer R.","Fischer G.F.","Henn T.","Weith A.","Barlow D.P."],"citationCrossReferences":[{"database":"PubMed","id":"8595419"},{"database":"DOI","id":"10.1093/hmg/4.10.1945"}],"title":"Conservation of a methylation imprint and a putative imprinting box at the human IGF2R locus.","publicationDate":"1995","journal":"Hum. Mol. Genet.","firstPage":"1945","lastPage":"1952","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}],"value":"PBL","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA58673.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X83700","properties":[{"key":"ProteinId","value":"CAA58673.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0N9R7","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0N9R7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Gene3D","id":"2.70.130.10","properties":[{"key":"EntryName","value":"Mannose-6-phosphate receptor binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009011","properties":[{"key":"EntryName","value":"Man6P_isomerase_rcpt-bd_dom_sf"}]},{"database":"SUPFAM","id":"SSF50911","properties":[{"key":"EntryName","value":"Mannose 6-phosphate receptor domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"EAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSV","length":43,"molWeight":4710,"crc64":"B35667D3B01D15D9","md5":"9EFC1C75DE3762A6989F496494052278"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI000011793D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q13660","uniProtkbId":"Q13660_HUMAN","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"1996-11-01","entryVersion":65,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}],"value":"Mannose 6-phosphate/insulin-like growth factor-II receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}],"value":"IGF2R"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}],"value":"mannose 6-phosphate"}]}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"}],"references":[{"referenceNumber":1,"citation":{"id":"7493029","citationType":"journal article","authors":["De Souza A.T.","Hankins G.R.","Washington M.K.","Orton T.C.","Jirtle R.L."],"citationCrossReferences":[{"database":"PubMed","id":"7493029"},{"database":"DOI","id":"10.1038/ng1295-447"}],"title":"M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.","publicationDate":"1995","journal":"Nat. Genet.","firstPage":"447","lastPage":"449","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAB35664.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S80783","properties":[{"key":"ProteinId","value":"AAB35664.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q13660","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q13660","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]}],"sequence":{"value":"PQWRDVIIVLKYVDGDLCPDGIRK","length":24,"molWeight":2799,"crc64":"E6F28C7F43E17602","md5":"4B5EBB2EF11E649B1B141E25749828C3"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0000073B3D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"S4R328","uniProtkbId":"S4R328_HUMAN","entryAudit":{"firstPublicDate":"2013-09-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-09-18","entryVersion":75,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"}],"value":"Insulin like growth factor 2 receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"}],"value":"IGF2R"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01262"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"MRH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51914"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"S4R328"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"S4R328"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473880.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL035691","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL353625","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"MassIVE","id":"S4R328","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1396","properties":[{"key":"antibodies","value":"756 antibodies from 44 providers"}]},{"database":"Ensembl","id":"ENST00000475834.2","properties":[{"key":"ProteinId","value":"ENSP00000473880.1"},{"key":"GeneId","value":"ENSG00000197081.16"}]},{"database":"UCSC","id":"uc063sql.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5467","properties":[{"key":"GeneName","value":"IGF2R"}]},{"database":"OpenTargets","id":"ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000197081","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000013943","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1471440_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4504960at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"IGF2R","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000197081","properties":[{"key":"ExpressionPatterns","value":"Expressed in stromal cell of endometrium and 195 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"S4R328","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005537","properties":[{"key":"GoTerm","value":"F:D-mannose binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0038023","properties":[{"key":"GoTerm","value":"F:signaling receptor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007041","properties":[{"key":"GoTerm","value":"P:lysosomal transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.70.130.10","properties":[{"key":"EntryName","value":"Mannose-6-phosphate receptor binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000479","properties":[{"key":"EntryName","value":"CIMR_rpt"}]},{"database":"InterPro","id":"IPR009011","properties":[{"key":"EntryName","value":"Man6P_isomerase_rcpt-bd_dom_sf"}]},{"database":"InterPro","id":"IPR044865","properties":[{"key":"EntryName","value":"MRH_dom"}]},{"database":"Pfam","id":"PF00878","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01404","properties":[{"key":"EntryName","value":"CIMR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50911","properties":[{"key":"EntryName","value":"Mannose 6-phosphate receptor domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51914","properties":[{"key":"EntryName","value":"MRH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XCRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQGNPWLPTKFHI","length":185,"molWeight":20469,"crc64":"E11435366FB69CA7","md5":"D871243328DFB26A551D33B6F39E0A52"},"extraAttributes":{"countByCommentType":{"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00033351E0"}}]}