{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9H3N8","secondaryAccessions":["B0YJ19","B2KJ48","Q4G0I6","Q9GZQ0"],"uniProtkbId":"HRH4_HUMAN","entryAudit":{"firstPublicDate":"2001-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":200,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histamine H4 receptor"},"shortNames":[{"value":"H4R"},{"value":"HH4R"}]},"alternativeNames":[{"fullName":{"value":"AXOR35"}},{"fullName":{"value":"G protein-coupled receptor 105"}},{"fullName":{"value":"GPRv53"}},{"fullName":{"value":"Pfi-013"}},{"fullName":{"value":"SP9144"}}]},"genes":[{"geneName":{"value":"HRH4"},"synonyms":[{"value":"GPCR105"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91ZY2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12503632"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26948974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29600327"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31583075"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39333117"}],"value":"G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed:26948974). Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine (PubMed:26948974). Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma (PubMed:29600327, PubMed:31583075). Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (PubMed:39333117). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34439793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39333117"}],"value":"Interacts with TSPAN4. Interacts with GNAI1 (PubMed:39333117)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9H3N8","intActId":"EBI-67111209"},"interactantTwo":{"uniProtKBAccession":"O60894","geneName":"RAMP1","intActId":"EBI-962893"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9H3N8","intActId":"EBI-67111209"},"interactantTwo":{"uniProtKBAccession":"O60895","geneName":"RAMP2","intActId":"EBI-9009040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9H3N8","intActId":"EBI-67111209"},"interactantTwo":{"uniProtKBAccession":"O60896","geneName":"RAMP3","intActId":"EBI-720447"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34439793"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9H3N8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9H3N8-2"],"sequenceIds":["VSP_042737"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12503632"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26948974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29600327"}],"value":"Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils and basophils (PubMed:12503632, PubMed:26948974, PubMed:29600327). Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL10/interleukin-10 or IL13/interleukin-13"}],"commentType":"INDUCTION"},{"texts":[{"value":"Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha-methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha-methylhistamine > R(-)-alpha-methylhistamine behave as full agonists"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"Histamine H4 receptor","featureId":"PRO_0000069693"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":362,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39333117"}]},{"type":"Alternative sequence","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18452403"}],"featureId":"VSP_042737","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in dbSNP:rs11665084","featureCrossReferences":[{"database":"dbSNP","id":"rs11665084"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10973974"}],"featureId":"VAR_033477","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"in dbSNP:rs11662595","featureCrossReferences":[{"database":"dbSNP","id":"rs11662595"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10973974"}],"featureId":"VAR_033478","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"More than 30-fold reduced binding affinities of histamine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39333117"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"More than 30-fold reduced binding affinities of histamine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39333117"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in Ref. 1; BAB13698","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Beta strand","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8HOC"}]},{"type":"Beta strand","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YFD"}]},{"type":"Helix","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Beta strand","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Turn","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]},{"type":"Helix","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8YN9"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10973974","citationType":"journal article","authors":["Oda T.","Morikawa N.","Saito Y.","Masuho Y.","Matsumoto S."],"citationCrossReferences":[{"database":"PubMed","id":"10973974"},{"database":"DOI","id":"10.1074/jbc.m006480200"}],"title":"Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"36781","lastPage":"36786","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS VAL-138 AND ARG-206"]},{"referenceNumber":2,"citation":{"id":"11118334","citationType":"journal article","authors":["Nakamura T.","Itadani H.","Hidaka Y.","Ohta M.","Tanaka K."],"citationCrossReferences":[{"database":"PubMed","id":"11118334"},{"database":"DOI","id":"10.1006/bbrc.2000.4008"}],"title":"Molecular cloning and characterization of a new human histamine receptor, HH4R.","publicationDate":"2000","journal":"Biochem. Biophys. Res. Commun.","firstPage":"615","lastPage":"620","volume":"279"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","CHARACTERIZATION"],"referenceComments":[{"value":"Leukocyte","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-AQ0TNR316GFL7","citationType":"submission","authors":["Jones P.G.","Wu S.","Betty M."],"title":"Cloning of a novel histamine receptor.