{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P38646","secondaryAccessions":["B2RCM1","P30036","P31932","Q1HB43","Q53H23","Q6GU03","Q9BWB7","Q9UC56"],"uniProtkbId":"HSPA9_HUMAN","entryAudit":{"firstPublicDate":"1995-02-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-05-27","entryVersion":248,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Stress-70 protein, mitochondrial"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18632665"}],"value":"mt-HSP70"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25615450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31177526"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"value":"75 kDa glucose-regulated protein"},"shortNames":[{"value":"GRP-75"}]},{"fullName":{"value":"Heat shock 70 kDa protein 9"}},{"fullName":{"value":"Heat shock protein family A member 9"}},{"fullName":{"value":"Mortalin"},"shortNames":[{"value":"MOT"}]},{"fullName":{"value":"Peptide-binding protein 74"},"shortNames":[{"value":"PBP74"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:5244"}],"value":"HSPA9"},"synonyms":[{"value":"GRP75"},{"value":"HSPA9B"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18632665"}],"value":"mt-HSP70"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0CS90"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16091382"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21123823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25615450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28848044"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31177526"}],"value":"Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25615450"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31177526"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18632665"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P11021"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28848044"}],"value":"The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. ATP binding in the NBD leads to a conformational change in the NBD, which is transferred through the interdomain linker (IDL) to the substrate-binding domain (SBD). This elicits a reduced substrate affinity and a faster substrate exchange rate. Upon hydrolysis of ATP to ADP, the protein undergoes a conformational change that increases its affinity for substrate proteins. It cycles through repeated phases of ATP hydrolysis and nucleotide exchange, facilitating repeated cycles of substrate binding and release (By similarity). Functions in collaboration with co-chaperones. Functions with the co-chaperone, DNLZ, to maintain solubility and regulate ATP hydrolysis (PubMed:18632665). Regulated by nucleotide exchange factors (NEFs) including GRPEL1 and GRPEL2, which facilitate the release of bound ADP to allow ATP rebinding (PubMed:28848044)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P48721"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10339406"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17331979"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20668094"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22114354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23462535"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23501103"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23541579"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23940031"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39737924"}],"value":"Interacts strongly with the intermediate form of FXN and weakly with its mature form (PubMed:17331979, PubMed:26702583). Interacts with HSCB (PubMed:20668094). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:22114354). Interacts with DNLZ, the interaction is required to prevent self-aggregation (PubMed:23462535, PubMed:18632665). Interacts with TESPA1 (PubMed:23501103). Interacts with PDPN (PubMed:23541579). Interacts with NFU1, NFS1 and ISCU (PubMed:26702583). Interacts with TP53; the interaction promotes TP53 degradation (PubMed:24625977). Interacts (via SBD domain) with UBXN2A; the interaction with UBXN2A inhibits HSPA9 interaction with and degradation of TP53, thereby promotes TP53 translocation to the nucleus (PubMed:24625977, PubMed:26634371). Interacts with ITPR1 AND VDAC1; this interaction couples ITPR1 to VDAC1 (By similarity). Interacts with the TIM23 mitochondrial inner membrane pre-sequence translocase complex (PubMed:10339406). Interacts with GRPEL1; GRPEL1 functions as a nucleotide exchange factor (NEF) for HSPA9 (PubMed:39737924)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q9H6A0","geneName":"DENND2D","intActId":"EBI-10307465"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"P00533","geneName":"EGFR","intActId":"EBI-297353"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q8TDU6","geneName":"GPBAR1","intActId":"EBI-2806519"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q9HAV7","geneName":"GRPEL1","intActId":"EBI-1043499"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q8IWL3","geneName":"HSCB","intActId":"EBI-1805738"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q8WX92","geneName":"NELFB","intActId":"EBI-347721"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"Q99650","geneName":"OSMR","intActId":"EBI-2804080"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"O15350","geneName":"TP73","intActId":"EBI-389606"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"P13693","geneName":"TPT1","intActId":"EBI-1783169"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P38646","intActId":"EBI-354932"},"interactantTwo":{"uniProtKBAccession":"A4D2J0","geneName":"YKT6","intActId":"EBI-10173443"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P48721"}],"value":"Found in a complex with HSPA9 and VDAC1 at the endoplasmic reticulum-mitochondria contact sites"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22002106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22002106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"}],"value":"Nucleus, nucleolus","id":"SL-0188"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P48721"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0DMV8"}],"value":"The N-terminal nucleotide binding domain (NBD) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Anemia, sideroblastic, 4","diseaseAccession":"DI-04677","acronym":"SIDBA4","description":"A form of sideroblastic anemia, a bone marrow disorder defined by the presence of pathologic iron deposits in erythroblast mitochondria. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. SIDBA4 has been reported to be inherited as an autosomal recessive disease, with a pseudodominant pattern of inheritance in some families.","diseaseCrossReference":{"database":"MIM","id":"182170"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Even-plus syndrome","diseaseAccession":"DI-04676","acronym":"EVPLS","description":"An autosomal recessive syndrome characterized by epiphyseal and vertebral dysplasia, prenatal-onset short stature, a distinct craniofacial phenotype with microtia, a flat facial profile with flat nose and triangular nares, cardiac malformations, and additional findings such as anal atresia, hypodontia, aplasia cutis, and others.","diseaseCrossReference":{"database":"MIM","id":"616854"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1286669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7498169"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9150948"}]},{"type":"Chain","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Stress-70 protein, mitochondrial","featureId":"PRO_0000013563"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Interaction with NFS1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"}]},{"type":"Region","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"Nucleotide-binding domain (NBD)","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24687350"}]},{"type":"Region","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Interaction with FXN and ISCU","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"}]},{"type":"Region","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Interdomain linker","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24687350"}]},{"type":"Region","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Substrate-binding domain (SBD)","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24687350"}]},{"type":"Region","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Binding site","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}],"ligand":{"name":"ADP","id":"ChEBI:CHEBI:456216"}},{"type":"Modified residue","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"N6-malonyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21908771"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"N6-succinyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Modified residue","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"N6-acetyllysine; alternate","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"N6-succinyllysine; alternate","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P38647"}]},{"type":"Natural