{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10321","secondaryAccessions":["O02863","O02864","O02865","O02866","O02958","O19505","O19652","O19676","O62879","O62882","O62883","O62888","O78060","O78061","O78062","O78063","O78067","O78068","O78069","O78072","O78083","O78090","O78091","O78149","O78165","O78166","O78178","O78202","O78203","O78211","O78214","P04222","P30499","P30500","P30501","P30502","P30503","P30504","P30505","P30506","P30507","P30508","P30509","P30510","P79498","Q07000","Q29631","Q29641","Q29643","Q29652","Q29743","Q29768","Q29862","Q29864","Q29865","Q29867","Q29921","Q29959","Q29960","Q29963","Q29986","Q29989","Q29990","Q29991","Q29992","Q29993","Q30192","Q31605","Q31627","Q860R1","Q860R2","Q95463","Q95603","Q95604","Q99528","Q9BD28","Q9GIK4","Q9GIK8","Q9GJ33","Q9MY30","Q9MY31","Q9MY35","Q9MY49","Q9MY74","Q9MYI3","Q9TNN7","Q9TNZ8","Q9TPS4","Q9TPV8","Q9TPX2","Q9TQB4","Q9TQJ5","Q9TQP9","Q9UM32","Q9UM33","Q9UM42","Q9UQS9"],"uniProtkbId":"HLAC_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-12-20","entryVersion":222,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"HLA class I histocompatibility antigen, C alpha chain"},"shortNames":[{"value":"HLA-C"}]},"alternativeNames":[{"fullName":{"value":"HLA-Cw"}},{"fullName":{"value":"Human leukocyte antigen C"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4933"}],"value":"HLA-C"},"synonyms":[{"value":"HLAC"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11172028"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20104487"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20439706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20972337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24091323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25311805"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29312307"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8265661"}],"value":"Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:11172028, PubMed:20104487, PubMed:20439706, PubMed:20972337, PubMed:24091323, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:25311805, PubMed:8265661)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12947002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20439706"}],"value":"ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12947002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20104487"}],"value":"ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11172028"}],"value":"ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24091323"}],"value":"ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29312307"}],"value":"ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12947002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990997"}],"value":"ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12947002"}],"value":"ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12947002"}],"value":"ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10850706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11323700"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141329"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18420581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20439706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20972337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24091323"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990997"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"value":"Heterotrimer that consists of an alpha chain HLA-C, a beta chain B2M and a peptide (peptide-HLA-C-B2M) (PubMed:10850706, PubMed:24990997, PubMed:28649982). Early in biogenesis, HLA-C-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:18420581). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the endoplasmic reticulum (ER) by TAP1-TAP2 transporter (By similarity). Being very selective in the peptide binding, forms a stable interaction with TAP1-TAP2, often leading to the accumulation of free heavy chains in the ER (PubMed:18420581). Only optimally assembled peptide-HLA-C-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-C (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (By similarity). One HLA-C molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction ensures peptide-HLA-C-B2M recognition by CD8-positive T cells only (By similarity). The peptide-HLA-C-B2M complex also interacts with KIRs. HLA-C type 1 (C1, with Asn104), including HLA-C*02, C*04, C*05, C*06 and C*15, interact with KIR2DL1 and KIR2DS1, and HLA-C type 2 (C2, with Lys104), including HLA-C*01, C*03, C*07 and C*08, interact with KIR2DL2 and KIR2DL3 (PubMed:10850706, PubMed:11323700, PubMed:16141329, PubMed:20439706, PubMed:20972337, PubMed:24091323)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11390610"}],"value":"(Microbial infection) Interacts with HTLV-1 p12I accessory protein"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"P43626","geneName":"KIR2DL1","intActId":"EBI-8684277"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"P43627","geneName":"KIR2DL2","intActId":"EBI-13941368"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"P43628","geneName":"KIR2DL3","intActId":"EBI-8632435"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"Q14954","geneName":"KIR2DS1","intActId":"EBI-2865976"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"P43632","geneName":"KIR2DS4","intActId":"EBI-13916812"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"Q14953","geneName":"KIR2DS5","intActId":"EBI-16823921"},"numberOfExperiments":30,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"Q14943","geneName":"KIR3DS1","intActId":"EBI-15316524"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"Q8N423","geneName":"LILRB2","intActId":"EBI-2816428"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10321","intActId":"EBI-1051396"},"interactantTwo":{"uniProtKBAccession":"F2VZG2","geneName":"KIR2DS4","intActId":"EBI-13917082"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18420581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20972337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18420581"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P10321-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P10321-2"],"sequenceIds":["VSP_060393","VSP_060394"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20972337"}],"value":"Ubiquitous. Highly expressed in fetal extravillous trophoblasts in the decidua basalis (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"value":"The alpha-1 domain is a structural part of the peptide-binding cleft"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10850706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990997"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"value":"The alpha-2 domain is a structural part of the peptide-binding cleft (PubMed:10850706, PubMed:24990997, PubMed:28649982). Mediates the interaction with TAP1-TAP2 complex"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04439"}],"value":"The alpha-3 Ig-like domain mediates the interaction with CD8 coreceptor"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37264229"}],"value":"The VL9 peptide/epitope (VMAPRT[V/L][L/V/I/F]L) derived from the signal sequence is loaded onto HLA-E and enables HLA-E expression at the plasma membrane. Distinct VL9 peptides presented by HLA-E variably affect its recognition by KLRD1-KLRC1 or KLRD1-KLRC2 receptors on NK cells, setting NK cell activation threshold. Common HLA-C allotypes contain functional VL9 peptides (VMAPRTLIL and VMAPRTLLL). VL9 peptides (VMAPRTALL and VMAPRQALL) derived from HLA-C*07, C*17 and C*18 allotypes display low affinity for HLA-E and fail to drive NK cell activation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18420581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"value":"N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28650991"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37264229"},{"evidenceCode":"ECO:0000305"}],"value":"Displays lower polymorphism than HLA-A and HLA-B. Polymorphic residues encode for alpha-1 and alpha-2 domains of the peptide-binding cleft, where they contribute to variations in peptide binding and TCR recognition among different alleles. The human population is estimated to have millions of HLA-C alleles. But only 14 common HLA-C alleles are considered core alleles, representing all functionally significant variation (polymorphism) in alpha-1 and alpha-2 domains. These are: C*01:02; C*02:02; C*03:02; C*04:01; C*05:01; C*06:02; C*07:01; C*07:04; C*08:01; C*12:02; C*14:02; C*15:02; C*16:01 and C*17:01. Among these, C*01:02; C*02:02; C*03:02; C*08:01; C*12:02; C*14:02 and C*15:02, were likely passed by introgression from archaic to modern humans. Functional alleles of more recent origin (non-core) were derived by recombination (PubMed:28650991). The sequence shown is that of C*07:02. The sequences of core alleles and common representative alleles of serologically distinct allele groups are described as variants of C*07:02. Allelic variations of HLA-C signal peptide regulate HLA-E recognition by KLRD1-KLRC1 and KLRD1-KLRC2 receptors in viral infection and tumorigenesis by affecting its processing and by changing the affinity of HLA-E-VL9 complex for KLRD1-KLRC1 and KLRD1-KLRC2 receptors"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Psoriasis 1","diseaseAccession":"DI-02231","acronym":"PSORS1","description":"A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.","diseaseCrossReference":{"database":"MIM","id":"177900"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16642438"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26621454"}],"value":"Disease susceptibility is associated with variants affecting the gene represented in this entry. Allele C*06:02 presents a melanocyte autoantigen ADAMTSL5 (VRSRRCLRL) to Valpha3S1/Vbeta13S1 TCR on CD8-positive T cells, and may trigger an autoimmune response against melanocytes"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"2914713"}],"value":"A transcript of allele C*16:01. This isoform lacks the transmembrane domain and is predicted to be a secreted protein"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"HLA class I histocompatibility antigen, C alpha chain","featureId":"PRO_0000018868"},{"type":"Topological domain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like C1-type"},{"type":"Region","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"VL9 epitope","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37264229"}]},{"type":"Region","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Connecting peptide"},{"type":"Binding site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:166823"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"ligand":{"name":"a peptide antigen","id":"ChEBI:CHEBI:166823","note":"self- and pathogen-derived peptide antigen"}},{"type":"Binding site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:166823"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"ligand":{"name":"a peptide antigen","id":"ChEBI:CHEBI:166823","note":"self- and pathogen-derived peptide antigen"}},{"type":"Binding site","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:166823"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"ligand":{"name":"a peptide antigen","id":"ChEBI:CHEBI:166823","note":"self- and pathogen-derived peptide antigen"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:166823"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"ligand":{"name":"a peptide antigen","id":"ChEBI:CHEBI:166823","note":"self- and pathogen-derived peptide antigen"}},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:166823"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}],"ligand":{"name":"a peptide antigen","id":"ChEBI:CHEBI:166823","note":"self- and pathogen-derived peptide antigen"}},{"type":"Modified residue","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01900"}]},{"type":"Modified residue","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01900"}]},{"type":"Glycosylation","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10850706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990997"}]},{"type":"Disulfide bond","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00114"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10850706"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990997"}]},{"type":"Alternative sequence","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"}],"featureId":"VSP_060393","alternativeSequence":{"originalSequence":"DLRSW","alternativeSequences":["HLRSC"]}},{"type":"Alternative sequence","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"}],"featureId":"VSP_060394","alternativeSequence":{"originalSequence":"SWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSS","alternativeSequences":["RW"]}},{"type":"Natural variant","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs41548123","featureCrossReferences":[{"database":"dbSNP","id":"rs41548123"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082408","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02 and allele C*16:01; dbSNP:rs2308525","featureCrossReferences":[{"database":"dbSNP","id":"rs2308525"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082409","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02 and allele C*16:01; dbSNP:rs2308527","featureCrossReferences":[{"database":"dbSNP","id":"rs2308527"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082410","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*17:01; dbSNP:rs1050451","featureCrossReferences":[{"database":"dbSNP","id":"rs1050451"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082411","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs41549413","featureCrossReferences":[{"database":"dbSNP","id":"rs41549413"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082412","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"in allele C*03:02, allele C*03:04, allele C*04:01 and allele C*17:01; dbSNP:rs2074493","featureCrossReferences":[{"database":"dbSNP","id":"rs2074493"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082413","alternativeSequence":{"originalSequence":"C","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in allele C*01:02; dbSNP:rs1131151","featureCrossReferences":[{"database":"dbSNP","id":"rs1131151"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"}],"featureId":"VAR_082414","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in allele C*01:02; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"}],"featureId":"VAR_082415","alternativeSequence":{"originalSequence":"D","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in allele C*04:01 and allele C*14:02; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"}],"featureId":"VAR_082416","alternativeSequence":{"originalSequence":"D","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*03:02, allele C*03:04, allele C*05:01, allele C*08:01, allele C*12:02, allele C*15:02, allele C*16:01 and allele C*17:01; dbSNP:rs9264668","featureCrossReferences":[{"database":"dbSNP","id":"rs9264668"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082417","alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*04:01 and allele C*14:02; dbSNP:rs1050445","featureCrossReferences":[{"database":"dbSNP","id":"rs1050445"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"}],"featureId":"VAR_082418","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in allele C*04:01; dbSNP:rs41542423","featureCrossReferences":[{"database":"dbSNP","id":"rs41542423"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"}],"featureId":"VAR_082419","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"in allele C*02:02; dbSNP:rs151341100","featureCrossReferences":[{"database":"dbSNP","id":"rs151341100"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"}],"featureId":"VAR_082420","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*03:02, allele