{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P25092","secondaryAccessions":["B2RMY6"],"uniProtkbId":"GUC2C_HUMAN","entryAudit":{"firstPublicDate":"1992-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-11-02","entryVersion":227,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11950846"}],"value":"Guanylyl cyclase C"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11950846"}],"value":"GC-C"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1718270"}],"value":"4.6.1.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1718270"}],"value":"Heat-stable enterotoxin receptor"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1718270"}],"value":"STA receptor"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1718270"}],"value":"hSTAR"}]},{"fullName":{"value":"Intestinal guanylate cyclase"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22521417"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4688"}],"value":"GUCY2C"},"synonyms":[{"value":"GUC2C"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1718270"}],"value":"STAR"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1680854"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1718270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22436048"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22521417"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8381596"}],"value":"Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:11950846, PubMed:1718270, PubMed:22436048, PubMed:22521417, PubMed:23269669). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP = 3',5'-cyclic GMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13665"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:57746"}],"ecNumber":"4.6.1.2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1718270"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13666"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950846"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"1718270"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11123935"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11950846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Homotrimer (PubMed:11123935). Interacts via its C-terminal region with NHERF4 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P25092","intActId":"EBI-2816795"},"interactantTwo":{"uniProtKBAccession":"Q86UT5-2","geneName":"NHERF4","intActId":"EBI-8299496"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"value":"The protein kinase domain is predicted to be catalytically inactive"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"value":"Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GUCY2C activation"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Diarrhea 6","diseaseAccession":"DI-03451","acronym":"DIAR6","description":"A relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis.","diseaseCrossReference":{"database":"MIM","id":"614616"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22436048"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Meconium ileus","diseaseAccession":"DI-03452","acronym":"MECIL","description":"A condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis.","diseaseCrossReference":{"database":"MIM","id":"614665"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22521417"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/43303/GUCY2C","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":1073,"modifier":"EXACT"}},"description":"Guanylyl cyclase C","featureId":"PRO_0000012376"},{"type":"Topological domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":1073,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00159"}]},{"type":"Domain","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00099"}]},{"type":"Site","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Not glycosylated","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}]},{"type":"Glycosylation","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"in dbSNP:rs56142849","featureCrossReferences":[{"database":"dbSNP","id":"rs56142849"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042221","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in a metastatic melanoma sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042222","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"in dbSNP:rs56275235","featureCrossReferences":[{"database":"dbSNP","id":"rs56275235"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042223","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"in dbSNP:rs1420635","featureCrossReferences":[{"database":"dbSNP","id":"rs1420635"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1680854"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1718270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8381596"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_049253","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"in MECIL; activation of guanylate cyclase activity is 60% lower than in wild-type; dbSNP:rs587776905","featureCrossReferences":[{"database":"dbSNP","id":"rs587776905"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22521417"}],"featureId":"VAR_068174","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"in dbSNP:rs55684775","featureCrossReferences":[{"database":"dbSNP","id":"rs55684775"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042224","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":610,"modifier":"EXACT"}},"description":"in dbSNP:rs55897626","featureCrossReferences":[{"database":"dbSNP","id":"rs55897626"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042225","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":840,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"in DIAR6; activating mutation; exposure of the mutant receptor to its ligands results in markedly increased production of cyclic