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Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P13265"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8CFZ4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610063"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16227623"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17549790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24496449"}],"value":"Heterodimer; disulfide-linked (PubMed:14610063). 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Cleavage is not required for stimulation of Wnt signaling or HCC growth (PubMed:16227623)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glypican family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/156/GPC3","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29345911"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Glypican-3 alpha subunit","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14610063"}],"featureId":"PRO_0000445410"},{"type":"Chain","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"Glypican-3 beta subunit","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14610063"}],"featureId":"PRO_0000445411"},{"type":"Propeptide","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":580,"modifier":"EXACT"}},"description":"Removed in mature form","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000012310"},{"type":"Site","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Cleavage","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610063"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15059894"}]},{"type":"Modified residue","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Pyrrolidone carboxylic acid","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29345911"}]},{"type":"Modified residue","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Lipidation","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":554,"modifier":"EXACT"}},"description":"GPI-anchor amidated asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29345911"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29345911"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29345911"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"O-linked (Xyl...) 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