C*03:04 and allele C*15:02; dbSNP:rs1050437","featureCrossReferences":[{"database":"dbSNP","id":"rs1050437"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082421","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*17:01; dbSNP:rs707911","featureCrossReferences":[{"database":"dbSNP","id":"rs707911"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082422","alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in allele C*05:01 and C*08:01; dbSNP:rs1050428","featureCrossReferences":[{"database":"dbSNP","id":"rs1050428"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082423","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in allele C*04:01; dbSNP:rs1050409","featureCrossReferences":[{"database":"dbSNP","id":"rs1050409"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"}],"featureId":"VAR_082424","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"in allele C*07:01, C*15:02; dbSNP:rs28626310","featureCrossReferences":[{"database":"dbSNP","id":"rs28626310"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10488744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2714852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"}],"featureId":"VAR_082425","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*05:01, allele C*08:01, allele C*14:02, allele C*15:02 and allele C*16:01; dbSNP:rs41543814","featureCrossReferences":[{"database":"dbSNP","id":"rs41543814"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082426","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*04:01, allele C*05:01, allele C*06:02, allele C*15:02, allele C*17:01 and allele C*18:01; dbSNP:rs2308557","featureCrossReferences":[{"database":"dbSNP","id":"rs2308557"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082427","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*04:01, allele C*05:01, allele C*06:02, allele C*15:02, allele C*17:01 and allele C*18:01; dbSNP:rs17408553","featureCrossReferences":[{"database":"dbSNP","id":"rs17408553"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082428","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*05:01, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*17:01; dbSNP:rs1131123","featureCrossReferences":[{"database":"dbSNP","id":"rs1131123"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082429","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"in allele C*03:02, allele C*03:04 and allele C*15:02; dbSNP:rs1131119","featureCrossReferences":[{"database":"dbSNP","id":"rs1131119"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082430","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in allele C*07:04; dbSNP:rs1071649","featureCrossReferences":[{"database":"dbSNP","id":"rs1071649"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7482492"}],"featureId":"VAR_082431","alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"in allele C*03:04, allele C*15:02 and allele C*17:01; dbSNP:rs1071649","featureCrossReferences":[{"database":"dbSNP","id":"rs1071649"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082432","alternativeSequence":{"originalSequence":"L","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*06:02, allele C*14:02 and allele C*16:01; dbSNP:rs1131118","featureCrossReferences":[{"database":"dbSNP","id":"rs1131118"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"}],"featureId":"VAR_082433","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in allele C*01:02; dbSNP:rs1131115","featureCrossReferences":[{"database":"dbSNP","id":"rs1131115"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"}],"featureId":"VAR_082434","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in allele C*04:01, allele C*14:02 and allele C*18:01; dbSNP:rs1131115","featureCrossReferences":[{"database":"dbSNP","id":"rs1131115"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"}],"featureId":"VAR_082435","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in allele C*07:01, allele C*02:02, allele C*03:02, allele C*03:04, allele C*05:01, allele C*06:02, allele C*07:04, allele C*08:01, allele C*12:02, allele C*15:02, allele C*16:01 and allele C*17:01; dbSNP:rs1131115","featureCrossReferences":[{"database":"dbSNP","id":"rs1131115"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10488744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2714852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082436","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in allele C*03:02 and allele C*03:04; dbSNP:rs34592426","featureCrossReferences":[{"database":"dbSNP","id":"rs34592426"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082437","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in allele C*15:02; dbSNP:rs2308574","featureCrossReferences":[{"database":"dbSNP","id":"rs2308574"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"}],"featureId":"VAR_082438","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"in allele C*04:01, allele C*05:01, allele C*08:01, allele C*17:01 and allele C*18:01; dbSNP:rs2308575","featureCrossReferences":[{"database":"dbSNP","id":"rs2308575"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082439","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in allele C*04:01, allele C*05:01, allele C*07:04, allele C*08:01, allele C*17:01 and allele C*18:01; dbSNP:rs713032","featureCrossReferences":[{"database":"dbSNP","id":"rs713032"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7482492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082440","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in allele C*15:02; dbSNP:rs1761318671","featureCrossReferences":[{"database":"dbSNP","id":"rs1761318671"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"}],"featureId":"VAR_082441","alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"in alleles C*01:02, C*03:04; dbSNP:rs713032","featureCrossReferences":[{"database":"dbSNP","id":"rs713032"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082442","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"in allele C*05:01","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082443","alternativeSequence":{"originalSequence":"T","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs142570222","featureCrossReferences":[{"database":"dbSNP","id":"rs142570222"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082444","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs1050366","featureCrossReferences":[{"database":"dbSNP","id":"rs1050366"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082445","alternativeSequence":{"originalSequence":"L","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*12:02, allele C*14:02, allele C*15:02, allele C*17:01 and allele C*18:01; dbSNP:rs2308590","featureCrossReferences":[{"database":"dbSNP","id":"rs2308590"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082446","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in allele C*08:01; dbSNP:rs41552817","featureCrossReferences":[{"database":"dbSNP","id":"rs41552817"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"}],"featureId":"VAR_082447","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in allele C*07:04; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7482492"}],"featureId":"VAR_082448","alternativeSequence":{"originalSequence":"L","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in allele C*16:01; dbSNP:rs2308592","featureCrossReferences":[{"database":"dbSNP","id":"rs2308592"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"}],"featureId":"VAR_082449","alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*04:01, allele C*05:01, allele C*14:02 and allele C*18:01; dbSNP:rs2308592","featureCrossReferences":[{"database":"dbSNP","id":"rs2308592"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082450","alternativeSequence":{"originalSequence":"L","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*06:02 and allele C*12:02; dbSNP:rs796925732","featureCrossReferences":[{"database":"dbSNP","id":"rs796925732"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"}],"featureId":"VAR_082451","alternativeSequence":{"originalSequence":"L","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in alleles C*02:02 and allele C*17:01; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082452","alternativeSequence":{"originalSequence":"T","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in allele C*03:02 and allele C*03:04; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082453","alternativeSequence":{"originalSequence":"T","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs2308598","featureCrossReferences":[{"database":"dbSNP","id":"rs2308598"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082454","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in allele C*03:02 and allele C*03:04; dbSNP:rs1050357","featureCrossReferences":[{"database":"dbSNP","id":"rs1050357"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"}],"featureId":"VAR_082455","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"in allele C*05:01, allele C*07:04 and allele C*08:01; dbSNP:rs1131103","featureCrossReferences":[{"database":"dbSNP","id":"rs1131103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7482492"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082456","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs1131096","featureCrossReferences":[{"database":"dbSNP","id":"rs1131096"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082457","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs1131096","featureCrossReferences":[{"database":"dbSNP","id":"rs1131096"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082458","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in allele C*16:01; dbSNP:rs1050343","featureCrossReferences":[{"database":"dbSNP","id":"rs1050343"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"}],"featureId":"VAR_082459","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs1050716","featureCrossReferences":[{"database":"dbSNP","id":"rs1050716"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082460","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"in allele C*02:02; dbSNP:rs41562012","featureCrossReferences":[{"database":"dbSNP","id":"rs41562012"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"}],"featureId":"VAR_082461","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"in alleles C*01:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*14:02 and allele C*18:01; dbSNP:rs1050328","featureCrossReferences":[{"database":"dbSNP","id":"rs1050328"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"}],"featureId":"VAR_082462","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"in allele C*01:02; dbSNP:rs1050276","featureCrossReferences":[{"database":"dbSNP","id":"rs1050276"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25944712"}],"featureId":"VAR_082463","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs707908","featureCrossReferences":[{"database":"dbSNP","id":"rs707908"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082464","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs2308622","featureCrossReferences":[{"database":"dbSNP","id":"rs2308622"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082465","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs1131015","featureCrossReferences":[{"database":"dbSNP","id":"rs1131015"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082466","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in allele C*17:01; requires 2 nucleotide substitutions; dbSNP:rs1211800658","featureCrossReferences":[{"database":"dbSNP","id":"rs1211800658"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082467","alternativeSequence":{"originalSequence":"L","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs2308628","featureCrossReferences":[{"database":"dbSNP","id":"rs2308628"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082468","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in alleles C*05:01 and allele C*08:01; dbSNP:rs9264621","featureCrossReferences":[{"database":"dbSNP","id":"rs9264621"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082469","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in allele C*04:01, allele C*17:01 and allele C*18:01; dbSNP:rs41556321","featureCrossReferences":[{"database":"dbSNP","id":"rs41556321"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082470","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in allele C*17:01","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082471","alternativeSequence":{"originalSequence":"IMGIVAGLAVLV","alternativeSequences":["NLGIVSGPAVLAVLAVLA"]}},{"type":"Natural variant","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs1050180","featureCrossReferences":[{"database":"dbSNP","id":"rs1050180"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082472","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02 and allele C*16:01; dbSNP:rs1050147","featureCrossReferences":[{"database":"dbSNP","id":"rs1050147"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082473","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"in allele C*04:01; dbSNP:rs146911342","featureCrossReferences":[{"database":"dbSNP","id":"rs146911342"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"}],"featureId":"VAR_082474","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"in allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02 and allele C*15:02","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082475","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs1130947","featureCrossReferences":[{"database":"dbSNP","id":"rs1130947"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082476","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"in allele C*02:02, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01 and allele C*18:01; dbSNP:rs1050105","featureCrossReferences":[{"database":"dbSNP","id":"rs1050105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082477","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs1130935","featureCrossReferences":[{"database":"dbSNP","id":"rs1130935"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082478","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"in allele C*17:01; dbSNP:rs41540416","featureCrossReferences":[{"database":"dbSNP","id":"rs41540416"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082479","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"in allele C*17:01; requires 2 nucleotide substitutions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"}],"featureId":"VAR_082480","alternativeSequence":{"originalSequence":"C","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs35708511","featureCrossReferences":[{"database":"dbSNP","id":"rs35708511"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082481","alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"in allele C*01:02, allele C*02:02, allele C*03:02, allele C*03:04, allele C*04:01, allele C*05:01, allele C*06:02, allele C*08:01, allele C*12:02, allele C*14:02, allele C*15:02, allele C*16:01, allele C*17:01 and allele C*18:01; dbSNP:rs1130838","featureCrossReferences":[{"database":"dbSNP","id":"rs1130838"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10372547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12622774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1317015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1384166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1598685"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1711567"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2715640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2787363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2914713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7905471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9008313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9098935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9211742"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.18"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.19"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.20"}],"featureId":"VAR_082482","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Impairs N-linked glycosylation resulting in impaired interaction with CANX and CALR chaperones as well as TAPBPL.