guanosine monophosphate; dbSNP:rs587776871","featureCrossReferences":[{"database":"dbSNP","id":"rs587776871"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22436048"}],"featureId":"VAR_067724","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"in dbSNP:rs34890806","featureCrossReferences":[{"database":"dbSNP","id":"rs34890806"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042226","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":1045,"modifier":"EXACT"},"end":{"value":1045,"modifier":"EXACT"}},"description":"in dbSNP:rs35617837","featureCrossReferences":[{"database":"dbSNP","id":"rs35617837"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042227","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1072,"modifier":"EXACT"}},"description":"in dbSNP:rs35179392","featureCrossReferences":[{"database":"dbSNP","id":"rs35179392"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17344846"}],"featureId":"VAR_042228","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"in Ref. 1; AAB19934","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"in Ref. 1; AAB19934","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"in Ref. 1; AAB19934","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":543,"modifier":"EXACT"}},"description":"in Ref. 1; AAB19934","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Helix","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8GHO"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0141","category":"Biological process","name":"cGMP biosynthesis"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1718270","citationType":"journal article","authors":["Singh S.","Singh G.","Heim J.-M.","Gerzer R."],"citationCrossReferences":[{"database":"PubMed","id":"1718270"},{"database":"DOI","id":"10.1016/0006-291x(91)91736-v"}],"title":"Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.","publicationDate":"1991","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1455","lastPage":"1463","volume":"179"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","CATALYTIC ACTIVITY","VARIANT LEU-281"]},{"referenceNumber":2,"citation":{"id":"1680854","citationType":"journal article","authors":["de Sauvage F.J.","Camerato T.R.","Goeddel D.V."],"citationCrossReferences":[{"database":"PubMed","id":"1680854"},{"database":"DOI","id":"10.1016/s0021-9258(18)55214-5"}],"title":"Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"17912","lastPage":"17918","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","VARIANT LEU-281"]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT LEU-281"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT LEU-281"]},{"referenceNumber":6,"citation":{"id":"8605253","citationType":"journal article","authors":["Mann E.A.","Jump M.L.","Giannella R.A."],"citationCrossReferences":[{"database":"PubMed","id":"8605253"},{"database":"DOI","id":"10.1016/0167-4781(95)00190-5"}],"title":"Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene.","publicationDate":"1996","journal":"Biochim. Biophys. Acta","firstPage":"7","lastPage":"10","volume":"1305"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"8381596","citationType":"journal article","authors":["Mann E.A.","Cohen M.B.","Giannella R.A."],"citationCrossReferences":[{"database":"PubMed","id":"8381596"},{"database":"DOI","id":"10.1152/ajpgi.1993.264.1.g172"}],"title":"Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells.","publicationDate":"1993","journal":"Am. J. Physiol.","firstPage":"G172","lastPage":"G178","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-1073","FUNCTION","VARIANT LEU-281"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"11123935","citationType":"journal article","authors":["Vijayachandra K.","Guruprasad M.","Bhandari R.","Manjunath U.H.","Somesh B.P.","Srinivasan N.","Suguna K.","Visweswariah S.S."],"citationCrossReferences":[{"database":"PubMed","id":"11123935"},{"database":"DOI","id":"10.1021/bi0013849"}],"title":"Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer.","publicationDate":"2000","journal":"Biochemistry","firstPage":"16075","lastPage":"16083","volume":"39"},"referencePositions":["SUBUNIT"]},{"referenceNumber":9,"citation":{"id":"11950846","citationType":"journal article","authors":["Scott R.O.","Thelin W.R.","Milgram S.L."],"citationCrossReferences":[{"database":"PubMed","id":"11950846"},{"database":"DOI","id":"10.1074/jbc.m202434200"}],"title":"A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"22934","lastPage":"22941","volume":"277"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH NHERF4"]},{"referenceNumber":10,"citation":{"id":"23269669","citationType":"journal article","authors":["Arshad N.","Ballal S.","Visweswariah S.S."],"citationCrossReferences":[{"database":"PubMed","id":"23269669"},{"database":"DOI","id":"10.1074/jbc.m112.413906"}],"title":"Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.","publicationDate":"2013","journal":"J. Biol. Chem.","firstPage":"3907","lastPage":"3917","volume":"288"},"referencePositions":["GLYCOSYLATION AT ASN-32; ASN-75; ASN-79; ASN-195; ASN-284; ASN-307; ASN-345 AND ASN-402","LACK OF GLYCOSYLATION AT ASN-357","FUNCTION","CATALYTIC ACTIVITY","INTERACTION WITH VIP36","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"22521417","citationType":"journal article","authors":["Romi H.","Cohen I.","Landau D.","Alkrinawi S.","Yerushalmi B.","Hershkovitz R.","Newman-Heiman N.","Cutting G.R.","Ofir R.","Sivan S.","Birk O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22521417"},{"database":"DOI","id":"10.1016/j.ajhg.2012.03.022"}],"title":"Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C.","publicationDate":"2012","journal":"Am. J. Hum. Genet.","firstPage":"893","lastPage":"899","volume":"90"},"referencePositions":["VARIANT MECIL GLY-387","FUNCTION","CHARACTERIZATION OF VARIANT MECIL