{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q02363","uniProtkbId":"ID2_HUMAN","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-02-01","entryVersion":211,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DNA-binding protein inhibitor ID-2"}},"alternativeNames":[{"fullName":{"value":"Class B basic helix-loop-helix protein 26"},"shortNames":[{"value":"bHLHb26"}]},{"fullName":{"value":"Inhibitor of DNA binding 2"}},{"fullName":{"value":"Inhibitor of differentiation 2"}}]},"genes":[{"geneName":{"value":"ID2"},"synonyms":[{"value":"BHLHB26"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20861012"}],"value":"Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41136"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10502414"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14752053"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20861012"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24586788"}],"value":"Interacts with GATA4 and NKX2-5 (By similarity). Interacts with NR0B2 (PubMed:14752053). Interacts with CLOCK and BMAL1 (PubMed:20861012). Interacts with IFI204 (By similarity). Interacts with NEDD9/HEF1 (PubMed:10502414). Interacts with ASB4; this interaction promotes ID2 proteasomal degradation (PubMed:24586788)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q6XD76","geneName":"ASCL4","intActId":"EBI-10254793"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q6P5X5","geneName":"C22orf39","intActId":"EBI-7317823"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"O95273","geneName":"CCNDBP1","intActId":"EBI-748961"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q9H0I2","geneName":"ENKD1","intActId":"EBI-744099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q9NW38","geneName":"FANCL","intActId":"EBI-2339898"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P11362-2","geneName":"FGFR1","intActId":"EBI-25852941"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q9BVV2","geneName":"FNDC11","intActId":"EBI-744935"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"O43559","geneName":"FRS3","intActId":"EBI-725515"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q5SUL5","geneName":"HLA-A","intActId":"EBI-8561769"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"O43464","geneName":"HTRA2","intActId":"EBI-517086"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q92993","geneName":"KAT5","intActId":"EBI-399080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q8TAP4-4","geneName":"LMO3","intActId":"EBI-11742507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"A6NI15","geneName":"MSGN1","intActId":"EBI-11991020"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q96HC4","geneName":"PDLIM5","intActId":"EBI-751267"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q13563","geneName":"PKD2","intActId":"EBI-7813714"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"A0A6Q8PF08","geneName":"PMP22","intActId":"EBI-50433196"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P62937-2","geneName":"PPIA","intActId":"EBI-25884072"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P23284","geneName":"PPIB","intActId":"EBI-359252"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P17252","geneName":"PRKCA","intActId":"EBI-1383528"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q15047-2","geneName":"SETDB1","intActId":"EBI-9090795"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q13148","geneName":"TARDBP","intActId":"EBI-372899"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q99081","geneName":"TCF12","intActId":"EBI-722877"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P15923","geneName":"TCF3","intActId":"EBI-769630"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P15923-1","geneName":"TCF3","intActId":"EBI-769645"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P15884","geneName":"TCF4","intActId":"EBI-533224"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"Q9BT92","geneName":"TCHP","intActId":"EBI-740781"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q02363","intActId":"EBI-713450"},"interactantTwo":{"uniProtKBAccession":"P61981","geneName":"YWHAG","intActId":"EBI-359832"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41136"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41136"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"value":"Highly expressed in early fetal tissues, including those of the central nervous system"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Found in most early fetal tissues but not in the corresponding mature tissues"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The bHLH domain is essential for its repressor activity towards the CLOCK-BMAL1 heterodimer"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24586788"}],"value":"Ubiquitinated in a ASB4-dependent manner, leading to proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41137"}],"value":"Phosphorylated in vitro by CDK1, PKA and PKC"}],"commentType":"PTM"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"DNA-binding protein inhibitor ID-2","featureId":"PRO_0000127240"},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"bHLH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Motif","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P41136"}]},{"type":"Sequence conflict","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in Ref. 2; AAA58681","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in Ref. 2; AAA58681","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4AYA"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4AYA"}]},{"type":"Helix","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4AYA"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4AYA"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"8294468","citationType":"journal article","authors":["Hara E.","Yamaguchi T.","Nojima H.","Ide T.","Campisi J.","Okayama H.","Oda K."],"citationCrossReferences":[{"database":"PubMed","id":"8294468"},{"database":"DOI","id":"10.1016/s0021-9258(17)42146-6"}],"title":"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.","publicationDate":"1994","journal":"J. Biol. Chem.","firstPage":"2139","lastPage":"2145","volume":"269"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"1741406","citationType":"journal article","authors":["Biggs J.","Murphy E.V.","Israel M.A."],"citationCrossReferences":[{"database":"PubMed","id":"1741406"},{"database":"DOI","id":"10.1073/pnas.89.4.1512"}],"title":"A human Id-like helix-loop-helix protein expressed during early development.