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"11179434","citationType":"journal article","authors":["Liu C.","Ma X.-J.","Jiang X.","Wilson S.J.","Hofstra C.L.","Blevitt J.","Pyati J.","Li X.","Chai W.","Carruthers N.","Lovenberg T.W."],"citationCrossReferences":[{"database":"PubMed","id":"11179434"},{"database":"DOI","id":"10.1124/mol.59.3.420"}],"title":"Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.","publicationDate":"2001","journal":"Mol. Pharmacol.","firstPage":"420","lastPage":"426","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","CHARACTERIZATION"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11181941","citationType":"journal article","authors":["Morse K.L.","Behan J.","Laz T.M.","West R.E. Jr.","Greenfeder S.A.","Anthes J.C.","Umland S.","Wan Y.","Hipkin R.W.","Gonsiorek W.","Shin N.","Gustafson E.L.","Qiao X.","Wang S.","Hedrick J.A.","Greene J.","Bayne M.","Monsma F.J. Jr."],"citationCrossReferences":[{"database":"PubMed","id":"11181941"}],"title":"Cloning and characterization of a novel human histamine receptor.","publicationDate":"2001","journal":"J. Pharmacol. Exp. Ther.","firstPage":"1058","lastPage":"1066","volume":"296"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","CHARACTERIZATION"],"referenceComments":[{"value":"Eosinophil","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"11179436","citationType":"journal article","authors":["Zhu Y.","Michalovich D.","Wu H.-L.","Tan K.B.","Dytko G.M.","Mannan I.J.","Boyce R.","Alston J.","Tierney L.A.","Li X.","Herrity N.C.","Vawter L.","Sarau H.M.","Ames R.S.","Davenport C.M.","Hieble P.","Wilson S.","Bergsma D.J.","Fitzgerald L.R."],"citationCrossReferences":[{"database":"PubMed","id":"11179436"},{"database":"DOI","id":"10.1124/mol.59.3.434"}],"title":"Cloning, expression, and pharmacological characterization of a novel human histamine receptor.","publicationDate":"2001","journal":"Mol. Pharmacol.","firstPage":"434","lastPage":"441","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":7,"citation":{"id":"12503632","citationType":"journal article","authors":["O'Reilly M.A.","Alpert R.","Jenkinson S.","Gladue R.P.","Foo S.","Trim S.","Peter B.","Trevethick M.","Fidock M."],"citationCrossReferences":[{"database":"PubMed","id":"12503632"},{"database":"DOI","id":"10.1081/rrs-120014612"}],"title":"Identification of a histamine H4 receptor on human eosinophils --role in eosinophil chemotaxis.","publicationDate":"2002","journal":"J. Recept. Signal Transduct.","firstPage":"431","lastPage":"448","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":8,"citation":{"id":"18452403","citationType":"journal article","authors":["van Rijn R.M.","van Marle A.","Chazot P.L.","Langemeijer E.","Qin Y.","Shenton F.C.","Lim H.D.","Zuiderveld O.P.","Sansuk K.","Dy M.","Smit M.J.","Tensen C.P.","Bakker R.A.","Leurs R."],"citationCrossReferences":[{"database":"PubMed","id":"18452403"},{"database":"DOI","id":"10.1042/bj20071583"}],"title":"Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.","publicationDate":"2008","journal":"Biochem. J.","firstPage":"121","lastPage":"131","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Umbilical cord blood","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"CI-A6VD5CI1Q2HUA","citationType":"submission","authors":["Puhl H.L. III","Ikeda S.R.","Aronstam R.S."],"title":"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).","publicationDate":"JUL-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":10,"citation":{"id":"CI-FDNV3U1C1I228","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"FEB-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":11,"citation":{"id":"16177791","citationType":"journal article","authors":["Nusbaum C.","Zody M.C.","Borowsky M.L.","Kamal M.","Kodira C.D.","Taylor T.D.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Abouelleil A.","Allen N.R.","Anderson S.","Bloom T.","Bugalter B.","Butler J.","Cook A.","DeCaprio D.","Engels R.","Garber M.","Gnirke A.","Hafez N.","Hall J.L.","Norman C.H.","Itoh T.","Jaffe D.B.","Kuroki Y.","Lehoczky J.","Lui A.","Macdonald P.","Mauceli E.","Mikkelsen T.S.","Naylor J.W.","Nicol R.","Nguyen C.","Noguchi H.","O'Leary S.B.","Piqani B.","Smith C.L.","Talamas J.A.","Topham K.","Totoki Y.","Toyoda A.","Wain H.M.","Young S.K.","Zeng Q.","Zimmer A.R.","Fujiyama A.","Hattori M.","Birren B.W.","Sakaki Y.