{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O43464","secondaryAccessions":["Q9HBZ4","Q9P0Y3","Q9P0Y4"],"uniProtkbId":"HTRA2_HUMAN","entryAudit":{"firstPublicDate":"2001-09-26","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-05-01","entryVersion":244,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Serine protease HTRA2, mitochondrial"},"ecNumbers":[{"value":"3.4.21.108"}]},"alternativeNames":[{"fullName":{"value":"High temperature requirement protein A2"},"shortNames":[{"value":"HtrA2"}]},{"fullName":{"value":"Omi stress-regulated endoprotease"}},{"fullName":{"value":"Serine protease 25"}},{"fullName":{"value":"Serine proteinase OMI"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"HTRA2"},"synonyms":[{"value":"OMI"},{"value":"PRSS25"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873535"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15200957"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19502560"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36758104"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36758105"}],"value":"Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560)"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10995577"}],"value":"Seems to be proteolytically inactive"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. 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Interacts with AREL1 (via HECT domain); in the cytoplasm following induction of apoptosis 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