{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P57764","secondaryAccessions":["A8K702","D3DWJ9","Q96Q98"],"uniProtkbId":"GSDMD_HUMAN","entryAudit":{"firstPublicDate":"2001-02-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-02-21","entryVersion":178,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26375259"}],"value":"Gasdermin-D"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15289881"}],"value":"Gasdermin domain-containing protein 1"}}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Gasdermin-D, N-terminal"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"GSDMD-NT"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31097341"}],"value":"hGSDMD-NTD"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Gasdermin-D, C-terminal"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"GSDMD-CT"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31097341"}],"value":"hGSDMD-CTD"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Gasdermin-D, p13"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37327784"}],"value":"Gasdermin-D, 13 kDa"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37327784"}],"value":"13 kDa GSDMD"}]}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35794369"}],"value":"Gasdermin-D, p40"}}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25697"}],"value":"GSDMD"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15289881"}],"value":"DFNA5L"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15289881"}],"value":"GSDMDC1"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"value":"FKSG10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39673710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40118151"}],"value":"Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27281216). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-D, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:26375003, PubMed:26375259, PubMed:27281216, PubMed:39673710, PubMed:40118151)"}],"commentType":"FUNCTION","molecule":"Gasdermin-D"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27418190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28392147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29898893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33472215"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34289345"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36227980"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37198476"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38040708"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38530158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40097387"}],"value":"Promotes pyroptosis in response to microbial infection and danger signals (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:28392147, PubMed:32820063, PubMed:34289345, PubMed:38040708, PubMed:38530158, PubMed:38599239). Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1, CASP4 or CASP5 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216, PubMed:29898893, PubMed:36227980). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukin-1 (IL1B and IL18) and triggering pyroptosis (PubMed:27281216, PubMed:27418190, PubMed:29898893, PubMed:33883744, PubMed:38040708, PubMed:38530158, PubMed:38599239). Gasdermin pores also allow the release of mature caspase-7 (CASP7) (By similarity). In some, but not all, cells types, pyroptosis is followed by pyroptotic cell death, which is caused by downstream activation of ninjurin-1 (NINJ1), which mediates membrane rupture (cytolysis) (PubMed:33472215, PubMed:37198476). Also forms pores in the mitochondrial membrane, resulting in release of mitochondrial DNA (mtDNA) into the cytosol (By similarity). Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (By similarity). Also active in response to MAP3K7/TAK1 inactivation by Yersinia toxin YopJ, which triggers cleavage by CASP8 and subsequent activation (By similarity). Required for mucosal tissue defense against enteric pathogens (By similarity). Activation of the non-canonical inflammasome in brain endothelial cells can lead to excessive pyroptosis, leading to blood-brain barrier breakdown (By similarity). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin (PubMed:27281216). Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216)"}],"commentType":"FUNCTION","molecule":"Gasdermin-D, N-terminal"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Transcription coactivator produced by the cleavage by CASP3 or CASP7 in the upper small intestine in response to dietary antigens (By similarity). Required to maintain food tolerance in small intestine: translocates to the nucleus and acts as a coactivator for STAT1 to induce the transcription of CIITA and MHC class II molecules, which in turn induce type 1 regulatory T (Tr1) cells in upper small intestine (By similarity)"}],"commentType":"FUNCTION","molecule":"Gasdermin-D, p13"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35794369"}],"value":"Produced by the cleavage by papain allergen (PubMed:35794369). After cleavage, moves to the plasma membrane and homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the specific release of mature interleukin-33 (IL33), promoting type 2 inflammatory immune response (PubMed:35794369)"}],"commentType":"FUNCTION","molecule":"Gasdermin-D, p40"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375259"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27418190"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28392147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29576317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29898893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38040708"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38324683"}],"value":"The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal (PubMed:26375003, PubMed:28928145, PubMed:29576317, PubMed:32109412). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-D, N-terminal) following cleavage by caspases CASP1, CASP4, CASP5 or CASP8 (PubMed:26375003, PubMed:26375259, PubMed:27418190, PubMed:29898893, PubMed:32109412). Cleavage at Asp-87 by CASP3 or CASP7 inactivates the ability to mediate pyroptosis (PubMed:28392147). Homooligomerization and pore formation is specifically inhibited by VHH(GSDMD-1) and, to a lesser extent, VHH(GSDMD-2) nanobodies, protecting against excessive pyroptosis (PubMed:38040708). Inhibited by small molecule NU6300, which covalently reacts with Cys-191, thereby preventing palmitoylation and pyroptosis (PubMed:38324683)"}],"commentType":"ACTIVITY REGULATION","molecule":"Gasdermin-D"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5Y4Y6"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34289345"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38040708"}],"value":"Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane (PubMed:33883744, PubMed:34289345, PubMed:38040708). Homooligomerization is promoted by the mTORC1 complex in macrophages (PubMed:34289345). In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor (By similarity). Although this recruitment is also observed in the absence of PYCARD, it is more efficient in its presence (By similarity)"}],"commentType":"SUBUNIT","molecule":"Gasdermin-D, N-terminal"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q86U10","geneName":"ASPG","intActId":"EBI-19946665"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"P29466","geneName":"CASP1","intActId":"EBI-516667"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q8NC69","geneName":"KCTD6","intActId":"EBI-2511344"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q6FHY5","geneName":"MEOX2","intActId":"EBI-16439278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"P25786","geneName":"PSMA1","intActId":"EBI-359352"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q86T24","geneName":"ZBTB33","intActId":"EBI-2515625"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q9BUY5","geneName":"ZNF426","intActId":"EBI-743265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"Q96NG5","geneName":"ZNF558","intActId":"EBI-373363"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P57764","intActId":"EBI-2798865"},"interactantTwo":{"uniProtKBAccession":"P0DTC9","geneName":"N","intActId":"EBI-25475856"},"numberOfExperiments":13,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Gasdermin-D","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"In response to a canonical inflammasome stimulus, such as nigericin, recruited to NLRP3 inflammasone with similar kinetics to that of uncleaved CASP1 precursor"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Inflammasome","id":"SL-0488"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Gasdermin-D, N-terminal","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Released in the extracellular milieu following pyroptosis"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36227980"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38530158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29898893"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Mitochondrion membrane","id":"SL-0171"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Gasdermin-D, N-terminal","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36227980"}],"value":"(Microbial infection) Upon infection by M.tuberculosis, localization to cell membrane is prevented by M.tuberculosis phosphatase PtpB that catalyzes dephosphorylation of phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol 4-phosphate, thereby inhibiting the membrane targeting of Gasdermin-D, N-terminal and subsequent cytokine release and