{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y2N7","secondaryAccessions":["B0M185","B4DNA2","I6L988","Q58A43","Q66K72","Q8WXA1","Q96K34","Q9H7Z9","Q9HAI2"],"uniProtkbId":"HIF3A_HUMAN","entryAudit":{"firstPublicDate":"2007-04-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-17","entryVersion":188,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11573933"}],"value":"Hypoxia-inducible factor 3-alpha"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11573933"}],"value":"HIF-3-alpha"},{"value":"HIF3-alpha"}]},"alternativeNames":[{"fullName":{"value":"Basic-helix-loop-helix-PAS protein MOP7"}},{"fullName":{"value":"Class E basic helix-loop-helix protein 17"},"shortNames":[{"value":"bHLHe17"}]},{"fullName":{"value":"HIF3-alpha-1"}},{"fullName":{"value":"Inhibitory PAS domain protein"},"shortNames":[{"value":"IPAS"}]},{"fullName":{"value":"Member of PAS protein 7"}},{"fullName":{"value":"PAS domain-containing protein 7"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:15825"}],"value":"HIF3A"},"synonyms":[{"value":"BHLHE17"},{"value":"MOP7"},{"value":"PASD7"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11573933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16126907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20416395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21069422"}],"value":"Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11573933"}],"value":"Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20416395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21069422"}],"value":"Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16126907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17998805"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20416395"}],"value":"Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805)"}],"commentType":"FUNCTION","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21069422"}],"value":"Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation"}],"commentType":"FUNCTION","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16126907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17998805"}],"value":"Isoform 2 interacts (via ODD domain) with VHL (via beta domain) (PubMed:12538644). Isoform 4 interacts with HIF1A; the interaction inhibits the binding of HIF1A to hypoxia-responsive element (HRE) and HIF1A/ARNT-dependent transcriptional activation (PubMed:16126907). Isoform 4 interacts with ARNT; the interaction occurs in a HIF1A- and DNA-binding-independent manner and does not induce HIF1A/ARNT-dependent transcriptional activation (PubMed:16126907). Isoform 4 interacts with EPAS1 (PubMed:17998805). Interacts with BAD, BCL2L2 and MCL1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9Y2N7-4","intActId":"EBI-38258397"},"interactantTwo":{"uniProtKBAccession":"Q16665","geneName":"HIF1A","intActId":"EBI-447269"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHS2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"}],"value":"In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16775626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"}],"value":"Nucleus speckle","id":"SL-0186"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9Y2N7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"}],"value":"HIF-3alpha1"}],"isoformIds":["Q9Y2N7-2"],"sequenceIds":["VSP_024520"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"}],"value":"HIF-3alpha2"}],"isoformIds":["Q9Y2N7-3"],"sequenceIds":["VSP_024526"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"}],"value":"HIF-3alpha4"}],"isoformIds":["Q9Y2N7-4"],"sequenceIds":["VSP_024523","VSP_024525"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"}],"value":"HIF-3alpha3"}],"isoformIds":["Q9Y2N7-5"],"sequenceIds":["VSP_024519"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"}],"value":"HIF-3alpha6"}],"isoformIds":["Q9Y2N7-6"],"sequenceIds":["VSP_024518","VSP_024521"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"isoformIds":["Q9Y2N7-7"],"sequenceIds":["VSP_043429"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12538644"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20416395"}],"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11573933"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16126907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16775626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20416395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21069422"}],"value":"Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells from umbilical cord and aortic endothelial cells) and in vascular smooth muscle cells (aorta) (PubMed:21069422). Strongly expressed in the heart, placenta, and skeletal muscle, whereas a weak expression profile was found in the lung, liver, and kidney (PubMed:12538644). Expressed weakly in cell renal cell carcinoma (CC-RCC) compared to normal renal cells (PubMed:16126907). Expression is down-regulated in numerous kidney tumor cells compared to non tumor kidney tissues (PubMed:16126907). Isoform 2 is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas and in numerous cancer cell lines (PubMed:20416395). Isoform 3 and isoform 4 are weakly expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:20416395). Isoform 4 is expressed in fetal tissues, such as heart, brain, thymus, lung, liver, skeletal kidney and spleen (PubMed:20416395). Isoform 3 is weakly expressed in fetal tissues, such as liver and kidney (PubMed:20416395)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16126907"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16775626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20416395"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21069422"}],"value":"Up-regulated