GLY-387"]},{"referenceNumber":12,"citation":{"id":"22436048","citationType":"journal article","authors":["Fiskerstrand T.","Arshad N.","Haukanes B.I.","Tronstad R.R.","Pham K.D.","Johansson S.","Havik B.","Tonder S.L.","Levy S.E.","Brackman D.","Boman H.","Biswas K.H.","Apold J.","Hovdenak N.","Visweswariah S.S.","Knappskog P.M."],"citationCrossReferences":[{"database":"PubMed","id":"22436048"},{"database":"DOI","id":"10.1056/nejmoa1110132"}],"title":"Familial diarrhea syndrome caused by an activating GUCY2C mutation.","publicationDate":"2012","journal":"N. Engl. J. Med.","firstPage":"1586","lastPage":"1595","volume":"366"},"referencePositions":["VARIANT DIAR6 ILE-840","FUNCTION","CHARACTERIZATION OF VARIANT DIAR6 ILE-840"]},{"referenceNumber":13,"citation":{"id":"17344846","citationType":"journal article","authors":["Greenman C.","Stephens P.","Smith R.","Dalgliesh G.L.","Hunter C.","Bignell G.","Davies H.","Teague J.","Butler A.","Stevens C.","Edkins S.","O'Meara S.","Vastrik I.","Schmidt E.E.","Avis T.","Barthorpe S.","Bhamra G.","Buck G.","Choudhury B.","Clements J.","Cole J.","Dicks E.","Forbes S.","Gray K.","Halliday K.","Harrison R.","Hills K.","Hinton J.","Jenkinson A.","Jones D.","Menzies A.","Mironenko T.","Perry J.","Raine K.","Richardson D.","Shepherd R.","Small A.","Tofts C.","Varian J.","Webb T.","West S.","Widaa S.","Yates A.","Cahill D.P.","Louis D.N.","Goldstraw P.","Nicholson A.G.","Brasseur F.","Looijenga L.","Weber B.L.","Chiew Y.-E.","DeFazio A.","Greaves M.F.","Green A.R.","Campbell P.","Birney E.","Easton D.F.","Chenevix-Trench G.","Tan M.-H.","Khoo S.K.","Teh B.T.","Yuen S.T.","Leung S.Y.","Wooster R.","Futreal P.A.","Stratton M.R."],"citationCrossReferences":[{"database":"PubMed","id":"17344846"},{"database":"DOI","id":"10.1038/nature05610"}],"title":"Patterns of somatic mutation in human cancer genomes.","publicationDate":"2007","journal":"Nature","firstPage":"153","lastPage":"158","volume":"446"},"referencePositions":["VARIANTS [LARGE SCALE ANALYSIS] ARG-30; ARG-61; GLN-114; LEU-464; LYS-610; VAL-859; ARG-1045 AND CYS-1072"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S57551","properties":[{"key":"ProteinId","value":"AAB19934.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M73489","properties":[{"key":"ProteinId","value":"AAA36655.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC007545","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010168","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471094","properties":[{"key":"ProteinId","value":"EAW96324.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC136544","properties":[{"key":"ProteinId","value":"AAI36545.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC136545","properties":[{"key":"ProteinId","value":"AAI36546.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U20230","properties":[{"key":"ProteinId","value":"AAC50381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS8664.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A40940","properties":[{"key":"EntryName","value":"OYHUHX"}]},{"database":"RefSeq","id":"NP_004954.2","properties":[{"key":"NucleotideSequenceId","value":"NM_004963.4"}]},{"database":"PDB","id":"8FX4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"D=419-1073"}]},{"database":"PDB","id":"8GHO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"C/G=93-110"}]},{"database":"PDB","id":"8GHP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"A=24-430"}]},{"database":"PDBsum","id":"8FX4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GHO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8GHP","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29523","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109239","properties":[{"key":"Interactions","value":"2"}]},{"database":"CORUM","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P25092","properties":[{"key":"Number of interactors","value":"485"}]},{"database":"IntAct","id":"P25092","properties":[{"key":"Interactions","value":"5"}]},{"database":"MINT","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000261170","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1795197","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB08890","properties":[{"key":"GenericName","value":"Linaclotide"}]},{"database":"DrugBank","id":"DB13170","properties":[{"key":"GenericName","value":"Plecanatide"}]},{"database":"DrugCentral","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1750","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"8.A.85.1.1","properties":[{"key":"FamilyName","value":"the guanylate cyclase (gc) family"}]},{"database":"GlyCosmos","id":"P25092","properties":[{"key":"glycosylation","value":"8 sites, No reported glycans"}]},{"database":"GlyGen","id":"P25092","properties":[{"key":"glycosylation","value":"8 sites, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GUCY2C","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"311033390","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000261170","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54253","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P25092","properties":[{"key":"antibodies","value":"2 sequenced antibodies"}]},{"database":"Antibodypedia","id":"12046","properties":[{"key":"antibodies","value":"330 antibodies from 29 providers"}]},{"database":"DNASU","id":"2984","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000261170.5","properties":[{"key":"ProteinId","value":"ENSP00000261170.3"},{"key":"GeneId","value":"ENSG00000070019.6"}]},{"database":"GeneID","id":"2984","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:2984","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000261170.5","properties":[{"key":"ProteinId","value":"ENSP00000261170.3"},{"key":"RefSeqNucleotideId","value":"NM_004963.4"},{"key":"RefSeqProteinId","value":"NP_004954.2"}]},{"database":"UCSC","id":"uc001rcd.