pyroptosis"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36227980"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Gasdermin-D, p13","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Gasdermin-D, C-terminal","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19051310"}],"value":"Expressed in the suprabasal cells of esophagus, as well as in the isthmus/neck, pit, and gland of the stomach, suggesting preferential expression in differentiating cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29576317"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29898893"}],"value":"Intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of cleavage by inflammatory caspases CASP1, CASP4 or CASP5 (PubMed:26375003, PubMed:28928145, PubMed:29576317, PubMed:29898893). The linker helix loop inserts into the N-terminal domain (PubMed:28928145). The intrinsic pyroptosis-inducing activity is carried by Gasdermin-D, N-terminal, that is released upon cleavage by inflammatory caspases (PubMed:26375003)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"value":"Forms a ring-shaped pore complex containing 27-28 subunits that inserts into the membrane (PubMed:33883744). The pore conduit is predominantly negatively charged, facilitating the release of mature interleukin-1 (IL1B and IL18) (PubMed:33883744). In contrast interleukin-1 precursors are not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744)"}],"commentType":"DOMAIN","molecule":"Gasdermin-D, N-terminal"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28045099"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28392147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29898893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35794369"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37327784"}],"value":"Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CASP7 inactivates the ability to mediate pyroptosis, but generates the Gasdermin-D, p13 chain, which translocates to the nucleus and acts as a transcription regulator (PubMed:28045099, PubMed:28392147, PubMed:37327784). Cleavage by papain allergen generates the Gasdermin-D, p40 chain (PubMed:35794369)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40097387"}],"value":"Ubiquitinated by TRAF1/TRAF2 complex at Lys-236 via 'Lys-63'-linked polyubiquitin chains; leading to pyroptosis activity"}],"commentType":"PTM","molecule":"Gasdermin-D, N-terminal"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D8T2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38324683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38530158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}],"value":"Palmitoylated at Cys-191 by ZDHHC5 and ZDHHC9 in response to microbial infection and danger signals (PubMed:38324683, PubMed:38530158, PubMed:38599239). Palmitoylation takes place before cleavage by caspases (CASP1, CASP4, CASP5 or CASP8) and is required for membrane translocation and pore formation (PubMed:38324683, PubMed:38530158, PubMed:38599239). Depalmitoylated by LYPLA2 (By similarity)"}],"commentType":"PTM","molecule":"Gasdermin-D"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}],"value":"Succination of Cys-191 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis (PubMed:32820063). Succination modification is catalyzed by a non-enzymatic reaction caused by an accumulation of fumarate (PubMed:32820063)"}],"commentType":"PTM","molecule":"Gasdermin-D"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37962578"}],"value":"Glycosylated: O-GlcNAcylation by OGT leads to reduced cleavage by CASP4 and decreased LPS-induced endothelial cell pyroptosis"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"value":"(Microbial infection) Cleaved and inactivated by Protease 3C from Human enterovirus 71 (EV71), preventing GSDMD-mediated pyroptosis"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35594856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39673710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40118151"}],"value":"(Microbial infection) Cleaved and inactivated at Leu-28 by the 3C-like proteinase nsp5 from human coronavirus SARS-CoV-2, preventing GSDMD-mediated pyroptosis (PubMed:35594856, PubMed:39673710, PubMed:40118151). The 3C-like proteinase nsp5 from human coronavirus SARS-CoV-2 also cleaves and activates GSDMD at His-270 and Asp-275, thereby promoting unconventional secretion of the viral nucleocapsid through gasdermin pores into the host extracellular space (PubMed:39673710)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34492225"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36599845"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36991122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36991125"}],"value":"(Microbial infection) Ubiquitinated by S.flexneri IpaH7.8, leading to its degradation by the proteasome"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Gasdermin-D","featureId":"PRO_0000148175"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Gasdermin-D, p40","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35794369"}],"featureId":"PRO_0000459018"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Gasdermin-D, N-terminal","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26375003"}],"featureId":"PRO_0000437526"},{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"Gasdermin-D, p13","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37327784"}],"featureId":"PRO_0000459017"},{"type":"Chain","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Gasdermin-D, C-terminal","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26375003"}],"featureId":"PRO_0000437527"},{"type":"Transmembrane","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Beta stranded","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6VFE"}]},{"type":"Transmembrane","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Beta stranded","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6VFE"}]},{"type":"Transmembrane","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Beta stranded","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6VFE"}]},{"type":"Transmembrane","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Beta stranded","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6VFE"}]},{"type":"Region","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Linker helix loop","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"}]},{"type":"Site","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"(Microbial infection) Cleavage; by coronavirus SARS-CoV-2 proteinase nsp5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39673710"}]},{"type":"Site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Cleavage; by CASP3 or CASP7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28045099"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28392147"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37327784"}]},{"type":"Site","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"(Microbial infection) Cleavage; by SARS-CoV-2 proteinase nsp5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40118151"}]},{"type":"Site","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"(Microbial infection) Cleavage; by enterovirus 71 (EV71) Protease 3C and coronavirus SARS-CoV-2 proteinase nsp5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35594856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40118151"}]},{"type":"Site","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"(Microbial infection) Cleavage; by coronavirus SARS-CoV-2 proteinase nsp5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39673710"}]},{"type":"Site","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"(Microbial infection) Cleavage; by coronavirus SARS-CoV-2 proteinase nsp5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39673710"}]},{"type":"Site","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Cleavage; by caspases CASP1, CASP4, CASP5 and CASP8","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29898893"}]},{"type":"Site","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Cleavage; by papain","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35794369"}]},{"type":"Modified residue","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15592455"}]},{"type":"Modified residue","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"S-(2-succinyl)cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}]},{"type":"Modified residue","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"15592455"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"S-(2-succinyl)cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}]},{"type":"Modified residue","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"S-(2-succinyl)cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}]},{"type":"Modified residue","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"S-(2-succinyl)cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}]},{"type":"Modified residue","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"S-(2-succinyl)cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32820063"}]},{"type":"Lipidation","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38324683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}]},{"type":"Glycosylation","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37962578"}],"featureId":""},{"type":"Cross-link","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40097387"}]},{"type":"Natural variant","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"found in a patient with autism; uncertain significance; increased palmitoylation and pyroptosis","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}],"featureId":"VAR_089418","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Impaired pore-formation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29695864"}],"alternativeSequence":{"originalSequence":"RVVRR","alternativeSequences":["AVVAA"]}},{"type":"Mutagenesis","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"No spontaneous pyroptosis-inducing activity; when associated with D-192.