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16177791"},{"database":"DOI","id":"10.1038/nature03983"}],"title":"DNA sequence and analysis of human chromosome 18.","publicationDate":"2005","journal":"Nature","firstPage":"551","lastPage":"555","volume":"437"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":12,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":14,"citation":{"id":"26948974","citationType":"journal article","authors":["Mommert S.","Kleiner S.","Gehring M.","Eiz-Vesper B.","Stark H.","Gutzmer R.","Werfel T.","Raap U."],"citationCrossReferences":[{"database":"PubMed","id":"26948974"},{"database":"DOI","id":"10.1111/all.12875"}],"title":"Human basophil chemotaxis and activation are regulated via the histamine H4 receptor.","publicationDate":"2016","journal":"Allergy","firstPage":"1264","lastPage":"1273","volume":"71"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":15,"citation":{"id":"29600327","citationType":"journal article","authors":["Mommert S.","Ratz L.","Stark H.","Gutzmer R.","Werfel T."],"citationCrossReferences":[{"database":"PubMed","id":"29600327"},{"database":"DOI","id":"10.1007/s00011-018-1140-0"}],"title":"The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1beta from fully differentiated M1 macrophages.","publicationDate":"2018","journal":"Inflamm. Res.","firstPage":"503","lastPage":"513","volume":"67"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":16,"citation":{"id":"31583075","citationType":"journal article","authors":["Peng H.","Wang J.","Ye X.Y.","Cheng J.","Huang C.Z.","Li L.Y.","Li T.Y.","Li C.W."],"citationCrossReferences":[{"database":"PubMed","id":"31583075"},{"database":"DOI","id":"10.1186/s13601-019-0288-1"}],"title":"Histamine H4 receptor regulates IL-6 and INF-gamma secretion in native monocytes from healthy subjects and patients with allergic rhinitis.","publicationDate":"2019","journal":"Clin. Transl. Allergy","firstPage":"49","lastPage":"49","volume":"9"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"34439793","citationType":"journal article","authors":["Ma X.","Verweij E.W.E.","Siderius M.","Leurs R.","Vischer H.F."],"citationCrossReferences":[{"database":"PubMed","id":"34439793"},{"database":"DOI","id":"10.3390/biom11081127"}],"title":"Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor.","publicationDate":"2021","journal":"Biomolecules","firstPage":"0","lastPage":"0","volume":"11"},"referencePositions":["INTERACTION WITH TSPAN4","SUBCELLULAR LOCATION"]},{"referenceNumber":18,"citation":{"id":"39333117","citationType":"journal article","authors":["Zhang X.","Liu G.","Zhong Y.N.","Zhang R.","Yang C.C.","Niu C.","Pu X.","Sun J.","Zhang T.","Yang L.","Zhang C.","Li X.","Shen X.","Xiao P.","Sun J.P.","Gong W."],"citationCrossReferences":[{"database":"PubMed","id":"39333117"},{"database":"DOI","id":"10.1038/s41467-024-52585-y"}],"title":"Structural basis of ligand recognition and activation of the histamine receptor family.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"8296","lastPage":"8296","volume":"15"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.30 ANGSTROMS) OF 1-382","DISULFIDE BONDS","INTERACTION WITH GNAI1","MUTAGENESIS OF PHE-344 AND TRP-348"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8YN9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8YNA"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB044934","properties":[{"key":"ProteinId","value":"BAB13698.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB045370","properties":[{"key":"ProteinId","value":"BAB20091.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF307973","properties":[{"key":"ProteinId","value":"AAG32052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF312230","properties":[{"key":"ProteinId","value":"AAK12081.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF329449","properties":[{"key":"ProteinId","value":"AAK43542.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF325356","properties":[{"key":"ProteinId","value":"AAL01684.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ298292","properties":[{"key":"ProteinId","value":"CAC83493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ835186","properties":[{"key":"ProteinId","value":"ABI54174.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY136745","properties":[{"key":"ProteinId","value":"AAN01271.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"EF444982","properties":[{"key":"ProteinId","value":"ACA05997.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC007922","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471088","properties":[{"key":"ProteinId","value":"EAX01189.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC069136","properties":[{"key":"ProteinId","value":"AAH69136.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC112348","properties":[{"key":"ProteinId","value":"AAI12349.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11887.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9H3N8-1"},{"database":"CCDS","id":"CCDS45841.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9H3N8-2"},{"database":"PIR","id":"JC7566","properties":[{"key":"EntryName","value":"JC7566"}]},{"database":"RefSeq","id":"NP_001137300.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001143828.2"}],"isoformId":"Q9H3N8-2"},{"database":"RefSeq","id":"NP_001153638.