{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O00198","uniProtkbId":"HRK_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1997-07-01","entryVersion":160,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Activator of apoptosis harakiri"}},"alternativeNames":[{"fullName":{"value":"BH3-interacting domain-containing protein 3"}},{"fullName":{"value":"Neuronal death protein DP5"}}]},"genes":[{"geneName":{"value":"HRK"},"synonyms":[{"value":"BID3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15031724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9130713"}],"value":"Promotes apoptosis"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15031724"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21731739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9130713"}],"value":"Interacts with BCL2 and BCL2L1. Interacts with C1QBP"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O00198","intActId":"EBI-701322"},"interactantTwo":{"uniProtKBAccession":"Q07817-1","geneName":"BCL2L1","intActId":"EBI-287195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O00198","intActId":"EBI-701322"},"interactantTwo":{"uniProtKBAccession":"Q07021","geneName":"C1QBP","intActId":"EBI-347528"},"numberOfExperiments":7,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Membrane","id":"SL-0162"},"topology":{"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"value":"The BH3 motif is required for the induction of cell death"}],"commentType":"DOMAIN"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/40865/HRK","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Activator of apoptosis harakiri","featureId":"PRO_0000143106"},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Motif","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"BH3"},{"type":"Helix","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9UGP"}]},{"type":"Helix","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2L5B"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"9130713","citationType":"journal article","authors":["Inohara N.","Ding L.","Chen S.","Nunez G."],"citationCrossReferences":[{"database":"PubMed","id":"9130713"},{"database":"DOI","id":"10.1093/emboj/16.7.1686"}],"title":"Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).","publicationDate":"1997","journal":"EMBO J.","firstPage":"1686","lastPage":"1694","volume":"16"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","INTERACTION WITH BCL2 AND BCL2L1"]},{"referenceNumber":2,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15031724","citationType":"journal article","authors":["Sunayama J.","Ando Y.","Itoh N.","Tomiyama A.","Sakurada K.","Sugiyama A.","Kang D.","Tashiro F.","Gotoh Y.","Kuchino Y.","Kitanaka C."],"citationCrossReferences":[{"database":"PubMed","id":"15031724"},{"database":"DOI","id":"10.1038/sj.cdd.4401418"}],"title":"Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.","publicationDate":"2004","journal":"Cell Death Differ.","firstPage":"771","lastPage":"781","volume":"11"},"referencePositions":["FUNCTION","INTERACTION WITH C1QBP AND BCL2L1","SUBCELLULAR LOCATION"]},{"referenceNumber":4,"citation":{"id":"21731739","citationType":"journal article","authors":["Barrera-Vilarmau S.","Obregon P.","de Alba E."],"citationCrossReferences":[{"database":"PubMed","id":"21731739"},{"database":"DOI","id":"10.1371/journal.pone.0021413"}],"title":"Intrinsic order and disorder in the BCL-2 member harakiri: insights into its proapoptotic activity.","publicationDate":"2011","journal":"PLoS ONE","firstPage":"E21413","lastPage":"E21413","volume":"6"},"referencePositions":["STRUCTURE BY NMR OF 22-91","SUBCELLULAR LOCATION","CIRCULAR DICHROISM","INTERACTION WITH BCL2 AND BCL2L1"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U76376","properties":[{"key":"ProteinId","value":"AAC34931.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC083806","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS9181.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_003797.1","properties":[{"key":"NucleotideSequenceId","value":"NM_003806.4"}]},{"database":"PDB","id":"2L58","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=22-53"}]},{"database":"PDB","id":"2L5B","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=61-91"}]},{"database":"PDB","id":"6XY4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.05 A"},{"key":"Chains","value":"B=26-51"}]},{"database":"PDB","id":"7P0U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.99 A"},{"key":"Chains","value":"C/E/G/U=26-51"}]},{"database":"PDB","id":"9LGU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"B/D/F/H/L/M=27-50"}]},{"database":"PDB","id":"9LI8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.32 A"},{"key":"Chains","value":"B=27-51"}]},{"database":"PDB","id":"9UGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.39 A"},{"key":"Chains","value":"B=27-51"}]},{"database":"AlphaFoldDB","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"114276","properties":[{"key":"Interactions","value":"16"}]},{"database":"ELM","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"O00198","properties":[{"key":"Number of interactors","value":"223"}]},{"database":"IntAct","id":"O00198","properties":[{"key":"Interactions","value":"7"}]},{"database":"NDEx","id":"IQUERY-CP-HRK","properties":[{"key":"Evidences","value":"4 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000257572","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HRK","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000257572","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18831","properties":[{"key":"antibodies","value":"215 antibodies from 31 providers"}]},{"database":"DNASU","id":"8739","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000257572.5","properties":[{"key":"ProteinId","value":"ENSP00000257572.4"},{"key":"GeneId","value":"ENSG00000135116.9"}]},{"database":"GeneID","id":"8739","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:8739","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000257572.5","properties":[{"key":"ProteinId","value":"ENSP00000257572.4"},{"key":"RefSeqNucleotideId","value":"NM_003806.4"},{"key":"RefSeqProteinId","value":"NP_003797.1"}]},{"database":"UCSC","id":"uc001twe.