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:4688","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA29069","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"2984","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"2984","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GUCY2C","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4688","properties":[{"key":"GeneName","value":"GUCY2C"}]},{"database":"HPA","id":"ENSG00000070019","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (intestine)"}]},{"database":"MalaCards","id":"GUCY2C","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"601330","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"614616","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"614665","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000070019","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"314373","properties":[{"key":"Disease","value":"Chronic infantile diarrhea due to guanylate cyclase 2C overactivity"}]},{"database":"Orphanet","id":"103908","properties":[{"key":"Disease","value":"Congenital sodium diarrhea"}]},{"database":"Orphanet","id":"314376","properties":[{"key":"Disease","value":"Intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000070019","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1023","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155955","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001072_1_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NPALGWK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"60033at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P25092","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"4.6.1.2","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8935690","properties":[{"key":"PathwayName","value":"Digestion"}]},{"database":"Reactome","id":"R-HSA-8942233","properties":[{"key":"PathwayName","value":"Intestinal infectious diseases"}]},{"database":"SignaLink","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P25092","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000070019","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"2984","properties":[{"key":"hits","value":"7 hits in 1163 CRISPR screens"}]},{"database":"ChiTaRS","id":"GUCY2C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Guanylate_cyclase_2C","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"2984","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P25092","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P25092","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"P25092","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000070019","properties":[{"key":"ExpressionPatterns","value":"Expressed in jejunal mucosa and 60 other cell types or tissues"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23269669"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004383","properties":[{"key":"GoTerm","value":"F:guanylate cyclase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11950846"}]},{"database":"GO","id":"GO:0001653","properties":[{"key":"GoTerm","value":"F:peptide receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0004672","properties":[{"key":"GoTerm","value":"F:protein kinase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015643","properties":[{"key":"GoTerm","value":"F:toxic substance binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0006182","properties":[{"key":"GoTerm","value":"P:cGMP biosynthetic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007168","properties":[{"key":"GoTerm","value":"P:receptor guanylyl cyclase signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd06369","properties":[{"key":"EntryName","value":"PBP1_GC_C_enterotoxin_receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd14044","properties":[{"key":"EntryName","value":"PK_GC-C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000364","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000015","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000185","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR018297","properties":[{"key":"EntryName","value":"A/G_cyclase_CS"}]},{"database":"InterPro","id":"IPR050401","properties":[{"key":"EntryName","value":"Cyclic_nucleotide_synthase"}]},{"database":"InterPro","id":"IPR042822","properties":[{"key":"EntryName","value":"GC-C_PK"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"InterPro","id":"IPR028082","properties":[{"key":"EntryName","value":"Peripla_BP_I"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"PANTHER","id":"PTHR11920","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11920:SF347","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53822","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like I"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00452","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF","length":1073,"molWeight":123403,"crc64":"486A4DE6F9097E22","md5":"52EDD741BEE5D20FAE1A1FD2E903FF7D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"PTM":1,"DISEASE":2,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":2,"Site":1,"Glycosylation":8,"Natural variant":11,"Sequence conflict":4,"Helix":1},"uniParcId":"UPI000013D135"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VL51","uniProtkbId":"A0ACI8VL51_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039999"}],"value":"Guanylyl cyclase C"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012202"}],"value":"4.6.1.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042221"}],"value":"Heat-stable enterotoxin receptor"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042330"}],"value":"Intestinal guanylate cyclase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"}],"value":"GUCY2C"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP = 3',5'-cyclic GMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13665"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:57746"}],"ecNumber":"4.6.