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160166.2"}]},{"database":"RefSeq","id":"NP_067637.2","properties":[{"key":"NucleotideSequenceId","value":"NM_021624.4"}],"isoformId":"Q9H3N8-1"},{"database":"PDB","id":"7YFC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"7YFD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"8HN8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=4-390"}]},{"database":"PDB","id":"8HOC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"R=4-390"}]},{"database":"PDB","id":"8JXT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.07 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"8JXV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.21 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"8JXW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"8JXX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"8YN9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"R=1-382"}]},{"database":"PDB","id":"8YNA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"R=1-382"}]},{"database":"PDB","id":"9JED","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.58 A"},{"key":"Chains","value":"R=1-390"}]},{"database":"PDB","id":"9JG1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.62 A"},{"key":"Chains","value":"R=1-207, R=289-368"}]},{"database":"PDB","id":"9L42","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-380"}]},{"database":"PDB","id":"9LRC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"R=2-390"}]},{"database":"PDB","id":"9LRE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"R=2-390"}]},{"database":"PDBsum","id":"7YFC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YFD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8HOC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JXT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JXV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JXW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JXX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8YN9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8YNA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JED","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9JG1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9L42","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LRC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LRE","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33785","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33786","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34908","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-34925","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36712","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36714","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36715","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36716","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39419","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39420","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61413","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-61447","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62803","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"121882","properties":[{"key":"Interactions","value":"1"}]},{"database":"CORUM","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9H3N8","properties":[{"key":"Number of interactors","value":"519"}]},{"database":"IntAct","id":"Q9H3N8","properties":[{"key":"Interactions","value":"3"}]},{"database":"NDEx","id":"IQUERY-CP-HRH4","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000256906","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3759","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB15027","properties":[{"key":"GenericName","value":"Adriforant"}]},{"database":"DrugBank","id":"DB00321","properties":[{"key":"GenericName","value":"Amitriptyline"}]},{"database":"DrugBank","id":"DB00543","properties":[{"key":"GenericName","value":"Amoxapine"}]},{"database":"DrugBank","id":"DB01238","properties":[{"key":"GenericName","value":"Aripiprazole"}]},{"database":"DrugBank","id":"DB00477","properties":[{"key":"GenericName","value":"Chlorpromazine"}]},{"database":"DrugBank","id":"DB00363","properties":[{"key":"GenericName","value":"Clozapine"}]},{"database":"DrugBank","id":"DB01142","properties":[{"key":"GenericName","value":"Doxepin"}]},{"database":"DrugBank","id":"DB05381","properties":[{"key":"GenericName","value":"Histamine"}]},{"database":"DrugBank","id":"DB20379","properties":[{"key":"GenericName","value":"Impromidine"}]},{"database":"DrugBank","id":"DB00408","properties":[{"key":"GenericName","value":"Loxapine"}]},{"database":"DrugBank","id":"DB06148","properties":[{"key":"GenericName","value":"Mianserin"}]},{"database":"DrugBank","id":"DB01620","properties":[{"key":"GenericName","value":"Pheniramine"}]},{"database":"DrugBank","id":"DB15220","properties":[{"key":"GenericName","value":"Seliforant"}]},{"database":"DrugBank","id":"DB12522","properties":[{"key":"GenericName","value":"Toreforant"}]},{"database":"DrugBank","id":"DB05032","properties":[{"key":"GenericName","value":"Votucalis"}]},{"database":"DrugCentral","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"265","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9H3N8","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9H3N8","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HRH4","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"14194819","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000256906","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"80734","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9H3N8-1"},{"database":"ProteomicsDB","id":"80735","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9H3N8-2"},{"database":"Antibodypedia","id":"7806","properties":[{"key":"antibodies","value":"283 