by hypoxia (at protein level) (PubMed:16775626). Induced by hypoxia (PubMed:16775626). Isoform 2, isoform 3, isoform 4 and isoform 5 are up-regulated by hypoxia in a HIF1A- and EPAS1/HIF2A-dependent manner (PubMed:19694616, PubMed:20416395, PubMed:21069422). Isoform 4 is down-regulated by hypoxia and up-regulated upon restoring normoxia in embryonic kidney cells (PubMed:16126907)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}],"value":"In normoxia, hydroxylated on Pro-492 in the oxygen-dependent degradation domain (ODD) by prolyl hydroxylase(s) (PHD). The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}],"value":"Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 5"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 6"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAL69947.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB13865.1","note":"Aberrant splicing site.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB14824.1","note":"Unlikely isoform. Aberrant splice sites.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB55324.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAD93355.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAG07185.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Hypoxia_inducible_factor","ftp":false,"note":"Hypoxia inducible factor entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"Hypoxia-inducible factor 3-alpha","featureId":"PRO_0000284414"},{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"bHLH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"PAS 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00140"}]},{"type":"Domain","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"PAS 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00140"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"}]},{"type":"Region","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q0VBL6"}]},{"type":"Region","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"ODD"},{"type":"Region","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"NTAD"},{"type":"Region","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"LRRLL"},{"type":"Motif","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"LAPYISMD"},{"type":"Compositional bias","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"4-hydroxyproline","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}]},{"type":"Cross-link","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}]},{"type":"Cross-link","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_043429","alternativeSequence":{"originalSequence":"MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLS","alternativeSequences":["MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAP"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_024518","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_024519","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11573933"}],"featureId":"VSP_024520","alternativeSequence":{"originalSequence":"MALGLQRA","alternativeSequences":["MDWQDH"]}},{"type":"Alternative sequence","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_024521","alternativeSequence":{"originalSequence":"ACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCD","alternativeSequences":["MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAP"]}},{"type":"Alternative sequence","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16126907"}],"featureId":"VSP_024523","alternativeSequence":{"originalSequence":"LLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRP","alternativeSequences":["CMYPISPGAKPAATWPPADTRTPQLPIPQDALPPHLNTSSLLPKPQGTVSFLAPSYPVPRSFSPHLPPWWP"]}},{"type":"Alternative sequence","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16126907"}],"featureId":"VSP_024525","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"featureId":"VSP_024526","alternativeSequence":{"originalSequence":"SFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD","alternativeSequences":["VCWGINGILWPSLPSWLKPTVL"]}},{"type":"Natural variant","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"in dbSNP:rs3764609","featureCrossReferences":[{"database":"dbSNP","id":"rs3764609"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_031731","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"in dbSNP:rs7253301","featureCrossReferences":[{"database":"dbSNP","id":"rs7253301"}],"featureId":"VAR_031732","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"No loss of ubiquitination. Reduced ubiquitination; when associated with R-570.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Reduced hydroxylation activity. Reduced ubiquitination.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"No loss of ubiquitination. Reduced ubiquitination; when associated with R-467.