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Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:18984161). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (PubMed:18984161, PubMed:9323129). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (PubMed:31799625). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (PubMed:16314521, PubMed:21816274, PubMed:31799625)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10500148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11714716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17178713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21816274"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22607171"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23022347"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26092730"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31799625"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9323129"}],"value":"Monomer (PubMed:26092730). Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:11714716, PubMed:16314521, PubMed:17178713, PubMed:9323129). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:16314521, PubMed:18984161, PubMed:9323129). Interacts with GEMIN5; the interaction is direct (PubMed:11714716, PubMed:17178713). Interacts (via C-terminus) with SMN1; the interaction is direct (PubMed:10500148, PubMed:17178713, PubMed:21816274, PubMed:22607171, PubMed:23022347, PubMed:26092730, PubMed:31799625). Interacts with SNRPD1; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts with SNRPD2; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPF; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPE; the interaction is direct (PubMed:21816274, PubMed:31799625). Interacts (via N-terminus) with SNRPG; the interaction is direct (PubMed:21816274)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"Q8N7W2-2","geneName":"BEND7","intActId":"EBI-10181188"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"P28358","geneName":"HOXD10","intActId":"EBI-12690664"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"Q0VD86","geneName":"INCA1","intActId":"EBI-6509505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"O60684","geneName":"KPNA6","intActId":"EBI-359923"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"P50221","geneName":"MEOX1","intActId":"EBI-2864512"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"P26367","geneName":"PAX6","intActId":"EBI-747278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"P20618","geneName":"PSMB1","intActId":"EBI-372273"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"O95059","geneName":"RPP14","intActId":"EBI-366542"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"Q16637","geneName":"SMN2","intActId":"EBI-395421"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"Q16637-2","geneName":"SMN2","intActId":"EBI-16014970"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"P62306","geneName":"SNRPF","intActId":"EBI-356900"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O14893","intActId":"EBI-443648"},"interactantTwo":{"uniProtKBAccession":"Q9NZD8","geneName":"SPG21","intActId":"EBI-742688"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. 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