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Abolished ubiquitination by S.flexneri IpaH7.8.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36991125"}],"alternativeSequence":{"originalSequence":"LDHGGEF","alternativeSequences":["VSGSRGD"]}},{"type":"Mutagenesis","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Abolished ability to form a pore.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"RKPSSSWFWKPR","alternativeSequences":["EEPSSSWFWEPE"]}},{"type":"Mutagenesis","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Abolished ability to form a pore.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"WFW","alternativeSequences":["GFG"]}},{"type":"Mutagenesis","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"In AP1; promotes ability to release of interleukin-1 (IL1B and IL18) precursors.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"DILEPDAAEPD","alternativeSequences":["AILAPDAAAPA"]}},{"type":"Mutagenesis","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"In AP2; promotes ability to release of interleukin-1 (IL1B and IL18) precursors.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"DGQIQGSVE","alternativeSequences":["AGQIQGSVA"]}},{"type":"Mutagenesis","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Decreased effectiveness in pore formation and pyroptosis induction. No effect on cleavage by CASP1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27418190"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Reduced ability to form a pore.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Abolished palmitoylation and ability to form a pore and mediate pyroptosis. Prevents binding to small molecule NU6300.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38324683"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Decreased induction of pyroptosis and defects in liposome-binding. No spontaneous pyroptosis-inducing activity; when associated with K-15.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36227980"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Abolished cleavage by enterovirus 71 (EV71) Protease 3C and human coronavirus SARS-CoV-2 3C-like proteinase nsp5.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35594856"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Reduced ability to form a pore.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33883744"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Fails to mediate pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Abolished ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Abolished ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Does not affect ability to induce pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Does not affect interaction with CASP4.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"}],"alternativeSequence":{"originalSequence":"FLT","alternativeSequences":["AAA"]}},{"type":"Mutagenesis","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Loss of cleavage by CASP1 and CASP4 and of LPS-induced pyroptosis. Does not affect interaction with CASP1 and CASP4.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26375003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38599239"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Constitutively active mutant; promotes activation of pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"}],"alternativeSequence":{"originalSequence":"VPAEGAFTEDFQGLRAEVET","alternativeSequences":["SGGGS"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Constitutively active mutant; promotes activation of pyroptosis.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A","R"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"No effect.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28928145"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Abolished generation of the Gasdermin-D, p40 chain and ability to promote secretion of IL33.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35794369"}],"alternativeSequence":{"originalSequence":"QGLR","alternativeSequences":["AAA"]}},{"type":"Mutagenesis","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Spontaneous pyroptosis-inducing activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Impairs interaction with CASP1 and CASP4 and subsequent cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"}],"alternativeSequence":{"originalSequence":"LDREL","alternativeSequences":["ADREA"]}},{"type":"Mutagenesis","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Does not affect cleavage by enterovirus 71 (EV71) Protease 3C.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28679757"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Abolished O-GlcNAcylation, leading to increased association with CASP4.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37962578"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Impairs interaction with CASP1 and CASP4 and subsequent cleavage.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32109412"}],"alternativeSequence":{"originalSequence":"VPEL","alternativeSequences":["APEA"]}},{"type":"Mutagenesis","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Spontaneous pyroptosis-inducing activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Spontaneous pyroptosis-inducing activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27281216"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"in Ref. 1; AAG22861","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"SGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEP","alternativeSequences":["PECWCRNSLSLLSTCWG"]}},{"type":"Sequence conflict","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"in Ref. 2; BAF84506","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Turn","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5NH1"}]},{"type":"Helix","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6AO4"}]},{"type":"Helix","location":{"start":{"value":365,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N9O"}]},{"type":"Beta strand","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Turn","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":427,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6KN0"}]},{"type":"Helix","location":{"start":{"value":437,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Turn","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Beta strand","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6AO4"}]},{"type":"Beta strand","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]},{"type":"Helix","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Z1X"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1271","category":"Cellular component","name":"Inflammasome"},{"id":"KW-0395","category":"Biological process","name":"Inflammatory response"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1210","category":"Biological process","name":"Necrosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FGDG8CC0VMJLV","citationType":"submission","authors":["Wang Y.-G."],"title":"Identification of FKSG10, a novel gene related to breast cancer.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L. III","Engels R.","Gloeckner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.J.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lymph","type":"TISSUE"},{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"28392147","citationType":"journal article","authors":["Taabazuing C.Y.","Okondo M.C.","Bachovchin D.A."],"citationCrossReferences":[{"database":"PubMed","id":"28392147"},{"database":"DOI","id":"10.1016/j.chembiol.2017.03.009"}],"title":"Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages.","publicationDate":"2017","journal":"Cell Chem. Biol.","firstPage":"507","lastPage":"514","volume":"24"},"referencePositions":["PROTEIN SEQUENCE OF 88-94","ACTIVITY REGULATION","PROTEOLYTIC CLEAVAGE"]},{"referenceNumber":7,"citation":{"id":"26375003","citationType":"journal article","authors":["Shi J.","Zhao Y.","Wang K.","Shi X.","Wang Y.","Huang H.","Zhuang Y.","Cai T.","Wang F.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"26375003"},{"database":"DOI","id":"10.1038/nature15514"}],"title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.","publicationDate":"2015","journal":"Nature","firstPage":"660","lastPage":"665","volume":"526"},"referencePositions":["PROTEIN SEQUENCE OF 276-281","FUNCTION","CLEAVAGE BY CASP1 AND CASP4","MUTAGENESIS OF ASP-275","AUTOINHIBITION"]},{"referenceNumber":8,"citation":{"id":"15289881","citationType":"journal article","authors":["Katoh M.","Katoh M."],"citationCrossReferences":[{"database":"PubMed","id":"15289881"},{"database":"DOI","id":"10.3892/ijo.25.3.765"}],"title":"Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico.","publicationDate":"2004","journal":"Int. J. Oncol.","firstPage":"765","lastPage":"770","volume":"25"},"referencePositions":["GENE STRUCTURE"]},{"referenceNumber":9,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.