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1512","lastPage":"1516","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"10502414","citationType":"journal article","authors":["Law S.F.","Zhang Y.-Z.","Fashena S.J.","Toby G.","Estojak J.","Golemis E.A."],"citationCrossReferences":[{"database":"PubMed","id":"10502414"},{"database":"DOI","id":"10.1006/excr.1999.4609"}],"title":"Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.","publicationDate":"1999","journal":"Exp. Cell Res.","firstPage":"224","lastPage":"235","volume":"252"},"referencePositions":["INTERACTION WITH NEDD9"]},{"referenceNumber":5,"citation":{"id":"14752053","citationType":"journal article","authors":["Kim J.Y.","Chu K.","Kim H.J.","Seong H.A.","Park K.C.","Sanyal S.","Takeda J.","Ha H.","Shong M.","Tsai M.J.","Choi H.S."],"citationCrossReferences":[{"database":"PubMed","id":"14752053"},{"database":"DOI","id":"10.1210/me.2003-0311"}],"title":"Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.","publicationDate":"2004","journal":"Mol. Endocrinol.","firstPage":"776","lastPage":"790","volume":"18"},"referencePositions":["INTERACTION WITH NR0B2"]},{"referenceNumber":6,"citation":{"id":"20861012","citationType":"journal article","authors":["Ward S.M.","Fernando S.J.","Hou T.Y.","Duffield G.E."],"citationCrossReferences":[{"database":"PubMed","id":"20861012"},{"database":"DOI","id":"10.1074/jbc.m110.175182"}],"title":"The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"38987","lastPage":"39000","volume":"285"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH CLOCK AND BMAL1"]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"24586788","citationType":"journal article","authors":["Townley-Tilson W.H.","Wu Y.","Ferguson J.E. III","Patterson C."],"citationCrossReferences":[{"database":"PubMed","id":"24586788"},{"database":"DOI","id":"10.1371/journal.pone.0089451"}],"title":"The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.","publicationDate":"2014","journal":"PLoS ONE","firstPage":"e89451","lastPage":"e89451","volume":"9"},"referencePositions":["INTERACTION WITH ASB4","UBIQUITINATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D13891","properties":[{"key":"ProteinId","value":"BAA02990.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M97796","properties":[{"key":"ProteinId","value":"AAA58681.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC030639","properties":[{"key":"ProteinId","value":"AAH30639.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1659.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A40227","properties":[{"key":"EntryName","value":"A40227"}]},{"database":"PIR","id":"JC2007","properties":[{"key":"EntryName","value":"JC2007"}]},{"database":"RefSeq","id":"NP_002157.2","properties":[{"key":"NucleotideSequenceId","value":"NM_002166.5"}]},{"database":"PDB","id":"4AYA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B=1-82"}]},{"database":"PDBsum","id":"4AYA","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109624","properties":[{"key":"Interactions","value":"96"}]},{"database":"DIP","id":"DIP-46874N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q02363","properties":[{"key":"Number of interactors","value":"1978"}]},{"database":"IntAct","id":"Q02363","properties":[{"key":"Interactions","value":"64"}]},{"database":"MINT","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ID2","properties":[{"key":"Evidences","value":"13 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000234091","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q02363","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ID2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"729806","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000234091","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58083","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"12350","properties":[{"key":"antibodies","value":"460 antibodies from 40 providers"}]},{"database":"DNASU","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000234091.8","properties":[{"key":"ProteinId","value":"ENSP00000234091.4"},{"key":"GeneId","value":"ENSG00000115738.11"}]},{"database":"Ensembl","id":"ENST00000331129.3","properties":[{"key":"ProteinId","value":"ENSP00000385465.2"},{"key":"GeneId","value":"ENSG00000115738.11"}]},{"database":"Ensembl","id":"ENST00000396290.2","properties":[{"key":"ProteinId","value":"ENSP00000379585.1"},{"key":"GeneId","value":"ENSG00000115738.11"}]},{"database":"Ensembl","id":"ENST00000855860.1","properties":[{"key":"ProteinId","value":"ENSP00000525919.1"},{"key":"GeneId","value":"ENSG00000115738.11"}]},{"database":"Ensembl","id":"ENST00000929710.1","properties":[{"key":"ProteinId","value":"ENSP00000599769.1"},{"key":"GeneId","value":"ENSG00000115738.11"}]},{"database":"GeneID","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3398","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000396290.2","properties":[{"key":"ProteinId","value":"ENSP00000379585.1"},{"key":"RefSeqNucleotideId","value":"NM_002166.5"},{"key":"RefSeqProteinId","value":"NP_002157.2"}]},{"database":"AGR","id":"HGNC:5361","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29609","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ID2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5361","properties":[{"key":"GeneName","value":"ID2"}]},{"database":"HPA","id":"ENSG00000115738","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (blood vessel, parathyroid gland)"}]},{"database":"MIM","id":"600386","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000115738","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000115738","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RZP5","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156464","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_116790_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FPTELMT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10047910at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q02363","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9031628","properties":[{"key":"PathwayName","value":"NGF-stimulated transcription"}]},{"database":"SignaLink","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000115738","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3398","properties":[{"key":"hits","value":"26 hits in 1147 CRISPR