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13666"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":1040,"modifier":"EXACT"}},"description":"Guanylyl cyclase C","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051393094"},{"type":"Transmembrane","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":749,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Domain","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":925,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50125"}]},{"type":"Binding site","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":830,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":873,"modifier":"EXACT"},"end":{"value":873,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":873,"modifier":"EXACT"},"end":{"value":873,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023293"}],"id":"KW-0141","category":"Biological process","name":"cGMP biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VL51"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VL51"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640842.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007545","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010168","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970783.1","properties":[{"key":"ProteinId","value":"ENSP00000640842.1"},{"key":"GeneId","value":"ENSG00000070019.6"}]},{"database":"HGNC","id":"HGNC:4688","properties":[{"key":"GeneName","value":"GUCY2C"}]},{"database":"OpenTargets","id":"ENSG00000070019","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155955","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd06369","properties":[{"key":"EntryName","value":"PBP1_GC_C_enterotoxin_receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd14044","properties":[{"key":"EntryName","value":"PK_GC-C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000364","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000185","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR050401","properties":[{"key":"EntryName","value":"Cyclic_nucleotide_synthase"}]},{"database":"InterPro","id":"IPR042822","properties":[{"key":"EntryName","value":"GC-C_PK"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"InterPro","id":"IPR028082","properties":[{"key":"EntryName","value":"Peripla_BP_I"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"PANTHER","id":"PTHR11920","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11920:SF347","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53822","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like I"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSALRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF","length":1040,"molWeight":119992,"crc64":"2E214BF049FE7C73","md5":"EA7D7215EFB4C939659922B887DBA633"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2,"Binding site":5},"uniParcId":"UPI004031D14C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PR72","uniProtkbId":"A0ACI8PR72_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"value":"Guanylate cyclase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"value":"4.6.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"}],"value":"GUCY2C"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP = 3',5'-cyclic GMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13665"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:57746"}],"ecNumber":"4.6.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13666"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000405"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":1084,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051506130"},{"type":"Transmembrane","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Domain","location":{"start":{"value":835,"modifier":"EXACT"},"end":{"value":965,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50125"}]},{"type":"Binding site","location":{"start":{"value":840,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":840,"modifier":"EXACT"},"end":{"value":840,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":841,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":884,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":884,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023293"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"id":"KW-0141","category":"Biological process","name":"cGMP biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000405"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PR72"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PR72"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000537678.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007545","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010168","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000867619.1","properties":[{"key":"ProteinId","value":"ENSP00000537678.1"},{"key":"GeneId","value":"ENSG00000070019.6"}]},{"database":"HGNC","id":"HGNC:4688","properties":[{"key":"GeneName","value":"GUCY2C"}]},{"database":"OpenTargets","id":"ENSG00000070019","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155955","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd06369","properties":[{"key":"EntryName","value":"PBP1_GC_C_enterotoxin_receptor"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd14044","properties":[{"key":"EntryName","value":"PK_GC-C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000364","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000015","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.2300:FF:000185","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR018297","properties":[{"key":"EntryName","value":"A/G_cyclase_CS"}]},{"database":"InterPro","id":"IPR050401","properties":[{"key":"EntryName","value":"Cyclic_nucleotide_synthase"}]},{"database":"InterPro","id":"IPR042822","properties":[{"key":"EntryName","value":"GC-C_PK"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"InterPro","id":"IPR028082","properties":[{"key":"EntryName","value":"Peripla_BP_I"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"PANTHER","id":"PTHR11920","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11920:SF347","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53822","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like