-M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37 AND TYR-158","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19051310","citationType":"journal article","authors":["Saeki N.","Usui T.","Aoyagi K.","Kim D.H.","Sato M.","Mabuchi T.","Yanagihara K.","Ogawa K.","Sakamoto H.","Yoshida T.","Sasaki H."],"citationCrossReferences":[{"database":"PubMed","id":"19051310"},{"database":"DOI","id":"10.1002/gcc.20636"}],"title":"Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.","publicationDate":"2009","journal":"Genes Chromosomes Cancer","firstPage":"261","lastPage":"271","volume":"48"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"26375259","citationType":"journal article","authors":["Kayagaki N.","Stowe I.B.","Lee B.L.","O'Rourke K.","Anderson K.","Warming S.","Cuellar T.","Haley B.","Roose-Girma M.","Phung Q.T.","Liu P.S.","Lill J.R.","Li H.","Wu J.","Kummerfeld S.","Zhang J.","Lee W.P.","Snipas S.J.","Salvesen G.S.","Morris L.X.","Fitzgerald L.","Zhang Y.","Bertram E.M.","Goodnow C.C.","Dixit V.M."],"citationCrossReferences":[{"database":"PubMed","id":"26375259"},{"database":"DOI","id":"10.1038/nature15541"}],"title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.","publicationDate":"2015","journal":"Nature","firstPage":"666","lastPage":"671","volume":"526"},"referencePositions":["FUNCTION","CLEAVAGE BY CASP4"]},{"referenceNumber":17,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"27418190","citationType":"journal article","authors":["Sborgi L.","Ruehl S.","Mulvihill E.","Pipercevic J.","Heilig R.","Stahlberg H.","Farady C.J.","Mueller D.J.","Broz P.","Hiller S."],"citationCrossReferences":[{"database":"PubMed","id":"27418190"},{"database":"DOI","id":"10.15252/embj.201694696"}],"title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.","publicationDate":"2016","journal":"EMBO J.","firstPage":"1766","lastPage":"1778","volume":"35"},"referencePositions":["FUNCTION (GASDERMIN-D","N-TERMINAL)","CLEAVAGE BY CASP1","MUTAGENESIS OF ILE-104"]},{"referenceNumber":19,"citation":{"id":"27281216","citationType":"journal article","authors":["Ding J.","Wang K.","Liu W.","She Y.","Sun Q.","Shi J.","Sun H.","Wang D.C.","Shao F."],"citationCrossReferences":[{"database":"PubMed","id":"27281216"},{"database":"DOI","id":"10.1038/nature18590"}],"title":"Pore-forming activity and structural autoinhibition of the gasdermin family.","publicationDate":"2016","journal":"Nature","firstPage":"111","lastPage":"116","volume":"535"},"referencePositions":["FUNCTION (GASDERMIN-D","N-TERMINAL)","LIPID-BINDING","SUBCELLULAR LOCATION","MUTAGENESIS OF GLU-15; LEU-192; LEU-290; TYR-373 AND ALA-377"]},{"referenceNumber":20,"citation":{"id":"28679757","citationType":"journal article","authors":["Lei X.","Zhang Z.","Xiao X.","Qi J.","He B.","Wang J."],"citationCrossReferences":[{"database":"PubMed","id":"28679757"},{"database":"DOI","id":"10.1128/jvi.01069-17"}],"title":"Enterovirus 71 inhibits pyroptosis through cleavage of gasdermin D.","publicationDate":"2017","journal":"J. Virol.","firstPage":"0","lastPage":"0","volume":"91"},"referencePositions":["CLEAVAGE BY HUMAN ENTEROVIRUS PROTEASE 3C","MUTAGENESIS OF GLN-193; ASP-234; LYS-235; LYS-236; GLN-237; ARG-238; THR-239; PHE-240; GLN-241; PRO-242; PRO-243 AND GLN-335"]},{"referenceNumber":21,"citation":{"id":"28045099","citationType":"journal article","authors":["Rogers C.","Fernandes-Alnemri T.","Mayes L.","Alnemri D.","Cingolani G.","Alnemri E.S."],"citationCrossReferences":[{"database":"PubMed","id":"28045099"},{"database":"DOI","id":"10.1038/ncomms14128"}],"title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.","publicationDate":"2017","journal":"Nat. Commun.","firstPage":"14128","lastPage":"14128","volume":"8"},"referencePositions":["CLEAVAGE BY CASP3"]},{"referenceNumber":22,"citation":{"id":"29898893","citationType":"journal article","authors":["Mulvihill E.","Sborgi L.","Mari S.A.","Pfreundschuh M.","Hiller S.","Mueller D.J."],"citationCrossReferences":[{"database":"PubMed","id":"29898893"},{"database":"DOI","id":"10.15252/embj.201798321"}],"title":"Mechanism of membrane pore formation by human gasdermin-D.","publicationDate":"2018","journal":"EMBO J.","firstPage":"0","lastPage":"0","volume":"37"},"referencePositions":["FUNCTION","CLEAVAGE BY CASP5","SUBCELLULAR LOCATION"]},{"referenceNumber":23,"citation":{"id":"29695864","citationType":"journal article","authors":["Ruan J.","Xia S.","Liu X.","Lieberman J.","Wu H."],"citationCrossReferences":[{"database":"PubMed","id":"29695864"},{"database":"DOI","id":"10.1038/s41586-018-0058-6"}],"title":"Cryo-EM structure of the gasdermin A3 membrane pore.","publicationDate":"2018","journal":"Nature","firstPage":"62","lastPage":"67","volume":"557"},"referencePositions":["MUTAGENESIS OF 7-ARG--ARG-11"]},{"referenceNumber":24,"citation":{"id":"32820063","citationType":"journal article","authors":["Humphries F.","Shmuel-Galia L.","Ketelut-Carneiro N.","Li S.","Wang B.","Nemmara V.V.","Wilson R.","Jiang Z.","Khalighinejad F.","Muneeruddin K.","Shaffer S.A.","Dutta R.","Ionete C.","Pesiridis S.","Yang S.","Thompson P.R.","Fitzgerald K.A."],"citationCrossReferences":[{"database":"PubMed","id":"32820063"},{"database":"DOI","id":"10.1126/science.abb9818"}],"title":"Succination inactivates gasdermin D and blocks pyroptosis.","publicationDate":"2020","journal":"Science","firstPage":"1633","lastPage":"1637","volume":"369"},"referencePositions":["FUNCTION","SUCCINATION AT CYS-56; CYS-191; CYS-268; CYS-309 AND CYS-467"]},{"referenceNumber":25,"citation":{"id":"34289345","citationType":"journal article","authors":["Evavold C.L.","Hafner-Bratkovic I.","Devant P.","D'Andrea J.M.","Ngwa E.M.","Borsic E.","Doench J.G.","LaFleur M.W.","Sharpe A.H.","Thiagarajah J.R.","Kagan J.C."],"citationCrossReferences":[{"database":"PubMed","id":"34289345"},{"database":"DOI","id":"10.1016/j.cell.2021.06.028"}],"title":"Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.","publicationDate":"2021","journal":"Cell","firstPage":"4495","lastPage":"4511","volume":"184"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":26,"citation":{"id":"34492225","citationType":"journal article","authors":["Luchetti G.","Roncaioli J.L.","Chavez R.A.","Schubert A.F.","Kofoed E.M.","Reja R.","Cheung T.K.","Liang Y.","Webster J.D.","Lehoux I.","Skippington E.","Reeder J.","Haley B.","Tan M.W.","Rose C.M.","Newton K.","Kayagaki N.","Vance R.E.","Dixit V.M."],"citationCrossReferences":[{"database":"PubMed","id":"34492225"},{"database":"DOI","id":"10.1016/j.chom.2021.08.010"}],"title":"Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.","publicationDate":"2021","journal":"Cell Host Microbe","firstPage":"1521","lastPage":"1530","volume":"29"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)"]},{"referenceNumber":27,"citation":{"id":"33472215","citationType":"journal article","authors":["Kayagaki N.","Kornfeld O.S.","Lee B.L.","Stowe I.B.","O'Rourke K.","Li Q.","Sandoval W.","Yan D.","Kang J.","Xu M.","Zhang J.","Lee W.P.","McKenzie B.S.","Ulas G.","Payandeh J.","Roose-Girma M.","Modrusan Z.","Reja R.","Sagolla M.","Webster J.D.","Cho V.","Andrews T.D.","Morris L.X.","Miosge L.A.","Goodnow C.C.","Bertram E.M.","Dixit V.M."],"citationCrossReferences":[{"database":"PubMed","id":"33472215"},{"database":"DOI","id":"10.1038/s41586-021-03218-7"}],"title":"NINJ1 mediates plasma membrane rupture during lytic cell death.","publicationDate":"2021","journal":"Nature","firstPage":"131","lastPage":"136","volume":"591"},"referencePositions":["FUNCTION"]},{"referenceNumber":28,"citation":{"id":"35794369","citationType":"journal article","authors":["Chen W.","Chen S.","Yan C.","Zhang Y.","Zhang R.","Chen M.","Zhong S.","Fan W.","Zhu S.","Zhang D.","Lu X.","Zhang J.","Huang Y.","Zhu L.","Li X.","Lv D.","Fu Y.","Iv H.","Ling Z.","Ma L.","Jiang H.","Long G.","Zhu J.","Wu D.","Wu B.","Sun B."],"citationCrossReferences":[{"database":"PubMed","id":"35794369"},{"database":"DOI","id":"10.1038/s41590-022-01255-6"}],"title":"Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion.","publicationDate":"2022","journal":"Nat. Immunol.","firstPage":"1021","lastPage":"1030","volume":"23"},"referencePositions":["FUNCTION (GASDERMIN-D","P40)","PROTEOLYTIC CLEAVAGE","MUTAGENESIS OF 288-GLN--ARG-291"]},{"referenceNumber":29,"citation":{"id":"35594856","citationType":"journal article","authoringGroup":["COVID Human Genetic Effort"],"authors":["Planes R.","Pinilla M.","Santoni K.","Hessel A.","Passemar C.","Lay K.","Paillette P.","Valadao A.C.","Robinson K.S.","Bastard P.","Lam N.","Fadrique R.","Rossi I.","Pericat D.","Bagayoko S.","Leon-Icaza S.A.","Rombouts Y.","Perouzel E.","Tiraby M.","Zhang Q.","Cicuta P.","Jouanguy E.","Neyrolles O.","Bryant C.E.","Floto A.R.","Goujon C.","Lei F.Z.","Martin-Blondel G.","Silva S.","Casanova J.L.","Cougoule C.","Reversade B.","Marcoux J.","Ravet E.","Meunier E."],"citationCrossReferences":[{"database":"PubMed","id":"35594856"},{"database":"DOI","id":"10.1016/j.molcel.2022.04.033"}],"title":"Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"2385","lastPage":"2400","volume":"82"},"referencePositions":["PROTEOLYTIC CLEAVAGE (MICROBIAL INFECTION)","MUTAGENESIS OF GLN-193"]},{"referenceNumber":30,"citation":{"id":"36227980","citationType":"journal article","authors":["Chai Q.","Yu S.","Zhong Y.","Lu Z.","Qiu C.","Yu Y.","Zhang X.","Zhang Y.","Lei Z.","Qiang L.","Li B.X.","Pang Y.","Qiu X.B.","Wang J.","Liu C.H."],"citationCrossReferences":[{"database":"PubMed","id":"36227980"},{"database":"DOI","id":"10.1126/science.abq0132"}],"title":"A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin.","publicationDate":"2022","journal":"Science","firstPage":"eabq0132","lastPage":"eabq0132","volume":"378"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","SUBCELLULAR LOCATION (MICROBIAL INFECTION)","MUTAGENESIS OF LEU-192"]},{"referenceNumber":31,"citation":{"id":"37327784","citationType":"journal article","authors":["He K.","Wan T.","Wang D.","Hu J.","Zhou T.","Tao W.","Wei Z.","Lu Q.","Zhou R.","Tian Z.","Flavell R.A.","Zhu