screens"}]},{"database":"ChiTaRS","id":"ID2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"ID2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q02363","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q02363","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q02363","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000115738","properties":[{"key":"ExpressionPatterns","value":"Expressed in popliteal artery and 207 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q02363","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20861012"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16311606"}]},{"database":"GO","id":"GO:0000791","properties":[{"key":"GoTerm","value":"C:euchromatin"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16311606"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0140416","properties":[{"key":"GoTerm","value":"F:transcription regulator inhibitor activity"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0044325","properties":[{"key":"GoTerm","value":"F:transmembrane transporter binding"},{"key":"GoEvidenceType","value":"IPI:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16311606"}]},{"database":"GO","id":"GO:0003166","properties":[{"key":"GoTerm","value":"P:bundle of His development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0090398","properties":[{"key":"GoTerm","value":"P:cellular senescence"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0048557","properties":[{"key":"GoTerm","value":"P:embryonic digestive tract morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061031","properties":[{"key":"GoTerm","value":"P:endodermal digestive tract morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043153","properties":[{"key":"GoTerm","value":"P:entrainment of circadian clock by photoperiod"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043353","properties":[{"key":"GoTerm","value":"P:enucleate erythrocyte differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0061030","properties":[{"key":"GoTerm","value":"P:epithelial cell differentiation involved in mammary gland alveolus development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007507","properties":[{"key":"GoTerm","value":"P:heart development"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0045475","properties":[{"key":"GoTerm","value":"P:locomotor rhythm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060749","properties":[{"key":"GoTerm","value":"P:mammary gland alveolus development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033598","properties":[{"key":"GoTerm","value":"P:mammary gland epithelial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003149","properties":[{"key":"GoTerm","value":"P:membranous septum morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045578","properties":[{"key":"GoTerm","value":"P:negative regulation of B cell differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:GDB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14627819"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051148","properties":[{"key":"GoTerm","value":"P:negative regulation of muscle cell differentiation"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048663","properties":[{"key":"GoTerm","value":"P:neuron fate commitment"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0021772","properties":[{"key":"GoTerm","value":"P:olfactory bulb development"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0048711","properties":[{"key":"GoTerm","value":"P:positive regulation of astrocyte differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0045777","properties":[{"key":"GoTerm","value":"P:positive regulation of blood pressure"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045600","properties":[{"key":"GoTerm","value":"P:positive regulation of fat cell differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045651","properties":[{"key":"GoTerm","value":"P:positive regulation of macrophage differentiation"},{"key":"GoEvidenceType","value":"ISS:ARUK-UCL"}]},{"database":"GO","id":"GO:0048661","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042752","properties":[{"key":"GoTerm","value":"P:regulation of circadian rhythm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000045","properties":[{"key":"GoTerm","value":"P:regulation of G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16311606"}]},{"database":"GO","id":"GO:0019216","properties":[{"key":"GoTerm","value":"P:regulation of lipid metabolic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000177","properties":[{"key":"GoTerm","value":"P:regulation of neural precursor cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045664","properties":[{"key":"GoTerm","value":"P:regulation of neuron differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16311606"}]},{"database":"CDD","id":"cd19692","properties":[{"key":"EntryName","value":"bHLH_dnHLH_ID2"},{"key":"MatchStatus","value":"1"}]},{"database":"DisProt","id":"DP02697","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"4.10.280.10:FF:000055","properties":[{"key":"EntryName","value":"DNA-binding protein inhibitor ID-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00819","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR026052","properties":[{"key":"EntryName","value":"DNA-bd_prot-inh"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11723","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN INHIBITOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11723:SF5","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN INHIBITOR ID-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00010","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG","length":134,"molWeight":14917,"crc64":"A0D98B96396EB11E","md5":"5E823B81B9BC0E7D18887CF775A5F988"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":29,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"PTM":2},"countByFeatureType":{"Chain":1,"Domain":1,"Motif":1,"Modified residue":2,"Sequence conflict":2,"Helix":3,"Beta strand":1},"uniParcId":"UPI00000012EE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q53T66","secondaryAccessions":["D6W4Y7"],"uniProtkbId":"Q53T66_HUMAN","entryAudit":{"firstPublicDate":"2005-05-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-24","entryVersion":164,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV35470.