variant","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"in dbSNP:rs17856004","featureCrossReferences":[{"database":"dbSNP","id":"rs17856004"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_046482","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in EVPLS; impairs ATP hydrolysis activity. Impairs thermostability. Increases the propensity for aggregation; dbSNP:rs751478142","featureCrossReferences":[{"database":"dbSNP","id":"rs751478142"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"}],"featureId":"VAR_076662","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in dbSNP:rs35091799","featureCrossReferences":[{"database":"dbSNP","id":"rs35091799"}],"featureId":"VAR_049622","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in EVPLS; impairs ATP hydrolysis activity. Impairs thermostability. Increases the propensity for aggregation; dbSNP:rs765368797","featureCrossReferences":[{"database":"dbSNP","id":"rs765368797"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26598328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30933555"}],"featureId":"VAR_076663","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_046483","alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"in dbSNP:rs199715716","featureCrossReferences":[{"database":"dbSNP","id":"rs199715716"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076664","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in SIDBA4; uncertain significance; dbSNP:rs768283289","featureCrossReferences":[{"database":"dbSNP","id":"rs768283289"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076665","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"in dbSNP:rs34558740","featureCrossReferences":[{"database":"dbSNP","id":"rs34558740"}],"featureId":"VAR_049623","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"in SIDBA4; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076666","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"in SIDBA4; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076667","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"in SIDBA4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076668","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076669","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"in dbSNP:rs147723579","featureCrossReferences":[{"database":"dbSNP","id":"rs147723579"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076670","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"in dbSNP:rs905439101","featureCrossReferences":[{"database":"dbSNP","id":"rs905439101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26491070"}],"featureId":"VAR_076671","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"No effect on interaction with UBXN2A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"Abolishes interaction with UBXN2A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Significant loss of interaction with FXN and ISCU. Significant increase in interaction with NFS1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26702583"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":555,"modifier":"EXACT"}},"description":"Reduces interaction with UBXN2A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Abolishes interaction with UBXN2A.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26634371"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"in Ref. 9; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in Ref. 9; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in Ref. 3; BAG37618","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in Ref. 7; AAH00478/AAH24034","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in Ref. 4; BAD96478","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"in Ref. 4; BAD96478","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"in Ref. 2; AAA67526","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6NHK"}]},{"type":"Beta strand","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Turn","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Turn","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLS"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLT"}]},{"type":"Beta strand","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6PMT"}]},{"type":"Helix","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Turn","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Turn","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Beta strand","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Turn","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6P2U"}]},{"type":"Helix","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLS"}]},{"type":"Beta strand","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Helix","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Helix","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLS"}]},{"type":"Beta strand","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Turn","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Beta strand","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Helix","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Helix","location":{"start":{"value":569,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3N8E"}]},{"type":"Helix","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLS"}]},{"type":"Helix","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9BLS"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0242","category":"Disease","name":"Dwarfism"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"7684501","citationType":"journal article","authors":["Domanico S.Z.","Denagel D.C.","Dahlseid J.N.","Green J.M.","Pierce S.K."],"citationCrossReferences":[{"database":"PubMed","id":"7684501"},{"database":"DOI","id":"10.1128/mcb.13.6.3598-3610.1993"}],"title":"Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.","publicationDate":"1993","journal":"Mol. Cell. Biol.","firstPage":"3598","lastPage":"3610","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"B-cell","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"7829505","citationType":"journal article","authors":["Bhattacharyya T.","Karnezis A.N.","Murphy S.P.","Hoang T.","Freeman B.C.","Phillips B.","Morimoto R.I."],"citationCrossReferences":[{"database":"PubMed","id":"7829505"},{"database":"DOI","id":"10.1074/jbc.270.4.1705"}],"title":"Cloning and subcellular localization of human mitochondrial hsp70.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"1705","lastPage":"1710","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-5AVBODINQ93DF","citationType":"submission","authors":["Suzuki Y.","Sugano S.","Totoki Y.","Toyoda A.","Takeda T.","Sakaki Y.","Tanaka A.","Yokoyama S."],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"CI-DIALQ4R1NGGOA","citationType":"submission","authoringGroup":["NIEHS SNPs program"],"publicationDate":"MAY-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANT TYR-184"]},{"referenceNumber":6,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT ARG-74"],"referenceComments":[{"value":"Muscle","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"9150948","citationType":"journal article","authors":["Ji H.","Reid G.E.","Moritz R.L.","Eddes J.S.","Burgess A.W.","Simpson R.J."],"citationCrossReferences":[{"database":"PubMed","id":"9150948"},{"database":"DOI","id":"10.1002/elps.1150180344"}],"title":"A two-dimensional gel database of human colon carcinoma proteins.","publicationDate":"1997","journal":"Electrophoresis","firstPage":"605","lastPage":"613","volume":"18"},"referencePositions":["PROTEIN SEQUENCE OF 47-68"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"7498169","citationType":"journal article","authors":["Giometti C.S.","Tollaksen S.L.","Chubb C.","Williams C.","Huberman E."],"citationCrossReferences":[{"database":"PubMed","id":"7498169"},{"database":"DOI","id":"10.1002/elps.11501601202"}],"title":"Analysis of proteins from human breast epithelial cells using two-dimensional gel electrophoresis.","publicationDate":"1995","journal":"Electrophoresis","firstPage":"1215","lastPage":"1224","volume":"16"},"referencePositions":["PROTEIN SEQUENCE OF 47-66"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"1286669","citationType":"journal article","authors":["Hochstrasser D.F.","Frutiger S.","Paquet N.","Bairoch A.","Ravier F.","Pasquali C.","Sanchez J.-C.","Tissot J.-D.","Bjellqvist B.","Vargas R.","Appel R.D.","Hughes G.J."],"citationCrossReferences":[{"database":"PubMed","id":"1286669"},{"database":"DOI","id":"10.1002/elps.11501301201"}],"title":"Human liver protein map: a reference database established by microsequencing and gel comparison.","publicationDate":"1992","journal":"Electrophoresis","firstPage":"992","lastPage":"1001","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 47-56"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"8313870","citationType":"journal article","authors":["Hughes G.J.","Frutiger S.","Paquet N.","Pasquali C.","Sanchez J.-C.","Tissot J.