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12538644"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in Ref. 5; BAB55324","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"in Ref. 5; BAB55324","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Beta strand","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Beta strand","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Helix","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Helix","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Helix","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Turn","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Helix","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Beta strand","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Beta strand","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Beta strand","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Helix","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]},{"type":"Beta strand","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4WN5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0379","category":"PTM","name":"Hydroxylation"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0346","category":"Biological process","name":"Stress response"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0043","category":"Disease","name":"Tumor suppressor"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"11573933","citationType":"journal article","authors":["Hara S.","Hamada J.","Kobayashi C.","Kondo Y.","Imura N."],"citationCrossReferences":[{"database":"PubMed","id":"11573933"},{"database":"DOI","id":"10.1006/bbrc.2001.5659"}],"title":"Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha.","publicationDate":"2001","journal":"Biochem. Biophys. Res. Commun.","firstPage":"808","lastPage":"813","volume":"287"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","FUNCTION (ISOFORM 2)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-A2MS6SG56CSE","citationType":"submission","authors":["Cheng J.Q."],"title":"Cloning and characterization of human inhibitory PAS domain protein.","publicationDate":"DEC-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"]},{"referenceNumber":3,"citation":{"id":"16126907","citationType":"journal article","authors":["Maynard M.A.","Evans A.J.","Hosomi T.","Hara S.","Jewett M.A.","Ohh M."],"citationCrossReferences":[{"database":"PubMed","id":"16126907"},{"database":"DOI","id":"10.1096/fj.05-3788com"}],"title":"Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.","publicationDate":"2005","journal":"FASEB J.","firstPage":"1396","lastPage":"1406","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)","FUNCTION (ISOFORM 4)","INTERACTION WITH HIF1A AND ARNT (ISOFORM 4)","INDUCTION (ISOFORM 4)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-C00L371MBH33O","citationType":"submission","authors":["Hara S.","Hosomi T.","Mita M.","Sakaue M.","Kondo Y."],"title":"HIF-3alpha2, one of splicing variants of human hypoxia-inducible factor-3alpha, functions as an inhibitor of hypoxia-induced gene expression and tumor growth.","publicationDate":"FEB-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 7)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-626 (ISOFORM 5)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-233 (ISOFORM 6)","VARIANT ARG-343"],"referenceComments":[{"value":"Embryo","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)","VARIANT ARG-343"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"12538644","citationType":"journal article","authors":["Maynard M.A.","Qi H.","Chung J.","Lee E.H.","Kondo Y.","Hara S.","Conaway R.C.","Conaway J.W.","Ohh M."],"citationCrossReferences":[{"database":"PubMed","id":"12538644"},{"database":"DOI","id":"10.1074/jbc.m208681200"}],"title":"Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"11032","lastPage":"11040","volume":"278"},"referencePositions":["INTERACTION WITH VHL (ISOFORM 2)","ALTERNATIVE SPLICING","UBIQUITINATION AT LYS-467 AND LYS-570","HYDROXYLATION AT PRO-492","TISSUE SPECIFICITY","MUTAGENESIS OF LYS-467; PRO-492 AND LYS-570"]},{"referenceNumber":10,"citation":{"id":"16775626","citationType":"journal article","authors":["Li Q.F.","Wang X.R.","Yang Y.W.","Lin H."],"citationCrossReferences":[{"database":"PubMed","id":"16775626"},{"database":"DOI","id":"10.1038/sj.cr.7310072"}],"title":"Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.","publicationDate":"2006","journal":"Cell Res.","firstPage":"548","lastPage":"558","volume":"16"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","INDUCTION"]},{"referenceNumber":11,"citation":{"id":"17998805","citationType":"journal article","authors":["Maynard M.A.","Evans A.J.","Shi W.","Kim W.Y.","Liu F.F.","Ohh M."],"citationCrossReferences":[{"database":"PubMed","id":"17998805"},{"database":"DOI","id":"10.4161/cc.6.22.4947"}],"title":"Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression.","publicationDate":"2007","journal":"Cell Cycle","firstPage":"2810","lastPage":"2816","volume":"6"},"referencePositions":["FUNCTION (ISOFORM 4)","INTERACTION WITH EPAS1 (ISOFORM 4)"]},{"referenceNumber":12,"citation":{"id":"19694616","citationType":"journal article","authors":["Tanaka T.","Wiesener M.","Bernhardt W.","Eckardt K.U.","Warnecke C."],"citationCrossReferences":[{"database":"PubMed","id":"19694616"},{"database":"DOI","id":"10.1042/bj20090120"}],"title":"The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.","publicationDate":"2009","journal":"Biochem. J.","firstPage":"143","lastPage":"151","volume":"424"},"referencePositions":["FUNCTION (ISOFORMS 3 AND 4)","SUBCELLULAR LOCATION","INDUCTION","TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"20416395","citationType":"journal article","authors":["Pasanen A.","Heikkila M.","Rautavuoma K.","Hirsila M.","Kivirikko K.I.","Myllyharju J."],"citationCrossReferences":[{"database":"PubMed","id":"20416395"},{"database":"DOI","id":"10.1016/j.biocel.2010.04.008"}],"title":"Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.","publicationDate":"2010","journal":"Int. J. Biochem. Cell Biol.","firstPage":"1189","lastPage":"1200","volume":"42"},"referencePositions":["FUNCTION (ISOFORMS 3 AND 4)","ALTERNATIVE SPLICING","TISSUE SPECIFICITY (ISOFORMS 2; 3 AND 4)","INDUCTION"]},{"referenceNumber":14,"citation":{"id":"21069422","citationType":"journal article","authors":["Augstein A.","Poitz D.M.","Braun-Dullaeus R.C.","Strasser R.H.","Schmeisser A."],"citationCrossReferences":[{"database":"PubMed","id":"21069422"},{"database":"DOI","id":"10.1007/s00018-010-0575-4"}],"title":"Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells.","publicationDate":"2011","journal":"Cell. Mol. Life Sci.","firstPage":"2627","lastPage":"2642","volume":"68"},"referencePositions":["FUNCTION (ISOFORMS 3 AND 5)","TISSUE SPECIFICITY","INDUCTION (ISOFORMS 2; 3 AND 5)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB054067","properties":[{"key":"ProteinId","value":"BAB69689.