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18420581"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Beta strand","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Turn","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1QQD"}]},{"type":"Helix","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VGD"}]},{"type":"Beta strand","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT6"}]},{"type":"Helix","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Helix","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]},{"type":"Beta strand","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1IM9"}]},{"type":"Beta strand","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2914713","citationType":"journal article","authors":["Cianetti L.","Testa U.","Scotto L.","la Valle R.","Simeone A.","Boccoli G.","Giannella G.","Peschle C.","Boncinelli E."],"citationCrossReferences":[{"database":"PubMed","id":"2914713"},{"database":"DOI","id":"10.1007/bf00395855"}],"title":"Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing.","publicationDate":"1989","journal":"Immunogenetics","firstPage":"80","lastPage":"91","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*16:01)","ALTERNATIVE SPLICING"]},{"referenceNumber":2,"citation":{"id":"2714852","citationType":"journal article","authors":["Pohla H.","Kuon W.","Tabaczewski P.","Doerner C.","Weiss E.H."],"citationCrossReferences":[{"database":"PubMed","id":"2714852"},{"database":"DOI","id":"10.1007/bf00352839"}],"title":"Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles.","publicationDate":"1989","journal":"Immunogenetics","firstPage":"297","lastPage":"307","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 77-309 (ALLELE C*07:01)"]},{"referenceNumber":3,"citation":{"id":"1711567","citationType":"journal article","authors":["Grassi F.","Meneveri R.","Gullberg M.","Lopalco L.","Rossi G.B.","Lanza P.","de Santis C.","Brattsand G.","Butto S.","Ginelli E.","Beretta A.","Siccardi A.G."],"citationCrossReferences":[{"database":"PubMed","id":"1711567"},{"database":"DOI","id":"10.1084/jem.174.1.53"}],"title":"Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains.","publicationDate":"1991","journal":"J. Exp. Med.","firstPage":"53","lastPage":"62","volume":"174"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*04:01)"]},{"referenceNumber":4,"citation":{"id":"1317015","citationType":"journal article","authors":["Belich M.P.","Madrigal J.A.","Hildebrand W.H.","Zemmour J.","Williams R.C.","Luz R.","Petzl-Erler M.L.","Parham P."],"citationCrossReferences":[{"database":"PubMed","id":"1317015"},{"database":"DOI","id":"10.1038/357326a0"}],"title":"Unusual HLA-B alleles in two tribes of Brazilian Indians.","publicationDate":"1992","journal":"Nature","firstPage":"326","lastPage":"329","volume":"357"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*04:01)"]},{"referenceNumber":5,"citation":{"id":"1384166","citationType":"journal article","authors":["Zemmour J.","Gumperz J.E.","Hildebrand W.H.","Ward F.E.","Marsh S.G.E.","Williams R.C.","Parham P."],"citationCrossReferences":[{"database":"PubMed","id":"1384166"},{"database":"DOI","id":"10.1111/j.1399-0039.1992.tb01943.x"}],"title":"The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes.","publicationDate":"1992","journal":"Tissue Antigens","firstPage":"249","lastPage":"257","volume":"39"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELES C*01:02; C*03:02 AND C*08:01)"]},{"referenceNumber":6,"citation":{"id":"7905471","citationType":"journal article","authors":["Vilches C.","de Pablo R.","Herrero M.J.","Moreno M.E.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"7905471"},{"database":"DOI","id":"10.1016/0198-8859(93)90509-y"}],"title":"Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw*1502) in Spanish gypsies.","publicationDate":"1993","journal":"Hum. Immunol.","firstPage":"259","lastPage":"263","volume":"37"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELES C*12:02 AND C*15:02)"]},{"referenceNumber":7,"citation":{"id":"7482492","citationType":"journal article","authors":["Vilches C.","Bunce M.","de Pablo R.","Herrero M.J.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"7482492"},{"database":"DOI","id":"10.1111/j.1399-0039.1995.tb02471.x"}],"title":"Anchored PCR cloning of the novel HLA-Cw*0704 allele detected by PCR-SSP.","publicationDate":"1995","journal":"Tissue Antigens","firstPage":"19","lastPage":"23","volume":"46"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*07:04)"]},{"referenceNumber":8,"citation":{"id":"8655361","citationType":"journal article","authors":["Wang H.","Tokunaga K.","Ishikawa Y.","Asahina A.","Kuwata S.","Akaza T.","Tadokoro K.","Shibata Y.","Takiguchi M.","Juji T."],"citationCrossReferences":[{"database":"PubMed","id":"8655361"},{"database":"DOI","id":"10.1016/0198-8859(95)00150-6"}],"title":"Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702.","publicationDate":"1996","journal":"Hum. Immunol.","firstPage":"52","lastPage":"58","volume":"45"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*07:02)"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"9008313","citationType":"journal article","authors":["Vilches C.","Bunce M.","Sanz L.","de Pablo R.","Puente S.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"9008313"},{"database":"DOI","id":"10.1111/j.1399-0039.1996.tb02694.x"}],"title":"Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706.","publicationDate":"1996","journal":"Tissue Antigens","firstPage":"698","lastPage":"702","volume":"48"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*18:01)"]},{"referenceNumber":10,"citation":{"id":"9211742","citationType":"journal article","authors":["Wells R.S.","Seielstad M.T.","Bunce M.","Tyan D.B.","Bekele E.","Parham P."],"citationCrossReferences":[{"database":"PubMed","id":"9211742"},{"database":"DOI","id":"10.1007/s002510050259"}],"title":"Cw*1701 defines a divergent african HLA-C allelic lineage.","publicationDate":"1997","journal":"Immunogenetics","firstPage":"173","lastPage":"180","volume":"46"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*17:01)"]},{"referenceNumber":11,"citation":{"id":"9098935","citationType":"journal article","authors":["Herrero M.J.","Vilches C.","de Pablo R.","Puente S.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"9098935"},{"database":"DOI","id":"10.1111/j.1399-0039.1997.tb02749.x"}],"title":"The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule.","publicationDate":"1997","journal":"Tissue Antigens","firstPage":"267","lastPage":"270","volume":"49"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*17:01)"]},{"referenceNumber":12,"citation":{"id":"10372547","citationType":"journal article","authors":["Baurain J.-F.","Coulie P.G."],"citationCrossReferences":[{"database":"PubMed","id":"10372547"},{"database":"DOI","id":"10.1034/j.1399-0039.1999.530508.x"}],"title":"Correction of HLA-Cw*0501 and identification of HLA-Cw*0711.","publicationDate":"1999","journal":"Tissue Antigens","firstPage":"510","lastPage":"512","volume":"53"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*05:01)"]},{"referenceNumber":13,"citation":{"id":"2787363","citationType":"journal article","authors":["Takiguchi M.","Nishimura I.","Hayashi H.","Karaki S.","Kariyone A.","Kano K."],"citationCrossReferences":[{"database":"PubMed","id":"2787363"},{"database":"DOI","id":"10.4049/jimmunol.143.4.1372"}],"title":"The structure and expression of genes encoding serologically undetected HLA-C locus antigens.","publicationDate":"1989","journal":"J. Immunol.","firstPage":"1372","lastPage":"1378","volume":"143"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE C*12:02)"]},{"referenceNumber":14,"citation":{"id":"2715640","citationType":"journal article","authors":["Parham P.","Lawlor D.A.","Lomen C.E.","Ennis P.D."],"citationCrossReferences":[{"database":"PubMed","id":"2715640"},{"database":"DOI","id":"10.4049/jimmunol.142.11.3937"}],"title":"Diversity and diversification of HLA-A,B,C alleles.","publicationDate":"1989","journal":"J. Immunol.","firstPage":"3937","lastPage":"3950","volume":"142"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE C*02:02)"]},{"referenceNumber":15,"citation":{"id":"1598685","citationType":"journal article","authors":["Steinle A.","Noessner E.","Schendel D.J."],"citationCrossReferences":[{"database":"PubMed","id":"1598685"},{"database":"DOI","id":"10.1111/j.1399-0039.1992.tb01923.x"}],"title":"Isolation and characterization of a genomic HLA-Cw6 clone.","publicationDate":"1992","journal":"Tissue Antigens","firstPage":"134","lastPage":"137","volume":"39"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE C*06:02)"]},{"referenceNumber":16,"citation":{"id":"10488744","citationType":"journal article","authors":["van der Vlies S.A.","Voorter C.E.","van den Berg-Loonen E.M."],"citationCrossReferences":[{"database":"PubMed","id":"10488744"},{"database":"DOI","id":"10.1034/j.1399-0039.1999.540208.x"}],"title":"There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5.","publicationDate":"1999","journal":"Tissue Antigens","firstPage":"169","lastPage":"177","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-338 (ALLELE C*07:01)"]},{"referenceNumber":17,"citation":{"id":"12622774","citationType":"journal article","authors":["Cox S.T.","McWhinnie A.J.","Robinson J.","Marsh S.G.E.","Parham P.","Madrigal J.A.","Little A.-M."],"citationCrossReferences":[{"database":"PubMed","id":"12622774"},{"database":"DOI","id":"10.1034/j.1399-0039.2003.610103.x"}],"title":"Cloning and sequencing full-length HLA-B and -C genes.","publicationDate":"2003","journal":"Tissue Antigens","firstPage":"20","lastPage":"48","volume":"61"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES C*07:02; C*04:01; C*15:02 AND C*18:01)"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"CI-4LFH5QPPPURUT","citationType":"submission","authors":["Domena J.D."],"publicationDate":"MAY-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*03:04)"]},{"referenceNumber":19,"citation":{"id":"CI-C6MDAUV9BKJU1","citationType":"submission","authors":["Zhang L.","Ellexson M.E.","Hildebrand W.H."],"publicationDate":"NOV-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*14:02)"]},{"referenceNumber":20,"citation":{"id":"CI-CT7RSJLQNCJEU","citationType":"submission","authors":["Ellexson M.E.","Zhang W.","Hildebrand W.H."],"title":"Cw*0501new.","publicationDate":"APR-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ALLELE C*05:01)"]},{"referenceNumber":21,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":22,"citation":{"id":"8265661","citationType":"journal article","authors":["Falk K.","Roetzschke O.","Grahovac B.","Schendel D.","Stevanovic S.","Gnau V.","Jung G.","Strominger J.L.","Rammensee H.G."],"citationCrossReferences":[{"database":"PubMed","id":"8265661"},{"database":"DOI","id":"10.1073/pnas.90.24.12005"}],"title":"Allele-specific peptide ligand motifs of HLA-C molecules.","publicationDate":"1993","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12005","lastPage":"12009","volume":"90"},"referencePositions":["FUNCTION"]},{"referenceNumber":23,"citation":{"id":"11390610","citationType":"journal article","authors":["Johnson J.M.","Nicot C.","Fullen J.","Ciminale V.","Casareto L.","Mulloy J.C.","Jacobson S.","Franchini G."],"citationCrossReferences":[{"database":"PubMed","id":"11390610"},{"database":"DOI","id":"10.1128/jvi.75.13.6086-6094.2001"}],"title":"Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.","publicationDate":"2001","journal":"J. Virol.","firstPage":"6086","lastPage":"6094","volume":"75"},"referencePositions":["INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I (MICROBIAL INFECTION)"]},{"referenceNumber":24,"citation":{"id":"11172028","citationType":"journal article","authoringGroup":["HIV Controller Study Collaboration"],"authors":["Addo M.M.","Altfeld M.","Rosenberg E.S.","Eldridge R.L.","Philips M.N.","Habeeb K.","Khatri A.","Brander C.","Robbins G.K.","Mazzara G.P.","Goulder P.J.","Walker B.D."],"citationCrossReferences":[{"database":"PubMed","id":"11172028"},{"database":"DOI","id":"10.1073/pnas.98.4.1781"}],"title":"The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.","publicationDate":"2001","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1781","lastPage":"1786","volume":"98"},"referencePositions":["FUNCTION (ALLELE C*05:01)"]},{"referenceNumber":25,"citation":{"id":"12947002","citationType":"journal article","authors":["Kondo E.","Akatsuka Y.","Kuzushima K.","Tsujimura K.","Asakura S.","Tajima K.","Kagami Y.","Kodera Y.","Tanimoto M.","Morishima Y.","Takahashi T."],"citationCrossReferences":[{"database":"PubMed","id":"12947002"},{"database":"DOI","id":"10.1182/blood-2003-03-0824"}],"title":"Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles.","publicationDate":"2004","journal":"Blood","firstPage":"630","lastPage":"638","volume":"103"},"referencePositions":["FUNCTION (ALLELES C*01:02; C*04:01; C*08:01; C*12:02 AND C*15:02)"]},{"referenceNumber":26,"citation":{"id":"16141329","citationType":"journal article","authors":["Stewart C.A.","Laugier-Anfossi F.","Vely F.","Saulquin X.","Riedmuller J.","Tisserant A.","Gauthier L.","Romagne F.","Ferracci G.","Arosa F.A.","Moretta A.","Sun P.D.","Ugolini S.","Vivier E."],"citationCrossReferences":[{"database":"PubMed","id":"16141329"},{"database":"DOI","id":"10.1073/pnas.0503594102"}],"title":"Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.","publicationDate":"2005","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13224","lastPage":"13229","volume":"102"},"referencePositions":["FUNCTION","INTERACTION WITH KIR2DL1; KIR2DL2; KIR2DL3 AND KIR2DS1"]},{"referenceNumber":27,"citation":{"id":"18420581","citationType":"journal article","authors":["Martayan A.","Sibilio L.","Setini A.","Lo Monaco E.","Tremante E.","Fruci D.","Colonna M.","Giacomini P."],"citationCrossReferences":[{"database":"PubMed","id":"18420581"},{"database":"DOI","id":"10.1074/jbc.m709175200"}],"title":"N-linked glycosylation selectively regulates the generic folding of HLA-Cw1.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"16469","lastPage":"16476","volume":"283"},"referencePositions":["INTERACTION WITH THE PEPTIDE LOADING COMPLEX","MUTAGENESIS OF SER-112","GLYCOSYLATION AT ASN-110","SUBCELLULAR LOCATION"]},{"referenceNumber":28,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":29,"citation":{"id":"20104487","citationType":"journal article","authors":["Makadzange A.T.","Gillespie G.","Dong T.","Kiama P.","Bwayo J.","Kimani J.","Plummer F.","Easterbrook P.","Rowland-Jones S.L."],"citationCrossReferences":[{"database":"PubMed","id":"20104487"},{"database":"DOI","id":"10.1002/eji.200939634"}],"title":"Characterization of an HLA-C-restricted CTL response in chronic HIV infection.","publicationDate":"2010","journal":"Eur. J. Immunol.","firstPage":"1036","lastPage":"1041","volume":"40"},"referencePositions":["FUNCTION (ALLELE C*04:01)"]},{"referenceNumber":30,"citation":{"id":"20972337","citationType":"journal article","authors":["Hiby S.E.","Apps R.","Sharkey A.M.","Farrell L.E.","Gardner L.","Mulder A.","Claas F.H.","Walker J.J.","Redman C.W.","Redman C.C.","Morgan L.","Tower C.","Regan L.","Moore G.E.","Carrington M.","Moffett A."],"citationCrossReferences":[{"database":"PubMed","id":"20972337"},{"database":"DOI","id":"10.1172/jci43998"}],"title":"Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2.","publicationDate":"2010","journal":"J. Clin. Invest.","firstPage":"4102","lastPage":"4110","volume":"120"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","INTERACTION WITH KIR2DL1 AND KIR2DS1"]},{"referenceNumber":31,"citation":{"id":"20439706","citationType":"journal article","authors":["Fadda L.","Borhis G.","Ahmed P.","Cheent K.","Pageon S.V.","Cazaly A.","Stathopoulos S.","Middleton D.","Mulder A.","Claas F.H.","Elliott T.","Davis D.M.","Purbhoo M.A.","Khakoo S.I."],"citationCrossReferences":[{"database":"PubMed","id":"20439706"},{"database":"DOI","id":"10.1073/pnas.0913745107"}],"title":"Peptide antagonism as a mechanism for NK cell activation.