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:5185","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29459","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8739","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"8739","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HRK","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5185","properties":[{"key":"GeneName","value":"HRK"}]},{"database":"HPA","id":"ENSG00000135116","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, choroid plexus, lymphoid tissue, pituitary gland, thyroid gland)"}]},{"database":"MIM","id":"603447","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000135116","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135116","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502T2F4","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007050","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2426351_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACWAWLC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9894001at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"O00198","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000135116","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"8739","properties":[{"key":"hits","value":"26 hits in 1138 CRISPR screens"}]},{"database":"ChiTaRS","id":"HRK","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"O00198","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HRK_(gene)","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"8739","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"O00198","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:O00198","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"O00198","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000135116","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 114 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"O00198","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15031724"}]},{"database":"GO","id":"GO:0051365","properties":[{"key":"GoTerm","value":"P:cellular response to potassium ion starvation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15031724"}]},{"database":"GO","id":"GO:0043525","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0031334","properties":[{"key":"GoTerm","value":"P:positive regulation of protein-containing complex assembly"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21041309"}]},{"database":"GO","id":"GO:0090200","properties":[{"key":"GoTerm","value":"P:positive regulation of release of cytochrome c from mitochondria"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21041309"}]},{"database":"InterPro","id":"IPR017249","properties":[{"key":"EntryName","value":"Apoptosis_activator_harakiri"}]},{"database":"InterPro","id":"IPR020728","properties":[{"key":"EntryName","value":"Bcl2_BH3_motif_CS"}]},{"database":"PANTHER","id":"PTHR15056","properties":[{"key":"EntryName","value":"ACTIVATOR OF APOPTOSIS HARAKIRI"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15056:SF0","properties":[{"key":"EntryName","value":"ACTIVATOR OF APOPTOSIS HARAKIRI"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15196","properties":[{"key":"EntryName","value":"Harakiri"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF037635","properties":[{"key":"EntryName","value":"BID3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01259","properties":[{"key":"EntryName","value":"BH3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL","length":91,"molWeight":9884,"crc64":"22E45FA2B0B7AA00","md5":"364323F918DB47DB99F9F86FC94DD002"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Motif":1,"Helix":2},"uniParcId":"UPI000012CBC6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"K7EJY7","uniProtkbId":"K7EJY7_HUMAN","entryAudit":{"firstPublicDate":"2013-01-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2013-01-09","entryVersion":48,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"}],"value":"Harakiri, BCL2 interacting protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"}],"value":"HRK"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"CI-41H864V3GU1JR","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM2DDAQPFF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JUL-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000465379.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC083806","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"K7EJY7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18831","properties":[{"key":"antibodies","value":"215 antibodies from 31 providers"}]},{"database":"Ensembl","id":"ENST00000550505.5","properties":[{"key":"ProteinId","value":"ENSP00000465379.1"},{"key":"GeneId","value":"ENSG00000135116.10"}]},{"database":"UCSC","id":"uc058ttd.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5185","properties":[{"key":"GeneName","value":"HRK"}]},{"database":"OpenTargets","id":"ENSG00000135116","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000135116","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000007050","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3431621_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9894001at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HRK","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000135116","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 114 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"K7EJY7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"AAAQVAALAAWLLGRRNL","length":18,"molWeight":1865,"crc64":"5C7178485D30ED36","md5":"158A9F23532A779AC7DC7471D348F0FC"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0002841234"}}]}