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF463492","properties":[{"key":"ProteinId","value":"AAL69947.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB118749","properties":[{"key":"ProteinId","value":"BAD93355.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB295039","properties":[{"key":"ProteinId","value":"BAG07185.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK021653","properties":[{"key":"ProteinId","value":"BAB13865.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK024095","properties":[{"key":"ProteinId","value":"BAB14824.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK027725","properties":[{"key":"ProteinId","value":"BAB55324.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK297828","properties":[{"key":"ProteinId","value":"BAG60164.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"AAD22668.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471126","properties":[{"key":"ProteinId","value":"EAW57410.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC026308","properties":[{"key":"ProteinId","value":"AAH26308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC080551","properties":[{"key":"ProteinId","value":"AAH80551.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS12681.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-1"},{"database":"CCDS","id":"CCDS12682.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-2"},{"database":"CCDS","id":"CCDS42580.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-7"},{"database":"PIR","id":"JC7771","properties":[{"key":"EntryName","value":"JC7771"}]},{"database":"RefSeq","id":"NP_071907.4","properties":[{"key":"NucleotideSequenceId","value":"NM_022462.4"}],"isoformId":"Q9Y2N7-7"},{"database":"RefSeq","id":"NP_690007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_152794.4"}],"isoformId":"Q9Y2N7-2"},{"database":"RefSeq","id":"NP_690008.2","properties":[{"key":"NucleotideSequenceId","value":"NM_152795.4"}],"isoformId":"Q9Y2N7-1"},{"database":"RefSeq","id":"XP_047295173.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047439217.1"}],"isoformId":"Q9Y2N7-7"},{"database":"RefSeq","id":"XP_054177731.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054321756.1"}],"isoformId":"Q9Y2N7-7"},{"database":"PDB","id":"4WN5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.15 A"},{"key":"Chains","value":"A/B=237-347"}]},{"database":"PDBsum","id":"4WN5","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122143","properties":[{"key":"Interactions","value":"5"}]},{"database":"ELM","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9Y2N7","properties":[{"key":"Number of interactors","value":"385"}]},{"database":"IntAct","id":"Q9Y2N7","properties":[{"key":"Interactions","value":"3"}]},{"database":"NDEx","id":"IQUERY-CP-HIF3A","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000366898","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9Y2N7","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"HIF3A","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"145558932","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000366898","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"85845","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-1"},{"database":"ProteomicsDB","id":"85846","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-2"},{"database":"ProteomicsDB","id":"85847","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-3"},{"database":"ProteomicsDB","id":"85849","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-5"},{"database":"ProteomicsDB","id":"85851","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9Y2N7-7"},{"database":"Antibodypedia","id":"18071","properties":[{"key":"antibodies","value":"385 antibodies from 30 providers"}]},{"database":"DNASU","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000244303.10","properties":[{"key":"ProteinId","value":"ENSP00000244303.6"},{"key":"GeneId","value":"ENSG00000124440.16"}],"isoformId":"Q9Y2N7-7"},{"database":"Ensembl","id":"ENST00000300862.7","properties":[{"key":"ProteinId","value":"ENSP00000300862.3"},{"key":"GeneId","value":"ENSG00000124440.16"}],"isoformId":"Q9Y2N7-2"},{"database":"Ensembl","id":"ENST00000377670.9","properties":[{"key":"ProteinId","value":"ENSP00000366898.3"},{"key":"GeneId","value":"ENSG00000124440.16"}],"isoformId":"Q9Y2N7-1"},{"database":"GeneID","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:64344","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000377670.9","properties":[{"key":"ProteinId","value":"ENSP00000366898.3"},{"key":"RefSeqNucleotideId","value":"NM_152795.4"},{"key":"RefSeqProteinId","value":"NP_690008.2"}]},{"database":"UCSC","id":"uc002peh.