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10160","lastPage":"10165","volume":"107"},"referencePositions":["FUNCTION (C*01:02)","INTERACTION WITH KIR2DL2 AND KIR2DL3"]},{"referenceNumber":32,"citation":{"id":"20356336","citationType":"journal article","authors":["Marsh S.G.","Albert E.D.","Bodmer W.F.","Bontrop R.E.","Dupont B.","Erlich H.A.","Fernandez-Vina M.","Geraghty D.E.","Holdsworth R.","Hurley C.K.","Lau M.","Lee K.W.","Mach B.","Maiers M.","Mayr W.R.","Mueller C.R.","Parham P.","Petersdorf E.W.","Sasazuki T.","Strominger J.L.","Svejgaard A.","Terasaki P.I.","Tiercy J.M.","Trowsdale J."],"citationCrossReferences":[{"database":"PubMed","id":"20356336"},{"database":"DOI","id":"10.1111/j.1399-0039.2010.01466.x"}],"title":"Nomenclature for factors of the HLA system, 2010.","publicationDate":"2010","journal":"Tissue Antigens","firstPage":"291","lastPage":"455","volume":"75"},"referencePositions":["NOMENCLATURE"]},{"referenceNumber":33,"citation":{"id":"24091323","citationType":"journal article","authors":["Xiong S.","Sharkey A.M.","Kennedy P.R.","Gardner L.","Farrell L.E.","Chazara O.","Bauer J.","Hiby S.E.","Colucci F.","Moffett A."],"citationCrossReferences":[{"database":"PubMed","id":"24091323"},{"database":"DOI","id":"10.1172/jci68991"}],"title":"Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation.","publicationDate":"2013","journal":"J. Clin. Invest.","firstPage":"4264","lastPage":"4272","volume":"123"},"referencePositions":["FUNCTION (ALLELE C*06:02)"]},{"referenceNumber":34,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":35,"citation":{"id":"25311805","citationType":"journal article","authors":["Rasmussen M.","Harndahl M.","Stryhn A.","Boucherma R.","Nielsen L.L.","Lemonnier F.A.","Nielsen M.","Buus S."],"citationCrossReferences":[{"database":"PubMed","id":"25311805"},{"database":"DOI","id":"10.4049/jimmunol.1401689"}],"title":"Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.","publicationDate":"2014","journal":"J. Immunol.","firstPage":"4790","lastPage":"4802","volume":"193"},"referencePositions":["FUNCTION"]},{"referenceNumber":36,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] MET-272","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":37,"citation":{"id":"29312307","citationType":"journal article","authors":["Hosie L.","Pachnio A.","Zuo J.","Pearce H.","Riddell S.","Moss P."],"citationCrossReferences":[{"database":"PubMed","id":"29312307"},{"database":"DOI","id":"10.3389/fimmu.2017.01776"}],"title":"Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8+ T-Cell Repertoire in Older People.","publicationDate":"2017","journal":"Front. Immunol.","firstPage":"1776","lastPage":"1776","volume":"8"},"referencePositions":["FUNCTION (ALLELE C*07:02)"]},{"referenceNumber":38,"citation":{"id":"37264229","citationType":"journal article","authors":["Lin Z.","Bashirova A.A.","Viard M.","Garner L.","Quastel M.","Beiersdorfer M.","Kasprzak W.K.","Akdag M.","Yuki Y.","Ojeda P.","Das S.","Andresson T.","Naranbhai V.","Horowitz A.","McMichael A.J.","Hoelzemer A.","Gillespie G.M.","Garcia-Beltran W.F.","Carrington M."],"citationCrossReferences":[{"database":"PubMed","id":"37264229"},{"database":"DOI","id":"10.1038/s41590-023-01523-z"}],"title":"HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.","publicationDate":"2023","journal":"Nat. Immunol.","firstPage":"1087","lastPage":"1097","volume":"24"},"referencePositions":["DOMAIN","POLYMORPHISM"]},{"referenceNumber":39,"citation":{"id":"10850706","citationType":"journal article","authors":["Boyington J.C.","Motyka S.A.","Schuck P.","Brooks A.G.","Sun P.D."],"citationCrossReferences":[{"database":"PubMed","id":"10850706"},{"database":"DOI","id":"10.1038/35014520"}],"title":"Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand.","publicationDate":"2000","journal":"Nature","firstPage":"537","lastPage":"543","volume":"405"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-302 (ALLELE C*03:04) IN COMPLEX WITH B2M PEPTIDE AND KIR2DL2","DISULFIDE BONDS","DOMAIN"]},{"referenceNumber":40,"citation":{"id":"11323700","citationType":"journal article","authors":["Fan Q.R.","Long E.O.","Wiley D.C."],"citationCrossReferences":[{"database":"PubMed","id":"11323700"},{"database":"DOI","id":"10.1038/87766"}],"title":"Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.","publicationDate":"2001","journal":"Nat. Immunol.","firstPage":"452","lastPage":"460","volume":"2"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 25-299 (ALLELE C*04:01) IN COMPLEX WITH B2M PEPTIDE AND KIR2DL1"]},{"referenceNumber":41,"citation":{"id":"24990997","citationType":"journal article","authors":["Choo J.A.","Liu J.","Toh X.","Grotenbreg G.M.","Ren E.C."],"citationCrossReferences":[{"database":"PubMed","id":"24990997"},{"database":"DOI","id":"10.1128/jvi.00855-14"}],"title":"The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.","publicationDate":"2014","journal":"J. Virol.","firstPage":"10613","lastPage":"10623","volume":"88"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 26-298 (ALLELE C*08:01) IN COMPLEX WITH B2M AND PEPTIDE","FUNCTION (ALLELE C*08:01)","DOMAIN","DISULFIDE BOND"]},{"referenceNumber":42,"citation":{"id":"28649982","citationType":"journal article","authors":["Kaur G.","Gras S.","Mobbs J.I.","Vivian J.P.","Cortes A.","Barber T.","Kuttikkatte S.B.","Jensen L.T.","Attfield K.E.","Dendrou C.A.","Carrington M.","McVean G.","Purcell A.W.","Rossjohn J.","Fugger L."],"citationCrossReferences":[{"database":"PubMed","id":"28649982"},{"database":"DOI","id":"10.1038/ncomms15924"}],"title":"Structural and regulatory diversity shape HLA-C protein expression levels.","publicationDate":"2017","journal":"Nat. Commun.","firstPage":"15924","lastPage":"15924","volume":"8"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 26-298 (ALLELE C*05:01) IN COMPLEX WITH B2M AND PEPTIDE","X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 26-300 (ALLELE C*07:02) IN COMPLEX WITH B2M AND PEPTIDE","SUBCELLULAR LOCATION","FUNCTION","DOMAIN"]},{"referenceNumber":43,"citation":{"id":"11122018","citationType":"journal article","authors":["Mallon E.","Bunce M.","Savoie H.","Rowe A.","Newson R.","Gotch F.","Bunker C.B."],"citationCrossReferences":[{"database":"PubMed","id":"11122018"},{"database":"DOI","id":"10.1046/j.1365-2133.2000.03885.x"}],"title":"HLA-C and guttate psoriasis.","publicationDate":"2000","journal":"Br. J. Dermatol.","firstPage":"1177","lastPage":"1182","volume":"143"},"referencePositions":["ASSOCIATION OF ALLELE C*06:02 WITH PSORIASIS"]},{"referenceNumber":44,"citation":{"id":"16235096","citationType":"journal article","authors":["Helms C.","Saccone N.L.","Cao L.","Daw J.A.W.","Cao K.","Hsu T.M.","Taillon-Miller P.","Duan S.","Gordon D.","Pierce B.","Ott J.","Rice J.","Fernandez-Vina M.A.","Kwok P.-Y.","Menter A.","Bowcock A.M."],"citationCrossReferences":[{"database":"PubMed","id":"16235096"},{"database":"DOI","id":"10.1007/s00439-005-0048-2"}],"title":"Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.","publicationDate":"2005","journal":"Hum. Genet.","firstPage":"466","lastPage":"476","volume":"118"},"referencePositions":["ASSOCIATION OF ALLELE C*06:02 WITH PSORIASIS"]},{"referenceNumber":45,"citation":{"id":"16642438","citationType":"journal article","authors":["Nair R.P.","Stuart P.E.","Nistor I.","Hiremagalore R.","Chia N.V.C.","Jenisch S.","Weichenthal M.","Abecasis G.R.","Lim H.W.","Christophers E.","Voorhees J.J.","Elder J.T."],"citationCrossReferences":[{"database":"PubMed","id":"16642438"},{"database":"DOI","id":"10.1086/503821"}],"title":"Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.","publicationDate":"2006","journal":"Am. J. Hum. Genet.","firstPage":"827","lastPage":"851","volume":"78"},"referencePositions":["INVOLVEMENT IN PSORS1 (ALLELE C*06:02)"]},{"referenceNumber":46,"citation":{"id":"26621454","citationType":"journal article","authors":["Arakawa A.","Siewert K.","Stoehr J.","Besgen P.","Kim S.M.","Ruehl G.","Nickel J.","Vollmer S.","Thomas P.","Krebs S.","Pinkert S.","Spannagl M.","Held K.","Kammerbauer C.","Besch R.","Dornmair K.","Prinz J.C."],"citationCrossReferences":[{"database":"PubMed","id":"26621454"},{"database":"DOI","id":"10.1084/jem.20151093"}],"title":"Melanocyte antigen triggers autoimmunity in human psoriasis.","publicationDate":"2015","journal":"J. Exp. Med.","firstPage":"2203","lastPage":"2212","volume":"212"},"referencePositions":["INVOLVEMENT IN PSORS1 (ALLELE C*06:02)"]},{"referenceNumber":47,"citation":{"id":"28650991","citationType":"journal article","authors":["Robinson J.","Guethlein L.A.","Cereb N.","Yang S.Y.","Norman P.J.","Marsh S.G.E.","Parham P."],"citationCrossReferences":[{"database":"PubMed","id":"28650991"},{"database":"DOI","id":"10.1371/journal.pgen.1006862"}],"title":"Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.","publicationDate":"2017","journal":"PLoS Genet.","firstPage":"E1006862","lastPage":"E1006862","volume":"13"},"referencePositions":["POLYMORPHISM"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M24097","properties":[{"key":"ProteinId","value":"AAA59656.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X58536","properties":[{"key":"ProteinId","value":"CAA41427.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M84386","properties":[{"key":"ProteinId","value":"AAA59705.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M84171","properties":[{"key":"ProteinId","value":"AAA59685.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M84172","properties":[{"key":"ProteinId","value":"AAA59686.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M84174","properties":[{"key":"ProteinId","value":"AAA59688.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X70856","properties":[{"key":"ProteinId","value":"CAA50209.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X67818","properties":[{"key":"ProteinId","value":"CAA48029.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X83394","properties":[{"key":"ProteinId","value":"CAA58313.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D38526","properties":[{"key":"ProteinId","value":"BAA07531.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D49819","properties":[{"key":"ProteinId","value":"BAA08625.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X96582","properties":[{"key":"ProteinId","value":"CAA65401.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U62824","properties":[{"key":"ProteinId","value":"AAB67322.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X98742","properties":[{"key":"ProteinId","value":"CAA67294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ010748","properties":[{"key":"ProteinId","value":"CAA09340.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M28172","properties":[{"key":"ProteinId","value":"AAA59670.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M24030","properties":[{"key":"ProteinId","value":"AAA59671.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z22752","properties":[{"key":"ProteinId","value":"CAA80437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z22753","properties":[{"key":"ProteinId","value":"CAA80437.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z22754","properties":[{"key":"ProteinId","value":"CAA80437.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y18533","properties":[{"key":"ProteinId","value":"CAB71800.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y18534","properties":[{"key":"ProteinId","value":"CAB71800.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y18535","properties":[{"key":"ProteinId","value":"CAB71800.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Y18536","properties":[{"key":"ProteinId","value":"CAB71800.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ293016","properties":[{"key":"ProteinId","value":"CAC04321.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ293017","properties":[{"key":"ProteinId","value":"CAC04322.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ278494","properties":[{"key":"ProteinId","value":"CAB95011.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ420250","properties":[{"key":"ProteinId","value":"CAD12435.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AJ420253","properties":[{"key":"ProteinId","value":"CAD12438.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M99389","properties":[{"key":"ProteinId","value":"AAA88088.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U41386","properties":[{"key":"ProteinId","value":"AAC32743.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U57028","properties":[{"key":"ProteinId","value":"AAD11469.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL671883","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS34393.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10321-1"},{"database":"RefSeq","id":"NP_002108.4","properties":[{"key":"NucleotideSequenceId","value":"NM_002117.6"}],"isoformId":"P10321-1"},{"database":"PDB","id":"1EFX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=26-302"}]},{"database":"PDB","id":"1IM9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/E=26-299"}]},{"database":"PDB","id":"1QQD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"3BZF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"P/Q=3-11"}]},{"database":"PDB","id":"4NT6","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"5VGD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.32 A"},{"key":"Chains","value":"A=26-302"}]},{"database":"PDB","id":"5VGE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=26-300"}]},{"database":"PDB","id":"5W67","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=25-300"}]},{"database":"PDB","id":"5W69","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/C/E/G=25-300"}]},{"database":"PDB","id":"5W6A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A/C=25-300"}]},{"database":"PDB","id":"6JTO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"6PA1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"A/E=25-301"}]},{"database":"PDB","id":"6PAG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=25-302"}]},{"database":"PDBsum","id":"1EFX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IM9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1QQD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3BZF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NT6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VGD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VGE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W67","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W69","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5W6A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6JTO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PA1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6PAG","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"MDRepo","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109352","properties":[{"key":"Interactions","value":"536"}]},{"database":"ComplexPortal","id":"CPX-26561","properties":[{"key":"EntryName","value":"Classical MHC Ia complex, HLA-C-B2M"}]},{"database":"FunCoup","id":"P10321","properties":[{"key":"Number of