S."],"citationCrossReferences":[{"database":"PubMed","id":"37327784"},{"database":"DOI","id":"10.1016/j.cell.2023.05.027"}],"title":"Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.","publicationDate":"2023","journal":"Cell","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["PROTEOLYTIC CLEAVAGE"]},{"referenceNumber":32,"citation":{"id":"36991122","citationType":"journal article","authors":["Wang C.","Shivcharan S.","Tian T.","Wright S.","Ma D.","Chang J.","Li K.","Song K.","Xu C.","Rathinam V.A.","Ruan J."],"citationCrossReferences":[{"database":"PubMed","id":"36991122"},{"database":"DOI","id":"10.1038/s41586-023-05832-z"}],"title":"Structural basis for GSDMB pore formation and its targeting by IpaH7.8.","publicationDate":"2023","journal":"Nature","firstPage":"590","lastPage":"597","volume":"616"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)"]},{"referenceNumber":33,"citation":{"id":"36991125","citationType":"journal article","authors":["Zhong X.","Zeng H.","Zhou Z.","Su Y.","Cheng H.","Hou Y.","She Y.","Feng N.","Wang J.","Shao F.","Ding J."],"citationCrossReferences":[{"database":"PubMed","id":"36991125"},{"database":"DOI","id":"10.1038/s41586-023-05872-5"}],"title":"Structural mechanisms for regulation of GSDMB pore-forming activity.","publicationDate":"2023","journal":"Nature","firstPage":"598","lastPage":"605","volume":"616"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)","MUTAGENESIS OF 16-LEU--PHE-22"]},{"referenceNumber":34,"citation":{"id":"37198476","citationType":"journal article","authors":["Degen M.","Santos J.C.","Pluhackova K.","Cebrero G.","Ramos S.","Jankevicius G.","Hartenian E.","Guillerm U.","Mari S.A.","Kohl B.","Mueller D.J.","Schanda P.","Maier T.","Perez C.","Sieben C.","Broz P.","Hiller S."],"citationCrossReferences":[{"database":"PubMed","id":"37198476"},{"database":"DOI","id":"10.1038/s41586-023-05991-z"}],"title":"Structural basis of NINJ1-mediated plasma membrane rupture in cell death.","publicationDate":"2023","journal":"Nature","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION"]},{"referenceNumber":35,"citation":{"id":"36599845","citationType":"journal article","authors":["Yin H.","Zheng J.","He Q.","Zhang X.","Li X.","Ma Y.","Liang X.","Gao J.","Kocsis B.L.","Li Z.","Liu X.","Alto N.M.","Li L.","Zhang H."],"citationCrossReferences":[{"database":"PubMed","id":"36599845"},{"database":"DOI","id":"10.1038/s41467-022-35725-0"}],"title":"Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.","publicationDate":"2023","journal":"Nat. Commun.","firstPage":"61","lastPage":"61","volume":"14"},"referencePositions":["UBIQUITINATION (MICROBIAL INFECTION)"]},{"referenceNumber":36,"citation":{"id":"39673710","citationType":"journal article","authors":["Grin P.M.","Baid K.","de Jesus H.C.R.","Kozarac N.","Bell P.A.","Jiang S.Z.","Kappelhoff R.","Butler G.S.","Leborgne N.G.F.","Pan C.","Pablos I.","Machado Y.","Vederas J.C.","Kim H.","Benarafa C.","Banerjee A.","Overall C.M."],"citationCrossReferences":[{"database":"PubMed","id":"39673710"},{"database":"DOI","id":"10.1016/j.celrep.2024.115080"}],"title":"SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro.","publicationDate":"2024","journal":"Cell Rep.","firstPage":"115080","lastPage":"115080","volume":"43"},"referencePositions":["FUNCTION","CLEAVAGE BY SARS-COV-2 3C-LIKE PROTEINASE NSP5 (MICROBIAL INFECTION)"]},{"referenceNumber":37,"citation":{"id":"37962578","citationType":"journal article","authors":["Yu F.","Zhang Z.","Leng Y.","Chen A.F."],"citationCrossReferences":[{"database":"PubMed","id":"37962578"},{"database":"DOI","id":"10.1007/s00011-023-01812-1"}],"title":"O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis.","publicationDate":"2024","journal":"Inflamm. Res.","firstPage":"5","lastPage":"17","volume":"73"},"referencePositions":["GLYCOSYLATION AT SER-338","MUTAGENESIS OF SER-338"]},{"referenceNumber":38,"citation":{"id":"38599239","citationType":"journal article","authors":["Du G.","Healy L.B.","David L.","Walker C.","El-Baba T.J.","Lutomski C.A.","Goh B.","Gu B.","Pi X.","Devant P.","Fontana P.","Dong Y.","Ma X.","Miao R.","Balasubramanian A.","Puthenveetil R.","Banerjee A.","Luo H.R.","Kagan J.C.","Oh S.F.","Robinson C.V.","Lieberman J.","Wu H."],"citationCrossReferences":[{"database":"PubMed","id":"38599239"},{"database":"DOI","id":"10.1038/s41586-024-07373-5"}],"title":"ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.","publicationDate":"2024","journal":"Nature","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","PALMITOYLATION AT CYS-191","MUTAGENESIS OF CYS-191 AND ASP-275","VARIANT ALA-41","CHARACTERIZATION OF VARIANT ALA-41"]},{"referenceNumber":39,"citation":{"id":"38324683","citationType":"journal article","authors":["Jiang X.","Zhang X.","Cai X.","Li N.","Zheng H.","Tang M.","Zhu J.","Su K.","Zhang R.","Ye N.","Peng J.","Zhao M.","Wu W.","Yang J.","Ye H."],"citationCrossReferences":[{"database":"PubMed","id":"38324683"},{"database":"DOI","id":"10.1126/sciadv.adi9284"}],"title":"NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.","publicationDate":"2024","journal":"Sci. Adv.","firstPage":"eadi9284","lastPage":"eadi9284","volume":"10"},"referencePositions":["PALMITOYLATION AT CYS-191","ACTIVITY REGULATION","MUTAGENESIS OF CYS-191"]},{"referenceNumber":40,"citation":{"id":"38530158","citationType":"journal article","authors":["Balasubramanian A.","Hsu A.Y.","Ghimire L.","Tahir M.","Devant P.","Fontana P.","Du G.","Liu X.","Fabin D.","Kambara H.","Xie X.","Liu F.","Hasegawa T.","Xu R.","Yu H.","Chen M.","Kolakowski S.","Trauger S.","Larsen M.R.","Wei W.","Wu H.","Kagan J.C.","Lieberman J.","Luo H.R."],"citationCrossReferences":[{"database":"PubMed","id":"38530158"},{"database":"DOI","id":"10.1126/sciimmunol.adn1452"}],"title":"The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.","publicationDate":"2024","journal":"Sci. Immunol.","firstPage":"eadn1452","lastPage":"eadn1452","volume":"9"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","PALMITOYLATION"]},{"referenceNumber":41,"citation":{"id":"40097387","citationType":"journal article","authors":["Chu X.","Zhang T.","Bukhari I.","Hu M.","Xu J.","Xing Y.","Liang X.","Zhang Z.","Zheng P."],"citationCrossReferences":[{"database":"PubMed","id":"40097387"},{"database":"DOI","id":"10.1038/s41419-025-07475-6"}],"title":"Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis.","publicationDate":"2025","journal":"Cell Death Dis.","firstPage":"181","lastPage":"181","volume":"16"},"referencePositions":["FUNCTION (GASDERMIN-D","N-TERMINAL)","UBIQUITINATION AT LYS-236"]},{"referenceNumber":42,"citation":{"id":"40118151","citationType":"journal article","authors":["Zhang Y.","Ji X.","Huang D.","Lu G.","Chen X."],"citationCrossReferences":[{"database":"PubMed","id":"40118151"},{"database":"DOI","id":"10.1016/j.virs.2025.03.006"}],"title":"The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D.","publicationDate":"2025","journal":"Virol. Sin.","firstPage":"324","lastPage":"332","volume":"40"},"referencePositions":["FUNCTION","CLEAVAGE BY SARS-COV-2 3C-LIKE PROTEINASE NSP5 (MICROBIAL INFECTION)"]},{"referenceNumber":43,"citation":{"id":"28928145","citationType":"journal article","authors":["Kuang S.","Zheng J.","Yang H.","Li S.","Duan S.","Shen Y.","Ji C.","Gan J.","Xu X.W.","Li J."],"citationCrossReferences":[{"database":"PubMed","id":"28928145"},{"database":"DOI","id":"10.1073/pnas.1708194114"}],"title":"Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.","publicationDate":"2017","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10642","lastPage":"10647","volume":"114"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 276-484","DOMAIN","ACTIVITY REGULATION","MUTAGENESIS OF GLU-15; LEU-192; 277-VAL--THR-296 AND PHE-283"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5WQT"}]},{"referenceNumber":44,"citation":{"id":"29576317","citationType":"journal article","authors":["Liu Z.","Wang C.","Rathkey J.K.","Yang J.","Dubyak G.R.","Abbott D.W.","Xiao T.S."],"citationCrossReferences":[{"database":"PubMed","id":"29576317"},{"database":"DOI","id":"10.1016/j.str.2018.03.002"}],"title":"Structures of the Gasdermin D C-terminal domains reveal mechanisms of autoinhibition.","publicationDate":"2018","journal":"Structure","firstPage":"778","lastPage":"784","volume":"26"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 277-484","DOMAIN","ACTIVITY REGULATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6AO4"}]},{"referenceNumber":45,"citation":{"id":"31097341","citationType":"journal article","authors":["Liu Z.","Wang C.","Yang J.","Zhou B.","Yang R.","Ramachandran R.","Abbott D.W.","Xiao T.S."],"citationCrossReferences":[{"database":"PubMed","id":"31097341"},{"database":"DOI","id":"10.1016/j.immuni.2019.04.017"}],"title":"Crystal structures of the full-length murine and human Gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization.","publicationDate":"2019","journal":"Immunity","firstPage":"43","lastPage":"49","volume":"51"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6N9O"}]},{"referenceNumber":46,"citation":{"id":"32109412","citationType":"journal article","authors":["Wang K.","Sun Q.","Zhong X.","Zeng M.","Zeng H.","Shi X.","Li Z.","Wang Y.","Zhao Q.","Shao F.","Ding J."],"citationCrossReferences":[{"database":"PubMed","id":"32109412"},{"database":"DOI","id":"10.1016/j.cell.2020.02.002"}],"title":"Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis.","publicationDate":"2020","journal":"Cell","firstPage":"941","lastPage":"955","volume":"180"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.79 ANGSTROMS) OF 283-480 IN COMPLEX WITH CASP1","ACTIVITY REGULATION","SUBCELLULAR LOCATION","PROTEOLYTIC CLEAVAGE","MUTAGENESIS OF 272-PHE--THR-274; ASP-275; 304-LEU--LEU-308 AND 364-VAL--LEU-367"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6KN0"}]},{"referenceNumber":47,"citation":{"id":"33883744","citationType":"journal