-D.","Bairoch A.","Appel R.D.","Hochstrasser D.F."],"citationCrossReferences":[{"database":"PubMed","id":"8313870"},{"database":"DOI","id":"10.1002/elps.11501401181"}],"title":"Human liver protein map: update 1993.","publicationDate":"1993","journal":"Electrophoresis","firstPage":"1216","lastPage":"1222","volume":"14"},"referencePositions":["SEQUENCE REVISION"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"CI-DN574ORD5TV2B","citationType":"submission","authors":["Lubec G.","Afjehi-Sadat L.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 86-99; 108-121; 160-173; 188-202; 207-234; 349-360; 378-391; 395-405; 469-485; 499-513 AND 542-555","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Cajal-Retzius cell","type":"TISSUE"},{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"14654843","citationType":"journal article","authors":["Andersen J.S.","Wilkinson C.J.","Mayor T.","Mortensen P.","Nigg E.A.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"14654843"},{"database":"DOI","id":"10.1038/nature02166"}],"title":"Proteomic characterization of the human centrosome by protein correlation profiling.","publicationDate":"2003","journal":"Nature","firstPage":"570","lastPage":"574","volume":"426"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Lymphoblast","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"10339406","citationType":"journal article","authors":["Bauer M.F.","Gempel K.","Reichert A.S.","Rappold G.A.","Lichtner P.","Gerbitz K.-D.","Neupert W.","Brunner M.","Hofmann S."],"citationCrossReferences":[{"database":"PubMed","id":"10339406"},{"database":"DOI","id":"10.1006/jmbi.1999.2751"}],"title":"Genetic and structural characterization of the human mitochondrial inner membrane translocase.","publicationDate":"1999","journal":"J. Mol. Biol.","firstPage":"69","lastPage":"82","volume":"289"},"referencePositions":["INTERACTION WITH THE TIM23 COMPLEX"]},{"referenceNumber":15,"citation":{"id":"16091382","citationType":"journal article","authors":["Pilzer D.","Fishelson Z."],"citationCrossReferences":[{"database":"PubMed","id":"16091382"},{"database":"DOI","id":"10.1093/intimm/dxh300"}],"title":"Mortalin/GRP75 promotes release of membrane vesicles from immune attacked cells and protection from complement-mediated lysis.","publicationDate":"2005","journal":"Int. Immunol.","firstPage":"1239","lastPage":"1248","volume":"17"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"17331979","citationType":"journal article","authors":["Shan Y.","Napoli E.","Cortopassi G."],"citationCrossReferences":[{"database":"PubMed","id":"17331979"},{"database":"DOI","id":"10.1093/hmg/ddm038"}],"title":"Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.","publicationDate":"2007","journal":"Hum. Mol. Genet.","firstPage":"929","lastPage":"941","volume":"16"},"referencePositions":["INTERACTION WITH FXN"]},{"referenceNumber":17,"citation":{"id":"18632665","citationType":"journal article","authors":["Zhai P.","Stanworth C.","Liu S.","Silberg J.J."],"citationCrossReferences":[{"database":"PubMed","id":"18632665"},{"database":"DOI","id":"10.1074/jbc.m803475200"}],"title":"The human escort protein Hep binds to the ATPase domain of mitochondrial hsp70 and regulates ATP hydrolysis.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"26098","lastPage":"26106","volume":"283"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION","INTERACTION WITH DNLZ"]},{"referenceNumber":18,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-135; LYS-138; LYS-143; LYS-234; LYS-288; LYS-300; LYS-567 AND LYS-646","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"20668094","citationType":"journal article","authors":["Uhrigshardt H.","Singh A.","Kovtunovych G.","Ghosh M.","Rouault T.A."],"citationCrossReferences":[{"database":"PubMed","id":"20668094"},{"database":"DOI","id":"10.1093/hmg/ddq301"}],"title":"Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.","publicationDate":"2010","journal":"Hum. Mol. Genet.","firstPage":"3816","lastPage":"3834","volume":"19"},"referencePositions":["INTERACTION WITH HSCB"]},{"referenceNumber":20,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":21,"citation":{"id":"21123823","citationType":"journal article","authors":["Chen T.H.","Kambal A.","Krysiak K.","Walshauser M.A.","Raju G.","Tibbitts J.F.","Walter M.J."],"citationCrossReferences":[{"database":"PubMed","id":"21123823"},{"database":"DOI","id":"10.1182/blood-2010-06-293167"}],"title":"Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.","publicationDate":"2011","journal":"Blood","firstPage":"1530","lastPage":"1539","volume":"117"},"referencePositions":["FUNCTION"]},{"referenceNumber":22,"citation":{"id":"21908771","citationType":"journal article","authors":["Peng C.","Lu Z.","Xie Z.","Cheng Z.","Chen Y.","Tan M.","Luo H.","Zhang Y.","He W.","Yang K.","Zwaans B.M.","Tishkoff D.","Ho L.","Lombard D.","He T.C.","Dai J.","Verdin E.","Ye Y.","Zhao Y."],"citationCrossReferences":[{"database":"PubMed","id":"21908771"},{"database":"DOI","id":"10.1074/mcp.m111.012658"}],"title":"The first identification of lysine malonylation substrates and its regulatory enzyme.","publicationDate":"2011","journal":"Mol. Cell. Proteomics","firstPage":"M111.012658.01","lastPage":"M111.012658.12","volume":"10"},"referencePositions":["MALONYLATION AT LYS-206"]},{"referenceNumber":23,"citation":{"id":"22114354","citationType":"journal article","authors":["Alkhaja A.K.","Jans D.C.","Nikolov M.","Vukotic M.","Lytovchenko O.","Ludewig F.","Schliebs W.","Riedel D.","Urlaub H.","Jakobs S.","Deckers M."],"citationCrossReferences":[{"database":"PubMed","id":"22114354"},{"database":"DOI","id":"10.1091/mbc.e11-09-0774"}],"title":"MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.","publicationDate":"2012","journal":"Mol. Biol. Cell","firstPage":"247","lastPage":"257","volume":"23"},"referencePositions":["IDENTIFICATION IN THE MINOS/MITOS COMPLEX"]},{"referenceNumber":24,"citation":{"id":"22002106","citationType":"journal article","authors":["Ahmad Y.","Boisvert F.M.","Lundberg E.","Uhlen M.","Lamond A.I."],"citationCrossReferences":[{"database":"PubMed","id":"22002106"},{"database":"DOI","id":"10.1074/mcp.m111.013680"}],"title":"Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.013680.01","lastPage":"M111.013680.15","volume":"11"},"referencePositions":["SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]"]},{"referenceNumber":25,"citation":{"id":"23501103","citationType":"journal article","authors":["Matsuzaki H.","Fujimoto T.","Tanaka M.","Shirasawa S."],"citationCrossReferences":[{"database":"PubMed","id":"23501103"},{"database":"DOI","id":"10.1016/j.bbrc.2013.02.099"}],"title":"Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux.","publicationDate":"2013","journal":"Biochem. Biophys. Res. Commun.","firstPage":"322","lastPage":"326","volume":"433"},"referencePositions":["INTERACTION WITH TESPA"]},{"referenceNumber":26,"citation":{"id":"23541579","citationType":"journal article","authors":["Tsuneki M.","Maruyama S.","Yamazaki M.","Xu B.","Essa A.","Abe T.","Babkair H.","Cheng J.","Yamamoto T.","Saku T."],"citationCrossReferences":[{"database":"PubMed","id":"23541579"},{"database":"DOI","id":"10.1016/j.bbrc.2013.03.057"}],"title":"Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.","publicationDate":"2013","journal":"Biochem. Biophys. Res. Commun.","firstPage":"124","lastPage":"130","volume":"434"},"referencePositions":["INTERACTION WITH PDPN"]},{"referenceNumber":27,"citation":{"id":"23462535","citationType":"journal article","authors":["Dores-Silva P.R.","Minari K.","Ramos C.H.","Barbosa L.R.","Borges J.C."],"citationCrossReferences":[{"database":"PubMed","id":"23462535"},{"database":"DOI","id":"10.1016/j.ijbiomac.2013.02.009"}],"title":"Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone.","publicationDate":"2013","journal":"Int. J. Biol. Macromol.","firstPage":"140","lastPage":"148","volume":"56"},"referencePositions":["INTERACTION WITH DNLZ"]},{"referenceNumber":28,"citation":{"id":"23940031","citationType":"journal article","authors":["Cai K.","Frederick R.O.","Kim J.H.","Reinen N.M.","Tonelli M.","Markley J.L."],"citationCrossReferences":[{"database":"PubMed","id":"23940031"},{"database":"DOI","id":"10.1074/jbc.m113.482042"}],"title":"Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"28755","lastPage":"28770","volume":"288"},"referencePositions":["INTERACTION WITH ISCU"]},{"referenceNumber":29,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-87 AND SER-408","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":30,"citation":{"id":"24625977","citationType":"journal article","authors":["Sane S.","Abdullah A.","Boudreau D.A.","Autenried R.K.","Gupta B.K.","Wang X.","Wang H.","Schlenker E.H.","Zhang D.","Telleria C.","Huang L.","Chauhan S.C.","Rezvani K."],"citationCrossReferences":[{"database":"PubMed","id":"24625977"},{"database":"DOI","id":"10.1038/cddis.2014.100"}],"title":"Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.","publicationDate":"2014","journal":"Cell Death Dis.","firstPage":"e1118","lastPage":"e1118","volume":"5"},"referencePositions":["FUNCTION","INTERACTION