interactors","value":"1634"}]},{"database":"IntAct","id":"P10321","properties":[{"key":"Interactions","value":"273"}]},{"database":"MINT","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-HLA-C","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000365402","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6066967","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"9.A.75.1.3","properties":[{"key":"FamilyName","value":"the mhc ii receptor (mhc2r) family"}]},{"database":"GlyConnect","id":"P10321","properties":[{"key":"glycosylation","value":"4 N-Linked glycans (1 site)"}]},{"database":"GlyCosmos","id":"P10321","properties":[{"key":"glycosylation","value":"2 sites, 5 glycans"}]},{"database":"GlyGen","id":"P10321","properties":[{"key":"glycosylation","value":"5 sites, 5 N-linked glycans (1 site), 2 O-linked glycans (4 sites)"}]},{"database":"iPTMnet","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HLA-C","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"34223716","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000365402","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51687","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52599","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54698","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54699","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54700","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54701","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54702","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54703","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58493","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61274","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61277","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61278","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"61279","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"75736","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"83917","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"26870","properties":[{"key":"antibodies","value":"376 antibodies from 30 providers"}]},{"database":"CPTC","id":"P10321","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"3107","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000376228.10","properties":[{"key":"ProteinId","value":"ENSP00000365402.5"},{"key":"GeneId","value":"ENSG00000204525.19"}],"isoformId":"P10321-1"},{"database":"GeneID","id":"3107","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3107","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000376228.10","properties":[{"key":"ProteinId","value":"ENSP00000365402.5"},{"key":"RefSeqNucleotideId","value":"NM_002117.6"},{"key":"RefSeqProteinId","value":"NP_002108.4"}]},{"database":"UCSC","id":"uc063wnd.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"UCSC","id":"uc063yse.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4933","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"3107","properties":[{"key":"Number of evidences","value":"2 evidence items across 2 molecular profiles"}]},{"database":"ClinPGx","id":"PA35057","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3107","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3107","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HLA-C","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4933","properties":[{"key":"GeneName","value":"HLA-C"}]},{"database":"HPA","id":"ENSG00000204525","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid)"}]},{"database":"MalaCards","id":"HLA-C","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"177900","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000204525","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"585909","properties":[{"key":"Disease","value":"B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204525","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RQEK","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01120000271826","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DYMERET","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P10321","properties":[{"key":"Number of GO annotations","value":"9 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1236974","properties":[{"key":"PathwayName","value":"ER-Phagosome pathway"}]},{"database":"Reactome","id":"R-HSA-1236977","properties":[{"key":"PathwayName","value":"Endosomal/Vacuolar pathway"}]},{"database":"Reactome","id":"R-HSA-198933","properties":[{"key":"PathwayName","value":"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"}]},{"database":"Reactome","id":"R-HSA-2172127","properties":[{"key":"PathwayName","value":"DAP12 interactions"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-877300","properties":[{"key":"PathwayName","value":"Interferon gamma signaling"}]},{"database":"Reactome","id":"R-HSA-909733","properties":[{"key":"PathwayName","value":"Interferon alpha/beta signaling"}]},{"database":"Reactome","id":"R-HSA-9705671","properties":[{"key":"PathwayName","value":"SARS-CoV-2 activates/modulates innate and adaptive immune responses"}]},{"database":"Reactome","id":"R-HSA-983170","properties":[{"key":"PathwayName","value":"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"}]},{"database":"SignaLink","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000204525","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3107","properties":[{"key":"hits","value":"296 hits in 1058 CRISPR screens"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P10321","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"HLA-C","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3107","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P10321","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P10321","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"Bgee","id":"ENSG00000204525","properties":[{"key":"ExpressionPatterns","value":"Expressed in blood and 99 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P10321","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22031944"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9754572"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20946353"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12486241"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20946353"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0042612","properties":[{"key":"GoTerm","value":"C:MHC class I protein complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22031944"}]},{"database":"GO","id":"GO:0032398","properties":[{"key":"GoTerm","value":"C:MHC class Ib protein complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10429675"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18420581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20972337"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28649982"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030667","properties":[{"key":"GoTerm","value":"C:secretory granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030881","properties":[{"key":"GoTerm","value":"F:beta-2-microglobulin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042605","properties":[{"key":"GoTerm","value":"F:peptide antigen binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22031944"}]},{"database":"GO","id":"GO:0048018","properties":[{"key":"GoTerm","value":"F:receptor ligand activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12486241"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0046977","properties":[{"key":"GoTerm","value":"F:TAP binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8617941"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8805302"}]},{"database":"GO","id":"GO:0002486","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22031944"}]},{"database":"GO","id":"GO:0002476","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002477","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation of exogenous peptide antigen via MHC class Ib"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10429675"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045954","properties":[{"key":"GoTerm","value":"P:positive regulation of natural killer cell mediated cytotoxicity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12486241"}]},{"database":"GO","id":"GO:0001916","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell mediated cytotoxicity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002715","properties":[{"key":"GoTerm","value":"P:regulation of natural killer cell mediated immunity"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10429675"}]},{"database":"CDD","id":"cd07698","properties":[{"key":"EntryName","value":"IgC1_MHC_I_alpha3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA","length":366,"molWeight":40649,"crc64":"59C23D95FD1D0BC8","md5":"59F04E9673074518E8BD30CFC9D88D00"},"extraAttributes":{"countByCommentType":{"FUNCTION":9,"SUBUNIT":2,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":4,"PTM":1,"POLYMORPHISM":1,"DISEASE":1,"MISCELLANEOUS":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":1,"Region":5,"Binding site":5,"Modified residue":2,"Glycosylation":1,"Disulfide bond":2,"Alternative sequence":2,"Natural variant":75,"Mutagenesis":1,"Beta strand":19,"Turn":1,"Helix":10},"uniParcId":"UPI000008AEBB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A173AD40","uniProtkbId":"A0A173AD40_HUMAN","entryAudit":{"firstPublicDate":"2016-09-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-09-07","entryVersion":54,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA51917.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA51917.1"}],"value":"HLA-C alpha chain"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA51917.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5015052222"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"8225443","citationType":"journal article","authors":["Pablo R.","Vilches C.","Moreno M.E.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"8225443"},{"database":"DOI","id":"10.1007/BF00171805"}],"title":"A novel HLA-C allele (Cw*1504) related to the Cw6.2 phenotype.","publicationDate":"1994","journal":"Immunogenetics","firstPage":"79","lastPage":"79","volume":"39"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA51917.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X73518","properties":[{"key":"ProteinId","value":"CAA51917.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A173AD40","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A173AD40","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLLLLLSGALALTETWACSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQTDRVNLRKLRGYYNQSEAGSHIIQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40863,"crc64":"02401B71897E240A","md5":"42F86D7BC84E65EA3F5A6147F9498C4B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000008A00E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A3S6RG30","uniProtkbId":"A0A3S6RG30_HUMAN","entryAudit":{"firstPublicDate":"2019-05-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-05-08","entryVersion":32,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AUQ33514.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AUQ33514.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AUQ33514.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5019334754"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HLJ"}]},{"type":"Disulfide bond","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HLJ"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HLJ"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FIDGGJ4Q7C8UD","citationType":"submission","authors":["Cereb N.","Yang S.Y."],"title":"HLA new alleles found by Histogenetics.","publicationDate":"DEC-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AUQ33514.1"}]},{"referenceNumber":2,"citation":{"id":"40877317","citationType":"journal article","authors":["Goto Y.","Ahn Y.M.","Toyoda M.","Hamana H.","Jin Y.","Aritsu Y.","Nakama T.","Tajima Y.","Maddumage J.C.","Li H.","Kitamatsu M.","Kishi H.","Yonekawa A.","Jayasinghe D.","Shimono N.","Nagasaki Y.","Minami R.","Toya T.","Sekiya N.","Tomita Y.","Chatzileontiadou D.S.M.","Nakata H.","Nakagawa S.","Sakagami T.","Ueno T.","Gras S.","Motozono C."],"citationCrossReferences":[{"database":"PubMed","id":"40877317"},{"database":"DOI","id":"10.1038/s41467-025-63288-3"}],"title":"Molecular basis of potent antiviral HLA-C-restricted CD8<sup>+</sup> T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope.","publicationDate":"2025","journal":"Nat. Commun.","firstPage":"8062","lastPage":"8062","volume":"16"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) OF 26-366","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HLJ"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG603119","properties":[{"key":"ProteinId","value":"AUQ33514.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"9HLJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"A=26-366"}]},{"database":"AlphaFoldDB","id":"A0A3S6RG30","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A3S6RG30","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A3S6RG30","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAWSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40969,"crc64":"5D94D34995903724","md5":"BEA4F84A95E06AD40D4424A9DECF34B4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI000FF8F7C2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A583ZBW7","uniProtkbId":"A0A583ZBW7_HUMAN","entryAudit":{"firstPublicDate":"2019-10-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-10-16","entryVersion":26,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59701.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59701.1"}],"value":"HLA-C protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59701.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5022233550"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2708822","citationType":"journal article","authors":["Ellis S.A.","Strachan T.","Palmer M.S.","McMichael A.J."],"citationCrossReferences":[{"database":"PubMed","id":"2708822"}],"title":"Complete nucleotide sequence of a unique HLA class I C locus product expressed on the human choriocarcinoma cell line BeWo.","publicationDate":"1989","journal":"J. Immunol.","firstPage":"3281","lastPage":"3285","volume":"142"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59701.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M26429","properties":[{"key":"ProteinId","value":"AAA59701.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A583ZBW7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A583ZBW7","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"A0A583ZBW7","properties":[{"key":"Interactions","value":"4"}]},{"database":"PeptideAtlas","id":"A0A583ZBW7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMEPRTLILLLSGALALTETWACSHSMKYFFTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYNRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMCGCDLGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEERRAYLEGTCVEWLRRYLENGKESLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVMVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIASKA","length":366,"molWeight":40965,"crc64":"285CCFCB92788744","md5":"A9016605C424B020B88CC512BBDA838D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000124E74"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A583ZBW9","uniProtkbId":"A0A583ZBW9_HUMAN","entryAudit":{"firstPublicDate":"2019-10-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-10-16","entryVersion":23,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}],"value":"MHC I HLA-Cx52"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2843461","citationType":"journal article","authors":["Takata H.","Inoko H.","Ando A.","Haranaka M.","Watanabe B.","Tsuji K.","Iri H."],"citationCrossReferences":[{"database":"PubMed","id":"2843461"},{"database":"DOI","id":"10.1007/BF00345504"}],"title":"Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.","publicationDate":"1988","journal":"Immunogenetics","firstPage":"265","lastPage":"270","volume":"28"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}],"value":"Periperal blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59847.