article","authors":["Xia S.","Zhang Z.","Magupalli V.G.","Pablo J.L.","Dong Y.","Vora S.M.","Wang L.","Fu T.M.","Jacobson M.P.","Greka A.","Lieberman J.","Ruan J.","Wu H."],"citationCrossReferences":[{"database":"PubMed","id":"33883744"},{"database":"DOI","id":"10.1038/s41586-021-03478-3"}],"title":"Gasdermin D pore structure reveals preferential release of mature interleukin-1.","publicationDate":"2021","journal":"Nature","firstPage":"607","lastPage":"611","volume":"593"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.90 ANGSTROMS) OF 1-241","SUBCELLULAR LOCATION","SUBUNIT","MUTAGENESIS OF 42-ARG--ARG-53; 48-TRP--TRP-50; 63-ASP--ASP-73; 87-ASP--GLU-95; ARG-174 AND LYS-204"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6VFE"}]},{"referenceNumber":48,"citation":{"id":"38040708","citationType":"journal article","authors":["Kopp A.","Hagelueken G.","Jamitzky I.","Moecking J.","Schiffelers L.D.J.","Schmidt F.I.","Geyer M."],"citationCrossReferences":[{"database":"PubMed","id":"38040708"},{"database":"DOI","id":"10.1038/s41467-023-43707-z"}],"title":"Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.","publicationDate":"2023","journal":"Nat. Commun.","firstPage":"7923","lastPage":"7923","volume":"14"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) IN COMPLEX WITH VHH NANOBODY","FUNCTION","SUBUNIT","ACTIVITY REGULATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7Z1X"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY008304","properties":[{"key":"ProteinId","value":"AAG22861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK022212","properties":[{"key":"ProteinId","value":"BAB13986.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291817","properties":[{"key":"ProteinId","value":"BAF84506.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471162","properties":[{"key":"ProteinId","value":"EAW82243.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471162","properties":[{"key":"ProteinId","value":"EAW82245.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC008904","properties":[{"key":"ProteinId","value":"AAH08904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC069000","properties":[{"key":"ProteinId","value":"AAH69000.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34956.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001159709.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001166237.1"}]},{"database":"RefSeq","id":"NP_079012.3","properties":[{"key":"NucleotideSequenceId","value":"NM_024736.7"}]},{"database":"PDB","id":"5NH1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.04 A"},{"key":"Chains","value":"A=278-484"}]},{"database":"PDB","id":"5WQT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.64 A"},{"key":"Chains","value":"A/B=276-484"}]},{"database":"PDB","id":"6AO4","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=277-484"}]},{"database":"PDB","id":"6KMZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.61 A"},{"key":"Chains","value":"E=287-480, H=286-480"}]},{"database":"PDB","id":"6KN0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"E/F=283-480"}]},{"database":"PDB","id":"6N9O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.50 A"},{"key":"Chains","value":"A/B/C/D=1-484"}]},{"database":"PDB","id":"6VFE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d=1-241"}]},{"database":"PDB","id":"7Z1X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.86 A"},{"key":"Chains","value":"A/D=1-484"}]},{"database":"PDB","id":"9E0V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.64 A"},{"key":"Chains","value":"A=276-484"}]},{"database":"PDBsum","id":"5NH1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5WQT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6AO4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KMZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KN0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N9O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6VFE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Z1X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E0V","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-21160","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122891","properties":[{"key":"Interactions","value":"27"}]},{"database":"DIP","id":"DIP-61775N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P57764","properties":[{"key":"Number of interactors","value":"325"}]},{"database":"IntAct","id":"P57764","properties":[{"key":"Interactions","value":"31"}]},{"database":"NDEx","id":"IQUERY-CP-GSDMD","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000433209","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4523247","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.C.123.1.1","properties":[{"key":"FamilyName","value":"the pore-forming gasdermin (gasdermin) family"}]},{"database":"GlyGen","id":"P57764","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GSDMD","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"13124058","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000433209","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"57029","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P57764","properties":[{"key":"antibodies","value":"3 sequenced antibodies"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"DNASU","id":"79792","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000262580.9","properties":[{"key":"ProteinId","value":"ENSP00000262580.4"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000526406.5","properties":[{"key":"ProteinId","value":"ENSP00000433209.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000615119.2","properties":[{"key":"ProteinId","value":"ENSP00000482096.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"Ensembl","id":"ENST00000631751.1","properties":[{"key":"ProteinId","value":"ENSP00000488012.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"Ensembl","id":"ENST00000866629.1","properties":[{"key":"ProteinId","value":"ENSP00000536688.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000866630.1","properties":[{"key":"ProteinId","value":"ENSP00000536689.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000866631.1","properties":[{"key":"ProteinId","value":"ENSP00000536690.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000866632.1","properties":[{"key":"ProteinId","value":"ENSP00000536691.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000866633.1","properties":[{"key":"ProteinId","value":"ENSP00000536692.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000917301.1","properties":[{"key":"ProteinId","value":"ENSP00000587360.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000917302.1","properties":[{"key":"ProteinId","value":"ENSP00000587361.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000967708.1","properties":[{"key":"ProteinId","value":"ENSP00000637767.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000967709.1","properties":[{"key":"ProteinId","value":"ENSP00000637768.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000967710.1","properties":[{"key":"ProteinId","value":"ENSP00000637769.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000967711.1","properties":[{"key":"ProteinId","value":"ENSP00000637770.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"GeneID","id":"79792","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:79792","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000262580.9","properties":[{"key":"ProteinId","value":"ENSP00000262580.4"},{"key":"RefSeqNucleotideId","value":"NM_024736.7"},{"key":"RefSeqProteinId","value":"NP_079012.3"}]},{"database":"UCSC","id":"uc003yyg.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:25697","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162390357","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79792","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"79792","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GSDMD","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"HPA","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"617042","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S0IQ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_040752_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WTLLEEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P57764","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000104518-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-111457","properties":[{"key":"PathwayName","value":"Release of apoptotic factors from the mitochondria"}]},{"database":"Reactome","id":"R-HSA-448706","properties":[{"key":"PathwayName","value":"Interleukin-1 processing"}]},{"database":"Reactome","id":"R-HSA-5620971","properties":[{"key":"PathwayName","value":"Pyroptosis"}]},{"database":"Reactome","id":"R-HSA-5686938","properties":[{"key":"PathwayName","value":"Regulation of TLR by endogenous ligand"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-9660826","properties":[{"key":"PathwayName","value":"Purinergic signaling in leishmaniasis infection"}]},{"database":"Reactome","id":"R-HSA-9960519","properties":[{"key":"PathwayName","value":"CASP4-mediated substrate cleavage"}]},{"database":"Reactome","id":"R-HSA-9960525","properties":[{"key":"PathwayName","value":"CASP5-mediated substrate cleavage"}]},{"database":"SignaLink","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P57764","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000104518","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"79792","properties":[{"key":"hits","value":"28 