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9Y2N7-1"},{"database":"AGR","id":"HGNC:15825","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29285","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HIF3A","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"HPA","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"609976","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3558","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_010044_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AEPRSHF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9Y2N7","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1234158","properties":[{"key":"PathwayName","value":"Regulation of gene expression by Hypoxia-inducible Factor"}],"isoformId":"Q9Y2N7-1"},{"database":"Reactome","id":"R-HSA-1234176","properties":[{"key":"PathwayName","value":"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"}]},{"database":"Reactome","id":"R-HSA-452723","properties":[{"key":"PathwayName","value":"Transcriptional regulation of pluripotent stem cells"}]},{"database":"Reactome","id":"R-HSA-8951664","properties":[{"key":"PathwayName","value":"Neddylation"}]},{"database":"SignaLink","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000124440","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"64344","properties":[{"key":"hits","value":"19 hits in 1154 CRISPR screens"}]},{"database":"CD-CODE","id":"804901D1","properties":[{"key":"EntryName","value":"Nuclear speckle"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9Y2N7","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9Y2N7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q9Y2N7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9Y2N7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31768607"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16775626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19694616"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11573933"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31768607"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31768607"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032364","properties":[{"key":"GoTerm","value":"P:intracellular oxygen homeostasis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"CDD","id":"cd19729","properties":[{"key":"EntryName","value":"bHLH-PAS_HIF3a_PASD7"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"3.30.450.20:FF:000005","properties":[{"key":"EntryName","value":"Hypoxia-inducible factor 1 subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.450.20:FF:000042","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.280.10:FF:000076","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"IDEAL","id":"IID00742","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR021537","properties":[{"key":"EntryName","value":"HIF_alpha-like"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR013767","properties":[{"key":"EntryName","value":"PAS_fold"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23171","properties":[{"key":"EntryName","value":"bHLH_HIF1A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11413","properties":[{"key":"EntryName","value":"HIF-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00989","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14598","properties":[{"key":"EntryName","value":"PAS_11"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD","length":669,"molWeight":72433,"crc64":"81C4C84517000DE2","md5":"13E55BBA270085F389A38C93FECBEF1F"},"extraAttributes":{"countByCommentType":{"FUNCTION":5,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":7,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":2,"MISCELLANEOUS":2,"SEQUENCE CAUTION":6,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":3,"Region":9,"Motif":2,"Compositional bias":5,"Modified residue":1,"Cross-link":2,"Alternative sequence":8,"Natural variant":2,"Mutagenesis":3,"Sequence conflict":2,"Beta strand":6,"Helix":5,"Turn":1},"uniParcId":"UPI00002026E2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"M0R104","uniProtkbId":"M0R104_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":77,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"}],"value":"HIF3A"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004324"}],"value":"Nucleus speckle","id":"SL-0186"}}]}],"features":[{"type":"Domain","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Region","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":472,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000471560.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_005259210.3","properties":[{"key":"NucleotideSequenceId","value":"XM_005259153.4"}]},{"database":"RefSeq","id":"XP_047295174.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047439218.1"}]},{"database":"RefSeq","id":"XP_054177732.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054321757.1"}]},{"database":"AlphaFoldDB","id":"M0R104","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"M0R104","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"M0R104","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18071","properties":[{"key":"antibodies","value":"385 antibodies from 30 providers"}]},{"database":"DNASU","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000600383.1","properties":[{"key":"ProteinId","value":"ENSP00000471560.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"GeneID","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc061aez.