WITH TP53 AND UBXN2A","SUBCELLULAR LOCATION"]},{"referenceNumber":31,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-513","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":33,"citation":{"id":"26491070","citationType":"journal article","authors":["Schmitz-Abe K.","Ciesielski S.J.","Schmidt P.J.","Campagna D.R.","Rahimov F.","Schilke B.A.","Cuijpers M.","Rieneck K.","Lausen B.","Linenberger M.L.","Sendamarai A.K.","Guo C.","Hofmann I.","Newburger P.E.","Matthews D.","Shimamura A.","Snijders P.J.","Towne M.C.","Niemeyer C.M.","Watson H.G.","Dziegiel M.H.","Heeney M.M.","May A.","Bottomley S.S.","Swinkels D.W.","Markianos K.","Craig E.A.","Fleming M.D."],"citationCrossReferences":[{"database":"PubMed","id":"26491070"},{"database":"DOI","id":"10.1182/blood-2015-09-659854"}],"title":"Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.","publicationDate":"2015","journal":"Blood","firstPage":"2734","lastPage":"2738","volume":"126"},"referencePositions":["INVOLVEMENT IN SIDBA4","VARIANTS SIDBA4 PRO-212; SER-388; LYS-415 AND 458-ILE-ASN-459 DEL","VARIANTS LEU-200; LYS-539; TRP-573 AND LYS-577"]},{"referenceNumber":34,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":35,"citation":{"id":"26598328","citationType":"journal article","authors":["Royer-Bertrand B.","Castillo-Taucher S.","Moreno-Salinas R.","Cho T.J.","Chae J.H.","Choi M.","Kim O.H.","Dikoglu E.","Campos-Xavier B.","Girardi E.","Superti-Furga G.","Bonafe L.","Rivolta C.","Unger S.","Superti-Furga A."],"citationCrossReferences":[{"database":"PubMed","id":"26598328"},{"database":"DOI","id":"10.1038/srep17154"}],"title":"Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia.","publicationDate":"2015","journal":"Sci. Rep.","firstPage":"17154","lastPage":"17154","volume":"5"},"referencePositions":["INVOLVEMENT IN EVPLS","VARIANTS EVPLS TRP-126 AND CYS-128"]},{"referenceNumber":36,"citation":{"id":"26634371","citationType":"journal article","authors":["Sane S.","Abdullah A.","Nelson M.E.","Wang H.","Chauhan S.C.","Newton S.S.","Rezvani K."],"citationCrossReferences":[{"database":"PubMed","id":"26634371"},{"database":"DOI","id":"10.1007/s12192-015-0661-5"}],"title":"Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.","publicationDate":"2016","journal":"Cell Stress Chaperones","firstPage":"313","lastPage":"326","volume":"21"},"referencePositions":["FUNCTION","INTERACTION WITH UBXN2A","MUTAGENESIS OF THR-441; PRO-442; LYS-555 AND ILE-558"]},{"referenceNumber":37,"citation":{"id":"25615450","citationType":"journal article","authors":["Dores-Silva P.R.","Barbosa L.R.","Ramos C.H.","Borges J.C."],"citationCrossReferences":[{"database":"PubMed","id":"25615450"},{"database":"DOI","id":"10.1371/journal.pone.0117170"}],"title":"Human mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organization.","publicationDate":"2015","journal":"PLoS ONE","firstPage":"e0117170","lastPage":"e0117170","volume":"10"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":38,"citation":{"id":"26702583","citationType":"journal article","authors":["Shan Y.","Cortopassi G."],"citationCrossReferences":[{"database":"PubMed","id":"26702583"},{"database":"DOI","id":"10.1016/j.mito.2015.12.005"}],"title":"Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.","publicationDate":"2016","journal":"Mitochondrion","firstPage":"94","lastPage":"103","volume":"26"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH FXN; NFU1; NFS1 AND ISCU","MUTAGENESIS OF GLY-489"]},{"referenceNumber":39,"citation":{"id":"24687350","citationType":"journal article","authors":["Amick J.","Schlanger S.E.","Wachnowsky C.","Moseng M.A.","Emerson C.C.","Dare M.","Luo W.I.","Ithychanda S.S.","Nix J.C.","Cowan J.A.","Page R.C.","Misra S."],"citationCrossReferences":[{"database":"PubMed","id":"24687350"},{"database":"DOI","id":"10.1002/pro.2466"}],"title":"Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.","publicationDate":"2014","journal":"Protein Sci.","firstPage":"833","lastPage":"842","volume":"23"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 52-431"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4KBO"}]},{"referenceNumber":40,"citation":{"id":"28848044","citationType":"journal article","authors":["Srivastava S.","Savanur M.A.","Sinha D.","Birje A.","Vigneshwaran R.","Saha P.P.","D'Silva P."],"citationCrossReferences":[{"database":"PubMed","id":"28848044"},{"database":"DOI","id":"10.1074/jbc.m117.788463"}],"title":"Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells.","publicationDate":"2017","journal":"J. Biol. Chem.","firstPage":"18075","lastPage":"18090","volume":"292"},"referencePositions":["FUNCTION","ACTIVITY REGULATION"]},{"referenceNumber":41,"citation":{"id":"31177526","citationType":"journal article","authors":["Moseng M.A.","Nix J.C.","Page R.C."],"citationCrossReferences":[{"database":"PubMed","id":"31177526"},{"database":"DOI","id":"10.1002/1873-3468.13475"}],"title":"2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.","publicationDate":"2019","journal":"FEBS Lett.","firstPage":"2030","lastPage":"2039","volume":"593"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 52-431 IN COMPLEX WITH ADP ANALOG","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6P2U"}]},{"referenceNumber":42,"citation":{"id":"30933555","citationType":"journal article","authors":["Moseng M.A.","Nix J.C.","Page R.C."],"citationCrossReferences":[{"database":"PubMed","id":"30933555"},{"database":"DOI","id":"10.1021/acs.jpcb.9b00071"}],"title":"Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.","publicationDate":"2019","journal":"J. Phys. Chem. B","firstPage":"3383","lastPage":"3396","volume":"123"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.78 ANGSTROMS) OF 54-429 IN COMPLEX WITH ADP","FUNCTION","CATALYTIC ACTIVITY","CHARACTERIZATION OF VARIANTS EVPLS TRP-126 AND CYS-128"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6NHK"}]},{"referenceNumber":43,"citation":{"id":"39737924","citationType":"journal article","authors":["Morizono M.A.","McGuire K.L.","Birouty N.I.","Herzik M.A."],"citationCrossReferences":[{"database":"PubMed","id":"39737924"},{"database":"DOI","id":"10.1038/s41467-024-54499-1"}],"title":"Structural insights into GrpEL1-mediated nucleotide and substrate release of human mitochondrial Hsp70.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"10815","lastPage":"10815","volume":"15"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.96 ANGSTROMS) OF 46-639","INTERACTION WITH GRPEL1"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"9BLS"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"9BLT"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"9BLU"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L11066","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L15189","properties":[{"key":"ProteinId","value":"AAA67526.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK315177","properties":[{"key":"ProteinId","value":"BAG37618.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK222758","properties":[{"key":"ProteinId","value":"BAD96478.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ531046","properties":[{"key":"ProteinId","value":"ABF50973.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471062","properties":[{"key":"ProteinId","value":"EAW62129.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000478","properties":[{"key":"ProteinId","value":"AAH00478.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC024034","properties":[{"key":"ProteinId","value":"AAH24034.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4208.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"B48127","properties":[{"key":"EntryName","value":"B48127"}]},{"database":"RefSeq","id":"NP_004125.3","properties":[{"key":"NucleotideSequenceId","value":"NM_004134.7"}]},{"database":"PDB","id":"3N8E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/B=439-597"}]},{"database":"PDB","id":"4KBO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A=52-431"}]},{"database":"PDB","id":"6NHK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"A/B=54-429"}]},{"database":"PDB","id":"6P2U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=52-431"}]},{"database":"PDB","id":"6PMT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=52-431"}]},{"database":"PDB","id":"9BLS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.96 A"},{"key":"Chains","value":"A=46-639"}]},{"database":"PDB","id":"9BLT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"A=46-639"}]},{"database":"PDB","id":"9BLU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"A=46-559"}]},{"database":"PDBsum","id":"3N8E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4KBO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6NHK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6P2U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PMT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BLS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BLT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9BLU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44675","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44676","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-44677","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109545","properties":[{"key":"Interactions","value":"785"}]},{"database":"ComplexPortal","id":"CPX-6129","properties":[{"key":"EntryName","value":"TIM23 