{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q969S8","secondaryAccessions":["Q08AP4","Q6STF9","Q96P77","Q96P78","Q9H028","Q9UGX1","Q9UGX2"],"uniProtkbId":"HDA10_HUMAN","entryAudit":{"firstPublicDate":"2003-01-10","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-12-01","entryVersion":193,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Polyamine deacetylase HDAC10"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}],"value":"3.5.1.48"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}],"value":"3.5.1.62"}]},"alternativeNames":[{"fullName":{"value":"Histone deacetylase 10"},"shortNames":[{"value":"HD10"}]}]},"genes":[{"geneName":{"value":"HDAC10"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11677242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11726666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21247901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23801752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26221039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29968769"}],"value":"Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(8)-acetylspermidine + H2O = spermidine + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23928"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:57834"},{"database":"ChEBI","id":"CHEBI:58535"}],"ecNumber":"3.5.1.48","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-acetylputrescine + H2O = putrescine + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23412"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:58263"},{"database":"ChEBI","id":"CHEBI:326268"}],"ecNumber":"3.5.1.62","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-acetylcadaverine + H2O = cadaverine + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51892"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:58384"},{"database":"ChEBI","id":"CHEBI:134408"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:58108"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:30089"},{"database":"ChEBI","id":"CHEBI:61930"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11677242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11726666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26221039"}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":110.0,"unit":"uM","substrate":"acetylcadaverine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]},{"constant":170.0,"unit":"uM","substrate":"acetylputrescine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]},{"constant":100.0,"unit":"uM","substrate":"N(8)-acetylspermidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]},{"constant":180.0,"unit":"uM","substrate":"N(1)-acetylspermine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]},{"constant":150.0,"unit":"uM","substrate":"N(1),N(8)-diacetylspermidine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28516954"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23801752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26221039"}],"value":"Interacts with HDAC3 (PubMed:11861901). Interacts with HDAC2 and NCOR2/SMRT (PubMed:11739383). Interacts with HSPA8/HSC70 (PubMed:23801752). Interacts with MSH2 (PubMed:26221039)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"Q92870-2","geneName":"APBB2","intActId":"EBI-21535880"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"P54252","geneName":"ATXN3","intActId":"EBI-946046"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"Q96CV9","geneName":"OPTN","intActId":"EBI-748974"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"Q7Z412","geneName":"PEX26","intActId":"EBI-752057"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"A0A6Q8PF08","geneName":"PMP22","intActId":"EBI-50433196"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"P37840","geneName":"SNCA","intActId":"EBI-985879"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969S8","intActId":"EBI-301762"},"interactantTwo":{"uniProtKBAccession":"Q9BYV2","geneName":"TRIM54","intActId":"EBI-2130429"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11726666"}],"value":"Excluded from nucleoli"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11677242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11726666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23801752"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11677242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11726666"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11677242"}],"value":"Alpha"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11726666"}],"value":"HDAC10b"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11739383"}],"value":"HDAC10v1"}],"isoformIds":["Q969S8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11677242"}],"value":"Beta"}],"isoformIds":["Q969S8-2"],"sequenceIds":["VSP_002089"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"A"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11739383"}],"value":"HDAC10v2"}],"isoformIds":["Q969S8-4"],"sequenceIds":["VSP_002090"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q969S8-5"],"sequenceIds":["VSP_014698","VSP_014699"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11677242"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11739383"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"}],"value":"Widely expressed with high levels in liver and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23801752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29968769"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23801752"}],"value":"In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752)"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11861901"}],"value":"Like some other members of the HD type 2 subfamily, such as HDAC4, inhibited by the antitumor drug trichostatin A (TSA)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 4"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the histone deacetylase family. 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However, histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901, PubMed:28516954). 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