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"79792","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P57764","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:P57764","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"P57764","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P57764","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0061702","properties":[{"key":"GoTerm","value":"C:canonical inflammasome complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1904813","properties":[{"key":"GoTerm","value":"C:ficolin-1-rich granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0072559","properties":[{"key":"GoTerm","value":"C:NLRP3 inflammasome complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36227980"}]},{"database":"GO","id":"GO:0035580","properties":[{"key":"GoTerm","value":"C:specific granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:1904724","properties":[{"key":"GoTerm","value":"C:tertiary granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:1901612","properties":[{"key":"GoTerm","value":"F:cardiolipin binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070300","properties":[{"key":"GoTerm","value":"F:phosphatidic acid binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005546","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-4,5-bisphosphate binding"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27281216"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36227980"}]},{"database":"GO","id":"GO:0070273","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-4-phosphate binding"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36227980"}]},{"database":"GO","id":"GO:0001786","properties":[{"key":"GoTerm","value":"F:phosphatidylserine binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0022829","properties":[{"key":"GoTerm","value":"F:wide pore channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"}]},{"database":"GO","id":"GO:0042742","properties":[{"key":"GoTerm","value":"P:defense response to bacterium"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050829","properties":[{"key":"GoTerm","value":"P:defense response to Gram-negative bacterium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050830","properties":[{"key":"GoTerm","value":"P:defense response to Gram-positive bacterium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046931","properties":[{"key":"GoTerm","value":"P:pore complex assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050729","properties":[{"key":"GoTerm","value":"P:positive regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"}]},{"database":"GO","id":"GO:0032731","properties":[{"key":"GoTerm","value":"P:positive regulation of interleukin-1 beta production"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009306","properties":[{"key":"GoTerm","value":"P:protein secretion"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993712"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37993714"}]},{"database":"GO","id":"GO:0141201","properties":[{"key":"GoTerm","value":"P:pyroptotic cell death"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36227980"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"38632402"}]},{"database":"GO","id":"GO:0070269","properties":[{"key":"GoTerm","value":"P:pyroptotic inflammatory response"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32109412"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"33883744"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36227980"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"InterPro","id":"IPR041263","properties":[{"key":"EntryName","value":"Gasdermin_PUB"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17708","properties":[{"key":"EntryName","value":"Gasdermin_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH","length":484,"molWeight":52801,"crc64":"F7CE8073E0C0194D","md5":"86CA62D0993D298691FAE6E6128B8471"},"extraAttributes":{"countByCommentType":{"FUNCTION":4,"ACTIVITY REGULATION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":5,"TISSUE SPECIFICITY":1,"DOMAIN":2,"PTM":8,"SIMILARITY":1},"countByFeatureType":{"Chain":5,"Transmembrane":4,"Region":1,"Site":8,"Modified residue":8,"Lipidation":1,"Glycosylation":1,"Cross-link":1,"Natural variant":1,"Mutagenesis":37,"Sequence conflict":2,"Helix":19,"Beta strand":16,"Turn":3},"uniParcId":"UPI00001291ED"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3V1A6","uniProtkbId":"G3V1A6_HUMAN","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":112,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"}],"value":"Gasdermin D"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Domain","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":504,"modifier":"EXACT"}},"description":"Gasdermin PUB","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF17708"}]},{"type":"Region","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022590"}],"id":"KW-1210","category":"Biological process","name":"Necrosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"G3V1A6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"G3V1A6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022452"}],"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":6,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19690332"}]},{"referenceNumber":7,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":8,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"23186163"}]},{"referenceNumber":9,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":10,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":11,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433958.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3V1A6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3V1A6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"32308","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000533063.5","properties":[{"key":"ProteinId","value":"ENSP00000433958.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000628703.2","properties":[{"key":"ProteinId","value":"ENSP00000486410.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc003yyf.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_040752_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"InterPro","id":"IPR041263","properties":[{"key":"EntryName","value":"Gasdermin_PUB"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17708","properties":[{"key":"EntryName","value":"Gasdermin_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MISAHCNLHLPGSSDSLASASQLLLAGRLPGRADAPDAPPSGRRRSRSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH","length":532,"molWeight":57735,"crc64":"00CF9D6D647A42B0","md5":"EDA8F0A3D36A9D1D8FC4C0AE62E12E74"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Region":1},"uniParcId":"UPI0000E5AF91"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PQ48","uniProtkbId":"E9PQ48_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":93,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Non-terminal residue","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PQ48"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PQ48"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434452.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PQ48","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PQ48","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22911","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000525721.1","properties":[{"key":"ProteinId","value":"ENSP00000434452.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000632347.1","properties":[{"key":"ProteinId","value":"ENSP00000488317.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qzc.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WTLLEEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSS","length":114,"molWeight":12462,"crc64":"2E2C7F5A881ABB23","md5":"BACDE76FB4AC73F21449B48ACE6B9492"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78583"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SUX0","uniProtkbId":"A0ACI8SUX0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"}],"value":"Gasdermin D"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Domain","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Gasdermin PUB","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF17708"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022590"}],"id":"KW-1210","category":"Biological process","name":"Necrosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SUX0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SUX0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022452"}],"id":"KW-1134","category":"Domain","name":"Transmembrane beta strand"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000587359.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000917300.1","properties":[{"key":"ProteinId","value":"ENSP00000587359.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"InterPro","id":"IPR041263","properties":[{"key":"EntryName","value":"Gasdermin_PUB"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17708","properties":[{"key":"EntryName","value":"Gasdermin_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH","length":329,"molWeight":35903,"crc64":"797A25A159CB397C","md5":"5FDB8C7F7AF70B65DEC27A1AA7647725"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI004031AB01"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PIB2","uniProtkbId":"E9PIB2_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":91,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Region","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PIB2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PIB2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000436684.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PIB2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PIB2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"20751","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000534018.5","properties":[{"key":"ProteinId","value":"ENSP00000436684.