mitochondrial inner membrane pre-sequence translocase complex, TIM17A variant"}]},{"database":"ComplexPortal","id":"CPX-6130","properties":[{"key":"EntryName","value":"TIM23 mitochondrial inner membrane pre-sequence translocase complex, TIM17B variant"}]},{"database":"CORUM","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-32936N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P38646","properties":[{"key":"Number of interactors","value":"1928"}]},{"database":"IntAct","id":"P38646","properties":[{"key":"Interactions","value":"241"}]},{"database":"MINT","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-HSPA9","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000297185","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295757","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P38646","properties":[{"key":"glycosylation","value":"1 site, 1 glycan"}]},{"database":"GlyGen","id":"P38646","properties":[{"key":"glycosylation","value":"6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HSPA9","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"21264428","properties":[{"key":"Description","value":"-"}]},{"database":"OGP","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00007765","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000297185","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55304","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P38646","properties":[{"key":"antibodies","value":"8 sequenced antibodies"}]},{"database":"Antibodypedia","id":"646","properties":[{"key":"antibodies","value":"780 antibodies from 51 providers"}]},{"database":"DNASU","id":"3313","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000297185.9","properties":[{"key":"ProteinId","value":"ENSP00000297185.3"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"GeneID","id":"3313","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3313","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000297185.9","properties":[{"key":"ProteinId","value":"ENSP00000297185.3"},{"key":"RefSeqNucleotideId","value":"NM_004134.7"},{"key":"RefSeqProteinId","value":"NP_004125.3"}]},{"database":"UCSC","id":"uc003ldf.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5244","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162391712","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3313","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3313","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HSPA9","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"HPA","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"HSPA9","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"182170","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"600548","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"616854","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"260305","properties":[{"key":"Disease","value":"Autosomal recessive sideroblastic anemia"}]},{"database":"Orphanet","id":"496751","properties":[{"key":"Disease","value":"EVEN-plus syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0102","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_005965_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MGTDWKI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P38646","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"5.6.1.10","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1268020","properties":[{"key":"PathwayName","value":"Mitochondrial protein import"}]},{"database":"Reactome","id":"R-HSA-3371453","properties":[{"key":"PathwayName","value":"Regulation of HSF1-mediated heat shock response"}]},{"database":"Reactome","id":"R-HSA-6799198","properties":[{"key":"PathwayName","value":"Complex I biogenesis"}]},{"database":"Reactome","id":"R-HSA-8949613","properties":[{"key":"PathwayName","value":"Cristae formation"}]},{"database":"Reactome","id":"R-HSA-8950505","properties":[{"key":"PathwayName","value":"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"}]},{"database":"Reactome","id":"R-HSA-9837999","properties":[{"key":"PathwayName","value":"Mitochondrial protein degradation"}]},{"database":"Reactome","id":"R-HSA-9841251","properties":[{"key":"PathwayName","value":"Mitochondrial unfolded protein response (UPRmt)"}]},{"database":"Reactome","id":"R-HSA-9865881","properties":[{"key":"PathwayName","value":"Complex III assembly"}]},{"database":"SignaLink","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000113013","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3313","properties":[{"key":"hits","value":"790 hits in 1138 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"CD-CODE","id":"DEE660B4","properties":[{"key":"EntryName","value":"Stress granule"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"HSPA9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P38646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HSPA9","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3313","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P38646","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P38646","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"P38646","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P38646","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24625977"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21423176"}]},{"database":"GO","id":"GO:0140275","properties":[{"key":"GoTerm","value":"C:MIB complex"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"26477565"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10339406"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"7865888"}]},{"database":"GO","id":"GO:0042645","properties":[{"key":"GoTerm","value":"C:mitochondrial nucleoid"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18063578"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26702583"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001405","properties":[{"key":"GoTerm","value":"C:PAM complex, Tim23 associated import motor"},{"key":"GoEvidenceType","value":"ISS:UniProt"}]},{"database":"GO","id":"GO:0001401","properties":[{"key":"GoTerm","value":"C:SAM complex"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"26477565"}]},{"database":"GO","id":"GO:0005744","properties":[{"key":"GoTerm","value":"C:TIM23 mitochondrial import inner membrane translocase complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10339406"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18632665"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25615450"}]},{"database":"GO","id":"GO:0017134","properties":[{"key":"GoTerm","value":"F:fibroblast growth factor binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031072","properties":[{"key":"GoTerm","value":"F:heat shock protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0044183","properties":[{"key":"GoTerm","value":"F:protein folding chaperone"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22681889"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19725078"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21753002"}]},{"database":"GO","id":"GO:0036444","properties":[{"key":"GoTerm","value":"P:calcium import into the mitochondrion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071347","properties":[{"key":"GoTerm","value":"P:cellular response to interleukin-1"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030218","properties":[{"key":"GoTerm","value":"P:erythrocyte differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21123823"}]},{"database":"GO","id":"GO:0007007","properties":[{"key":"GoTerm","value":"P:inner mitochondrial membrane organization"},{"key":"GoEvidenceType","value":"IC:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26477565"}]},{"database":"GO","id":"GO:0006886","properties":[{"key":"GoTerm","value":"P:intracellular protein transport"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10339406"}]},{"database":"GO","id":"GO:0016226","properties":[{"key":"GoTerm","value":"P:iron-sulfur cluster assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26702583"}]},{"database":"GO","id":"GO:0043066","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic process"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16130169"}]},{"database":"GO","id":"GO:0045647","properties":[{"key":"GoTerm","value":"P:negative regulation of erythrocyte differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21123823"}]},{"database":"GO","id":"GO:1902037","properties":[{"key":"GoTerm","value":"P:negative regulation of hematopoietic stem cell differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:1903707","properties":[{"key":"GoTerm","value":"P:negative regulation of hemopoiesis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0030150","properties":[{"key":"GoTerm","value":"P:protein import into mitochondrial matrix"},{"key":"GoEvidenceType","value":"ISS:UniProt"}]},{"database":"GO","id":"GO:0042026","properties":[{"key":"GoTerm","value":"P:protein refolding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045646","properties":[{"key":"GoTerm","value":"P:regulation of erythrocyte differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26702583"}]},{"database":"GO","id":"GO:0051593","properties":[{"key":"GoTerm","value":"P:response to folic acid"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0097068","properties":[{"key":"GoTerm","value":"P:response to thyroxine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009636","properties":[{"key":"GoTerm","value":"P:response to toxic substance"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003520","properties":[{"key":"EntryName","value":"PRK05183.