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"64344","properties":[{"key":"hits","value":"19 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"M0R104","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"3.30.450.20:FF:000042","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR021537","properties":[{"key":"EntryName","value":"HIF_alpha-like"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11413","properties":[{"key":"EntryName","value":"HIF-1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14598","properties":[{"key":"EntryName","value":"PAS_11"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAPQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGFHFVTQSGVQWHKHSSPQPRPPGLK","length":594,"molWeight":64082,"crc64":"00A4DAE1AFCB39B8","md5":"1399C7A14487B040D7A8503DBC879797"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":3,"Compositional bias":3},"uniParcId":"UPI0002A470BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YDZ5","uniProtkbId":"H0YDZ5_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":93,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"}],"value":"HIF3A"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Region","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434653.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_690009.1","properties":[{"key":"NucleotideSequenceId","value":"NM_152796.2"}]},{"database":"AlphaFoldDB","id":"H0YDZ5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YDZ5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"37562","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18071","properties":[{"key":"antibodies","value":"385 antibodies from 30 providers"}]},{"database":"DNASU","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000472815.5","properties":[{"key":"ProteinId","value":"ENSP00000434653.2"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"GeneID","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc002pej.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"64344","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_595743_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"64344","properties":[{"key":"hits","value":"19 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"3.30.450.20:FF:000042","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001610","properties":[{"key":"EntryName","value":"PAC"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14598","properties":[{"key":"EntryName","value":"PAS_11"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00086","properties":[{"key":"EntryName","value":"PAC"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAPQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDPSTPLLNLNEPLGFHFVTQSGVQWHKHSSPQPRPPGLK","length":450,"molWeight":48574,"crc64":"75E1791B14449283","md5":"402461A89C8DE0DC9A6D8414C4AEFF26"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1},"uniParcId":"UPI0000140906"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PJR0","uniProtkbId":"E9PJR0_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":80,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"}],"value":"HIF3A"}}],"features":[{"type":"Region","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435532.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PJR0","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000526506.5","properties":[{"key":"ProteinId","value":"ENSP00000432613.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"Ensembl","id":"ENST00000528563.5","properties":[{"key":"ProteinId","value":"ENSP00000435532.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"Ensembl","id":"ENST00000600879.5","properties":[{"key":"ProteinId","value":"ENSP00000469031.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"UCSC","id":"uc061aeu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2775252_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]}],"sequence":{"value":"MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAPQGSGTRWEQGENHWMPAT","length":69,"molWeight":7261,"crc64":"77FE79BD881B6B06","md5":"29BCEF3804B25353CEC743E865AB07DD"},"extraAttributes":{"countByFeatureType":{"Region":1},"uniParcId":"UPI0001F77CFC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PNQ7","uniProtkbId":"E9PNQ7_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":84,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"}],"value":"HIF3A"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"BHLH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50888"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helix-loop-helix motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Compositional bias","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432809.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PNQ7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PNQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000533789.5","properties":[{"key":"ProteinId","value":"ENSP00000432809.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"UCSC","id":"uc061aes.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_172787_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PNQ7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"4.10.280.10:FF:000076","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23171","properties":[{"key":"EntryName","value":"bHLH_HIF1A"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAAGAHWTQHL","length":81,"molWeight":9229,"crc64":"CE9436B4527E9925","md5":"F1891B2D0467C8B43DEA636A7ACBE5F6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1},"uniParcId":"UPI0001F77CFA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YE02","uniProtkbId":"H0YE02_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":58,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"}],"value":"HIF3A"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434700.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000531043.1","properties":[{"key":"ProteinId","value":"ENSP00000434700.