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M21963","properties":[{"key":"ProteinId","value":"AAA59847.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A583ZBW9","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A583ZBW9","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYDQVAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":325,"molWeight":36287,"crc64":"76FE2654B36F1EBC","md5":"F189F6E63A58105C682B90A8FBC09FEC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI000016AD5B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T3P0R0","uniProtkbId":"A0A7T3P0R0_HUMAN","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":19,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QPZ44574.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QPZ44574.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QPZ44574.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5031296408"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-10J69236M1S02","citationType":"submission","authors":["Qu J.","Wang X.","Cui Y."],"publicationDate":"FEB-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QPZ44574.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT090745","properties":[{"key":"ProteinId","value":"QPZ44574.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A7T3P0R0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A7T3P0R0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARTAEQLRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIMGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40805,"crc64":"2A9FCF1392BB486A","md5":"E7E6FB57EA962787B01F9C593CCCC56C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI001935DCE9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A866W3Y5","uniProtkbId":"A0A866W3Y5_HUMAN","entryAudit":{"firstPublicDate":"2021-09-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-09-29","entryVersion":18,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77917.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77917.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77917.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5032748693"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77917.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-CMUVTL5PR4N0V","citationType":"submission","authors":["Yang E.K.L.","Li T.Y."],"publicationDate":"MAY-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77917.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT542321","properties":[{"key":"ProteinId","value":"QOE77917.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A866W3Y5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A866W3Y5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A866W3Y5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMKYFFTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMCGCDLGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVMVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":365,"molWeight":40879,"crc64":"ADF8886B5FCE22C9","md5":"9725542A3C3388FE9E38A39EBB259A7E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00025744A4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B2G4X1","uniProtkbId":"B2G4X1_HUMAN","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-06-10","entryVersion":90,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002776162"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8CKIJ8FCIHN9C","citationType":"submission","authors":["Anholts J.D.H."],"publicationDate":"APR-2008","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}]},{"referenceNumber":2,"citation":{"id":"19744147","citationType":"journal article","authors":["Anholts J.D.","Aneq M.","Dirks H.L.","Tas A.","Verduyn W.","Oudshoorn M."],"citationCrossReferences":[{"database":"PubMed","id":"19744147"},{"database":"DOI","id":"10.1111/j.1399-0039.2009.01334.x"}],"title":"Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1.","publicationDate":"2009","journal":"Tissue Antigens","firstPage":"424","lastPage":"428","volume":"74"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAQ51272.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AM991287","properties":[{"key":"ProteinId","value":"CAQ51272.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B2G4X1","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B2G4X1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFSTSVSWPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPREPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEAGSHTLQRMFGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWKPSSQPTIPIVGIVAGLAVLAVLAVLGAMVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":365,"molWeight":40880,"crc64":"02EB3969348DCBE7","md5":"11E3A611B01FDAB05268D4F724DE52B3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI0001739F5F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C1K0Y1","uniProtkbId":"C1K0Y1_HUMAN","entryAudit":{"firstPublicDate":"2009-05-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-26","entryVersion":115,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACN97199.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CEF48080.1"}],"value":"HLA class I antigen"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59687.1"}],"value":"Lymphocyte antigen"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACN97199.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACN97199.1"}],"value":"HLA-Cw"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59687.1"}],"value":"HLA-C"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5015087677"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTN"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTP"}]},{"type":"Disulfide bond","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTN"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTP"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTN"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTP"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2715640","citationType":"journal article","authors":["Parham P.","Lawlor D.A.","Lomen C.E.","Ennis P.D."],"citationCrossReferences":[{"database":"PubMed","id":"2715640"}],"title":"Diversity and diversification of HLA-A,B,C alleles.","publicationDate":"1989","journal":"J. Immunol.","firstPage":"3937","lastPage":"3950","volume":"142"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59687.1"}]},{"referenceNumber":2,"citation":{"id":"1384166","citationType":"journal article","authors":["Zemmour J.","Gumperz J.E.","Hildebrand W.H.","Ward F.E.","Marsh S.G.E.","Williams R.C.","Parham P."],"citationCrossReferences":[{"database":"PubMed","id":"1384166"},{"database":"DOI","id":"10.1111/j.1399-0039.1992.tb01943.x"}],"title":"The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes.","publicationDate":"1992","journal":"Tissue Antigens","firstPage":"249","lastPage":"257","volume":"39"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA59687.1"}]},{"referenceNumber":3,"citation":{"id":"CI-26JA6VOHFF6IF","citationType":"submission","authors":["Xu Y.","Deng Z.","Yang B."],"title":"HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region.","publicationDate":"FEB-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACN97199.1"}]},{"referenceNumber":4,"citation":{"id":"CI-F8GKTP9KF1ISV","citationType":"journal article","authors":["Xu Y.-P.","Yang B.-C.","Zeng J.-Q.","Wang D.-M.","Deng Z.-H."],"title":"Characterization of the genomic full-length sequence of HLA-Cw*010201, Cw*0706, and Cw*0801 in Chinese individuals.","publicationDate":"2010","journal":"Tissue Antigens","firstPage":"179","lastPage":"181","volume":"75"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACN97199.1"}]},{"referenceNumber":5,"citation":{"id":"CI-13BNE6TNAUCH","citationType":"submission","authors":["McWhinnie A.J.","Robinson J."],"title":"Full gene sequence of new HLA-C allele C*08new.","publicationDate":"NOV-2013","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CDK41175.1"}],"value":"Saliva collection","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CDK41175.1"}]},{"referenceNumber":6,"citation":{"id":"28547825","citationType":"journal article","authors":["Albrecht V.","Zweiniger C.","Surendranath V.","Lang K.","Schofl G.","Dahl A.","Winkler S.","Lange V.","Bohme I.","Schmidt A.H."],"citationCrossReferences":[{"database":"PubMed","id":"28547825"},{"database":"DOI","id":"10.1111/tan.13057"}],"title":"Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.","publicationDate":"2017","journal":"HLA","firstPage":"79","lastPage":"87","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CEF48080.1"}]},{"referenceNumber":7,"citation":{"id":"32461371","citationType":"journal article","authors":["Sim M.J.W.","Lu J.","Spencer M.","Hopkins F.","Tran E.","Rosenberg S.A.","Long E.O.","Sun P.D."],"citationCrossReferences":[{"database":"PubMed","id":"32461371"},{"database":"DOI","id":"10.1073/pnas.1921964117"}],"title":"High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.","publicationDate":"2020","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12826","lastPage":"12835","volume":"117"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 25-298","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ULI"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6ULK"}]},{"referenceNumber":8,"citation":{"id":"33537173","citationType":"journal article","authors":["Bai P.","Li Y.","Zhou Q.","Xia J.","Wei P.C.","Deng H.","Wu M.","Chan S.K.","Kappler J.W.","Zhou Y.","Tran E.","Marrack P.","Yin L."],"citationCrossReferences":[{"database":"PubMed","id":"33537173"},{"database":"DOI","id":"10.1080/2162402x.2020.1868130"}],"title":"Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy.","publicationDate":"2021","journal":"OncoImmunology","firstPage":"1868130","lastPage":"1868130","volume":"10"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 26-298","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTN"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"6JTP"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M84173","properties":[{"key":"ProteinId","value":"AAA59687.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"FJ785733","properties":[{"key":"ProteinId","value":"ACN97199.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HG794366","properties":[{"key":"ProteinId","value":"CDK41175.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"LN600090","properties":[{"key":"ProteinId","value":"CEF48080.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"6JTN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"6JTP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"6ULI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"A=25-298"}]},{"database":"PDB","id":"6ULK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=25-298"}]},{"database":"PDB","id":"6ULN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"A=25-298"}]},{"database":"PDB","id":"6ULR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=25-298"}]},{"database":"PDB","id":"6UON","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/D=25-298"}]},{"database":"PDBsum","id":"6JTN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6JTP","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"C1K0Y1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C1K0Y1","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40871,"crc64":"D343B054568EA32C","md5":"B15A8232E3E0D966ACE89F125650DA57"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":2},"uniParcId":"UPI0000124E7C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C5IYE7","uniProtkbId":"C5IYE7_HUMAN","entryAudit":{"firstPublicDate":"2009-07-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-07-28","entryVersion":107,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA53783.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA53783.1"}],"value":"HLA-C alpha chain (Cw*CL10V)"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA53783.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014569020"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7860363","citationType":"journal article","authors":["Vilches C.","Herrero M.J.","de Pablo R.","Moreno M.E.","Bunce M.","Kreisler M."],"citationCrossReferences":[{"database":"PubMed","id":"7860363"},{"database":"DOI","id":"10.1016/0198-8859(94)90011-6"}],"title":"Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw*1602.","publicationDate":"1994","journal":"Hum. Immunol.","firstPage":"167","lastPage":"170","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAA53783.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X76189","properties":[{"key":"ProteinId","value":"CAA53783.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"C5IYE7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"C5IYE7","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"C5IYE7","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40855,"crc64":"2848E9237F7F8297","md5":"DF0BDD3F299627BC2D7AC16AD93313E4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000008ADB3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8SNA8","uniProtkbId":"Q8SNA8_HUMAN","entryAudit":{"firstPublicDate":"2002-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-06-01","entryVersion":134,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA00027.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA00027.1"}],"value":"MHC HLA-Cw11 chain"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA00027.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA00027.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"2715640","citationType":"journal article","authors":["Parham P.","Lawlor D.A.","Lomen C.E.","Ennis P.D."],"citationCrossReferences":[{"database":"PubMed","id":"2715640"}],"title":"Diversity and diversification of HLA-A,B,C alleles.","publicationDate":"1989","journal":"J. Immunol.","firstPage":"3937","lastPage":"3950","volume":"142"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA00027.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M24031","properties":[{"key":"ProteinId","value":"AAA00027.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"A59028","properties":[{"key":"EntryName","value":"A59028"}]},{"database":"PIR","id":"C37028","properties":[{"key":"EntryName","value":"C37028"}]},{"database":"AlphaFoldDB","id":"Q8SNA8","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8SNA8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARTAEQLRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":341,"molWeight":38059,"crc64":"5B08CA847644264E","md5":"FD042313BF5C628EEA9C2B88BE4E37B7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI000008A614"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A140T9W2","uniProtkbId":"A0A140T9W2_HUMAN","entryAudit":{"firstPublicDate":"2016-05-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-05-11","entryVersion":44,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415025.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415025.2"}],"value":"Major histocompatibility complex, class I, C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415025.2"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5007305487"},{"type":"Transmembrane","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A140T9W2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A140T9W2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":2,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000415025.2"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A140T9W2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A140T9W2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A140T9W2","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000433153.6","properties":[{"key":"ProteinId","value":"ENSP00000415025.2"},{"key":"GeneId","value":"ENSG00000225691.7"}]},{"database":"HGNC","id":"HGNC:4933","properties":[{"key":"GeneName","value":"HLA-C"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSASNSAQGSDESLIACKA","length":355,"molWeight":39941,"crc64":"F468D044543F139D","md5":"74C7D0D7856EBA75FA10CAFC477D0942"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1},"uniParcId":"UPI000165DCA7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1W2PRX1","uniProtkbId":"A0A1W2PRX1_HUMAN","entryAudit":{"firstPublicDate":"2017-06-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2017-06-07","entryVersion":39,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000492523.