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":679,"molWeight":73680,"crc64":"90969A8D06757753","md5":"FFD0033C3C8A991266D6B6E401300F41"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":11,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"DISEASE":2,"SIMILARITY":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Region":6,"Compositional bias":1,"Binding site":7,"Modified residue":26,"Natural variant":14,"Mutagenesis":5,"Sequence conflict":7,"Beta strand":30,"Helix":24,"Turn":6},"uniParcId":"UPI000012BA4E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V2G2","uniProtkbId":"A0A7I2V2G2_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":587,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V2G2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V2G2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502902.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V2G2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2V2G2","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677066.1","properties":[{"key":"ProteinId","value":"ENSP00000502902.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"Ensembl","id":"ENST00000678300.1","properties":[{"key":"ProteinId","value":"ENSP00000503259.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"Ensembl","id":"ENST00000678384.1","properties":[{"key":"ProteinId","value":"ENSP00000503992.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MGTDWKI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000309","properties":[{"key":"EntryName","value":"Mitochondrial type HSP70, putative"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":610,"molWeight":66602,"crc64":"6BED23E48BA353A9","md5":"4B269932A83DDB92D520718FB0ECC0C2"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0000E20AD4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V2S7","uniProtkbId":"A0A7I2V2S7_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":638,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V2S7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V2S7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503066.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V2S7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2V2S7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677425.1","properties":[{"key":"ProteinId","value":"ENSP00000503066.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V2S7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"InterPro","id":"IPR056546","properties":[{"key":"EntryName","value":"MreB_MamK-like"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06723","properties":[{"key":"EntryName","value":"MreB_Mbl"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":648,"molWeight":70320,"crc64":"E488FB8B2F24D97B","md5":"F4FF24B7EC1FD60E7549D12B668C48F1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0003E62121"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2YQB2","uniProtkbId":"A0A7I2YQB2_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2YQB2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2YQB2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503219.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2YQB2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2YQB2","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000678051.1","properties":[{"key":"ProteinId","value":"ENSP00000503219.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MGTDWKI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2YQB2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000309","properties":[{"key":"EntryName","value":"Mitochondrial type HSP70, putative"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":577,"molWeight":63187,"crc64":"54C3397FAA4627CE","md5":"87AF32A72D307298D9101D034364EC16"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0018BE3B9F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UEA8","uniProtkbId":"A0ACI8UEA8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":740,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":740,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UEA8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UEA8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616906.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946847.1","properties":[{"key":"ProteinId","value":"ENSP00000616906.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKEICKKKKNEPGKKRSWTRWMPHILRNPRGRVQWLTPVIPALWEAKAGGSRGQEIETILANTVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":740,"molWeight":80726,"crc64":"B9F5811BB94E35EF","md5":"88B70F4C03C04DC6746E608F1260D846"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040326ED1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UH90","uniProtkbId":"A0ACI8UH90_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UH90"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UH90"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616904.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946845.1","properties":[{"key":"ProteinId","value":"ENSP00000616904.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003520","properties":[{"key":"EntryName","value":"PRK05183.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADELKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":676,"molWeight":73335,"crc64":"3B39A0EEEA9C34DB","md5":"32A2CCF1FCA0655F1D776FC199ED8F45"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI004031418B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8P859","uniProtkbId":"A0ACI8P859_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":579,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8P859"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8P859"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522938.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000852879.1","properties":[{"key":"ProteinId","value":"ENSP00000522938.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":676,"molWeight":73325,"crc64":"C731A40B4E22AA0D","md5":"08D01F6D0010BFBDF3945A386E0C0EC1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040322097"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TVC6","uniProtkbId":"A0ACI8TVC6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":675,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TVC6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TVC6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606394.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000936335.1","properties":[{"key":"ProteinId","value":"ENSP00000606394.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGLVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":675,"molWeight":73139,"crc64":"BB7C9D6CA1E84A63","md5":"FD938698CDCDBDB14F5896922F390377"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI00403253AA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TVE0","uniProtkbId":"A0ACI8TVE0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TVE0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TVE0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606399.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000936340.1","properties":[{"key":"ProteinId","value":"ENSP00000606399.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":533,"molWeight":58140,"crc64":"78ABEE27CE074ED2","md5":"1CF2A0C35FAFBACF82F2CCA0E5B8C16A"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040322198"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TVG3","uniProtkbId":"A0ACI8TVG3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":685,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TVG3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TVG3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606397.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000936338.1","properties":[{"key":"ProteinId","value":"ENSP00000606397.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003520","properties":[{"key":"EntryName","value":"PRK05183.