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"UCSC","id":"uc061afd.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2418728_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YE02","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRNGDSGFSLLECQSWLCILSQMTSPLCATISSPILWNHNRTCLVQSF","length":93,"molWeight":10307,"crc64":"3DB1C3F639A64F83","md5":"F3B787C09648556876B913B06AEEBC25"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0001F77D00"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PLC8","uniProtkbId":"E9PLC8_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":74,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"}],"value":"Hypoxia inducible factor 3 subunit alpha"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"}],"value":"HIF3A"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Non-terminal residue","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.","Terry A.","Schmutz J.","Lamerdin J.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000435200.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PLC8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PLC8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"18071","properties":[{"key":"antibodies","value":"385 antibodies from 30 providers"}]},{"database":"Ensembl","id":"ENST00000533145.5","properties":[{"key":"ProteinId","value":"ENSP00000435200.1"},{"key":"GeneId","value":"ENSG00000124440.16"}]},{"database":"UCSC","id":"uc061aev.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:15825","properties":[{"key":"GeneName","value":"HIF3A"}]},{"database":"OpenTargets","id":"ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000124440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000161745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1762981_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"Bgee","id":"ENSG00000124440","properties":[{"key":"ExpressionPatterns","value":"Expressed in mucosa of stomach and 151 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PLC8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00130","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"InterPro","id":"IPR035965","properties":[{"key":"EntryName","value":"PAS-like_dom_sf"}]},{"database":"InterPro","id":"IPR013767","properties":[{"key":"EntryName","value":"PAS_fold"}]},{"database":"NCBIfam","id":"TIGR00229","properties":[{"key":"EntryName","value":"sensory_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00989","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00091","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55785","properties":[{"key":"EntryName","value":"PYP-like sensor domain (PAS domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRPAAGAARRPRCCTSWLTRCPSPAASAPTWTRPLSCASPSATCACTASAPQATRMYPHFLGGAWEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKV","length":148,"molWeight":16009,"crc64":"900BA85F67C7A374","md5":"A04FE8C9537F4C4C34DC81C1100F6CBB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F77CFD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"O95262","uniProtkbId":"O95262_HUMAN","entryAudit":{"firstPublicDate":"1999-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-05-01","entryVersion":123,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}],"value":"Hypoxia-inducible factor 3 alpha subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}],"value":"HIF3A"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"BHLH","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50888"}]},{"type":"Domain","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"PAS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50112"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helix-loop-helix motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00981"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-35SMFO911S9V4","citationType":"submission","authors":["Gu Y.Z.","Moran S.M.","Hogenesch J.B.","Wartman L.","Bradfield C.A."],"title":"Human HIF3-alpha partial cDNA.","publicationDate":"JUL-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC99397.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF079154","properties":[{"key":"ProteinId","value":"AAC99397.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"O95262","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"O95262","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"O95262","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6021714at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"HIF3A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"4.10.280.10:FF:000076","properties":[{"key":"EntryName","value":"hypoxia-inducible factor 3-alpha isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.450.20","properties":[{"key":"EntryName","value":"PAS domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR000014","properties":[{"key":"EntryName","value":"PAS"}]},{"database":"PANTHER","id":"PTHR23043","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23043:SF18","properties":[{"key":"EntryName","value":"HYPOXIA-INDUCIBLE FACTOR 3-ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23171","properties":[{"key":"EntryName","value":"bHLH_HIF1A"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50112","properties":[{"key":"EntryName","value":"PAS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ","length":115,"molWeight":12795,"crc64":"39EDB30677C7A361","md5":"630EE49489E4A13DE76EC3FD79B0DB2C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Region":2,"Non-terminal residue":2},"uniParcId":"UPI0000071538"}}]}