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040556"}],"value":"DNA-binding protein inhibitor ID-2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043116"}],"value":"Inhibitor of DNA binding 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042951"}],"value":"Inhibitor of differentiation 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV35470.1"}],"value":"GIG8"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX01018.1"}],"value":"ID2"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX01018.1"}],"value":"hCG_1784377"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037646"}],"value":"Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049994"}],"value":"Interacts with GATA4 and NKX2-5. Interacts with NR0B2. Interacts with CLOCK and BMAL1. Interacts with IFI204. Interacts with NEDD9/HEF1. Interacts with ASB4; this interaction promotes ID2 proteasomal degradation"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"BHLH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50888"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Helix-loop-helix motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023108"}],"id":"KW-0090","category":"Biological process","name":"Biological rhythms"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022491"}],"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX01018.1"}]},{"referenceNumber":2,"citation":{"id":"CI-176OEU9TE6SAQ","citationType":"submission","authors":["Kim J.W."],"title":"Identification of human cell growth-inhibiting gene.","publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAV35470.1"}]},{"referenceNumber":3,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAX01018.1"}]},{"referenceNumber":4,"citation":{"id":"CI-6MEA4GF1I55C2","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Kaida T.","Tsuchiya K.","Iida Y.","Takayama Y.","Murakawa K.","Kanehori K.","Andoh T.","Kagawa N.","Sato R.","Kawamura Y.","Tanaka S.","Kisu Y.","Sugano S.","Goshima N.","Nomura N.","Isogai T."],"title":"NEDO functional analysis of protein and research application project.","publicationDate":"JAN-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG34927.1"}],"value":"Thymus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAG34927.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY634687","properties":[{"key":"ProteinId","value":"AAV35470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK311988","properties":[{"key":"ProteinId","value":"BAG34927.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471053","properties":[{"key":"ProteinId","value":"EAX01018.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_002157.2","properties":[{"key":"NucleotideSequenceId","value":"NM_002166.5"}]},{"database":"AlphaFoldDB","id":"Q53T66","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q53T66","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"12350","properties":[{"key":"antibodies","value":"460 antibodies from 40 providers"}]},{"database":"DNASU","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3398","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc002qza.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ClinPGx","id":"PA29609","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3398","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000115738","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_116790_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FPTELMT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10047910at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3398","properties":[{"key":"hits","value":"26 hits in 1147 CRISPR screens"}]},{"database":"ChiTaRS","id":"ID2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000791","properties":[{"key":"GoTerm","value":"C:euchromatin"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0061629","properties":[{"key":"GoTerm","value":"F:RNA polymerase II-specific DNA-binding transcription factor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0140416","properties":[{"key":"GoTerm","value":"F:transcription regulator inhibitor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0090398","properties":[{"key":"GoTerm","value":"P:cellular senescence"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0032922","properties":[{"key":"GoTerm","value":"P:circadian regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048557","properties":[{"key":"GoTerm","value":"P:embryonic digestive tract morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0061031","properties":[{"key":"GoTerm","value":"P:endodermal digestive tract morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043153","properties":[{"key":"GoTerm","value":"P:entrainment of circadian clock by photoperiod"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0061030","properties":[{"key":"GoTerm","value":"P:epithelial cell differentiation involved in mammary gland alveolus development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045475","properties":[{"key":"GoTerm","value":"P:locomotor rhythm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033598","properties":[{"key":"GoTerm","value":"P:mammary gland epithelial cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003149","properties":[{"key":"GoTerm","value":"P:membranous septum morphogenesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051148","properties":[{"key":"GoTerm","value":"P:negative regulation of muscle cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045777","properties":[{"key":"GoTerm","value":"P:positive regulation of blood pressure"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048661","properties":[{"key":"GoTerm","value":"P:positive regulation of smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd19692","properties":[{"key":"EntryName","value":"bHLH_dnHLH_ID2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.280.10:FF:000055","properties":[{"key":"EntryName","value":"DNA-binding protein inhibitor ID-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR026052","properties":[{"key":"EntryName","value":"DNA-bd_prot-inh"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11723","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN INHIBITOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11723:SF5","properties":[{"key":"EntryName","value":"DNA-BINDING PROTEIN INHIBITOR ID-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00010","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG","length":134,"molWeight":14917,"crc64":"A0D98B96396EB11E","md5":"5E823B81B9BC0E7D18887CF775A5F988"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":1},"uniParcId":"UPI00000012EE"}}]}