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIIFVSYSKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":685,"molWeight":74377,"crc64":"4036F764087E1685","md5":"53CF0935F42F3A48479B3BB3EC9FD4BE"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI004031E666"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V3F7","uniProtkbId":"A0A7I2V3F7_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":603,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V3F7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V3F7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503373.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V3F7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A7I2V3F7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677064.1","properties":[{"key":"ProteinId","value":"ENSP00000503373.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V3F7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":603,"molWeight":65856,"crc64":"C9E46160F100E8FF","md5":"1B82F7E723A59EF8BB7BE9437A656D18"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0018B70292"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TVF3","uniProtkbId":"A0ACI8TVF3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TVF3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TVF3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000606396.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000936337.1","properties":[{"key":"ProteinId","value":"ENSP00000606396.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000001","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":501,"molWeight":54538,"crc64":"24B8A8BFB34BDB8A","md5":"635C9F77F287242B0B46D02D98477FA4"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI004031AF6D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UEB0","uniProtkbId":"A0ACI8UEB0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":549,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":562,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UEB0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UEB0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616907.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946848.1","properties":[{"key":"ProteinId","value":"ENSP00000616907.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":572,"molWeight":62495,"crc64":"2B5E1FB56B240FA6","md5":"03860B5109BEAA5AE819A1E8C91E6D6E"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040319FEB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UHN1","uniProtkbId":"A0ACI8UHN1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":586,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UHN1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UHN1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616903.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946844.1","properties":[{"key":"ProteinId","value":"ENSP00000616903.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":609,"molWeight":65965,"crc64":"BB7DF0CC1DDE2D5F","md5":"8D358AE4F61CCC448E697343CB7E2CA1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI00403197A1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0Y8K0","uniProtkbId":"H0Y8K0_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":75,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0Y8K0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0Y8K0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000421311.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0Y8K0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0Y8K0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35718","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000504902.6","properties":[{"key":"ProteinId","value":"ENSP00000421311.2"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"UCSC","id":"uc063hmb.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2326101_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HSPA9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKEICKKKKNEPGKKRSWTRWMPHILRNPRGRVQWLTPVIPALWEAKAGGSRGSADCTGSFWQSPK","length":458,"molWeight":50037,"crc64":"2526E230872C1331","md5":"FBFAADB9BF10CBFBE547F36F915DA543"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"uniParcId":"UPI0000EE35CB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PB05","uniProtkbId":"A0ACI8PB05_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":637,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PB05"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PB05"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522940.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000852881.1","properties":[{"key":"ProteinId","value":"ENSP00000522940.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100934","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), C-terminal subdomain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":660,"molWeight":71556,"crc64":"B734C0726953A995","md5":"EF2EC7C4C2932109D0CD6F10427CBB64"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI004031D6DD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UI18","uniProtkbId":"A0ACI8UI18_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UI18"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UI18"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616902.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946843.1","properties":[{"key":"ProteinId","value":"ENSP00000616902.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":644,"molWeight":69913,"crc64":"9BE3DB7339773422","md5":"79C67CE46A908626FB3F2D6D5824EE02"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040320F3B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UI31","uniProtkbId":"A0ACI8UI31_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":677,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UI31"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UI31"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616901.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946842.1","properties":[{"key":"ProteinId","value":"ENSP00000616901.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":677,"molWeight":73453,"crc64":"29D9823812DC7915","md5":"62131D217A04B816F79F645D1D4904BA"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040315A23"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8N1C8","uniProtkbId":"Q8N1C8_HUMAN","entryAudit":{"firstPublicDate":"2002-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":114,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH30634.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH30634.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":658,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":671,"modifier":"EXACT"},"end":{"value":681,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH30634.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH30634.1"}],"value":"Lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH30634.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC030634","properties":[{"key":"ProteinId","value":"AAH30634.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q8N1C8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8N1C8","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q8N1C8","properties":[{"key":"Interactions","value":"2"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HSPA9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003520","properties":[{"key":"EntryName","value":"PRK05183.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GTVISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKRAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGRTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":681,"molWeight":73854,"crc64":"ED085ED5D90AEB27","md5":"B588AD1FF23CED8417857FF61712B05D"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00000717D4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UEN7","uniProtkbId":"A0ACI8UEN7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":649,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":662,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UEN7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UEN7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616905.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946846.1","properties":[{"key":"ProteinId","value":"ENSP00000616905.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":672,"molWeight":72866,"crc64":"7531F8EDD1AA4553","md5":"19D74F351D187DC6693B56A210573191"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040323462"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6RCD7","uniProtkbId":"D6RCD7_HUMAN","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":76,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019355"}],"value":"Stress-70 protein, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012554"}],"value":"3.6.4.10"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031419"}],"value":"75 kDa glucose-regulated protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030055"}],"value":"Heat shock 70 kDa protein 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"}],"value":"HSPA9"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.10","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050527"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Coiled coil","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003322"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"D6RCD7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"D6RCD7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000423759.