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000492523.1"}],"value":"Major histocompatibility complex, class I, C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000492523.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A1W2PRX1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A1W2PRX1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":2,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000492523.1"}]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"A0A1W2PRX1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A1W2PRX1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A1W2PRX1","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000639331.1","properties":[{"key":"ProteinId","value":"ENSP00000492523.1"},{"key":"GeneId","value":"ENSG00000228299.9"}]},{"database":"HGNC","id":"HGNC:4933","properties":[{"key":"GeneName","value":"HLA-C"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":244,"molWeight":26887,"crc64":"71F96684676A1483","md5":"F1FCFA936F5C6574B67758AF9C7352EC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0009B4EC77"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2R4FYN5","uniProtkbId":"A0A2R4FYN5_HUMAN","entryAudit":{"firstPublicDate":"2018-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-06-20","entryVersion":32,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVT42619.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVT42619.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVT42619.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5033319574"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"29549179","citationType":"journal article","authors":["Nemat-Gorgani N.","Hilton H.G.","Henn B.M.","Lin M.","Gignoux C.R.","Myrick J.W.","Werely C.J.","Granka J.M.","Moller M.","Hoal E.G.","Yawata M.","Yawata N.","Boelen L.","Asquith B.","Parham P.","Norman P.J."],"citationCrossReferences":[{"database":"PubMed","id":"29549179"}],"title":"Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa.","publicationDate":"2018","journal":"J. Immunol.","firstPage":"2640","lastPage":"2655","volume":"200"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVT42619.1"}]},{"referenceNumber":2,"citation":{"id":"CI-3KDG6FQSR5836","citationType":"submission","authors":["Cereb N.","Yang S.Y."],"title":"HLA new alleles found by Histogenetics.","publicationDate":"SEP-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AZL48880.1"}]},{"referenceNumber":3,"citation":{"id":"CI-6JBN62OS54F6U","citationType":"submission","authors":["Lazaro A.","Hou L.","Enriquez E.","Hurley C.K."],"publicationDate":"DEC-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QHD25642.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG584051","properties":[{"key":"ProteinId","value":"AUQ33495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"MG491998","properties":[{"key":"ProteinId","value":"AVT42619.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"MH974043","properties":[{"key":"ProteinId","value":"AZL48880.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"MK165855","properties":[{"key":"ProteinId","value":"AZU90354.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"MN853598","properties":[{"key":"ProteinId","value":"QHD25642.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A2R4FYN5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A2R4FYN5","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A2R4FYN5","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLLLLLSGALALTETWACSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQTDRVNLRKLRGYYNQSEAGSHIIQRMYGCDLGPDGRLLRGHDQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQQDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40869,"crc64":"41061F3CB71FD335","md5":"36833BF2FDEA100F02421319355FA33C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000D20EEA9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A583ZC41","uniProtkbId":"A0A583ZC41_HUMAN","entryAudit":{"firstPublicDate":"2019-10-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-10-16","entryVersion":26,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC18746.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC18746.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC18746.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5022208795"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11972880","citationType":"journal article","authors":["Cox S.T.","Ogilvie H.","Bohan E.M.","Holman R.","Prentice H.G.","Potter M.","Madrigal J.A.","Little A.-M."],"citationCrossReferences":[{"database":"PubMed","id":"11972880"},{"database":"DOI","id":"10.1034/j.1399-0039.2002.590110.x"}],"title":"Sequence of two new HLA-Cw alleles: HLA-Cw*0313 and HLA-Cw*1208.","publicationDate":"2002","journal":"Tissue Antigens","firstPage":"49","lastPage":"51","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAC18746.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ298116","properties":[{"key":"ProteinId","value":"CAC18746.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A583ZC41","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A583ZC41","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEARSHTLQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40948,"crc64":"E0CC568797EF6D9F","md5":"DCEC48A2609044A47BB4DC5664C4B526"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000089F0F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A6F8VJ76","uniProtkbId":"A0A6F8VJ76_HUMAN","entryAudit":{"firstPublicDate":"2020-08-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2020-10-07","entryVersion":24,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCB28913.2"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCB28913.2"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCB28913.2"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5026970871"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4G"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4H"}]},{"type":"Disulfide bond","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4G"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4H"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCB28913.2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4G"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4H"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-9I1C3IDBOK0IJ","citationType":"submission","authors":["Shimizu M.","Uchida M.","Takada S."],"title":"HLA-C*JRC-C-020.","publicationDate":"MAR-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BCB28913.2"}]},{"referenceNumber":2,"citation":{"id":"40185448","citationType":"journal article","authors":["Liu Q.","Yang M.","Zhong P.","Wei Q.","Jiao H.","Meng J.","Ding L.","Zhu X.","Wei P."],"citationCrossReferences":[{"database":"PubMed","id":"40185448"},{"database":"DOI","id":"10.1016/j.ijbiomac.2025.142772"}],"title":"Micropolymorphism outside the peptide-binding groove of human leukocyte antigen (HLA)-C*14 modulates structural stability and shapes immune responses.","publicationDate":"2025","journal":"Int. J. Biol. Macromol.","firstPage":"142772","lastPage":"142772","volume":"309"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 26-298","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4G"},{"evidenceCode":"ECO:0007829","source":"PDB","id":"9L4H"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"LC533104","properties":[{"key":"ProteinId","value":"BCB28913.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"9L4G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"PDB","id":"9L4H","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=26-298"}]},{"database":"AlphaFoldDB","id":"A0A6F8VJ76","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A6F8VJ76","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A6F8VJ76","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFSTSVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMFGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":365,"molWeight":40748,"crc64":"DC446777E0150C12","md5":"AD80B4420265DB78A8342CAB14B378E4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Disulfide bond":2,"Non-terminal residue":1},"uniParcId":"UPI0015987312"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A866W2K2","uniProtkbId":"A0A866W2K2_HUMAN","entryAudit":{"firstPublicDate":"2021-09-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-09-29","entryVersion":18,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77923.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77923.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77923.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5032987143"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77923.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-CMUVMET1M5RSP","citationType":"submission","authors":["Yang E.K.L.","Li T.Y."],"publicationDate":"SEP-2020","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QOE77923.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT951236","properties":[{"key":"ProteinId","value":"QOE77923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A866W2K2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A0A866W2K2","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVRFDSDPASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQWRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":365,"molWeight":40795,"crc64":"9FEA59189659669C","md5":"76B07D9E191919252FE8AD4C4959707F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI001AF31C31"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6H578","uniProtkbId":"A6H578_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-07-24","entryVersion":107,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}],"value":"HLA-C"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002698080"},{"type":"Transmembrane","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-4AKI9JIKQASHB","citationType":"submission","authors":["Anholts J.D.H."],"publicationDate":"JUN-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}]},{"referenceNumber":2,"citation":{"id":"19744147","citationType":"journal article","authors":["Anholts J.D.","Aneq M.","Dirks H.L.","Tas A.","Verduyn W.","Oudshoorn M."],"citationCrossReferences":[{"database":"PubMed","id":"19744147"},{"database":"DOI","id":"10.1111/j.1399-0039.2009.01334.x"}],"title":"Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1.","publicationDate":"2009","journal":"Tissue Antigens","firstPage":"424","lastPage":"428","volume":"74"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO00835.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AM748044","properties":[{"key":"ProteinId","value":"CAO00835.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A6H578","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6H578","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07698","properties":[{"key":"EntryName","value":"IgC1_MHC_I_alpha3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAASSNSAQGSDESLITCK","length":365,"molWeight":40561,"crc64":"D53D95FD1D0BC837","md5":"32D39E0165CED5B05114BD05A33ED896"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0001574D3B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A6YS06","uniProtkbId":"A6YS06_HUMAN","entryAudit":{"firstPublicDate":"2007-08-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-08-21","entryVersion":96,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR58849.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR58849.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR58849.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002705752"},{"type":"Transmembrane","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR58849.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17900285","citationType":"journal article","authors":["Endres R.O.","Redman H.","Baumbach A.","Capper J."],"citationCrossReferences":[{"database":"PubMed","id":"17900285"},{"database":"DOI","id":"10.1111/j.1399-0039.2007.00940.x"}],"title":"A novel HLA-C locus allele with codon 54 deletion, Cw*0346.","publicationDate":"2007","journal":"Tissue Antigens","firstPage":"524","lastPage":"525","volume":"70"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABR58849.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF650024","properties":[{"key":"ProteinId","value":"ABR58849.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A6YS06","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A6YS06","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":364,"molWeight":40662,"crc64":"9A68BBB608E99DE3","md5":"2F554043329765F13609EFDC9E5DF6C3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI000157B08D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7MAP6","uniProtkbId":"A7MAP6_HUMAN","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-10-02","entryVersion":96,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002713074"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-4AKI28V6M35DS","citationType":"submission","authors":["Anholts J.D.H."],"publicationDate":"AUG-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}]},{"referenceNumber":2,"citation":{"id":"19744147","citationType":"journal article","authors":["Anholts J.D.","Aneq M.","Dirks H.L.","Tas A.","Verduyn W.","Oudshoorn M."],"citationCrossReferences":[{"database":"PubMed","id":"19744147"},{"database":"DOI","id":"10.1111/j.1399-0039.2009.01334.x"}],"title":"Thirty-six novel HLA alleles: 7 HLA-A, 11 HLA-B, 15 HLA-C and 3 HLA-DRB1.","publicationDate":"2009","journal":"Tissue Antigens","firstPage":"424","lastPage":"428","volume":"74"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}],"value":"Blood","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAO98750.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AM849814","properties":[{"key":"ProteinId","value":"CAO98750.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7MAP6","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A7MAP6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFSTSVSWPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPREPWVEQEGPEYWDRETQKYKRQAQADRVNLRKLRGYYNQSEDGSHTLQRMFGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWKPSSQPTIPIVGIVAGLAVLAVLAVLGAMVAVVMCRRKSSGGKGGSCSQAASTNSAQGSDESLIACK","length":365,"molWeight":40938,"crc64":"43EB3968658DCD3E","md5":"07EAEDBDEF56797083289A6B91A19FE1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00015BFD11"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B8YBG3","uniProtkbId":"B8YBG3_HUMAN","entryAudit":{"firstPublicDate":"2009-03-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-03-03","entryVersion":115,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QAV56460.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QAV56460.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QAV56460.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5015087483"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"29329284","citationType":"journal article","authors":["Li H.","Ivarsson M.A.","Walker-Sperling V.E.","Subleski J.","Johnson J.K.","Wright P.W.","Carrington M.","Bjorkstrom N.K.","McVicar D.W.","Anderson S.K."],"citationCrossReferences":[{"database":"PubMed","id":"29329284"},{"database":"DOI","id":".1371/journal.pgen.1007163"}],"title":"Identification of an elaborate NK-specific system regulating HLA-C expression.","publicationDate":"2018","journal":"PLoS Genet.","firstPage":"e1007163","lastPage":"e1007163","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QAV56460.1"}]},{"referenceNumber":2,"citation":{"id":"CI-5GAIDJKBNIQS2","citationType":"submission","authors":["Goodson-Gregg J.","Li H.","Anderson S.K."],"title":"Tuning of NK-specific HLA-C expression by alternative mRNA splicing.","publicationDate":"APR-2018","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QAV56460.