antibodies from 31 providers"}]},{"database":"DNASU","id":"59340","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000256906.5","properties":[{"key":"ProteinId","value":"ENSP00000256906.4"},{"key":"GeneId","value":"ENSG00000134489.7"}],"isoformId":"Q9H3N8-1"},{"database":"Ensembl","id":"ENST00000426880.2","properties":[{"key":"ProteinId","value":"ENSP00000402526.2"},{"key":"GeneId","value":"ENSG00000134489.7"}],"isoformId":"Q9H3N8-2"},{"database":"GeneID","id":"59340","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:59340","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000256906.5","properties":[{"key":"ProteinId","value":"ENSP00000256906.4"},{"key":"RefSeqNucleotideId","value":"NM_021624.4"},{"key":"RefSeqProteinId","value":"NP_067637.2"}]},{"database":"UCSC","id":"uc002kvi.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9H3N8-1"},{"database":"AGR","id":"HGNC:17383","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134982275","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"59340","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"59340","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HRH4","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:17383","properties":[{"key":"GeneName","value":"HRH4"}]},{"database":"HPA","id":"ENSG00000134489","properties":[{"key":"ExpressionPatterns","value":"Not detected"}]},{"database":"MIM","id":"606792","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000134489","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000134489","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000162118","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_11_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CVFWLIT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10071887at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9H3N8","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-390650","properties":[{"key":"PathwayName","value":"Histamine receptors"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"SignaLink","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000134489","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"59340","properties":[{"key":"hits","value":"17 hits in 1145 CRISPR screens"}]},{"database":"GeneWiki","id":"Histamine_H4_receptor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"59340","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9H3N8","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q9H3N8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"Q9H3N8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000134489","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 41 other cell types or tissues"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34439793"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004969","properties":[{"key":"GoTerm","value":"F:histamine receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030594","properties":[{"key":"GoTerm","value":"F:neurotransmitter receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007197","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007193","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"39333117"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007187","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0043408","properties":[{"key":"GoTerm","value":"P:regulation of MAPK cascade"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd15295","properties":[{"key":"EntryName","value":"7tmA_Histamine_H4R"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000257","properties":[{"key":"EntryName","value":"Histamine H4 receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR008102","properties":[{"key":"EntryName","value":"Histamine_H4_rcpt"}]},{"database":"PANTHER","id":"PTHR24247","properties":[{"key":"EntryName","value":"5-HYDROXYTRYPTAMINE RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24247:SF199","properties":[{"key":"EntryName","value":"HISTAMINE H4 RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR01726","properties":[{"key":"EntryName","value":"HISTAMINEH4R"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS","length":390,"molWeight":44496,"crc64":"C986B8AE7FF912C3","md5":"C41889372E0438E6B305BE543713F09D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Glycosylation":2,"Disulfide bond":1,"Alternative sequence":1,"Natural variant":2,"Mutagenesis":2,"Sequence conflict":1,"Helix":16,"Beta strand":3,"Turn":1},"uniParcId":"UPI0000039A92"}}]}