I"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00452","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELESLYTFEAICLHVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF","length":1084,"molWeight":124681,"crc64":"6F769EB080773D31","md5":"C6B14B035B41211862E96A9ADD49E556"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2,"Binding site":5},"uniParcId":"UPI004031627F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VL61","uniProtkbId":"A0ACI8VL61_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"value":"Guanylate cyclase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"value":"4.6.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"}],"value":"GUCY2C"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP = 3',5'-cyclic GMP + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13665"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:57746"}],"ecNumber":"4.6.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13666"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00036920"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004251"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000405"}],"value":"Belongs to the adenylyl cyclase class-4/guanylyl cyclase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":988,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051383423"},{"type":"Transmembrane","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Domain","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"Guanylate cyclase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50125"}]},{"type":"Binding site","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":745,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2","note":"catalytic"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023293"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003431"}],"id":"KW-0141","category":"Biological process","name":"cGMP biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000405"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00099"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VL61"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VL61"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000640843.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC007545","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010168","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000970784.1","properties":[{"key":"ProteinId","value":"ENSP00000640843.1"},{"key":"GeneId","value":"ENSG00000070019.6"}]},{"database":"HGNC","id":"HGNC:4688","properties":[{"key":"GeneName","value":"GUCY2C"}]},{"database":"OpenTargets","id":"ENSG00000070019","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155955","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"CDD","id":"cd07302","properties":[{"key":"EntryName","value":"CHD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd14044","properties":[{"key":"EntryName","value":"PK_GC-C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000364","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.1230:FF:000015","properties":[{"key":"EntryName","value":"Guanylate cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.1230","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001054","properties":[{"key":"EntryName","value":"A/G_cyclase"}]},{"database":"InterPro","id":"IPR018297","properties":[{"key":"EntryName","value":"A/G_cyclase_CS"}]},{"database":"InterPro","id":"IPR050401","properties":[{"key":"EntryName","value":"Cyclic_nucleotide_synthase"}]},{"database":"InterPro","id":"IPR042822","properties":[{"key":"EntryName","value":"GC-C_PK"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR029787","properties":[{"key":"EntryName","value":"Nucleotide_cyclase"}]},{"database":"InterPro","id":"IPR028082","properties":[{"key":"EntryName","value":"Peripla_BP_I"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR001245","properties":[{"key":"EntryName","value":"Ser-Thr/Tyr_kinase_cat_dom"}]},{"database":"PANTHER","id":"PTHR11920","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11920:SF347","properties":[{"key":"EntryName","value":"GUANYLYL CYCLASE C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00211","properties":[{"key":"EntryName","value":"Guanylate_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07714","properties":[{"key":"EntryName","value":"PK_Tyr_Ser-Thr"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00044","properties":[{"key":"EntryName","value":"CYCc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55073","properties":[{"key":"EntryName","value":"Nucleotide cyclase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53822","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like I"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00452","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50125","properties":[{"key":"EntryName","value":"GUANYLATE_CYCLASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKTLLLDLALWSLLFQPGWLSFSSQNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF","length":988,"molWeight":114231,"crc64":"74965FC94A92C749","md5":"03F30F3CD86D291E8DBCBCD512C48B59"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2,"Binding site":5},"uniParcId":"UPI0040325B82"}}]}