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6RCD7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"D6RCD7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"D6RCD7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"13898","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"646","properties":[{"key":"antibodies","value":"780 antibodies from 51 providers"}]},{"database":"Ensembl","id":"ENST00000507115.6","properties":[{"key":"ProteinId","value":"ENSP00000423759.2"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"UCSC","id":"uc063hmc.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3260338_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HSPA9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"D6RCD7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11733","properties":[{"key":"EntryName","value":"ASKHA_NBD_HSP70_HSPA9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000020","properties":[{"key":"EntryName","value":"Chaperone protein HscA homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.30.30:FF:000003","properties":[{"key":"EntryName","value":"Heat shock protein 9"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000004","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.30.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00332","properties":[{"key":"EntryName","value":"DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR012725","properties":[{"key":"EntryName","value":"Chaperone_DnaK"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"NCBIfam","id":"NF001413","properties":[{"key":"EntryName","value":"PRK00290.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003520","properties":[{"key":"EntryName","value":"PRK05183.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR02350","properties":[{"key":"EntryName","value":"prok_dnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00329","properties":[{"key":"EntryName","value":"HSP70_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKVQGLKWILILT","length":665,"molWeight":72251,"crc64":"6009778ADB75B280","md5":"87CAAC21A543D5A68A229993718E6175"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Coiled coil":1},"uniParcId":"UPI0018BB7031"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V2K6","uniProtkbId":"A0A7I2V2K6_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":23,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"}],"value":"Heat shock protein family A (Hsp70) member 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"}],"value":"HSPA9"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V2K6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V2K6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000502970.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V2K6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677553.1","properties":[{"key":"ProteinId","value":"ENSP00000502970.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V2K6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASNQGSSCWY","length":56,"molWeight":6024,"crc64":"6B188BBC7E474749","md5":"BA50C8B4364064E5EA949F207DD6C30F"},"extraAttributes":{"uniParcId":"UPI0018B56E6C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2V4A9","uniProtkbId":"A0A7I2V4A9_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"}],"value":"Heat shock protein family A (Hsp70) member 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"}],"value":"HSPA9"}}],"features":[{"type":"Region","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2V4A9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2V4A9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000503650.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7I2V4A9","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000677527.1","properties":[{"key":"ProteinId","value":"ENSP00000503650.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2V4A9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQIRSNQGSSCWY","length":38,"molWeight":3931,"crc64":"E7E51F8A29E866B8","md5":"4BB3530610D5898F06D83C9F835BE59C"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0001D3B8C2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R1C3","uniProtkbId":"A0ACI8R1C3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"}],"value":"Heat shock protein family A (Hsp70) member 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"}],"value":"HSPA9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R1C3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R1C3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000522939.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000852880.1","properties":[{"key":"ProteinId","value":"ENSP00000522939.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"OpenTargets","id":"ENSG00000113013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"2.60.34.10:FF:000014","properties":[{"key":"EntryName","value":"Chaperone protein DnaK HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000309","properties":[{"key":"EntryName","value":"Mitochondrial type HSP70, putative"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.640.10:FF:000003","properties":[{"key":"EntryName","value":"Molecular chaperone DnaK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1270.10:FF:000011","properties":[{"key":"EntryName","value":"stress-70 protein, mitochondrial isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1270.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.90.640.10","properties":[{"key":"EntryName","value":"Actin, Chain A, domain 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.34.10","properties":[{"key":"EntryName","value":"Substrate Binding Domain Of DNAk, Chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR029048","properties":[{"key":"EntryName","value":"HSP70_C_sf"}]},{"database":"InterPro","id":"IPR029047","properties":[{"key":"EntryName","value":"HSP70_peptide-bd_sf"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"PANTHER","id":"PTHR19375","properties":[{"key":"EntryName","value":"HEAT SHOCK PROTEIN 70KDA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00301","properties":[{"key":"EntryName","value":"HEATSHOCK70"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF100920","properties":[{"key":"EntryName","value":"Heat shock protein 70kD (HSP70), peptide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01036","properties":[{"key":"EntryName","value":"HSP70_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISASRAAAARLVGAAASRGPTAARHQTGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ","length":413,"molWeight":44696,"crc64":"1FE15FD484F747F2","md5":"5E231E95FFC6D1873D836D73A18624F7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0040315576"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7I2YQQ5","uniProtkbId":"A0A7I2YQQ5_HUMAN","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-04-07","entryVersion":25,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"}],"value":"Heat shock protein family A (Hsp70) member 9"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"}],"value":"HSPA9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007381"}],"value":"Belongs to the heat shock protein 70 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5029553326"},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A7I2YQQ5"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A7I2YQQ5"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000504274.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC011385","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC113340","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000678794.1","properties":[{"key":"ProteinId","value":"ENSP00000504274.1"},{"key":"GeneId","value":"ENSG00000113013.17"}]},{"database":"HGNC","id":"HGNC:5244","properties":[{"key":"GeneName","value":"HSPA9"}]},{"database":"GeneTree","id":"ENSGT00920000149123","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2401965at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000113013","properties":[{"key":"ExpressionPatterns","value":"Expressed in adrenal tissue and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A7I2YQQ5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR018181","properties":[{"key":"EntryName","value":"Heat_shock_70_CS"}]},{"database":"InterPro","id":"IPR013126","properties":[{"key":"EntryName","value":"Hsp_70_fam"}]},{"database":"Pfam","id":"PF00012","properties":[{"key":"EntryName","value":"HSP70"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00297","properties":[{"key":"EntryName","value":"HSP70_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XVLLHLSAMISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGAGECRRCQNHPFSCGLYSRW","length":100,"molWeight":10612,"crc64":"1E485AE02863F5C5","md5":"AD9998B68B23F31E2535820D05667254"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Non-terminal residue":1},"uniParcId":"UPI0001D3B8C0"}}]}