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000631389.1","properties":[{"key":"ProteinId","value":"ENSP00000488049.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qzd.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_887241_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELQAQRRPWRTQLGSMGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPS","length":277,"molWeight":30825,"crc64":"CBFE1148ED8D320A","md5":"245FFADAD8697DC19E51E2EC5777A69B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78584"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PNZ0","uniProtkbId":"E9PNZ0_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-10-05","entryVersion":96,"sequenceVersion":8},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Non-terminal residue","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PNZ0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PNZ0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000437065.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PNZ0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PNZ0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"22564","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000533888.1","properties":[{"key":"ProteinId","value":"ENSP00000437065.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000631550.1","properties":[{"key":"ProteinId","value":"ENSP00000488419.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qze.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WTLLEEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSR","length":153,"molWeight":17130,"crc64":"37C2933C6B5703C0","md5":"7DDBAAB3CB71AA12D7511539B302DF19"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0003F47F72"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PRF1","uniProtkbId":"E9PRF1_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":88,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Non-terminal residue","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PRF1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PRF1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000432351.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PRF1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PRF1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"23298","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000529854.1","properties":[{"key":"ProteinId","value":"ENSP00000432351.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000631917.1","properties":[{"key":"ProteinId","value":"ENSP00000488563.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qyz.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_3162382_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WTLLEEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSW","length":48,"molWeight":5369,"crc64":"70836087A9E87264","md5":"651C73FC76B3A13E9E21F4BDE61DEFCB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78581"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PQR9","uniProtkbId":"E9PQR9_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":95,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"}],"value":"GSDMD"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004308"}],"value":"Endomembrane system","id":"SL-0147"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009279"}],"value":"Belongs to the gasdermin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Gasdermin pore forming","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04598"}]},{"type":"Non-terminal residue","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PQR9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PQR9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15592455","citationType":"journal article","authors":["Rush J.","Moritz A.","Lee K.A.","Guo A.","Goss V.L.","Spek E.J.","Zhang H.","Zha X.M.","Polakiewicz R.D.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"15592455"},{"database":"DOI","id":"10.1038/nbt1046"}],"title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.","publicationDate":"2005","journal":"Nat. Biotechnol.","firstPage":"94","lastPage":"101","volume":"23"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"15592455"}]},{"referenceNumber":4,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000434386.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9PQR9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"E9PQR9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"23099","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"27909","properties":[{"key":"antibodies","value":"208 antibodies from 34 providers"}]},{"database":"Ensembl","id":"ENST00000533348.5","properties":[{"key":"ProteinId","value":"ENSP00000434386.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000633391.1","properties":[{"key":"ProteinId","value":"ENSP00000487934.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qza.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_144519_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WTLLEEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR040460","properties":[{"key":"EntryName","value":"Gasdermin_pore"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04598","properties":[{"key":"EntryName","value":"Gasdermin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVL","length":164,"molWeight":18320,"crc64":"E158F47315732D57","md5":"3407F7AEAC5FDE8ED1727991B8F260A5"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78582"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YDB0","uniProtkbId":"H0YDB0_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2012-02-22","entryVersion":76,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"}],"value":"Gasdermin D"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"}],"value":"GSDMD"}}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Gasdermin PUB","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF17708"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YDB0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YDB0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16421571","citationType":"journal article","authors":["Nusbaum C.","Mikkelsen T.S.","Zody M.C.","Asakawa S.","Taudien S.","Garber M.","Kodira C.D.","Schueler M.G.","Shimizu A.","Whittaker C.A.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Yang X.","Allen N.R.","Anderson S.","Asakawa T.","Blechschmidt K.","Bloom T.","Borowsky M.L.","Butler J.","Cook A.","Corum B.","DeArellano K.","DeCaprio D.","Dooley K.T.","Dorris L.III.","Engels R.","Glockner G.","Hafez N.","Hagopian D.S.","Hall J.L.","Ishikawa S.K.","Jaffe D.B.","Kamat A.","Kudoh J.","Lehmann R.","Lokitsang T.","Macdonald P.","Major J.E.","Matthews C.D.","Mauceli E.","Menzel U.","Mihalev A.H.","Minoshima S.","Murayama Y.","Naylor J.W.","Nicol R.","Nguyen C.","O'Leary S.B.","O'Neill K.","Parker S.C.","Polley A.","Raymond C.K.","Reichwald K.","Rodriguez J.","Sasaki T.","Schilhabel M.","Siddiqui R.","Smith C.L.","Sneddon T.P.","Talamas J.A.","Tenzin P.","Topham K.","Venkataraman V.","Wen G.","Yamazaki S.","Young S.K.","Zeng Q.","Zimmer A.R.","Rosenthal A.","Birren B.W.","Platzer M.","Shimizu N.","Lander E.S."],"citationCrossReferences":[{"database":"PubMed","id":"16421571"},{"database":"DOI","id":"10.1038/nature04406"}],"title":"DNA sequence and analysis of human chromosome 8.","publicationDate":"2006","journal":"Nature","firstPage":"331","lastPage":"335","volume":"439"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":5,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"25944712"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000433263.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC067930","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"ProteomicsDB","id":"37334","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000525208.1","properties":[{"key":"ProteinId","value":"ENSP00000433263.1"},{"key":"GeneId","value":"ENSG00000104518.12"}]},{"database":"Ensembl","id":"ENST00000632705.1","properties":[{"key":"ProteinId","value":"ENSP00000487774.1"},{"key":"GeneId","value":"ENSG00000278718.3"}]},{"database":"UCSC","id":"uc064qzl.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:25697","properties":[{"key":"GeneName","value":"GSDMD"}]},{"database":"OpenTargets","id":"ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000104518","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183140","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1207202_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9035105at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"GSDMD","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"Bgee","id":"ENSG00000104518","properties":[{"key":"ExpressionPatterns","value":"Expressed in spleen and 97 other cell types or tissues"}]},{"database":"InterPro","id":"IPR007677","properties":[{"key":"EntryName","value":"Gasdermin"}]},{"database":"InterPro","id":"IPR041263","properties":[{"key":"EntryName","value":"Gasdermin_PUB"}]},{"database":"PANTHER","id":"PTHR16399","properties":[{"key":"EntryName","value":"GASDERMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR16399:SF15","properties":[{"key":"EntryName","value":"GASDERMIN-D"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17708","properties":[{"key":"EntryName","value":"Gasdermin_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELPLGAECPVAGAQHHVPAPRAPGEQLGRRSTGLGLAGRVWPRAGGGHSPRVLGAAGPGPHVCTLRLPGTAIRTEPGAPLACARAWPGSSPAGQSVCPPAASPRKARSPVAMWPVYHGAQELGKHNKGGIRRK","length":231,"molWeight":23914,"crc64":"89588282632411A5","md5":"022D3D28C5E9DE166DDBA90ADE685AE5"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F78586"}}]}