{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O15379","secondaryAccessions":["D3DQE1","O43268","Q9UEI5","Q9UEV0"],"uniProtkbId":"HDAC3_HUMAN","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1998-07-15","entryVersion":244,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone deacetylase 3"},"shortNames":[{"value":"HD3"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23911289"}],"value":"3.5.1.98"}]},"alternativeNames":[{"fullName":{"value":"Protein deacetylase HDAC3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15653507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25301942"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21444723"}],"value":"3.5.1.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein deacylase HDAC3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29192674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34545082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34608293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"38961290"}],"value":"3.5.1.-"}]},{"fullName":{"value":"RPD3-2"}},{"fullName":{"value":"SMAP45"}}]},"genes":[{"geneName":{"value":"HDAC3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88895"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15653507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21444723"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23911289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25190803"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25301942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28167758"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29192674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32404892"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34545082"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34608293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38961290"}],"value":"Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:21030595, PubMed:21444723, PubMed:23911289, PubMed:25301942, PubMed:28167758, PubMed:28497810, PubMed:32404892, PubMed:22230954). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity (PubMed:23911289, PubMed:22230954). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 (PubMed:15653507, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl), 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) and isonicotinyl acyl groups from lysine residues, leading to protein decrotonylation, delactylation, de-2-hydroxyisobutyrylation and deisonicotinylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293, PubMed:34545082, PubMed:35044827). Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:58196"},{"database":"Rhea","id":"RHEA-COMP:9845"},{"database":"Rhea","id":"RHEA-COMP:11338"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"3.5.1.98","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23911289"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:58197"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23911289"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:58108"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:61930"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15653507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25301942"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21444723"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:58109"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15653507"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25301942"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21444723"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69172"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13707"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:35899"},{"database":"ChEBI","id":"CHEBI:137954"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34608293"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69173"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28497810"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34608293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + H2O = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69176"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:15921"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:19641"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:144968"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29192674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:69177"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29192674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-[(S)-lactoyl]-L-lysyl-[protein] + H2O = (S)-lactate + L-lysyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:81387"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:19466"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16651"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:231527"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"38961290"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:81388"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35044827"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"38961290"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-isonicotinyl-L-lysyl-[protein] + H2O = isonicotinate + L-lysyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:83543"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:20155"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:38186"},{"database":"ChEBI","id":"CHEBI:233146"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34545082"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:83544"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34545082"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"}],"value":"Inositol tetraphosphate (1D-myo-inositol 1,4,5,6-tetrakisphosphate) promotes the histone deacetylase activity by acting as an intermolecular glue between HDAC3 and NCOR2, thereby promoting its association with the N-Cor complex, a prerequisite for the histone deacetylase activity"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88895"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P6W3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10655483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10669754"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10860984"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10898795"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11006275"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11466315"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11533236"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11931768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14525983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14633989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15297880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15927959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16569215"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18279852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18417529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19409814"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21914818"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22230954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23911289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25190803"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28167758"}],"value":"Interacts with HDAC7 and HDAC9 (PubMed:10655483, PubMed:11466315). Interacts with DAXX, KDM4A, HDAC10 and DACH1 (PubMed:10669754, PubMed:11861901, PubMed:14525983, PubMed:15927959). Found in a complex with NCOR1 and NCOR2 (PubMed:10860984, PubMed:22230954). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:11931768). Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY (PubMed:10898795, PubMed:11006275, PubMed:15297880). Interacts with BTBD14B (By similarity). Interacts with GLIS2 (By similarity). Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Component of the Notch corepressor complex (PubMed:19409814). Interacts with CBFA2T3 and NKAP (PubMed:11533236, PubMed:19409814). Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1 (PubMed:14633989). Interacts with ZMYND15 (By similarity). Interacts with SMRT/NCOR2 and BCL6 on DNA enhancer elements (PubMed:23911289). Interacts with INSM1 (PubMed:16569215, PubMed:18417529). Interacts with XBP1 isoform 1; the interaction occurs in endothelial cell (EC) under disturbed flow (PubMed:25190803). Interacts (via C-terminus) with CCAR2 (via N-terminus) (PubMed:21030595). Interacts with and deacetylates MEF2D (PubMed:21030595). Interacts with BEND3 (PubMed:21914818). Interacts with NKAPL (By similarity). Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:18279852). Interacts weakly with CRY1; this interaction is enhanced in the presence of FBXL3 (By similarity). Interacts with FBXL3 and BMAL1 (By similarity). Interacts with NCOR1 (By similarity). Interacts with RARA (PubMed:28167758). Interacts with SETD5 (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15572445"}],"value":"(Microbial infection) Interacts with human cytomegalovirus (HHV-5) immediate early protein IE1; this interaction decreases histone acetylation and allows transcriptional activation by the virus"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"O43823","geneName":"AKAP8","intActId":"EBI-1237481"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q9ULX6","geneName":"AKAP8L","intActId":"EBI-357530"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q9UKG1","geneName":"APPL1","intActId":"EBI-741243"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P24385","geneName":"CCND1","intActId":"EBI-375001"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P23771","geneName":"GATA3","intActId":"EBI-6664760"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q13227","geneName":"GPS2","intActId":"EBI-713355"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q13547","geneName":"HDAC1","intActId":"EBI-301834"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"O60341","geneName":"KDM1A","intActId":"EBI-710124"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q969R5","geneName":"L3MBTL2","intActId":"EBI-739909"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P43356","geneName":"MAGEA2B","intActId":"EBI-5650739"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q9UIS9","geneName":"MBD1","intActId":"EBI-867196"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P01106","geneName":"MYC","intActId":"EBI-447544"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"O75376","geneName":"NCOR1","intActId":"EBI-347233"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q9Y618","geneName":"NCOR2","intActId":"EBI-80830"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q15466","geneName":"NR0B2","intActId":"EBI-3910729"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P48552","geneName":"NRIP1","intActId":"EBI-746484"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P00558","geneName":"PGK1","intActId":"EBI-709599"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P00558-1","geneName":"PGK1","intActId":"EBI-16177310"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P60510","geneName":"PPP4C","intActId":"EBI-1046072"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q15022","geneName":"SUZ12","intActId":"EBI-1264675"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"O09106","geneName":"Hdac1","intActId":"EBI-301912"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P08393","geneName":"ICP0","intActId":"EBI-6148881"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q60974","geneName":"Ncor1","intActId":"EBI-349004"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"Q8CBD1","geneName":"Nrip1","intActId":"EBI-1771626"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"O15379","intActId":"EBI-607682"},"interactantTwo":{"uniProtKBAccession":"P12504","geneName":"vif","intActId":"EBI-779991"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21030595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25190803"}],"value":"Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). 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