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MH254930","properties":[{"key":"ProteinId","value":"QAV56460.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"B8YBG3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B8YBG3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"B8YBG3","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWAGSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEARSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40960,"crc64":"06E55685EB1F6D9E","md5":"24D499D946686FCE42B69DFC5CD66982"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000008AE9D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G1FTT7","uniProtkbId":"G1FTT7_HUMAN","entryAudit":{"firstPublicDate":"2011-10-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-10-19","entryVersion":66,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}],"value":"HLA-C"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003412676"},{"type":"Transmembrane","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-416FSG997CC1Q","citationType":"submission","authors":["Zhu F.","Wang W.","Yan L."],"title":"A novel HLA-C*07 allele.","publicationDate":"JUL-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}]},{"referenceNumber":2,"citation":{"id":"22671707","citationType":"journal article","authors":["Zhang W.","Wang W.","He J.","Zhu F.M.","Lv H.J."],"citationCrossReferences":[{"database":"PubMed","id":"22671707"},{"database":"DOI","id":"10.1111/j.1399-0039.2012.01904.x"}],"title":"Sequence-based HLA high-resolution typing of a bone marrow donor/recipient pair reveals the novel HLA allele HLA-C*07:208.","publicationDate":"2012","journal":"Tissue Antigens","firstPage":"276","lastPage":"278","volume":"80"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK81423.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN256033","properties":[{"key":"ProteinId","value":"AEK81423.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G1FTT7","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"G1FTT7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07698","properties":[{"key":"EntryName","value":"IgC1_MHC_I_alpha3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTPADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCK","length":365,"molWeight":40603,"crc64":"F320F99D0067AD3F","md5":"1DFDB9E26ABAC1E09FCAE18652CF99E4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00021B0D9D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H8XVX3","uniProtkbId":"H8XVX3_HUMAN","entryAudit":{"firstPublicDate":"2012-05-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-05-16","entryVersion":60,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCG58320.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCG58320.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCG58320.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5033698381"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"24033148","citationType":"journal article","authors":["Cisneros E.","Martinez-Pomar N.","Vilches M.","Martin P.","de Pablo R.","Nunez Del Prado N.","Nieto A.","Matamoros N.","Moraru M.","Vilches C."],"citationCrossReferences":[{"database":"PubMed","id":"24033148"},{"database":"DOI","id":"10.1111/tan.12192"}],"title":"Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08).","publicationDate":"2013","journal":"Tissue Antigens","firstPage":"280","lastPage":"285","volume":"82"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCG58320.1"}]},{"referenceNumber":2,"citation":{"id":"CI-FIDG1I4AEQ0QF","citationType":"submission","authors":["Cereb N.","Yang S.Y."],"title":"HLA new alleles found by Histogenetics.","publicationDate":"NOV-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AUQ33507.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG584063","properties":[{"key":"ProteinId","value":"AUQ33507.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HE793166","properties":[{"key":"ProteinId","value":"CCG58320.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H8XVX3","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"H8XVX3","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40857,"crc64":"B45FC1988DE315F0","md5":"BE7DED1D4FAF416D225C16504B65C96D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000256F794"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H9TV73","uniProtkbId":"H9TV73_HUMAN","entryAudit":{"firstPublicDate":"2012-06-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-06-13","entryVersion":62,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFG26503.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFG26503.1"}],"value":"MHC class I antigen"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFG26503.1"}],"value":"HLA-C"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003622822"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":365,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFG26503.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"22489950","citationType":"journal article","authors":["Lee K.W."],"citationCrossReferences":[{"database":"PubMed","id":"22489950"},{"database":"DOI","id":"10.1111/j.1399-0039.2012.01858.x"}],"title":"Full-length coding sequences of the two novel HLA-C alleles, C*14:36 and C*01:02:15.","publicationDate":"2012","journal":"Tissue Antigens","firstPage":"389","lastPage":"390","volume":"79"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFG26503.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ313994","properties":[{"key":"ProteinId","value":"AFG26503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H9TV73","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H9TV73","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"H9TV73","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMFGCYLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVAGLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACK","length":365,"molWeight":40815,"crc64":"5F7A79890D39C8C6","md5":"2EB4A53BA3D1E789E9928CC6F97DBB82"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0002573A36"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5RIP0","uniProtkbId":"Q5RIP0_HUMAN","entryAudit":{"firstPublicDate":"2005-05-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-05-10","entryVersion":173,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACX53677.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBD34075.1"}],"value":"HLA class I histocompatibility antigen C alpha chain"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACX53677.1"}],"value":"MHC class I antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACX53677.1"}],"value":"HLA-Cw"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASE99672.1"}],"value":"HLA-C"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002297"}],"value":"Involved in the presentation of foreign antigens to the immune system"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q5RIP0","intActId":"EBI-22185566"},"interactantTwo":{"uniProtKBAccession":"P43626","geneName":"KIR2DL1","intActId":"EBI-8684277"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004162"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006909"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004439"}],"value":"Belongs to the MHC class I family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5015098007"},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Region","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022859"}],"id":"KW-0391","category":"Biological process","name":"Immunity"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022451"}],"id":"KW-0490","category":"Cellular component","name":"MHC I"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-5N868M9BN1B8G","citationType":"submission","authors":["Xu Y.","Deng Z.","Wang D."],"title":"Characterization and polymorphism analyses of HLA-C genomic full length in Chinese Han population.","publicationDate":"SEP-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACX53677.1"}]},{"referenceNumber":2,"citation":{"id":"23714642","citationType":"journal article","authors":["Hosomichi K.","Jinam T.A.","Mitsunaga S.","Nakaoka H.","Inoue I."],"citationCrossReferences":[{"database":"PubMed","id":"23714642"},{"database":"DOI","id":"10.1186/1471-2164-14-355"}],"title":"Phase-defined complete sequencing of the HLA genes by next-generation sequencing.","publicationDate":"2013","journal":"BMC Genomics","firstPage":"355","lastPage":"355","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAN59840.1"}]},{"referenceNumber":3,"citation":{"id":"28547825","citationType":"journal article","authors":["Albrecht V.","Zweiniger C.","Surendranath V.","Lang K.","Schofl G.","Dahl A.","Winkler S.","Lange V.","Bohme I.","Schmidt A.H."],"citationCrossReferences":[{"database":"PubMed","id":"28547825"},{"database":"DOI","id":"10.1111/tan.13057"}],"title":"Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.","publicationDate":"2017","journal":"HLA","firstPage":"79","lastPage":"87","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CUU97220.1"}]},{"referenceNumber":4,"citation":{"id":"30337930","citationType":"journal article","authors":["Suzuki S.","Ranade S.","Osaki K.","Ito S.","Shigenari A.","Ohnuki Y.","Oka A.","Masuya A.","Harting J.","Baybayan P.","Kitazume M.","Sunaga J.","Morishima S.","Morishima Y.","Inoko H.","Kulski J.K.","Shiina T."],"citationCrossReferences":[{"database":"PubMed","id":"30337930"},{"database":"DOI","id":".3389/fimmu.2018.02294"}],"title":"Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.","publicationDate":"2018","journal":"Front. Immunol.","firstPage":"2294","lastPage":"2294","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBD34075.1"}]},{"referenceNumber":5,"citation":{"id":"29327506","citationType":"journal article","authors":["Hurley C.K.","Hou L.","Lazaro A.","Gerfen J.","Enriquez E.","Galarza P.","Rodriguez Cardozo M.B.","Halagan M.","Maiers M.","Behm D.","Ng J."],"citationCrossReferences":[{"database":"PubMed","id":"29327506"},{"database":"DOI","id":".1111/tan.13210"}],"title":"Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.","publicationDate":"2018","journal":"HLA","firstPage":"175","lastPage":"186","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASE99672.1"}]},{"referenceNumber":6,"citation":{"id":"CI-29VJ7HJTLP21N","citationType":"journal article","authors":["Mimori T.","Yasuda J.","Kuroki Y.","Shibata T.F.","Katsuoka F.","Saito S.","Nariai N.","Ono A.","Nakai-Inagaki N.","Misawa K.","Tateno K.","Kawai Y.","Fuse N.","Hozawa A.","Kuriyama S.","Sugawara J.","Minegishi N.","Suzuki K.","Kinoshita K.","Nagasaki M.","Yamamoto M."],"title":"Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing.","publicationDate":"2018","journal":"Pharmacogenomics J.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBD74454.1"}]},{"referenceNumber":7,"citation":{"id":"31026377","citationType":"journal article","authors":["Balas A.","Moreno-Hidalgo M.A.","Alenda R.","Garcia-Sanchez F.","Vicario J.L."],"citationCrossReferences":[{"database":"PubMed","id":"31026377"}],"title":"Characterization of two new HLA-C alleles, HLA-C*05:01:01:17 and -C*16:152.","publicationDate":"2019","journal":"HLA","firstPage":"159","lastPage":"160","volume":"94"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QEQ51219.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ895733","properties":[{"key":"ProteinId","value":"ACX53677.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KY622036","properties":[{"key":"ProteinId","value":"ASE99672.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB774994","properties":[{"key":"ProteinId","value":"BAN59840.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"LC257757","properties":[{"key":"ProteinId","value":"BBD34075.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"LC326218","properties":[{"key":"ProteinId","value":"BBD74454.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"LN912893","properties":[{"key":"ProteinId","value":"CUU97220.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"MK641846","properties":[{"key":"ProteinId","value":"QEQ51219.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q5RIP0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5RIP0","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"Q5RIP0","properties":[{"key":"Interactions","value":"3"}]},{"database":"OrthoDB","id":"9447187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HLA-B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031901","properties":[{"key":"GoTerm","value":"C:early endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012507","properties":[{"key":"GoTerm","value":"C:ER to Golgi transport vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098553","properties":[{"key":"GoTerm","value":"C:lumenal side of endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0030670","properties":[{"key":"GoTerm","value":"C:phagocytic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0019882","properties":[{"key":"GoTerm","value":"P:antigen processing and presentation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21025","properties":[{"key":"EntryName","value":"IgC1_MHC_Ib_HLA-Cw3-4"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000014","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.500.10:FF:000001","properties":[{"key":"EntryName","value":"H-2 class I histocompatibility antigen, alpha chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.500.10","properties":[{"key":"EntryName","value":"MHC class I-like antigen recognition-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003006","properties":[{"key":"EntryName","value":"Ig/MHC_CS"}]},{"database":"InterPro","id":"IPR003597","properties":[{"key":"EntryName","value":"Ig_C1-set"}]},{"database":"InterPro","id":"IPR050208","properties":[{"key":"EntryName","value":"MHC_class-I_related"}]},{"database":"InterPro","id":"IPR011161","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog"}]},{"database":"InterPro","id":"IPR037055","properties":[{"key":"EntryName","value":"MHC_I-like_Ag-recog_sf"}]},{"database":"InterPro","id":"IPR011162","properties":[{"key":"EntryName","value":"MHC_I/II-like_Ag-recog"}]},{"database":"InterPro","id":"IPR001039","properties":[{"key":"EntryName","value":"MHC_I_a_a1/a2"}]},{"database":"InterPro","id":"IPR010579","properties":[{"key":"EntryName","value":"MHC_I_a_C"}]},{"database":"PANTHER","id":"PTHR16675:SF251","properties":[{"key":"EntryName","value":"HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16675","properties":[{"key":"EntryName","value":"MHC CLASS I-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07654","properties":[{"key":"EntryName","value":"C1-set"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00129","properties":[{"key":"EntryName","value":"MHC_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06623","properties":[{"key":"EntryName","value":"MHC_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01638","properties":[{"key":"EntryName","value":"MHCCLASSI"}]},{"database":"SMART","id":"SM00407","properties":[{"key":"EntryName","value":"IGc1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54452","properties":[{"key":"EntryName","value":"MHC antigen-recognition domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00290","properties":[{"key":"EntryName","value":"IG_MHC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVNLRKLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADKAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA","length":366,"molWeight":40912,"crc64":"26454A7EE68151DA","md5":"936EAC4AAFB5C5F5EBB3B3C9E8C9BC65"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000008A060"}}]}